ATE512T1 - NEW IMIDAZO(2.1-B)-(1.3.4)-THIADIAZOLS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. - Google Patents

NEW IMIDAZO(2.1-B)-(1.3.4)-THIADIAZOLS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.

Info

Publication number
ATE512T1
ATE512T1 AT79101541T AT79101541T ATE512T1 AT E512 T1 ATE512 T1 AT E512T1 AT 79101541 T AT79101541 T AT 79101541T AT 79101541 T AT79101541 T AT 79101541T AT E512 T1 ATE512 T1 AT E512T1
Authority
AT
Austria
Prior art keywords
thiadiazols
preparation
pharmaceuticals containing
new imidazo
compounds
Prior art date
Application number
AT79101541T
Other languages
German (de)
Inventor
Harald Dr. Horstmann
Karl-August Dr. Meng
Friedel Dr. Seuter
Eike Dr. Moeller
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE512T1 publication Critical patent/ATE512T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to certain new imidazo [2,1-b]-[1,3,4]-thiadiazole compounds, to the provision of pharmaceutical compositions containing said compounds and to the use of said compounds and compositions as antithrombotic agents and thrombolytic agents.
AT79101541T 1978-05-31 1979-05-21 NEW IMIDAZO(2.1-B)-(1.3.4)-THIADIAZOLS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. ATE512T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782823686 DE2823686A1 (en) 1978-05-31 1978-05-31 IMIDAZO SQUARE BRACKETS ON 2.1 SQUARE BRACKETS FOR SQUARE BRACKETS ON 1.3.4 SQUARE BRACKETS FOR -THIADIAZOLE
EP79101541A EP0005783B1 (en) 1978-05-31 1979-05-21 Imidazo (2.1-b)-(1.3.4)-thiadiazoles, process for their preparation and their use in medicaments

Publications (1)

Publication Number Publication Date
ATE512T1 true ATE512T1 (en) 1982-01-15

Family

ID=6040588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101541T ATE512T1 (en) 1978-05-31 1979-05-21 NEW IMIDAZO(2.1-B)-(1.3.4)-THIADIAZOLS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.

Country Status (12)

Country Link
US (1) US4265898A (en)
EP (1) EP0005783B1 (en)
JP (1) JPS54157564A (en)
AT (1) ATE512T1 (en)
AU (1) AU523229B2 (en)
CA (1) CA1128941A (en)
DE (2) DE2823686A1 (en)
DK (1) DK225579A (en)
ES (1) ES481155A1 (en)
FI (1) FI66390C (en)
HU (1) HU179411B (en)
IL (1) IL57420A (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO811630L (en) * 1980-05-29 1981-11-30 Bayer Ag IMIDAZOAZOLYLIC ACID AMOIDS, NEW INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, THEIR PREPARATION AND THEIR USE AS A MEDICINE
IT8148047A0 (en) * 1981-03-18 1981-03-18 Manetti & Roberts Italo Brit ORGANIC COMPOUNDS DERIVED FROM 2-AMI NO-5-(O-SULFAMIDOPHENIL)-1,3,4-THIADIAZOLE THEIR THERAPEUTIC APPLICATION AND PROCEDURE FOR THEIR PREPARATION
DE3208437A1 (en) * 1982-03-09 1983-09-15 Bayer Ag, 5090 Leverkusen IMIDAZOTHIADIAZOLALKENCARBONIC ACID AMIDES, NEW INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
US4968494A (en) * 1987-03-27 1990-11-06 Merck & Co., Inc. Methods and compositions for thrombolytic therapy
US5077285A (en) * 1989-07-31 1991-12-31 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5030644A (en) * 1989-07-31 1991-07-09 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5021440A (en) * 1989-07-31 1991-06-04 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US4968713A (en) * 1989-07-31 1990-11-06 Merck & Co., Inc. Certain imidazole compounds as transglutaminase inhibitors
US5019572A (en) * 1990-02-07 1991-05-28 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5047416A (en) * 1989-07-31 1991-09-10 Merck & Co., Inc. Triazole compounds and their use as transglutaminase inhibitors
US8173661B2 (en) 2006-11-08 2012-05-08 The Rockefeller University Alpha-IIB-beta-3 inhibitors and uses thereof
EP2593106A4 (en) 2010-07-16 2014-01-01 Univ Rockefeller ORGANIC COMPOUNDS
EP2804610B1 (en) * 2012-01-16 2018-10-31 The Rockefeller University Organic compounds
WO2013163244A1 (en) * 2012-04-26 2013-10-31 Bristol-Myers Squibb Company Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
AU2013251680A1 (en) * 2012-04-26 2014-11-13 Bristol-Myers Squibb Company Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
BR112014026643B1 (en) 2012-04-26 2023-03-07 Universite De Montreal IMIDAZOTIADIAZOLE AND IMIDAZOPIRAZINE DERIVATIVES AS PROTEASE-ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR THE TREATMENT OF PLATELET AGGREGATION, THEIR USES AND PHARMACEUTICAL COMPOSITION
EP2682395A1 (en) * 2012-07-04 2014-01-08 Laboratorios Del. Dr. Esteve, S.A. Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
US9598419B1 (en) 2014-06-24 2017-03-21 Universite De Montreal Imidazotriazine and imidazodiazine compounds
US9617279B1 (en) 2014-06-24 2017-04-11 Bristol-Myers Squibb Company Imidazooxadiazole compounds
WO2017184520A1 (en) * 2016-04-18 2017-10-26 Vanderbilt University Substituted and fused 6-membered protease activated receptor 4 (par-4) antagonists
CN112074522B (en) * 2018-05-16 2022-08-26 深圳信立泰药业股份有限公司 Compounds as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation
CN112074521B (en) * 2018-05-16 2022-08-09 深圳信立泰药业股份有限公司 Compounds as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation
CN112770747A (en) * 2018-06-19 2021-05-07 塞莱科治疗股份有限公司 Deuterated RUC-4
US20250042920A1 (en) * 2021-11-29 2025-02-06 Ocean University Of China Imidazothiazole derivative, preparation method therefor, and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3726891A (en) * 1970-12-02 1973-04-10 Shell Oil Co Fused 1,2,4-thiadiazolines
US3804823A (en) * 1972-02-15 1974-04-16 Eastman Kodak Co Heterocyclic containing monoazo compounds
GB1464259A (en) * 1975-10-03 1977-02-09 Pfizer Ltd Imidazo-thiazole and -thiadiazole sulphonamides and their use as therapeutic agents
US4042372A (en) * 1976-11-19 1977-08-16 Eli Lilly And Company Substituted thiadiazolotriazinediones and method of preparation

Also Published As

Publication number Publication date
IL57420A (en) 1983-06-15
EP0005783B1 (en) 1981-12-30
DE2823686A1 (en) 1979-12-06
DE2961667D1 (en) 1982-02-18
JPS54157564A (en) 1979-12-12
CA1128941A (en) 1982-08-03
ES481155A1 (en) 1979-11-16
FI66390C (en) 1984-10-10
IL57420A0 (en) 1979-09-30
FI66390B (en) 1984-06-29
AU4760679A (en) 1979-12-06
AU523229B2 (en) 1982-07-15
EP0005783A1 (en) 1979-12-12
FI791708A (en) 1979-12-01
US4265898A (en) 1981-05-05
HU179411B (en) 1982-10-28
DK225579A (en) 1979-12-01

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