AU7518694A - Retroviral protease inhibitors and combinations thereof - Google Patents

Retroviral protease inhibitors and combinations thereof

Info

Publication number
AU7518694A
AU7518694A AU75186/94A AU7518694A AU7518694A AU 7518694 A AU7518694 A AU 7518694A AU 75186/94 A AU75186/94 A AU 75186/94A AU 7518694 A AU7518694 A AU 7518694A AU 7518694 A AU7518694 A AU 7518694A
Authority
AU
Australia
Prior art keywords
combinations
protease inhibitors
retroviral protease
retroviral
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU75186/94A
Inventor
Min S Chang
Daniel P. Getman
Richard A. Mueller
James C Ottinger
James C Stolzenbach
John J Talley
Michael L Vazquez
Gary A. De Crescenzo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/253,531 external-priority patent/US5750648A/en
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Publication of AU7518694A publication Critical patent/AU7518694A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU75186/94A 1993-08-20 1994-08-09 Retroviral protease inhibitors and combinations thereof Abandoned AU7518694A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10978793A 1993-08-20 1993-08-20
US08/253,531 US5750648A (en) 1993-08-20 1994-06-03 Retroviral protease inhibitors and combinations thereof
PCT/US1994/008697 WO1995006061A1 (en) 1993-08-20 1994-08-09 Retroviral protease inhibitors and combinations thereof
US109787 2002-03-28
US253531 2005-10-18

Publications (1)

Publication Number Publication Date
AU7518694A true AU7518694A (en) 1995-03-21

Family

ID=26807360

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75186/94A Abandoned AU7518694A (en) 1993-08-20 1994-08-09 Retroviral protease inhibitors and combinations thereof

Country Status (3)

Country Link
AU (1) AU7518694A (en)
IL (1) IL110724A (en)
WO (1) WO1995006061A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
DE69830241T2 (en) * 1997-02-14 2006-01-26 G.D. Searle Llc, Chicago USE OF N-SUBSTITUTED 1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS IN COMBINATION THERAPY OF INFECTIONS CAUSED BY HEPATITISVIRUS
EP1030839B1 (en) 1997-11-10 2004-02-04 G.D. SEARLE & CO. Use of alkylated iminosugars to treat multidrug resistance
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ES2272054T3 (en) 1998-02-12 2007-04-16 United Therapeutics Corporation USE OF N-SUBSTITUTED-1,5-DIDESOXI-1,5-IMINO-D-GLUCITOL COMPOUNDS TO TREAT INFECTIONS BY HEPATITIS VIRUSES.
AU3858600A (en) 1999-02-12 2001-02-19 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
AU3595500A (en) 1999-02-12 2000-08-29 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
ES2387579T3 (en) 2000-01-19 2012-09-26 Abbott Laboratories Pharmaceutical formulations of enhanced HIV protease inhibitors
CN102816111B (en) 2007-03-12 2014-08-06 尼克塔治疗公司 Oligomer-protease inhibitor conjugates
US9095620B2 (en) 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
WO2010144869A2 (en) 2009-06-12 2010-12-16 Nektar Therapeutics Protease inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69130070T2 (en) * 1990-11-19 1999-04-29 Monsanto Co., St. Louis, Mo. RETROVIRAL PROTEASE INHIBITORS
DK0641333T3 (en) * 1992-05-20 1996-09-02 Monsanto Co Process for the preparation of intermediates useful in the synthesis of retrovirus protease inhibitors

Also Published As

Publication number Publication date
IL110724A0 (en) 1994-11-11
IL110724A (en) 1999-08-17
WO1995006061A1 (en) 1995-03-02

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