BE875475A - Iminoquinazolines - Google Patents

Iminoquinazolines

Info

Publication number
BE875475A
BE875475A BE0/194524A BE194524A BE875475A BE 875475 A BE875475 A BE 875475A BE 0/194524 A BE0/194524 A BE 0/194524A BE 194524 A BE194524 A BE 194524A BE 875475 A BE875475 A BE 875475A
Authority
BE
Belgium
Prior art keywords
iminoquinazolines
Prior art date
Application number
BE0/194524A
Other languages
English (en)
Inventor
W Beverung
R Partyka
T Jenks
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE875475A publication Critical patent/BE875475A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE0/194524A 1978-04-10 1979-04-10 Iminoquinazolines BE875475A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/894,464 US4146718A (en) 1978-04-10 1978-04-10 Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides

Publications (1)

Publication Number Publication Date
BE875475A true BE875475A (fr) 1979-10-10

Family

ID=25403115

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/194524A BE875475A (fr) 1978-04-10 1979-04-10 Iminoquinazolines

Country Status (19)

Country Link
US (1) US4146718A (fr)
JP (2) JPS54135794A (fr)
AU (1) AU527748B2 (fr)
BE (1) BE875475A (fr)
CA (1) CA1109067A (fr)
CH (1) CH639079A5 (fr)
DE (1) DE2914494A1 (fr)
DK (1) DK156062C (fr)
FI (1) FI66616C (fr)
FR (1) FR2422649A1 (fr)
GB (1) GB2018765B (fr)
GR (1) GR72937B (fr)
HU (2) HU179424B (fr)
IE (1) IE48150B1 (fr)
NL (1) NL191182C (fr)
SE (2) SE445217B (fr)
SU (1) SU1120923A3 (fr)
YU (1) YU40554B (fr)
ZA (1) ZA791727B (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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US4739056A (en) * 1986-11-26 1988-04-19 Syntex (U.S.A.) Inc. N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds
US5391737A (en) * 1991-05-22 1995-02-21 Egis Gyogyszergyar Process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one
JPH05271200A (ja) * 1991-05-22 1993-10-19 Egyt Gyogyszervegyeszeti Gyar ６，７−ジクロロ−１，５−ジヒドロ−イミダゾ〔２，１−ｂ〕キナゾリン−２〔３Ｈ〕−オンの製造方法
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US6187779B1 (en) 1998-11-20 2001-02-13 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en) 1998-11-23 2002-04-09 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted benzimidazole derivatives
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EP1216037A2 (fr) 1999-09-21 2002-06-26 Emory University Procedes et compositions pour le traitement de troubles lies aux plaquettes au moyen d'agents inhibiteurs de trajet de mpl
US6194420B1 (en) * 1999-11-30 2001-02-27 Roberts Laboratories Inc. 2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof
US6555547B1 (en) 2000-02-28 2003-04-29 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
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US6388073B1 (en) 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
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EP1589973B2 (fr) * 2003-01-23 2012-12-26 Shire Biopharmaceuticals Holdings Ireland Limited Formulation et methodes de traitement de la thrombocythemie
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US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
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EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
WO2007047978A2 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
EP2314289A1 (fr) 2005-10-31 2011-04-27 Braincells, Inc. Modulation de la neurogenese dont la médiation est assurée par récepteur gaba
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US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7678808B2 (en) * 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
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CA2663347A1 (fr) * 2006-09-19 2008-03-27 Braincells, Inc. Modulation induite par ppar de la neurogenese
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623749D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8304420B2 (en) * 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
AR064106A1 (es) 2006-12-05 2009-03-11 Bayer Schering Pharma Ag Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
KR20090115151A (ko) * 2007-02-06 2009-11-04 씨아이피엘에이 엘티디. 에틸-ｎ-(2,3-디클로로-6-니트로벤질)글라이신 염산염의 제조방법
CN101463035A (zh) * 2007-12-19 2009-06-24 华生制药私人有限公司 生产盐酸阿那格雷一水合物的改进方法
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
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WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
EP2945948B1 (fr) 2013-01-18 2020-04-29 Synthon BV Forme cristalline ii de chlorhydrate d'anagrélide monohydraté
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CN107903217B (zh) * 2017-11-16 2021-11-23 湖北省宏源药业科技股份有限公司 一种阿那格雷杂质b的制备方法
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
GR72937B (fr) 1984-01-13
JPH0312066B2 (fr) 1991-02-19
ZA791727B (en) 1980-05-28
SE8404061L (sv) 1984-08-10
SE7903198L (sv) 1979-10-11
JPH0222276A (ja) 1990-01-25
IE790753L (en) 1979-10-10
US4146718A (en) 1979-03-27
DK156062B (da) 1989-06-19
GB2018765A (en) 1979-10-24
FI66616C (fi) 1984-11-12
JPS54135794A (en) 1979-10-22
SE445217B (sv) 1986-06-09
DE2914494C2 (fr) 1989-07-20
CA1109067A (fr) 1981-09-15
NL7902825A (nl) 1979-10-12
FR2422649A1 (fr) 1979-11-09
GB2018765B (en) 1982-08-04
FI66616B (fi) 1984-07-31
IE48150B1 (en) 1984-10-17
HU179424B (en) 1982-10-28
DK156062C (da) 1989-11-06
NL191182C (nl) 1995-03-01
AU527748B2 (en) 1983-03-24
SU1120923A3 (ru) 1984-10-23
FR2422649B1 (fr) 1983-07-29
FI791125A (fi) 1979-10-11
AU4588979A (en) 1979-10-18
HU187562B (en) 1986-01-28
JPH0233035B2 (fr) 1990-07-25
YU40554B (en) 1986-02-28
SE8404061D0 (sv) 1984-08-10
DK144779A (da) 1979-10-11
SE454990B (sv) 1988-06-13
CH639079A5 (de) 1983-10-31
DE2914494A1 (de) 1979-10-18
YU83079A (en) 1983-12-31
NL191182B (nl) 1994-10-03

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: BRISTOL-MYERS CY

Effective date: 19990410