BG102174A - Ароматни съединения и фармацевтични състави, които ги съдържат - Google Patents

Ароматни съединения и фармацевтични състави, които ги съдържат

Info

Publication number
BG102174A
BG102174A BG102174A BG10217498A BG102174A BG 102174 A BG102174 A BG 102174A BG 102174 A BG102174 A BG 102174A BG 10217498 A BG10217498 A BG 10217498A BG 102174 A BG102174 A BG 102174A
Authority
BG
Bulgaria
Prior art keywords
hydroxybenzylamino
benzoic
dihydroxybenzylamino
hydroxybenzoic
alkyl
Prior art date
Application number
BG102174A
Other languages
English (en)
Other versions
BG63778B1 (bg
Inventor
Gloria Breault
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512475.6A external-priority patent/GB9512475D0/en
Priority claimed from GBGB9601465.9A external-priority patent/GB9601465D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BG102174A publication Critical patent/BG102174A/bg
Publication of BG63778B1 publication Critical patent/BG63778B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретението се отнася до съединения с формула, в която А в даден случай означава заместена пръстенна система при условие, че групите -СН(R3)N(R2)B-R1 и -OD се намират в положение 1,2 една къмдруга при пръстенни въглеродни атоми, и пръстенният въглероден атом, разположен на ортомясто по отношение на -OD-свързващата група (следователно на 3-о място по отношение на свързващата група -СНR3NR2-), нее заместен; В в даден е случай заместена пръстенна система; R1 се намира в пръстен В в положение 1,3 или 1,4 по отношение на свързващата група -СН(R3)N(R2)- и има значенията, посочени в описанието; R2 е водород, С1-С6 алкил, в даден случай заместен с хидрокси, циано или трифлуорметил, С2-С6 алкенил(при условие, че двойната връзка не е на 1-о място), С2-С6 алкинил (при условие, че тройнатавръзка не е на 1-во място), фенил С1-С3 алкил или пиридилС1-С3 алкил; R3 е водород, метил или етил; D е водород, евентуално заместен 5-7-членен карбоциклен пръстен, съдържащ една двойна връзка, С1-С3 алкил,заместен в даден случай със заместен 5-7-членен карбоциклен пръстен, съдържащ една двойна връзка, или D е група с формула -(СН2)nCH(R4)C(R5)=C(R6)R7 и N-оксиди на -NR2, когато е химически възможно; S-оксиди на пръстени съдържащи сяра, когато е химически възможно. Изобретението се отнася и до техни фармацевтично приемливи соли и in vivo хидролизуеми естери и техни амиди, с изключение на 4-[5-карбокси-2-хидроксибензиламино]бензоена, 4-[2,5-дихидроксибензиламино]бензоена, 5-[2-хидроксибе
BG102174A 1995-06-20 1998-01-09 Ароматни съединения и фармацевтични състави, които ги съдържат BG63778B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9512475.6A GB9512475D0 (en) 1995-06-20 1995-06-20 Aromatic compounds
GBGB9601465.9A GB9601465D0 (en) 1996-01-25 1996-01-25 Aromatic compounds
PCT/GB1996/001443 WO1997000864A1 (en) 1995-06-20 1996-06-17 Aromatic compounds and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
BG102174A true BG102174A (bg) 1998-09-30
BG63778B1 BG63778B1 (bg) 2002-12-29

Family

ID=26307242

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102174A BG63778B1 (bg) 1995-06-20 1998-01-09 Ароматни съединения и фармацевтични състави, които ги съдържат

Country Status (29)

Country Link
US (2) US6100258A (bg)
EP (1) EP0847391B1 (bg)
JP (1) JP3949167B2 (bg)
KR (1) KR19990023007A (bg)
CN (1) CN1114598C (bg)
AR (1) AR004670A1 (bg)
AT (1) ATE211132T1 (bg)
AU (1) AU699691B2 (bg)
BG (1) BG63778B1 (bg)
BR (1) BR9608908A (bg)
CA (1) CA2220529A1 (bg)
CZ (1) CZ290924B6 (bg)
DE (1) DE69618210T2 (bg)
DK (1) DK0847391T3 (bg)
EE (1) EE9700342A (bg)
ES (1) ES2169248T3 (bg)
HR (1) HRP960289B1 (bg)
HU (1) HUP9802705A3 (bg)
IL (1) IL118663A (bg)
MX (1) MX9710261A (bg)
MY (1) MY132432A (bg)
NO (1) NO311131B1 (bg)
NZ (1) NZ311083A (bg)
PL (1) PL324166A1 (bg)
PT (1) PT847391E (bg)
RU (1) RU2198878C2 (bg)
SK (1) SK282458B6 (bg)
TW (1) TW502026B (bg)
WO (1) WO1997000864A1 (bg)

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IL118663A0 (en) 1996-10-31
HRP960289A2 (en) 1997-12-31
KR19990023007A (ko) 1999-03-25
IL118663A (en) 2001-04-30
PL324166A1 (en) 1998-05-11
MX9710261A (es) 1998-03-29
NZ311083A (en) 2000-01-28
CZ411097A3 (cs) 1998-03-18
AU6232196A (en) 1997-01-22
BR9608908A (pt) 1999-03-02
EE9700342A (et) 1998-06-15
CN1114598C (zh) 2003-07-16
CZ290924B6 (cs) 2002-11-13
BG63778B1 (bg) 2002-12-29
HRP960289B1 (en) 2002-10-31
DE69618210T2 (de) 2002-07-18
CA2220529A1 (en) 1997-01-09
HUP9802705A3 (en) 1999-03-29
SK282458B6 (sk) 2002-02-05
NO975984L (no) 1997-12-19
RU2198878C2 (ru) 2003-02-20
CN1193966A (zh) 1998-09-23
JPH11507939A (ja) 1999-07-13
PT847391E (pt) 2002-06-28
US6100258A (en) 2000-08-08
TW502026B (en) 2002-09-11
NO975984D0 (no) 1997-12-19
DK0847391T3 (da) 2002-03-25
NO311131B1 (no) 2001-10-15
EP0847391A1 (en) 1998-06-17
WO1997000864A1 (en) 1997-01-09
EP0847391B1 (en) 2001-12-19
AR004670A1 (es) 1999-03-10
SK173397A3 (en) 1998-07-08
ES2169248T3 (es) 2002-07-01
MY132432A (en) 2007-10-31
DE69618210D1 (de) 2002-01-31
US6313148B1 (en) 2001-11-06
ATE211132T1 (de) 2002-01-15
AU699691B2 (en) 1998-12-10
HUP9802705A2 (hu) 1999-02-01
JP3949167B2 (ja) 2007-07-25

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