CO4940447A1 - TRICYCLIC COMPOUNDS USEFUL AS INHIBITORS OF THE TRANSFER RASA OF PROTEIN TO FARNESILO - Google Patents

TRICYCLIC COMPOUNDS USEFUL AS INHIBITORS OF THE TRANSFER RASA OF PROTEIN TO FARNESILO

Info

Publication number
CO4940447A1
CO4940447A1 CO98034143A CO98034143A CO4940447A1 CO 4940447 A1 CO4940447 A1 CO 4940447A1 CO 98034143 A CO98034143 A CO 98034143A CO 98034143 A CO98034143 A CO 98034143A CO 4940447 A1 CO4940447 A1 CO 4940447A1
Authority
CO
Colombia
Prior art keywords
protein
farnesilo
rasa
inhibitors
transfer
Prior art date
Application number
CO98034143A
Other languages
Spanish (es)
Inventor
Alan B Cooper
A Desai Jagdish
K Sansena Anil
James J-S Wang
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4940447A1 publication Critical patent/CO4940447A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen nuevos compuestos de fórmulaAsí mismo se describe un método para inhibir la función transferasa de proteína al farnesilo y porlo tanto para inhibir el desarrollo anormal de las células. El método comprende administrar uncompuesto de la precedente fórmula a un sistema biológico. En particular, el método inhibe eldesarrollo anormal de las células en un mamífero tal como un ser humano. También se describe unmétodo para provocar una respuesta antialérgica mediante la administración de estos compuestos.Novel compounds of formula are described. A method is also described to inhibit the protein transferase function to farnesyl and therefore to inhibit abnormal cell development. The method comprises administering a compound of the preceding formula to a biological system. In particular, the method inhibits abnormal cell development in a mammal such as a human. Also described is a method of eliciting an allergy response by administering these compounds.

CO98034143A 1997-06-17 1998-06-16 TRICYCLIC COMPOUNDS USEFUL AS INHIBITORS OF THE TRANSFER RASA OF PROTEIN TO FARNESILO CO4940447A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87774397A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
CO4940447A1 true CO4940447A1 (en) 2000-07-24

Family

ID=25370623

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98034143A CO4940447A1 (en) 1997-06-17 1998-06-16 TRICYCLIC COMPOUNDS USEFUL AS INHIBITORS OF THE TRANSFER RASA OF PROTEIN TO FARNESILO

Country Status (13)

Country Link
EP (1) EP0989984A1 (en)
JP (1) JP2002504145A (en)
KR (1) KR20010013825A (en)
CN (1) CN1266432A (en)
AR (1) AR015122A1 (en)
AU (1) AU744153B2 (en)
CA (1) CA2293713C (en)
CO (1) CO4940447A1 (en)
HU (1) HUP0004274A3 (en)
IL (1) IL133388A0 (en)
NZ (1) NZ501418A (en)
WO (1) WO1998057961A1 (en)
ZA (1) ZA985214B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102548986A (en) 2009-06-05 2012-07-04 链接医药公司 Aminopyrrolidinone derivatives and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them
DK0723538T3 (en) * 1993-10-15 2002-03-18 Schering Corp Tricyclic carbamate compounds useful for inhibition of G protein function and for the treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
EP1380581A1 (en) * 1995-12-22 2004-01-14 Schering Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
AU8058198A (en) 1999-01-04
AU744153B2 (en) 2002-02-14
CA2293713A1 (en) 1998-12-23
EP0989984A1 (en) 2000-04-05
KR20010013825A (en) 2001-02-26
WO1998057961A1 (en) 1998-12-23
IL133388A0 (en) 2001-04-30
ZA985214B (en) 1999-01-07
NZ501418A (en) 2001-04-27
HUP0004274A2 (en) 2001-08-28
CA2293713C (en) 2006-12-05
CN1266432A (en) 2000-09-13
AR015122A1 (en) 2001-04-18
HUP0004274A3 (en) 2002-03-28
JP2002504145A (en) 2002-02-05

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