CU23526B6 - Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética - Google Patents
Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabéticaInfo
- Publication number
- CU23526B6 CU23526B6 CU20060192A CU20060192A CU23526B6 CU 23526 B6 CU23526 B6 CU 23526B6 CU 20060192 A CU20060192 A CU 20060192A CU 20060192 A CU20060192 A CU 20060192A CU 23526 B6 CU23526 B6 CU 23526B6
- Authority
- CU
- Cuba
- Prior art keywords
- peripheral nerves
- restoration
- diabetic neuropathy
- morfofunctional
- manifestations
- Prior art date
Links
- 210000000578 peripheral nerve Anatomy 0.000 title abstract 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 abstract 4
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 2
- 206010029240 Neuritis Diseases 0.000 abstract 2
- 229940116977 epidermal growth factor Drugs 0.000 abstract 2
- 230000008595 infiltration Effects 0.000 abstract 2
- 238000001764 infiltration Methods 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 1
- 229940035674 anesthetics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000000609 ganglia Anatomy 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 208000005877 painful neuropathy Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención es aplicable en medicina humana, y se relaciona con un método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética de tipo sensitivo motora, dolorosa; y las manifestaciones de neuritis isquémica, mediante la infiltración del Factor de Crecimiento Epidérmico (del inglés Epidermal Growth Factor, abreviado EGF). También incluye una composición que comprende EGF, el que puede ser formulado junto a anestésicos o analgésicos, o encapsulado en microesferas; que se administra mediante infiltración en la periferia de troncos y/o ganglios neviosos, para la restauración morfofuncional de nervios periféricos en la neuropatía sensitivo-motora, dolorosa, así como las manifestaciones de neuritis isquémica.
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060192A CU23526B6 (es) | 2006-10-03 | 2006-10-03 | Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética |
US12/443,837 US8642552B2 (en) | 2006-10-03 | 2007-10-01 | Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy |
DK07817382.0T DK2075004T3 (da) | 2006-10-03 | 2007-10-01 | Anvendelse af epidermal vækstfaktor til morphofunktionel genoprettelse af perifere nerver ved diabetisk neuropati |
PL07817382T PL2075004T3 (pl) | 2006-10-03 | 2007-10-01 | Zastosowanie naskórkowego czynnika wzrostu do odbudowy morfofunkcjonalnej nerwów obwodowych w neuropatii cukrzycowej |
BRPI0719816A BRPI0719816B8 (pt) | 2006-10-03 | 2007-10-01 | uso do fator de crescimento epidérmico (egf) humano para preparar uma composição farmacêutica injetável para a restauração morfofuncional de nervos periféricos em neuropatia diabética e a referida composição |
PCT/CU2007/000018 WO2008040260A1 (es) | 2006-10-03 | 2007-10-01 | Uso del factor de crecimiento epidérmico para la restauración morfofuncional de nervios periféricos en la neuropatía diabética |
PT07817382T PT2075004E (pt) | 2006-10-03 | 2007-10-01 | Uso de fator de crescimento epidérmico na restauração morfofuncional de nervos periféricos na neuropatia diabética |
EP07817382A EP2075004B1 (en) | 2006-10-03 | 2007-10-01 | Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy |
JP2009530751A JP5508853B2 (ja) | 2006-10-03 | 2007-10-01 | 糖尿病性神経障害における末梢神経の形態機能的回復のための上皮増殖因子の使用 |
ARP070104350A AR063088A1 (es) | 2006-10-03 | 2007-10-01 | Uso del factor de crecimiento epidermico para la restauracion morfofuncoional de nervios perifericos en la neuropatia diabetica |
RU2009116646/15A RU2460536C2 (ru) | 2006-10-03 | 2007-10-01 | Применение эпидермального фактора роста для морфофункционального восстановления периферических нервов при диабетической невропатии |
KR1020097009188A KR101464208B1 (ko) | 2006-10-03 | 2007-10-01 | 당뇨성 신경병증에서 말초 신경의 형태기능의 복원을 위한 상피 성장인자의 용도 |
MX2009003678A MX2009003678A (es) | 2006-10-03 | 2007-10-01 | Uso del factor de crecimiento epidermico para la restauracion morfofuncional de nervios perifericos en la neuropatia diabetica. |
CA2665117A CA2665117C (en) | 2006-10-03 | 2007-10-01 | Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy |
CN2007800422158A CN101573130B (zh) | 2006-10-03 | 2007-10-01 | 表皮生长因子用于在糖尿病性神经病中外周神经的形态功能恢复的用途 |
AT07817382T ATE544462T1 (de) | 2006-10-03 | 2007-10-01 | Verwendung des epidermalen wachstumsfaktors zur morphofunktionellen wiederherstellung von peripheren nerven bei diabetischer neuropathie |
AU2007304640A AU2007304640B2 (en) | 2006-10-03 | 2007-10-01 | Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy |
ES07817382T ES2386058T3 (es) | 2006-10-03 | 2007-10-01 | Uso del factor del crecimiento epidérmico para la restauración morfofuncional de nervios periféricos en la neuropatía diabética |
CL200702862A CL2007002862A1 (es) | 2006-10-03 | 2007-10-03 | Uso del factor de crecimiento epidermico (egf) para tratar neuropatia sensitivo-motora, dolorosa y manifestaciones de neuritis isquemicas; composicion farmaceutica que comprende egf; y uso de la composicion antes dicha. |
ZA200902311A ZA200902311B (en) | 2006-10-03 | 2009-04-02 | Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy |
US14/140,849 US9034826B2 (en) | 2006-10-03 | 2013-12-26 | Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060192A CU23526B6 (es) | 2006-10-03 | 2006-10-03 | Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23526B6 true CU23526B6 (es) | 2010-05-19 |
Family
ID=38925545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20060192A CU23526B6 (es) | 2006-10-03 | 2006-10-03 | Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética |
Country Status (20)
Country | Link |
---|---|
US (2) | US8642552B2 (es) |
EP (1) | EP2075004B1 (es) |
JP (1) | JP5508853B2 (es) |
KR (1) | KR101464208B1 (es) |
CN (1) | CN101573130B (es) |
AR (1) | AR063088A1 (es) |
AT (1) | ATE544462T1 (es) |
AU (1) | AU2007304640B2 (es) |
BR (1) | BRPI0719816B8 (es) |
CA (1) | CA2665117C (es) |
CL (1) | CL2007002862A1 (es) |
CU (1) | CU23526B6 (es) |
DK (1) | DK2075004T3 (es) |
ES (1) | ES2386058T3 (es) |
MX (1) | MX2009003678A (es) |
PL (1) | PL2075004T3 (es) |
PT (1) | PT2075004E (es) |
RU (1) | RU2460536C2 (es) |
WO (1) | WO2008040260A1 (es) |
ZA (1) | ZA200902311B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101252740B1 (ko) * | 2011-05-25 | 2013-04-11 | 연세대학교 산학협력단 | 센서 및 센싱방법 |
EP2737895A1 (en) * | 2012-11-30 | 2014-06-04 | Praxis Pharmaceutical, S.A. | Microparticles with EGF, method of preparation and use |
AU2013362134B2 (en) * | 2012-12-21 | 2018-07-05 | Sykehuset Sorlandet Hf | EGFR targeted therapy of neurological disorders and pain |
CA2920835A1 (en) | 2013-08-20 | 2015-02-26 | Anutra Medical, Inc. | Syringe fill system and method |
IL312865B1 (en) | 2013-09-11 | 2025-02-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-reducing agents |
USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
MX2017004306A (es) | 2014-10-01 | 2017-12-20 | Eagle Biologics Inc | Formulaciones de polisacáridos y ácido nucleico que contienen agentes de reducción de viscosidad. |
RU2585421C1 (ru) * | 2014-12-24 | 2016-05-27 | Артур Владимирович Маргасов | Способ восстановления поврежденного нерва |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
SE9601243D0 (sv) | 1996-03-29 | 1996-03-29 | Hans Arne Hansson | Promotion of regeneration of organized tissues |
AU2231399A (en) | 1998-01-20 | 1999-08-02 | Aurx, Inc. | A herpes virus vector |
US6444205B2 (en) | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
SE9804064D0 (sv) | 1998-11-25 | 1998-11-25 | A & Science Invest Ab | Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells |
EP1169052B1 (en) * | 1999-04-15 | 2005-07-20 | Caritas St. Elizabeth's Medical Center of Boston, Inc. | Vegf angiogenic growth factors for treatment of peripheral neuropathy |
WO2002012335A2 (en) | 2000-08-10 | 2002-02-14 | Pharmacia Corporation | A NEW EGF MOTIF REPEAT PROTEIN OBTAINED FROM A cDNA LIBRARY FROM HS-5 STROMAL CELL LINE |
CU23157A1 (es) | 2001-01-03 | 2006-07-18 | Ct Ingenieria Genetica Biotech | COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL |
US20040120925A1 (en) | 2001-03-12 | 2004-06-24 | Masahiro Toda | Remedies for nerve damages |
JP2006152001A (ja) | 2001-03-12 | 2006-06-15 | Institute Of Gene & Brain Science | 神経損傷の治療薬 |
HK1077740A1 (en) * | 2001-12-20 | 2006-02-24 | Ct Ingenieria Genetica Biotech | Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation |
US7465463B2 (en) * | 2002-09-04 | 2008-12-16 | Polyheal, Ltd. | Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues |
US20070122487A1 (en) * | 2003-03-19 | 2007-05-31 | University Of Kentucky Research Foundation | (Poly(acryloyl-hydroxyethyl starch)-plga composition microspheres |
EP2289526B1 (en) * | 2003-04-25 | 2014-06-11 | The University of Pittsburgh | Muscle derived cells (mdcs) for promoting and enhancing nerve repair and regeneration. |
WO2006012707A1 (en) | 2004-08-06 | 2006-02-09 | Gropep Limited | Method for treating diabetes |
KR20070100948A (ko) * | 2005-01-21 | 2007-10-15 | 노오쓰웨스턴 유니버시티 | 세포의 캡슐화 방법 및 조성물 |
KR100765496B1 (ko) | 2005-12-09 | 2007-10-10 | 경희대학교 산학협력단 | 히레귤린 베타1의 egf-성 도메인 펩타이드를 암호화하는dna 서열을 포함하는 재조합 아데노바이러스 및 이를포함하는 신경세포 분화 및 재생용 약학 조성물 |
-
2006
- 2006-10-03 CU CU20060192A patent/CU23526B6/es active IP Right Grant
-
2007
- 2007-10-01 PL PL07817382T patent/PL2075004T3/pl unknown
- 2007-10-01 CA CA2665117A patent/CA2665117C/en not_active Expired - Fee Related
- 2007-10-01 EP EP07817382A patent/EP2075004B1/en not_active Not-in-force
- 2007-10-01 AR ARP070104350A patent/AR063088A1/es unknown
- 2007-10-01 MX MX2009003678A patent/MX2009003678A/es active IP Right Grant
- 2007-10-01 JP JP2009530751A patent/JP5508853B2/ja active Active
- 2007-10-01 ES ES07817382T patent/ES2386058T3/es active Active
- 2007-10-01 WO PCT/CU2007/000018 patent/WO2008040260A1/es active Application Filing
- 2007-10-01 KR KR1020097009188A patent/KR101464208B1/ko active IP Right Grant
- 2007-10-01 CN CN2007800422158A patent/CN101573130B/zh not_active Expired - Fee Related
- 2007-10-01 BR BRPI0719816A patent/BRPI0719816B8/pt not_active IP Right Cessation
- 2007-10-01 RU RU2009116646/15A patent/RU2460536C2/ru active
- 2007-10-01 US US12/443,837 patent/US8642552B2/en active Active
- 2007-10-01 AT AT07817382T patent/ATE544462T1/de active
- 2007-10-01 DK DK07817382.0T patent/DK2075004T3/da active
- 2007-10-01 AU AU2007304640A patent/AU2007304640B2/en not_active Ceased
- 2007-10-01 PT PT07817382T patent/PT2075004E/pt unknown
- 2007-10-03 CL CL200702862A patent/CL2007002862A1/es unknown
-
2009
- 2009-04-02 ZA ZA200902311A patent/ZA200902311B/xx unknown
-
2013
- 2013-12-26 US US14/140,849 patent/US9034826B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE544462T1 (de) | 2012-02-15 |
CL2007002862A1 (es) | 2008-05-23 |
US8642552B2 (en) | 2014-02-04 |
BRPI0719816A2 (pt) | 2015-09-08 |
PT2075004E (pt) | 2012-05-02 |
US20100136062A1 (en) | 2010-06-03 |
PL2075004T3 (pl) | 2012-09-28 |
JP2010505773A (ja) | 2010-02-25 |
ES2386058T3 (es) | 2012-08-08 |
CA2665117A1 (en) | 2008-04-10 |
JP5508853B2 (ja) | 2014-06-04 |
AU2007304640A1 (en) | 2008-04-10 |
EP2075004B1 (en) | 2012-02-08 |
US9034826B2 (en) | 2015-05-19 |
MX2009003678A (es) | 2009-04-22 |
DK2075004T3 (da) | 2012-05-14 |
CN101573130A (zh) | 2009-11-04 |
CA2665117C (en) | 2015-04-14 |
ZA200902311B (en) | 2010-04-28 |
CN101573130B (zh) | 2012-10-31 |
AU2007304640B2 (en) | 2013-01-17 |
KR101464208B1 (ko) | 2014-12-04 |
BRPI0719816B8 (pt) | 2021-05-25 |
US20140105990A1 (en) | 2014-04-17 |
WO2008040260A1 (es) | 2008-04-10 |
KR20090103862A (ko) | 2009-10-01 |
BRPI0719816B1 (pt) | 2018-04-24 |
RU2009116646A (ru) | 2010-11-10 |
AR063088A1 (es) | 2008-12-23 |
EP2075004A1 (en) | 2009-07-01 |
RU2460536C2 (ru) | 2012-09-10 |
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