DK131858B - Analogifremgangsmåde til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf.

Info

Publication number: DK131858B
Authority: DK; Denmark
Prior art keywords: amino; preparation; acid addition; addition salts; analogous process
Prior art date: 1970-10-05

Application number

DK480171AA

Other languages

English (en)

Other versions

DK131858C (da

Inventor

G G D Angelis

H-J E Hess

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-10-05

Filing date

1971-10-01

Publication date

1975-09-15

1971-10-01 Application filed by Pfizer filed Critical Pfizer

1973-03-16 Priority to DK142973A priority Critical patent/DK130971B/da

1975-09-15 Publication of DK131858B publication Critical patent/DK131858B/da

1976-02-16 Application granted granted Critical

1976-02-16 Publication of DK131858C publication Critical patent/DK131858C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK480171A 1970-10-05 1971-10-01 Analogifremgangsmade til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf DK131858C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK142973A DK130971B (da)	1970-10-05	1973-03-16	Analogifremgangsmåde til fremstilling af 4-hydroxy-5-ethyl-6-phenylpyrimidin.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US7821670A	1970-10-05	1970-10-05

Publications (2)

Publication Number	Publication Date
DK131858B true DK131858B (da)	1975-09-15
DK131858C DK131858C (da)	1976-02-16

Family

ID=22142671

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK480171A DK131858C (da)	1970-10-05	1971-10-01	Analogifremgangsmade til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf

Country Status (16)

Country	Link
US (1)	US3707560A (da)
JP (2)	JPS5648511B1 (da)
AT (4)	AT316563B (da)
AU (1)	AU465734B2 (da)
BE (1)	BE773484A (da)
CA (1)	CA988519A (da)
CH (4)	CH554876A (da)
DE (2)	DE2165962C2 (da)
DK (1)	DK131858C (da)
ES (4)	ES395676A1 (da)
FI (1)	FI55502C (da)
FR (1)	FR2110227B1 (da)
GB (2)	GB1373535A (da)
NL (1)	NL168511C (da)
SE (2)	SE385885B (da)
ZA (1)	ZA716615B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3908012A (en) *	1970-10-05	1975-09-23	Pfizer	Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
US3859288A (en) *	1970-10-05	1975-01-07	Pfizer	Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3895112A (en) *	1970-10-05	1975-07-15	Pfizer	Arylpyrimidines in the relaxation of smooth muscle
US3835132A (en) *	1972-02-01	1974-09-10	Shell Oil Co	Morpholino-piperazinyl pyrimidines
US3950525A (en) *	1973-06-19	1976-04-13	Pfizer Inc.	Relaxation of smooth muscle in a mammal
DE2343419A1 (de) *	1973-08-29	1975-03-13	Gruenenthal Chemie	Verfahren zur herstellung von pyrimidinderivaten
US4725600A (en) *	1984-07-13	1988-02-16	Fujisawa Pharmaceutical Co., Ltd.	Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4935516A (en) *	1988-01-29	1990-06-19	Ube Industries, Ltd.	Process for preparing 4-hydroxypyrimidine
JPH0625157B2 (ja) *	1988-01-29	1994-04-06	宇部興産株式会社	４―ヒドロキシピリミジン類の製造方法
DE3825647A1 (de) *	1988-07-28	1990-02-01	Geyer Gmbh & Co Christian	Vorrichtung zur befestigung eines elektrischen schaltgeraetes
DE3905364A1 (de) *	1989-02-22	1990-08-23	Hoechst Ag	Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
JP2003505384A (ja)	1999-07-15	2003-02-12	ファーマコピーア，インコーポレーティッド	ブラジキニンｂ１受容体アンタゴニスト
US7731985B2 (en) *	2002-03-15	2010-06-08	Ciba Specialty Chemicals Corporation	4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
PL375552A1 (en) *	2002-05-22	2005-11-28	Amgen Inc.	Vanilloid receptor ligands and their medical applications
EP1611128A2 (en) *	2003-03-28	2006-01-04	Pharmacia & Upjohn Company LLC	Positive allosteric modulators of the nicotinic acetylcholine receptor
WO2006113769A1 (en) *	2005-04-15	2006-10-26	Amgen Inc.	Vanilloid receptor ligands and their use in treatments
JP2009164373A (ja) *	2008-01-08	2009-07-23	Toshiba Corp	半導体装置
KR20120131161A (ko) *	2010-01-25	2012-12-04	씨에이치디아이 파운데이션, 인코포레이티드	특정 키뉴레닌-3-모노옥시게나제 억제제, 그의 제약 조성물 및 사용 방법
EA201490279A1 (ru)	2011-08-30	2014-08-29	Схди Фаундейшн, Инк.	Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения
EP2750677B1 (en)	2011-08-30	2017-03-22	CHDI Foundation, Inc.	Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CR20170061A (es)	2014-07-17	2017-07-17	Chdi Foundation Inc	Métodos y composiciones para el tratamiento de trastornos relacionados con vih

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3047462A (en) *	1959-03-06	1962-07-31	Lab Jacques Logeais Soc D Expl	Quinazolone anti-inflammatory composition

1970
- 1970-10-05 US US78216A patent/US3707560A/en not_active Expired - Lifetime
1971
- 1971-09-30 FI FI2734/71A patent/FI55502C/fi active
- 1971-10-01 DK DK480171A patent/DK131858C/da not_active IP Right Cessation
- 1971-10-02 DE DE2165962A patent/DE2165962C2/de not_active Expired
- 1971-10-02 DE DE2149249A patent/DE2149249C3/de not_active Expired
- 1971-10-04 CA CA124,312A patent/CA988519A/en not_active Expired
- 1971-10-04 GB GB4615871A patent/GB1373535A/en not_active Expired
- 1971-10-04 GB GB3831673A patent/GB1373536A/en not_active Expired
- 1971-10-04 SE SE7112534-8A patent/SE385885B/xx unknown
- 1971-10-04 ES ES395676A patent/ES395676A1/es not_active Expired
- 1971-10-04 ZA ZA716615A patent/ZA716615B/xx unknown
- 1971-10-04 SE SE7410488A patent/SE390304B/xx unknown
- 1971-10-05 FR FR7135815A patent/FR2110227B1/fr not_active Expired
- 1971-10-05 AT AT00149/73A patent/AT316563B/de not_active IP Right Cessation
- 1971-10-05 AT AT605473A patent/AT317229B/de not_active IP Right Cessation
- 1971-10-05 AT AT00148/73A patent/AT315856B/de not_active IP Right Cessation
- 1971-10-05 JP JP7823771A patent/JPS5648511B1/ja active Pending
- 1971-10-05 CH CH1452971A patent/CH554876A/fr not_active IP Right Cessation
- 1971-10-05 CH CH772973A patent/CH542218A/fr not_active IP Right Cessation
- 1971-10-05 AT AT858071A patent/AT314540B/de not_active IP Right Cessation
- 1971-10-05 BE BE773484A patent/BE773484A/xx not_active IP Right Cessation
- 1971-10-05 CH CH1532172A patent/CH554346A/fr not_active IP Right Cessation
- 1971-10-05 NL NLAANVRAGE7113670,A patent/NL168511C/xx not_active IP Right Cessation
- 1971-10-05 CH CH1521472A patent/CH554875A/fr not_active IP Right Cessation
- 1971-10-06 AU AU34259/71A patent/AU465734B2/en not_active Expired
1973
- 1973-11-02 ES ES420209A patent/ES420209A1/es not_active Expired
- 1973-11-02 ES ES420211A patent/ES420211A1/es not_active Expired
- 1973-11-02 ES ES420210A patent/ES420210A1/es not_active Expired
1980
- 1980-08-11 JP JP11016380A patent/JPS5636468A/ja active Granted

Also Published As

Publication number	Publication date
AU465734B2 (en)	1975-10-09
ZA716615B (en)	1972-06-28
ES395676A1 (es)	1974-10-16
NL7113670A (da)	1972-04-07
NL168511B (nl)	1981-11-16
CH554876A (fr)	1974-10-15
GB1373535A (en)	1974-11-13
ES420211A1 (es)	1976-03-16
CH542218A (fr)	1973-11-15
JPS5636468A (en)	1981-04-09
FR2110227A1 (da)	1972-06-02
GB1373536A (en)	1974-11-13
DK131858C (da)	1976-02-16
DE2149249A1 (de)	1972-04-13
ES420210A1 (es)	1976-06-01
CH554346A (fr)	1974-09-30
CA988519A (en)	1976-05-04
ES420209A1 (es)	1976-06-01
JPS5648511B1 (da)	1981-11-16
AT316563B (de)	1974-06-15
AT315856B (de)	1974-05-15
FI55502B (fi)	1979-04-30
DE2149249B2 (de)	1974-11-07
DE2165962C2 (de)	1982-05-13
JPS578107B2 (da)	1982-02-15
FI55502C (fi)	1979-08-10
CH554875A (fr)	1974-10-15
AU3425971A (en)	1973-04-12
NL168511C (nl)	1982-04-16
FR2110227B1 (da)	1975-02-07
US3707560A (en)	1972-12-26
SE385885B (sv)	1976-07-26
BE773484A (fr)	1972-04-05
SE7410488L (da)	1974-08-16
DE2149249C3 (de)	1975-07-03
DE2165962A1 (de)	1972-08-31
AT314540B (de)	1974-04-10
AT317229B (de)	1974-08-26
SE390304B (sv)	1976-12-13

Legal Events

Date	Code	Title	Description
1985-06-03	PBP	Patent lapsed

Publication	Publication Date	Title
DK129446B (da)	1974-10-14	Analogifremgangsmåde til fremstilling af fenoxyhydroxypropylaminer eller syreadditionssalte heraf.
DK124547B (da)	1972-10-30	Analogifremgangsmåde til fremstilling af (3-amino-2-hydroxy-propyloxy)-thiochromanderivater eller syreadditionssalte deraf.
DK134984B (da)	1977-02-21	Analogifremgangsmåde til fremstilling af alfa-alkylaminopropiophenoner eller syreadditionssalte heraf.
DK131858B (da)	1975-09-15	Analogifremgangsmåde til fremstilling af 4-amino-6-arylpyrimidin-forbindelser eller syreadditionssalte deraf.
DK139717B (da)	1979-04-02	Analogifremgangsmåde til fremstilling af beta-aryl-2-aminoalkoxystyroler eller syreadditionssalte heraf.
DK131287B (da)	1975-06-23	Analogifremgangsmåde til fremstilling af 2-phenylimino-imidazolidiner eller syreadditionssalte deraf.
DK136526B (da)	1977-10-24	Analogifremgangsmåde til fremstilling af substituerede naphthylalkylaminer eller syreadditionssalte deraf.
DK139575B (da)	1979-03-12	Analogifremgangsmåde til fremstilling af 2-aminomethylen-1-indanon-forbindelser eller syreadditionssalte deraf.
DK138641B (da)	1978-10-09	Analogifremgangsmåde til fremstilling af tricycliske forbindelser eller syreadditionssalte deraf.
DK129577B (da)	1974-10-28	Analogifremgangsmåde til fremstilling af phenacetylguanidiner eller syreadditionssalte deraf.
DK129513B (da)	1974-10-21	Analogifremgangsmåde til fremstilling af basisk substituerede alkylidenaminooxyalkylcarboxylsyreestere eller syreadditionssalte deraf.
DK131778B (da)	1975-09-01	Fremgangsmåde til fremstilling af substituerede 3-hydroksymetylisokinolinderivater eller syreadditionssalte heraf.
DK131857B (da)	1975-09-15	Analogifremgangsmåde til fremstilling af 4-hydroxymethyl-1-phthalazonderivater eller syreadditionssalte deraf.
DK137757B (da)	1978-05-01	Analogifremgangsmåde til fremstilling af pyridylpiperaziner eller syreadditionssalte deraf.
DK129454B (da)	1974-10-14	Analogifremgangsmåde til fremstilling af ergonorcornin eller syreadditionssalte deraf.
DK129164B (da)	1974-09-02	Analogifremgangsmåde til fremstilling af 3-alkyl-5-aryloxymethylisoxazoler eller syreadditionssalte deraf.
DK130288B (da)	1975-02-03	Analogifremgangsmåde til fremstilling af alkanolaminderivater eller syreadditionssalte deraf.
DK136242B (da)	1977-09-12	Analogifremgangsmåde til fremstilling af substituerede benzyloxyaminer eller deres syreadditionssalte.
DK131727B (da)	1975-08-25	Analogifremgangsmåde til fremstilling af oxazinobenzoxaziner eller syreadditionssalte deraf.
DK127431B (da)	1973-11-05	Analogifremgangsmåde til fremstilling af thiepinderivater eller syreadditionssalte deraf.
DK137834B (da)	1978-05-16	Analogifremgangsmåde til fremstilling af triazolobenzodiazepinderivater eller syreadditionssalte deraf.
DK134023B (da)	1976-08-30	Analogifremgangsmåde til fremstilling af acyloxypiperazinylforbindelser eller syreadditionssalte deraf.
DK127501B (da)	1973-11-19	Analogifremgangsmåde til fremstilling af substituerede phenoxyethylaminer eller deres syreadditionssalte.
DK129839B (da)	1974-11-25	Analogifremgangsmåde til fremstilling af N-vinylquinoloner eller syreadditionssalte deraf.
DK131570B (da)	1975-08-04	Analogifremgangsmåde til fremstilling af thienylalkanderivater eller syreadditionssalte deraf.