DK166088C - 2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler - Google Patents

2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler

Info

Publication number
DK166088C
DK166088C DK691287A DK691287A DK166088C DK 166088 C DK166088 C DK 166088C DK 691287 A DK691287 A DK 691287A DK 691287 A DK691287 A DK 691287A DK 166088 C DK166088 C DK 166088C
Authority
DK
Denmark
Prior art keywords
anticancing
compounds
agents
fluoruridin
deoxy
Prior art date
Application number
DK691287A
Other languages
English (en)
Other versions
DK691287D0 (da
DK166088B (da
DK691287A (da
Inventor
Setsuro Fujii
Mitsuru Hirohashi
Yoshihito Yamamoto
Yutaka Kojima
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK691287D0 publication Critical patent/DK691287D0/da
Publication of DK691287A publication Critical patent/DK691287A/da
Publication of DK166088B publication Critical patent/DK166088B/da
Application granted granted Critical
Publication of DK166088C publication Critical patent/DK166088C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK691287A 1986-04-30 1987-12-29 2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler DK166088C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP10128586 1986-04-30
JP10128586 1986-04-30
JP4575487 1987-02-27
JP4575487 1987-02-27
PCT/JP1987/000275 WO1987006582A1 (en) 1986-04-30 1987-04-30 5-fluorouracil derivative
JP8700275 1987-04-30

Publications (4)

Publication Number Publication Date
DK691287D0 DK691287D0 (da) 1987-12-29
DK691287A DK691287A (da) 1988-02-19
DK166088B DK166088B (da) 1993-03-08
DK166088C true DK166088C (da) 1993-08-23

Family

ID=26385819

Family Applications (1)

Application Number Title Priority Date Filing Date
DK691287A DK166088C (da) 1986-04-30 1987-12-29 2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler

Country Status (9)

Country Link
US (1) US5047521A (da)
EP (1) EP0247381B1 (da)
JP (1) JPH07103112B1 (da)
KR (1) KR950002161B1 (da)
DE (1) DE3786834T2 (da)
DK (1) DK166088C (da)
ES (1) ES2058073T3 (da)
GB (1) GB2200352B (da)
WO (1) WO1987006582A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
WO2004074253A1 (en) * 2003-02-22 2004-09-02 Merck Patent Gmbh Cyanopyridone derivatives as liquid crystals
US20080050425A1 (en) * 2003-05-20 2008-02-28 Jonathan Lewis Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex
JP2007077109A (ja) * 2005-09-16 2007-03-29 Tokyo Institute Of Technology ヌクレオシド誘導体及びその製造方法
US7561776B2 (en) * 2005-11-29 2009-07-14 Petrospec Engineering Ltd. Method of preventing hydrogen darkening of optic fibre
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
HUE033401T2 (en) * 2009-10-27 2017-11-28 Delta-Fly Pharma Inc New 5-fluorouracil derivative
US11760773B2 (en) 2018-02-02 2023-09-19 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124765A (en) * 1975-05-13 1978-11-07 Ono Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
JPS6011704B2 (ja) * 1976-07-30 1985-03-27 大鵬薬品工業株式会社 ５−フルオルウラシル誘導体の製造法
JPS5379879A (en) * 1976-12-23 1978-07-14 Mitsui Toatsu Chem Inc 1,3-substituted-5-fluorouracils and process for their preparation
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
GB2072164B (en) * 1980-02-15 1983-12-21 Funai Pharmaceutical Ind Ltd 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives
JPS5929699A (ja) * 1982-08-11 1984-02-16 Funai Corp ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤
JPS58185522A (ja) * 1983-02-28 1983-10-29 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体
CA1227794A (en) * 1983-05-23 1987-10-06 Jun-Ichi Yamashita 2'-deoxy-5- substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same
JPS6061593A (ja) * 1983-09-14 1985-04-09 Taiho Yakuhin Kogyo Kk ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤
DE3481191D1 (de) * 1983-07-20 1990-03-08 Teijin Ltd Antineoplastisches mittel.
US4515618A (en) * 1983-12-07 1985-05-07 Chevron Research Company 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives
DE3585869D1 (de) * 1984-10-30 1992-05-21 Otsuka Pharma Co Ltd Zusammensetzung zur steigerung der antikrebsaktivitaet einer antikrebsverbindung.
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
JPH02187484A (ja) * 1989-01-13 1990-07-23 Okitsumo Kk 紙用瞬間接着剤

Also Published As

Publication number Publication date
DE3786834T2 (de) 1994-03-03
DK691287D0 (da) 1987-12-29
EP0247381A2 (en) 1987-12-02
DK166088B (da) 1993-03-08
GB2200352A (en) 1988-08-03
DE3786834D1 (de) 1993-09-09
WO1987006582A1 (en) 1987-11-05
US5047521A (en) 1991-09-10
KR950002161B1 (ko) 1995-03-14
EP0247381A3 (en) 1988-11-23
GB2200352B (en) 1990-07-25
ES2058073T3 (es) 1994-11-01
EP0247381B1 (en) 1993-08-04
KR880701232A (ko) 1988-07-26
JPH07103112B1 (da) 1995-11-08
DK691287A (da) 1988-02-19
GB8730031D0 (en) 1988-02-03

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