EP0509281A2 - Container closure with perforable seal - Google Patents

Container closure with perforable seal Download PDF

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Publication number
EP0509281A2
EP0509281A2 EP92105139A EP92105139A EP0509281A2 EP 0509281 A2 EP0509281 A2 EP 0509281A2 EP 92105139 A EP92105139 A EP 92105139A EP 92105139 A EP92105139 A EP 92105139A EP 0509281 A2 EP0509281 A2 EP 0509281A2
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EP
European Patent Office
Prior art keywords
closure
container
closure body
container closure
incision
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP92105139A
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German (de)
French (fr)
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EP0509281A3 (en
EP0509281B1 (en
Inventor
Jürgen Schwab
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Siemens Healthcare Diagnostics Products GmbH
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Behringwerke AG
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Publication date
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Publication of EP0509281A2 publication Critical patent/EP0509281A2/en
Publication of EP0509281A3 publication Critical patent/EP0509281A3/en
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Publication of EP0509281B1 publication Critical patent/EP0509281B1/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Definitions

  • the invention relates to a container closure with a pierceable closure body for removing or adding liquids by means of a blunt hollow needle from or in a container, this closure body consisting at least partially of a highly elastic material which is cut at least 75% of its thickness at the piercing point .
  • the closure can be carried out independently in the form of a stopper or as an insert plate for a closure.
  • samples mostly human body fluids, control samples, some analyte-containing liquids are pipetted with an artificial matrix and reagents with the help of automatic pipetting stations.
  • these devices consist of a cannula movable in the X-Y-Z direction, which is connected to a pump device via a flexible hose. Due to the design of these devices, only small forces can be exerted on the cannula. For reasons of occupational safety, the use of ground cannulas is prohibited.
  • samples / test tubes must be used for various reasons, e.g. B. Infection risk or risk of evaporation, be hermetically sealed before, during and after the pipetting and this closure must also be guaranteed after multiple / repeated use.
  • Devices in the sense of this invention are understood to mean all instruments which or with which a liquid transfer can be carried out or carried out in or from a container. Devices that carry out this transfer automatically are preferred. Devices which are used in the field of diagnosis of diseases of the human or animal organism are particularly preferred.
  • Similar container closures are already known for containers with pharmaceutical contents.
  • the cannula of a syringe is used to pierce the closure body at a possibly weakened point and the bottle contents are filled into the injection syringe without the bottle closure needing to be removed.
  • the closure bodies are designed as stoppers sitting in the bottle neck, the shaft of which is hollow apart from a base surface, this base surface having a convex curvature pointing away from the interior of the bottle.
  • closure bodies of such known bottle closures generally consist of butyl, natural or silicone rubber or similar materials which are sufficiently chemically resistant to their surroundings and in particular to the contents of the bottle.
  • Such a known design is such. B. in the patent specification DE 19 01 239.
  • a disadvantage of the known embodiments is that they cannot be used for blunt cannulas and that even when using ground injection needles, a relatively large force has to be used to pierce the closure bodies.
  • the present invention was therefore based on the object of providing a closure body which can be pierced with little force by means of a blunt cannula for liquid transfer and thereby ensures a safe and hygienic closure before, during and after removal, in particular after repeated use.
  • This closure body should be as similar as possible in its outer contours to the previously known and used closure bodies, so that, for. B. the existing machines for closing do not need to be converted.
  • a container closure as described above is preferred, the incision (9) consisting of 4 preferably of equal length, starting from the center of the closure body, arranged at right angles to one another (24).
  • the invention further relates to a container closure as described above, which consists of a closure body lower part (15) and a cover membrane (14).
  • the invention also relates to a container closure as described above, the closure consisting of a plate (20).
  • Containers in the sense of the present invention are, for. B. Vessels that are used to hold samples of body fluids, such as. B. test tubes or blood collection vessels, also containers that serve to hold reagents or liquid waste in devices.
  • B. Vessels that are used to hold samples of body fluids, such as. B. test tubes or blood collection vessels, also containers that serve to hold reagents or liquid waste in devices.
  • the various embodiments are known to the person skilled in the art.
  • the container closure according to the invention can in principle be part of any closure device known per se to the person skilled in the art, which can be made partially or entirely from a highly elastic material.
  • the material thickness of the closure body in the area of the perforation point is 0.1-5, preferably 1-3, particularly preferably 2 mm.
  • a container closure consists of a closure body 1 and optionally a flange (2) (Fig. 1) - or screw cap.
  • the crimp cap 2 is ring-shaped and engages under the flange-like collar (4) of the neck (5) of a container, the screw cap accordingly engages in a thread of the neck of a container (3).
  • the crimp cap (2) or the screw cap leave the end face (6) of the closure body free in the central area.
  • the closure body (1) is pressed under a sealing pressure against the neck (5) of the container and fixed there.
  • the closure body (1) has a preferably cruciform incision (24) of preferably about 5 mm, starting from the center M of the closure body (1), the incision preferably between 75 and 90% of the Cut the material thickness at the incision point (9).
  • the remaining membrane (12) ensures u. a. the hermetic seal and the necessary mechanical stability during storage and transport.
  • the material thickness in the incised part (9) is preferably 0.1-5 mm. This ensures that enough material is available around the puncture in order to obtain a sufficient sealing distance for the secure closure of the container (3) after the cannula has been pulled out of the incision site (9).
  • the entire incision site (9) is first stretched by the pressure of the cannula (10).
  • tensile forces occur in the region of the membrane (12) in accordance with the further expansion, which lead to the membrane (12) tearing at the point of penetration.
  • the cannula (10), then sealed by the material of the closure body at the point of penetration, can remove liquid from the container or dispense it into the container.
  • the closure body (1) shown in FIG. 3 has a separate cover membrane (14) which can be connected to the bottom part of the closure body (15) either by pressure, adhesion or cohesion.
  • the lower part of the closure body (15) is cut through at the incision point (9) over the entire material thickness.
  • the membrane (14) can preferably be made from a less elastic material with low tensile strength, such as aluminum foil. In this case, the material thickness can also be less than 0.1 mm.
  • the closure body (1) shown in Figure 5 (ac) consists of a plate (20) made of a highly elastic material (septum) and a crimp cap (2) or a screw cap, which either directly attaches the plate (20) to the flange surface of the Press collar (4) (Fig. 5 a) of the container (3) or a carrier (21) (Fig. 5 c), which in turn can be made of an elastic material.
  • the puncture area (23) (cf. claims 1 and 2) of the plate can be designed as shown in FIGS. 1 - (FIGS. 5 a and 5 c) or as shown in FIG. 3 (FIG. 5 b).
  • the closure body can be cut in a line, cross (FIG. 2 a) or star shape (FIG. 2 b) in each of the inventive embodiments. Designs with a cross-shaped and three-pronged incision are preferred.
  • the incisions are preferably made so that they are open to the inside of the container (22).

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)

Abstract

The invention relates to a container closure with a perforable seal (1) for removing or adding liquids by means of a blunt hollow needle (10) from or into a container (3), said seal consisting at least partially of a highly elastic material which is grooved to at least 75% of its thickness at the perforation point (23). In this case, the closure can be constructed independently in the form of a stopper or as an insertion plate for a closure.

Description

Die Erfindung betrifft einen Behälterverschluß mit einem durchstoßbaren Verschlußkörper zur Entnahme oder zur Zugabe von Flüssigkeiten mittels einer stumpfen Hohlnadel aus einem oder in einem Behälter, wobei dieser Verschlußkörper zumindest teilweise aus einem hochelastischem Material besteht, das zu mindestens 75 % seiner Dicke an der Durchstoßstelle eingeschnitten ist. Der Verschluß kann dabei eigenständig in Form eines Stopfens oder als Einlageplättchen für einen Verschluß ausgeführt werden.The invention relates to a container closure with a pierceable closure body for removing or adding liquids by means of a blunt hollow needle from or in a container, this closure body consisting at least partially of a highly elastic material which is cut at least 75% of its thickness at the piercing point . The closure can be carried out independently in the form of a stopper or as an insert plate for a closure.

Im Bereich der Diagnostika-Geräte werden Proben, meist menschlicher Körperflüssigkeiten, Kontrollproben, zum Teil analytenthaltende Flüssigkeiten mit einer künstlichen Matrix und Reagenzien mit Hilfe automatischer Pipettierstationen pipettiert. Im wesentlichen bestehen diese Geräte aus einer in X-Y-Z-Richtung beweglichen Kanüle, die über einen flexiblen Schlauch mit einer Pumpeinrichtung verbunden ist. Aufgrund der Bauart dieser Geräte können nur geringe Kräfte auf die Kanüle ausgeübt werden. Aus Gründen der Arbeitssicherheit verbietet sich die Verwendung von angeschliffenen Kanülen.In the field of diagnostic devices, samples, mostly human body fluids, control samples, some analyte-containing liquids are pipetted with an artificial matrix and reagents with the help of automatic pipetting stations. Essentially, these devices consist of a cannula movable in the X-Y-Z direction, which is connected to a pump device via a flexible hose. Due to the design of these devices, only small forces can be exerted on the cannula. For reasons of occupational safety, the use of ground cannulas is prohibited.

Die Proben/Reagenzgefäße müssen aus unterschiedlichen Gründen wie z. B. Infektionsrisiko oder Verdunstungsgefahr, vor, während und nach der Pipettierung hermetisch verschlossen sein und dieser Verschluß muß auch nach mehr/vielmaligem Gebrauch gewährleistet sein.The samples / test tubes must be used for various reasons, e.g. B. Infection risk or risk of evaporation, be hermetically sealed before, during and after the pipetting and this closure must also be guaranteed after multiple / repeated use.

Unter Geräten im Sinne dieser Erfindung werden alle Instrumente, die oder mit denen ein Flüssigkeitstransfer in einem oder aus einem Behälter durchführen bzw. durchgeführt werden kann, verstanden. Bevorzugt sind dabei Geräte die diesen Transfer automatisch durchführen. Besonders bevorzugt sind dabei solche Geräte, die im Bereich der Diagnose von Erkrankungen des menschlichen oder tierischen Organismus eingesetzt werden.Devices in the sense of this invention are understood to mean all instruments which or with which a liquid transfer can be carried out or carried out in or from a container. Devices that carry out this transfer automatically are preferred. Devices which are used in the field of diagnosis of diseases of the human or animal organism are particularly preferred.

Ähnliche Behälterverschlüsse sind bereits für Behälter mit pharmazeutischem Inhalt bekannt. Dabei wird mit der Kanüle einer Spritze der Verschlußkörper an einer gegebenenfalls geschwächten Stelle durchstoßen und der Flascheninhalt wird in die Injektionsspritze gefüllt, ohne daß der Flaschenverschluß entfernt zu werden braucht. Um diesen Vorgang zu erleichtern ist es ebenfalls bekannt, daß die Verschlußkörper als im Flaschenhals sitzende Stopfen ausgebildet sind, deren Schaft von einer Bodenfläche abgesehen hohl ist, wobei diese Bodenfläche eine konvexe, vom Flascheninneren wegweisende Wölbung besitzen.Similar container closures are already known for containers with pharmaceutical contents. In this case, the cannula of a syringe is used to pierce the closure body at a possibly weakened point and the bottle contents are filled into the injection syringe without the bottle closure needing to be removed. In order to facilitate this process, it is also known that the closure bodies are designed as stoppers sitting in the bottle neck, the shaft of which is hollow apart from a base surface, this base surface having a convex curvature pointing away from the interior of the bottle.

Die Verschlußkörper derartiger bekannter Flaschenverschlüsse bestehen in der Regel aus Butyl- , Natur- oder Siliconkautschuk oder dergleichen Werkstoffe, die gegen ihre Umgebung sowie insbesondere gegenüber dem Flascheninhalt genügend chemisch resistent sind. Eine solche bekannte Ausführung ist z. B. in der Patentschrift DE 19 01 239 ausgeführt.The closure bodies of such known bottle closures generally consist of butyl, natural or silicone rubber or similar materials which are sufficiently chemically resistant to their surroundings and in particular to the contents of the bottle. Such a known design is such. B. in the patent specification DE 19 01 239.

Nachteilig bei den bekannten Ausführungsformen ist, daß sie nicht für stumpfe Kanülen verwendbar sind und selbst bei der Verwendung von geschliffenen Injektionsnadeln eine relativ große Kraft zum Durchstoßen der Verschlußkörper aufgewendet werden muß.A disadvantage of the known embodiments is that they cannot be used for blunt cannulas and that even when using ground injection needles, a relatively large force has to be used to pierce the closure bodies.

Der vorliegenden Erfindung lag also die Aufgabe zugrunde, einen Verschlußkörper bereitzustellen, der mit geringem Kraftaufwand mittels einer stumpfen Kanüle zum Flüssigkeitstransfer durchstoßen werden kann und dabei vor, während und nach der Entnahme einen sicheren und hygienischen Verschluß gewährleistet, namentlich bei mehrmaligem Gebrauch. Dieser Verschlußkörper sollte in seinen äußeren Umrißformen den bisher bekannten und verwendeten Verschlußkörpern möglichst ähnlich sein, so daß z. B. die bereits vorhandenen Maschinen zum Verschließen nicht umgestellt werden brauchen.The present invention was therefore based on the object of providing a closure body which can be pierced with little force by means of a blunt cannula for liquid transfer and thereby ensures a safe and hygienic closure before, during and after removal, in particular after repeated use. This closure body should be as similar as possible in its outer contours to the previously known and used closure bodies, so that, for. B. the existing machines for closing do not need to be converted.

Die erfindungsgemäße Lösung besteht nun darin, daß bei einem solchen Flaschenverschluß die Kombination folgender Merkmale vorgesehen ist:

  • Behälterverschluß mit einem durchstoßbaren Verschlußkörper zum Flüssigkeitstransfer mittels einer Hohlnadel aus einem oder in einen Behälter, wobei dieser Verschlußkörper gekennzeichnet ist durch die Kombination folgender Merkmale:
    • a) Der Verschlußkörper (1) besteht zumindest im Durchstoßungsbereich (23) aus elastischem Material, wie Natur- oder Synthesekautschuk, wie z.
    • B. Silikon-, Brombutyl- oder Chlorbutylkautschuk der gegebenenfalls auch mit PTFE beschichtet sein kann, insbesondere aus einem Butylkautschuk
    • b) der Verschlußkörper ist im Durchstoßungsbereich (23) zu mindestens 75 % der Dicke eingeschnitten (9), vorzugsweise vom Behälterinneren her.
The solution according to the invention now consists in the fact that the combination of the following features is provided in such a bottle closure:
  • Container closure with a pierceable closure body for liquid transfer by means of a hollow needle from or into a container, this closure body being characterized by the combination of the following features:
    • a) The closure body (1) consists at least in the penetration area (23) made of elastic material, such as natural or synthetic rubber, such as.
    • B. silicone, bromobutyl or chlorobutyl rubber which can optionally also be coated with PTFE, in particular from a butyl rubber
    • b) the closure body is cut in the penetration area (23) to at least 75% of the thickness (9), preferably from the inside of the container.

Bevorzugt ist dabei ein Behälterverschluß wie oben beschrieben, wobei der Einschnitt (9) aus 4 vorzugsweise gleichlangen, vom Mittelpunkt des Verschlußkörpers ausgehenden, rechtwinklig zueinander angeordneten Schnitten (24) besteht.A container closure as described above is preferred, the incision (9) consisting of 4 preferably of equal length, starting from the center of the closure body, arranged at right angles to one another (24).

Gegenstand der Erfindung ist ferner ein Behälterverschluß wie vorstehend beschrieben, der aus einem Verschlußkörperunterteil (15) und einer Abdeckmembran (14) besteht.The invention further relates to a container closure as described above, which consists of a closure body lower part (15) and a cover membrane (14).

Gegenstand der Erfindung ist auch ein Behälterverschluß wie vorstehend beschrieben, wobei der Verschluß aus einem Plättchen (20) besteht.The invention also relates to a container closure as described above, the closure consisting of a plate (20).

Versuche haben nun überraschenderweise gezeigt, daß bei erfindungsgemäßer Ausbildung des Verschlußkörpers sowohl der Forderung nach der Durchstoßbarkeit, als auch der Forderung nach Wiederverschließbarkeit und Sicherheit Rechnung getragen werden kann. Die Materialstärke des Verschlußkörpers kann in weiten Bereichen variieren.Experiments have now surprisingly shown that when the closure body is designed according to the invention, both the requirement for penetrability and the requirement for reclosability and security are taken into account can be worn. The material thickness of the closure body can vary widely.

Behälter im Sinne der vorliegenden Erfindung sind z. B. Gefäße, die zur Aufnahme von Proben von Körperflüssigkeiten dienen, wie z. B. Reagenzgläser oder Blutentnahmegefäße, ferner Behälter, die zur Aufnahme von Reagenzien oder Flüssigabfall in Geräten dienen. Die verschiedenen Ausführungsformen sind dem Fachmann bekannt.Containers in the sense of the present invention are, for. B. Vessels that are used to hold samples of body fluids, such as. B. test tubes or blood collection vessels, also containers that serve to hold reagents or liquid waste in devices. The various embodiments are known to the person skilled in the art.

Der erfindungsgemäße Behälterverschluß kann grundsätzlich Bestandteil jeder dem Fachmann an sich bekannten Verschlußeinrichtung sein, die teilweise oder ganz aus einem hochelastischen Material gefertigt werden kann.The container closure according to the invention can in principle be part of any closure device known per se to the person skilled in the art, which can be made partially or entirely from a highly elastic material.

In einer bevorzugten Form ist die Materialstärke des Verschlußkörpers im Bereich der Perforationsstelle 0,1 - 5, bevorzugterweise 1 - 3, besonders bevorzugterweise 2 mm.In a preferred form, the material thickness of the closure body in the area of the perforation point is 0.1-5, preferably 1-3, particularly preferably 2 mm.

Nachstehend wird die Erfindung anhand der Zeichnungen noch näher erläutert. Es zeigen in unterschiedlichen Maßstäben

  • Figur 1:
    • Einen Längsschnitt durch einen Flaschenverschluß und den oberen Teil einer Flasche
  • Figur 2 a und b:
    • Aufsichten auf zwei Ausführungsformen eines Flaschenverschlusses mit unterschiedlich geformten Einschitten.
  • Figur 3:
    • Einen Längsschnitt durch eine weitere Ausführungsform des Verschlußkörpers mit separater Membran.
  • Figur 4 a und b:
    • Längsschnitte durch einen Behälterverschluß gemäß Figur 1 mit verschiedenen Durchdringungstiefen der Kanüle.
  • Figur 5 a bis c:
    • Längsschnitte durch weitere bevorzugte Ausführungsformen des Behälterverschlusses.
The invention is explained in more detail below with reference to the drawings. They show on different scales
  • Figure 1:
    • A longitudinal section through a bottle cap and the top of a bottle
  • Figure 2a and b:
    • Top views of two embodiments of a bottle stopper with differently shaped sections.
  • Figure 3:
    • A longitudinal section through a further embodiment of the closure body with a separate membrane.
  • Figure 4 a and b:
    • Longitudinal sections through a container closure according to Figure 1 with different penetration depths of the cannula.
  • Figure 5 a to c:
    • Longitudinal sections through further preferred embodiments of the container closure.

Ein Behälterverschluß besteht aus einem Verschlußkörper 1 und gegebenenfalls einer Bördel (2) (Fig. 1)- oder Schraubkappe. Die Bördelkappe 2 ist ringförmig ausgebildet und greift unter den flanschartigen Kragen (4) des Halses (5) eines Behälters, die Schraubkappe greift entsprechend in ein Gewinde des Halses eines Behälters (3). Die Bördelkappe (2) bzw. die Schraubkappe lassen die Stirnfläche (6) des Verschlußkörpers im mittleren Bereich frei. In üblicher Weise wird dadurch der Verschlußkörper (1) unter einem Dichtdruck an den Hals (5) des Behälters gepreßt und dort festgelegt.A container closure consists of a closure body 1 and optionally a flange (2) (Fig. 1) - or screw cap. The crimp cap 2 is ring-shaped and engages under the flange-like collar (4) of the neck (5) of a container, the screw cap accordingly engages in a thread of the neck of a container (3). The crimp cap (2) or the screw cap leave the end face (6) of the closure body free in the central area. In the usual way, the closure body (1) is pressed under a sealing pressure against the neck (5) of the container and fixed there.

In der Mitte der Stirnfläche (6) weist der Verschlußkörper (1) einen vorzugsweise kreuzförmigen Einschnitt (24) von bevorzugterweise etwa 5 mm, ausgehend vom Mittelpunkt M des Verschlußkörpers (1) aus, auf, wobei der Einschnitt bevorzugterweise zwischen 75 und 90 % der Materialstärke an der Einschnittstelle (9) durchtrennt. Die bestehenbleibende Membran (12) gewährleistet u. a. den hermetischen Verschluß und die nötige mechanische Stabilität bei Lagerung und Transport. Die Materialstärke im eingeschnittenen Teil (9) beträgt bevorzugterweise 0,1 - 5 mm. Dadurch wird gewährleistet, daß um den Durchstoß herum genügend Material vorhanden ist, um eine ausreichende Dichtungsstrecke zum sicheren Verschluß des Behälters (3) nach dem Herausziehen der Kanüle aus der Einschnittstelle (9) zu erhalten.In the middle of the end face (6) the closure body (1) has a preferably cruciform incision (24) of preferably about 5 mm, starting from the center M of the closure body (1), the incision preferably between 75 and 90% of the Cut the material thickness at the incision point (9). The remaining membrane (12) ensures u. a. the hermetic seal and the necessary mechanical stability during storage and transport. The material thickness in the incised part (9) is preferably 0.1-5 mm. This ensures that enough material is available around the puncture in order to obtain a sufficient sealing distance for the secure closure of the container (3) after the cannula has been pulled out of the incision site (9).

Die besondere Arbeitsweise beim erfindungsgemäßen Behälterverschluß wird nachstehend erläutert (Fig. 4 a, b).The special operation of the container closure according to the invention is explained below (Fig. 4 a, b).

Beim Auftreffen der Kanüle (10) auf die Oberfläche (11) des Verschlußkörpers (1) wird zunächst die gesamte Einschnittstelle (9) durch den Druck der Kanüle (10) gedehnt. Bei weiterem Vordringen der Kanüle treten entsprechend der weiteren Dehnung im Bereich der Membran (12) Zugkräfte auf, die zum Zerreißen der Membran (12) an der Eindringstelle führen. Die Kanüle (10) kann dann, durch das Material des Verschlußkörpers an der Eindringstelle abgedichtet, Flüssigkeit aus dem Behälter entnehmen oder in den Behälter abgeben.When the cannula (10) hits the surface (11) of the closure body (1), the entire incision site (9) is first stretched by the pressure of the cannula (10). As the cannula advances further, tensile forces occur in the region of the membrane (12) in accordance with the further expansion, which lead to the membrane (12) tearing at the point of penetration. The cannula (10), then sealed by the material of the closure body at the point of penetration, can remove liquid from the container or dispense it into the container.

Der in Figur 3 dargestellte Verschlußkörper (1) besitzt eine gesonderte Abdeckmembran (14), die entweder durch Druck, Adhäsion oder Kohäsion mit dem Verschlußkörperunterteil (15) verbunden sein kann. Das Verschlußkörperunterteil (15) ist an der Einschnittstelle (9) über die gesamte Materialstärke hin durchschnitten. Die Membran (14) kann bevorzugterweise aus einem wenig elastischen Material geringer Reißfestigkeit hergestellt werden, wie zum Beispiel Aluminiumfolie. In diesem Fall kann die Materialstärke auch weniger als 0,1 mm betragen.The closure body (1) shown in FIG. 3 has a separate cover membrane (14) which can be connected to the bottom part of the closure body (15) either by pressure, adhesion or cohesion. The lower part of the closure body (15) is cut through at the incision point (9) over the entire material thickness. The membrane (14) can preferably be made from a less elastic material with low tensile strength, such as aluminum foil. In this case, the material thickness can also be less than 0.1 mm.

Der in der Figur 5 (a-c) dargestellte Verschlußkörper (1) besteht aus einem Plättchen (20) aus einem hochelastischen Material (Septum) und einer Bördelkappe (2) bzw. einer Schraubkappe, die das Plättchen (20) entweder direkt auf die Flanschfläche des Kragens (4) (Fig. 5 a) des Behälters (3) oder einen Träger (21) (Fig. 5 c) drücken, der seinerseits aus einem elastischen Material gefertigt sein kann. Der Durchstoßungsbereich (23) (vgl. Anspruch 1 und 2) des Plättchens kann wie in Fig. 1 - (Fig. 5 a und 5 c) oder wie in Figur 3 (Fig. 5 b) dargestellt, ausgebildet sein.The closure body (1) shown in Figure 5 (ac) consists of a plate (20) made of a highly elastic material (septum) and a crimp cap (2) or a screw cap, which either directly attaches the plate (20) to the flange surface of the Press collar (4) (Fig. 5 a) of the container (3) or a carrier (21) (Fig. 5 c), which in turn can be made of an elastic material. The puncture area (23) (cf. claims 1 and 2) of the plate can be designed as shown in FIGS. 1 - (FIGS. 5 a and 5 c) or as shown in FIG. 3 (FIG. 5 b).

Wie in Figur 2 dargestellt, kann der Verschlußkörper in jeder der erfinderischen Ausführungsformen linien-, kreuz- (Fig. 2 a) oder sternförmig (Fig. 2 b) eingeschnitten sein. Bevorzugt sind Ausführungen mit kreuzförmigem und dreizackigem Einschnitt.As shown in FIG. 2, the closure body can be cut in a line, cross (FIG. 2 a) or star shape (FIG. 2 b) in each of the inventive embodiments. Designs with a cross-shaped and three-pronged incision are preferred.

Bevorzugterweise werden die Einschnitte so ausgeführt, daß sie zur Behälterinnenseite (22) offen sind.The incisions are preferably made so that they are open to the inside of the container (22).

Claims (4)

1. Behälterverschluß mit einem durchstoßbaren Verschlußkörper zum Flüssigkeitstransfer mittels einer Hohlnadel aus einem oder in einen Behälter, wobei dieser Verschlußkörper gekennzeichnet ist durch die Kombination folgender Merkmale: a) Der Verschlußkörper (1) besteht zumindest im Durchstoßungsbereich (23) aus elastischem Material wie Natur- oder Synthesekautschuk, wie z. B. Silikon-, Brombutyl-oder Chlorbutylkautschuk der gegebenenfalls auch mit PTFE beschichtet sein kann, insbesondere aus Butylkautschuk, b) der Verschlußkörper ist im Durchstoßungsbereich (23) zu mindestens 75 % der Dicke eingeschnitten (9), vorzugsweise vom Behälterinneren (22) her. 1. Container closure with a pierceable closure body for liquid transfer by means of a hollow needle from or into a container, this closure body being characterized by the combination of the following features: a) The closure body (1) consists at least in the penetration area (23) made of elastic material such as natural or synthetic rubber, such as. B. silicone, bromobutyl or chlorobutyl rubber which can optionally also be coated with PTFE, in particular from butyl rubber, b) the closure body is cut in the penetration area (23) to at least 75% of the thickness (9), preferably from the inside of the container (22). 2. Behälterverschluß gemäß Anspruch 1, dadurch gekennzeichnet, daß der Einschnitt (9) aus 4 vorzugsweise gleichlangen, vom Mittelpunkt des Verschlußkörpers ausgehenden, rechtwinklig zueinander angeordneten Schnitten (24) besteht.2. Container closure according to claim 1, characterized in that the incision (9) consists of 4 preferably of equal length, starting from the center of the closure body, arranged at right angles to each other cuts (24). 3. Behälterverschluß gemäß mindestens einem der Ansprüche 1 und 2, dadurch gekennzeichnet, daß er aus einem Verschlußkörperunterteil (15) und einer Abdeckmembran (14) besteht.3. Container closure according to at least one of claims 1 and 2, characterized in that it consists of a closure body lower part (15) and a cover membrane (14). 4. Behälterverschluß gemäß mindestens einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß der Verschluß aus einem Plättchen (20) besteht.4. Container closure according to at least one of claims 1 to 3, characterized in that the closure consists of a plate (20).
EP92105139A 1991-04-13 1992-03-25 Container closure with perforable seal Expired - Lifetime EP0509281B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4112209 1991-04-13
DE4112209A DE4112209A1 (en) 1991-04-13 1991-04-13 CONTAINER CLOSURE WITH PUSHABLE BODY

Publications (3)

Publication Number Publication Date
EP0509281A2 true EP0509281A2 (en) 1992-10-21
EP0509281A3 EP0509281A3 (en) 1993-03-10
EP0509281B1 EP0509281B1 (en) 1996-08-21

Family

ID=6429581

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92105139A Expired - Lifetime EP0509281B1 (en) 1991-04-13 1992-03-25 Container closure with perforable seal

Country Status (9)

Country Link
US (1) US6024235A (en)
EP (1) EP0509281B1 (en)
JP (1) JPH05124664A (en)
AT (1) ATE141568T1 (en)
AU (1) AU663314B2 (en)
CA (1) CA2065925C (en)
DE (2) DE4112209A1 (en)
DK (1) DK0509281T3 (en)
ES (1) ES2092589T3 (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003373A1 (en) * 1992-08-07 1994-02-17 The West Company, Incorporated Needleless access stopper
WO1995004511A1 (en) * 1993-08-11 1995-02-16 Michael John Smith Improvements in and relating to dressings
EP0675830A1 (en) * 1992-12-30 1995-10-11 Abbott Laboratories Thin diaphragm stopper for blunt entry device
WO1997022537A1 (en) * 1995-12-20 1997-06-26 Gate Gourmet Zürich Ag Foodstuff package, process and device for heat-treating a foodstuff vacuum-packed in such a package
WO1998017146A2 (en) * 1996-10-23 1998-04-30 Musetta, Angela Dispenser for fluid or pasty substances and related method of manufacture
FR2772727A1 (en) * 1997-12-24 1999-06-25 Rvp Finance Non-return seal for container neck opening
WO2000059797A1 (en) * 1999-04-01 2000-10-12 Pentapharm Ag Stopper
EP1046915A2 (en) 1999-04-19 2000-10-25 Dade Behring Marburg GmbH Closing device for reagent containers
CH691122A5 (en) * 1995-12-20 2001-04-30 Gate Gourmet Zuerich Ag Packaging for heat treated food e.g. vegetables, meat, sauces and like
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WO2007145767A2 (en) * 2006-06-07 2007-12-21 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
WO2008068663A1 (en) * 2006-12-01 2008-06-12 Koninklijke Philips Electronics N. V. Needle interface for fluid connections
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Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002940A1 (en) * 1991-07-30 1993-02-18 The Wellcome Foundation Limited Cap for a container
DE29602657U1 (en) * 1996-02-15 1996-04-04 Halder, Werner, 88480 Achstetten Storage container for small items
DE19754625C2 (en) * 1997-12-09 2002-01-24 Helvoet Pharma Stopper for closing infusion bottles
DE19812057B4 (en) * 1998-03-19 2008-11-06 Schott Ag Process for the industrial production of a storage container made of glass or plastic, filled with medical substances such as pharmaceuticals and diagnostics
CA2262477C (en) * 1998-05-16 2008-02-12 Bracco International B.V. Multiple use universal stopper
US6461345B1 (en) * 1998-11-16 2002-10-08 Merck & Co., Inc. Cannula operated pinch valve
JP2000262405A (en) * 1999-03-18 2000-09-26 Soc Prod Nestle Sa Sealed cartridge for drink extraction
EP1211184B1 (en) * 1999-04-20 2010-01-20 JMS Co., Ltd. Cap for container and adaptor for liquid communication
US6716396B1 (en) 1999-05-14 2004-04-06 Gen-Probe Incorporated Penetrable cap
JP2002000700A (en) * 1999-10-05 2002-01-08 Otsuka Pharmaceut Factory Inc Cap and drug container using the same
WO2001030663A1 (en) * 1999-10-26 2001-05-03 Wellman Industrial Plastics Co. Pty. Limited Container and lid combination with tamper evident mechanism
JP2001327576A (en) * 2000-05-22 2001-11-27 Otsuka Pharmaceut Factory Inc Cap and drug container using the same
JP4477216B2 (en) * 2000-10-26 2010-06-09 株式会社大塚製薬工場 Cap, method of manufacturing the same, and drug container using the cap
WO2002072265A1 (en) 2001-03-09 2002-09-19 Gen-Probe Incorporated Penetrable cap
JP4758018B2 (en) * 2001-03-28 2011-08-24 株式会社大塚製薬工場 Chemical container
JP3935394B2 (en) * 2001-05-14 2007-06-20 株式会社大塚製薬工場 Elastic sealing body, method for producing the same, and drug container using the same
US20030052074A1 (en) * 2001-09-17 2003-03-20 Chang Min Shuan Closure for container for holding biological samples
AR037781A1 (en) * 2001-12-10 2004-12-01 Alcoa Gmbh Verpackwerke CONTAINER, IN PARTICULAR, BOTTLE FOR DRINKS
US20030121878A1 (en) * 2001-12-27 2003-07-03 Finneran James G. Versatile vial and plug system
AU2002951318A0 (en) * 2002-09-10 2002-09-26 Manley, David William A closure
FI112898B (en) * 2002-09-18 2004-01-30 Nokia Corp Voice call establishment request processing method in library involves receiving silent messages through user interface of called and/or calling terminals when two -way voice call between terminals is not allowed
US6772892B2 (en) * 2002-11-19 2004-08-10 E. & J. Gallo Winery Reusable closure system for bottle-type containers
CA2525053A1 (en) * 2003-05-22 2004-12-02 Otsuka Pharmaceutical Factory, Inc. Sealing body, cap with the sealing body, and medical container
GB2417875B (en) * 2004-09-01 2009-01-28 Quickwave Internat Corp Cooking apparatus and method of use
US20060226113A1 (en) * 2005-04-06 2006-10-12 Clark Douglas P Liquid vial closure with improved anti-evaporation features
US20060226112A1 (en) * 2005-04-06 2006-10-12 Clark Douglas P Liquid vial closure with improved anti-evaporation features
KR100590189B1 (en) * 2005-10-31 2006-06-19 넥솔테크(주) A coffee pod including inner frame
DE202006001995U1 (en) * 2006-02-07 2006-06-08 Sarstedt Ag & Co. Sample vessel for holding small quantities of liquid for analysis
US8387811B2 (en) 2007-04-16 2013-03-05 Bd Diagnostics Pierceable cap having piercing extensions
US8387810B2 (en) * 2007-04-16 2013-03-05 Becton, Dickinson And Company Pierceable cap having piercing extensions for a sample container
EP1995182A1 (en) * 2007-05-25 2008-11-26 F.Hoffmann-La Roche Ag A sealing cap for a fluid container and a blood collection device
US8783484B2 (en) 2007-08-31 2014-07-22 Saint-Gobain Performance Plastics Corporation Septa
US20100206836A1 (en) * 2007-10-18 2010-08-19 Tsuyoshi Koshidaka Vial rubber-stopper
JP2009298480A (en) * 2008-05-12 2009-12-24 Kokoku Intech Co Ltd Erosol product and jetting member used for the same
US20110303670A1 (en) * 2008-12-10 2011-12-15 Raymond John Baker Secure closure
US20120265163A1 (en) * 2011-04-14 2012-10-18 Marc Bunjiun Cheng Coupling system to transfer material between containers
JP2013016320A (en) * 2011-07-01 2013-01-24 Maspro Denkoh Corp Waterproof cap for electronic equipment case
CN102389372A (en) * 2011-07-26 2012-03-28 海南卫康制药(潜山)有限公司 Puncture-free bottle stopper and use method thereof
US20130178793A1 (en) * 2011-07-29 2013-07-11 Victor Matias Pump-to-Bottle Bag
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EP2631011B1 (en) * 2012-02-24 2015-03-25 F. Hoffmann-La Roche AG Closure with septum strip
US20130240530A1 (en) * 2012-03-16 2013-09-19 Fisher Scientific Company, L.L.C. Bromobutyl rubber-based self-resealing septum and closure assembly
US20130245592A1 (en) * 2012-03-16 2013-09-19 Fisher Scientific Company L.L.C. Chlorobutyl rubber-based self-resealing septum and closure assembly
US20140202979A1 (en) * 2013-01-22 2014-07-24 General Electric Company Apparatus for storage and sampling of de-ionized water samples and the like
WO2019083492A1 (en) * 2017-10-23 2019-05-02 Aptargroup, Inc. Valve
CN112978074A (en) * 2019-11-10 2021-06-18 王志远 Novel beer glass bottle sealing cover and using method
JP2023154285A (en) * 2022-04-06 2023-10-19 明彦 谷 Liquid injection device and closed container into which liquid is injected using the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1946566B2 (en) * 1969-09-13 1975-07-10 Pharma-Gummi Wimmer West Gmbh, 5180 Eschweiler Bottle stopper with a pierceable stopper body for taking medication
DE2655902C2 (en) * 1976-12-09 1979-01-11 Siemens Ag, 1000 Berlin Und 8000 Muenchen Bottle cap
US4545497A (en) * 1984-11-16 1985-10-08 Millipore Corporation Container cap with frangible septum
DE3543825A1 (en) * 1984-12-21 1986-06-26 Schiwa GmbH, 4519 Glandorf Closure piece for infusion containers
US4635807A (en) * 1983-03-17 1987-01-13 Schering Corporation Stopper for sterile fluid containers

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2099370A (en) * 1935-09-07 1937-11-16 Monnier Vital Phial
US2153981A (en) * 1936-04-03 1939-04-11 Winthrop Chem Co Inc Medicinal container
GB558998A (en) * 1942-08-24 1944-01-31 William Simon Freeman Improvements in or relating to stoppers for bottles and other containers
US2579724A (en) * 1946-04-15 1951-12-25 Breakstone Seymour Valved closure plug for insertion in the neck of a bottle
US3067425A (en) * 1959-11-09 1962-12-11 Goodrich Co B F Flying suit helmet with penetrable sealing closure structure
US3343699A (en) * 1966-02-09 1967-09-26 Flake Ice Machines Inc Combination cap and tapping plug for spouts, bottles or the like
US3496969A (en) * 1967-05-12 1970-02-24 Sterigard Corp Valve for pressurizing a container
DE1901239C3 (en) * 1969-01-11 1975-11-06 Pharma-Gummi Wimmer West Gmbh, 5180 Eschweiler Bottle stopper with a pierceable stopper for withdrawing medication
US3823840A (en) * 1972-08-04 1974-07-16 Silver J Prepunctured closure
US4186840A (en) * 1976-03-04 1980-02-05 Becton, Dickinson And Company Cannulapierceable, self-sealing closure
US4163500A (en) * 1978-01-23 1979-08-07 Siemens Aktiengesellschaft Bottle seal
JPS56119254A (en) * 1980-02-25 1981-09-18 Takeda Chemical Industries Ltd Rubber stopper for vial
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
AT380392B (en) * 1985-01-24 1986-05-12 C A Greiner & S Hne Ges M B H BLOOD SAMPLING!
DE3674949D1 (en) * 1985-05-28 1990-11-22 Daikyo Gomu Seiko Kk RESIN LAMINATED PLASTIC PLUG AND THEIR PRODUCTION.
US4834152A (en) * 1986-02-27 1989-05-30 Intelligent Medicine, Inc. Storage receptacle sealing and transfer apparatus
US5060812A (en) * 1990-09-06 1991-10-29 International Medication Systems, Limited Medication container stopper which can be punctured by nozzle of a hypodermic syringe
US5111946A (en) * 1990-11-30 1992-05-12 Elliot Glanz Safety bottle

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1946566B2 (en) * 1969-09-13 1975-07-10 Pharma-Gummi Wimmer West Gmbh, 5180 Eschweiler Bottle stopper with a pierceable stopper body for taking medication
DE2655902C2 (en) * 1976-12-09 1979-01-11 Siemens Ag, 1000 Berlin Und 8000 Muenchen Bottle cap
US4635807A (en) * 1983-03-17 1987-01-13 Schering Corporation Stopper for sterile fluid containers
US4545497A (en) * 1984-11-16 1985-10-08 Millipore Corporation Container cap with frangible septum
DE3543825A1 (en) * 1984-12-21 1986-06-26 Schiwa GmbH, 4519 Glandorf Closure piece for infusion containers

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5433330A (en) * 1992-08-07 1995-07-18 The West Company, Incorporated Needleless access stopper
WO1994003373A1 (en) * 1992-08-07 1994-02-17 The West Company, Incorporated Needleless access stopper
EP0675830A1 (en) * 1992-12-30 1995-10-11 Abbott Laboratories Thin diaphragm stopper for blunt entry device
EP0675830A4 (en) * 1992-12-30 1997-12-29 Abbott Lab Thin diaphragm stopper for blunt entry device.
WO1995004511A1 (en) * 1993-08-11 1995-02-16 Michael John Smith Improvements in and relating to dressings
CH691122A5 (en) * 1995-12-20 2001-04-30 Gate Gourmet Zuerich Ag Packaging for heat treated food e.g. vegetables, meat, sauces and like
WO1997022537A1 (en) * 1995-12-20 1997-06-26 Gate Gourmet Zürich Ag Foodstuff package, process and device for heat-treating a foodstuff vacuum-packed in such a package
US6056985A (en) * 1995-12-20 2000-05-02 Gate Gourmet Zurich Ag Foodstuff package, process and device for heat-treating a foodstuff vacuum-packed in such a package
WO1998017146A2 (en) * 1996-10-23 1998-04-30 Musetta, Angela Dispenser for fluid or pasty substances and related method of manufacture
WO1998017146A3 (en) * 1996-10-23 1998-11-05 Musetta Angela Dispenser for fluid or pasty substances and related method of manufacture
FR2772727A1 (en) * 1997-12-24 1999-06-25 Rvp Finance Non-return seal for container neck opening
JP2002541029A (en) * 1999-04-01 2002-12-03 ペンタファルム アクチェンゲゼルシャフト Stopper
WO2000059796A1 (en) * 1999-04-01 2000-10-12 Pentapharm Ag Stopper
WO2000059797A1 (en) * 1999-04-01 2000-10-12 Pentapharm Ag Stopper
EP1046915A2 (en) 1999-04-19 2000-10-25 Dade Behring Marburg GmbH Closing device for reagent containers
AT500525A1 (en) * 2003-04-17 2006-01-15 Greiner Bio One Gmbh RECEIVING DEVICE AND SEALING DEVICE AND CAP SHAPED LOCKING DEVICE
EP1652787A1 (en) * 2004-10-26 2006-05-03 Dade Behring Marburg GmbH Piercable flexible device for closing a container for liquid
GB2451407A (en) * 2006-06-07 2009-01-28 J G Finnereran Associates Inc Two piece seal vial assembly
WO2007145767A3 (en) * 2006-06-07 2008-02-14 J G Finneran Associates Inc Two-piece seal vial assembly
WO2007145767A2 (en) * 2006-06-07 2007-12-21 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
US7934614B2 (en) 2006-06-07 2011-05-03 J. G. Finneran Associates, Inc. Two-piece seal vial assembly
GB2451407B (en) * 2006-06-07 2011-09-07 J G Finneran Associates Inc Two piece seal vial assembly
WO2008068663A1 (en) * 2006-12-01 2008-06-12 Koninklijke Philips Electronics N. V. Needle interface for fluid connections
JP2010511171A (en) * 2006-12-01 2010-04-08 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Needle interface for fluid connection
CN101548182B (en) * 2006-12-01 2012-10-10 皇家飞利浦电子股份有限公司 Needle interface for fluid connections
US9063108B2 (en) 2006-12-01 2015-06-23 Koninklijke Philips N.V. Needle interface for fluid connections
DE102012007887A1 (en) * 2012-04-23 2013-10-24 Erwin Quarder Systemtechnik Gmbh Sample vessel i.e. multi-corrugated board, for examination of e.g. biological cell sample, has closure unit returning back into closed position from open position by return forces after termination of force by opening unit
EP3563929A1 (en) * 2018-04-30 2019-11-06 Firmenich SA Apparatus for customized production of a flavoring agent mix

Also Published As

Publication number Publication date
ATE141568T1 (en) 1996-09-15
EP0509281A3 (en) 1993-03-10
CA2065925A1 (en) 1992-10-14
JPH05124664A (en) 1993-05-21
ES2092589T3 (en) 1996-12-01
AU1482192A (en) 1992-10-15
CA2065925C (en) 2005-06-14
EP0509281B1 (en) 1996-08-21
DE59206931D1 (en) 1996-09-26
AU663314B2 (en) 1995-10-05
US6024235A (en) 2000-02-15
DE4112209A1 (en) 1992-10-15
DK0509281T3 (en) 1997-01-06

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