ES391633A1 - 2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides - Google Patents

2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides

Info

Publication number
ES391633A1
ES391633A1 ES391633A ES391633A ES391633A1 ES 391633 A1 ES391633 A1 ES 391633A1 ES 391633 A ES391633 A ES 391633A ES 391633 A ES391633 A ES 391633A ES 391633 A1 ES391633 A1 ES 391633A1
Authority
ES
Spain
Prior art keywords
group
member selected
formula
compound
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES391633A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES391633A1 publication Critical patent/ES391633A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/115—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)

Abstract

A procedure for the preparation of a 2,2-diaryl-4-piperidinobutyramide selected from the group of compounds represented by the formula: **(See formula)** and the therapeutically active acid addition salts thereof, where: R is a member selected from the group consisting of hydrogen and methyl; Ar1 is a member selected from the group consisting of phenyl and halophenyl; Ar2 is a member selected from the group consisting of phenyl and halophenyl; -Alq- is a member selected from the group consisting of -CH2CH2- and -CH2CH (CH3) -; -N = Z is a member selected from the group consisting of: **(See formula)** lower alkyl and R3 is a member selected from the group consisting of lower alkyl and benzyl; Ar3 is a member selected from the group consisting of phenyl and substituted phenyl, the latter being substituted phenyl containing at least one member selected from the group consisting of lower alkyl, lower alkoxy, halogen and trifluoromethyl; with the proviso that, when -Alq- is -CH2CH (CH3) - then -N = Z is different from -N (CH2CH = CH2) 2; whose procedure is characterized by: (i) reacting a compound of formula **(See formula)** where AN is a suitable anion, or a compound of the formula **(See formula)** with a compound of formula **(See formula)** in an organic solvent, in the presence of a base, in order to prepare a compound of formula (I); and separating the product from the reaction mixture, and, if desired, preparing an acid addition salt of the therapeutically active compounds (1). (Machine-translation by Google Translate, not legally binding)
ES391633A 1970-06-01 1971-05-27 2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides Expired ES391633A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4253070A 1970-06-01 1970-06-01
US12960771A 1971-03-30 1971-03-30

Publications (1)

Publication Number Publication Date
ES391633A1 true ES391633A1 (en) 1975-09-16

Family

ID=26719340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES391633A Expired ES391633A1 (en) 1970-06-01 1971-05-27 2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides

Country Status (18)

Country Link
JP (1) JPS5754508B1 (en)
AT (1) AT312606B (en)
BE (1) BE767798A (en)
CH (2) CH553182A (en)
CS (1) CS171232B2 (en)
DE (2) DE2126559C3 (en)
DK (1) DK137382B (en)
ES (1) ES391633A1 (en)
FI (1) FI54472C (en)
FR (1) FR2100711B1 (en)
GB (1) GB1319040A (en)
HK (1) HK78076A (en)
HU (1) HU166420B (en)
IL (1) IL36949A (en)
NL (1) NL173848C (en)
NO (1) NO133547C (en)
PL (1) PL81548B1 (en)
SE (1) SE369418B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585374A (en) * 1992-08-05 1996-12-17 John Wyeth Brother, Limited Amide derivatives
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
GB9502644D0 (en) * 1995-02-10 1995-03-29 Zeneca Ltd Heterocyclic derivatives
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
WO1997024325A1 (en) * 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
JP4625637B2 (en) 2002-02-22 2011-02-02 シャイア エルエルシー Active substance delivery system and method for protecting and administering an active substance
CN110357808A (en) * 2019-06-13 2019-10-22 上海上药新亚药业有限公司 A kind of crystallization processes of loperamide hydrochloride

Also Published As

Publication number Publication date
DK137382C (en) 1978-08-07
CS171232B2 (en) 1976-10-31
CH553182A (en) 1974-08-30
JPS5754508B1 (en) 1982-11-18
HU166420B (en) 1975-03-28
DK137382B (en) 1978-02-27
GB1319040A (en) 1973-05-31
NL7106829A (en) 1971-12-03
DE2126559C3 (en) 1982-01-14
FR2100711B1 (en) 1974-09-27
DE2167193C2 (en) 1983-05-19
IL36949A (en) 1974-07-31
AT312606B (en) 1974-01-10
FI54472C (en) 1978-12-11
CH549015A (en) 1974-05-15
BE767798A (en) 1971-11-29
NL173848C (en) 1984-03-16
IL36949A0 (en) 1971-07-28
HK78076A (en) 1976-12-17
FI54472B (en) 1978-08-31
FR2100711A1 (en) 1972-03-24
DE2126559A1 (en) 1972-10-05
NO133547C (en) 1976-05-19
SE369418B (en) 1974-08-26
NO133547B (en) 1976-02-09
DE2126559B2 (en) 1981-02-26
PL81548B1 (en) 1975-08-30

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