ES423958A1 - Process for the manufacture of indole derivatives - Google Patents
Process for the manufacture of indole derivativesInfo
- Publication number
- ES423958A1 ES423958A1 ES423958A ES423958A ES423958A1 ES 423958 A1 ES423958 A1 ES 423958A1 ES 423958 A ES423958 A ES 423958A ES 423958 A ES423958 A ES 423958A ES 423958 A1 ES423958 A1 ES 423958A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- salt
- indole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for obtaining indole derivatives, of the general formula: ** (see formula) ** Wherein y is hydrogen or a methoxy radical and z is a 7-chloro, 2-methyl or 2-methylthio radical; and its pharmaceutically acceptable base addition salts; characterized in that it comprises stages of: A) reacting a compound of formulas: Wherein y is defined as above, with a compound of formula: ** (see formula) ** Wherein x is a chlorine, bromine or iodine atom and z is defined as above, to give a compound of formula: ** (see formula) ** As the salt of the corresponding acid of formula hx, wherein x is defined as above; y B) heating the compound of formula iv or a salt thereof, at 40-160º c; and when a pharmaceutically acceptable salt is desired, react the acid of formula i with a base that provides a pharmaceutically acceptable cation. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1073673A GB1407658A (en) | 1973-03-06 | 1973-03-06 | Process for the manufacture of indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES423958A1 true ES423958A1 (en) | 1976-05-16 |
Family
ID=9973351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES423958A Expired ES423958A1 (en) | 1973-03-06 | 1974-02-06 | Process for the manufacture of indole derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5058083A (en) |
| AT (1) | AT333747B (en) |
| BE (1) | BE811657A (en) |
| DD (1) | DD110273A5 (en) |
| DE (1) | DE2410699A1 (en) |
| DK (1) | DK134403B (en) |
| ES (1) | ES423958A1 (en) |
| FR (1) | FR2220528B1 (en) |
| GB (1) | GB1407658A (en) |
| IE (1) | IE38970B1 (en) |
| LU (1) | LU69542A1 (en) |
| MC (1) | MC1017A1 (en) |
| NL (1) | NL7402369A (en) |
| PL (1) | PL91000B1 (en) |
| YU (1) | YU55774A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0200356D0 (en) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| WO2008012511A1 (en) | 2006-07-22 | 2008-01-31 | Oxagen Limited | Compounds having crth2 antagonist activity |
| BRPI0906786B1 (en) | 2008-01-18 | 2021-10-05 | Atopix Therapeutics Limited | COMPOUND, PROCESS FOR THE PREPARATION OF A COMPOUND, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION, AND, PRODUCT |
| US20100022613A1 (en) | 2008-01-22 | 2010-01-28 | Oxagen Limited | Compounds Having CRTH2 Antagonist Activity |
| EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
-
1973
- 1973-03-06 GB GB1073673A patent/GB1407658A/en not_active Expired
-
1974
- 1974-02-05 IE IE21274A patent/IE38970B1/en unknown
- 1974-02-06 ES ES423958A patent/ES423958A1/en not_active Expired
- 1974-02-21 NL NL7402369A patent/NL7402369A/xx unknown
- 1974-02-26 DK DK102074A patent/DK134403B/en unknown
- 1974-02-27 BE BE141465A patent/BE811657A/en unknown
- 1974-03-04 YU YU55774A patent/YU55774A/en unknown
- 1974-03-04 DD DD17692974A patent/DD110273A5/xx unknown
- 1974-03-04 LU LU69542A patent/LU69542A1/xx unknown
- 1974-03-04 PL PL16924274A patent/PL91000B1/en unknown
- 1974-03-05 MC MC1099A patent/MC1017A1/en unknown
- 1974-03-05 FR FR7407494A patent/FR2220528B1/fr not_active Expired
- 1974-03-05 AT AT182374A patent/AT333747B/en not_active IP Right Cessation
- 1974-03-06 JP JP2609874A patent/JPS5058083A/ja active Pending
- 1974-03-06 DE DE19742410699 patent/DE2410699A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7402369A (en) | 1974-09-10 |
| AT333747B (en) | 1976-12-10 |
| DD110273A5 (en) | 1974-12-12 |
| IE38970B1 (en) | 1978-07-05 |
| JPS5058083A (en) | 1975-05-20 |
| GB1407658A (en) | 1975-09-24 |
| DK134403B (en) | 1976-11-01 |
| YU55774A (en) | 1982-06-30 |
| IE38970L (en) | 1974-09-06 |
| DK134403C (en) | 1977-03-28 |
| LU69542A1 (en) | 1974-06-21 |
| BE811657A (en) | 1974-08-27 |
| ATA182374A (en) | 1976-04-15 |
| FR2220528A1 (en) | 1974-10-04 |
| DE2410699A1 (en) | 1974-09-12 |
| FR2220528B1 (en) | 1977-09-23 |
| MC1017A1 (en) | 1975-02-28 |
| PL91000B1 (en) | 1977-02-28 |
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