ES423971A1 - PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES.Info
- Publication number
- ES423971A1 ES423971A1 ES74423971A ES423971A ES423971A1 ES 423971 A1 ES423971 A1 ES 423971A1 ES 74423971 A ES74423971 A ES 74423971A ES 423971 A ES423971 A ES 423971A ES 423971 A1 ES423971 A1 ES 423971A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- radical
- signifies
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003939 benzylamines Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- -1 morpholinocarbonylmethyl radical Chemical class 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- YUDRVAHLXDBKSR-UHFFFAOYSA-N [CH]1CCCCC1 Chemical compound [CH]1CCCCC1 YUDRVAHLXDBKSR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of new benzylamines of the general formula I, **(See formula)** where Hal signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, R2 signifies the morpholinocarbonylmethyl radical, a branched alcohol radical with 3 to 5 carbon atoms or a group of the formula **(See formula)** where R3 signifies a hydrogen atom or an alcohol group with 1 to 4 carbon atoms, n signifies the numbers 0, 1 or 2 and the two radicals A and B signify hydrogen atoms or together the group **(See formula)** where R5 represents a hydrogen atom or a lower alcohol radical with 1 or 2 carbon atoms and m means the numbers 1 or 2, R4 means a straight chain or branched alcohol radical with 1 to 4 carbon atoms, an alkenyl radical with 2 to 4 carbon atoms or a cycloalcohyl radical with 3 or 4 carbon atoms and l signify the numbers 1 or 2, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II **(See formula)** Wherein R1, Hal and l are as initially defined and R'2 means a hydrogen atom or an alcohol radical with 1 to 4 carbon atoms and, with the exception of branched alcohol radicals with 3 to 5 carbon atoms and of the radicals substituted with hydroxyl groups, it has the meanings initially mentioned for R2, with a compound of the general formula III, **(See formula)** where R'4 represents a branched alcohol radical with 3 to 5 carbon atoms, the cyclohexyl radical and has the initially mentioned meanings for R4 with the exception of hydrogen, and W represents a halogen atom or a sulfonic acid radical; and a compound of the general formula I, obtained according to the procedure, is subsequently transformed, if desired, into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722251891 DE2251891C3 (en) | 1972-10-23 | Benzylamines, their physiologically acceptable salts, processes for their preparation and pharmaceuticals containing them | |
| DE19732320967 DE2320967C3 (en) | 1973-04-26 | New benzylamines, their physiologically acceptable salts, processes for their production and pharmaceuticals containing them | |
| DE2346743A DE2346743C3 (en) | 1972-10-23 | 1973-09-17 | 2- or 4-Hydroxy-3,5-dihalogenobenzylamines, their physiologically tolerable salts, processes for their preparation and medicaments containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES423971A1 true ES423971A1 (en) | 1976-06-16 |
Family
ID=27184785
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES74423971A Expired ES423971A1 (en) | 1972-10-23 | 1974-03-06 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
| ES423969A Expired ES423969A1 (en) | 1972-10-23 | 1974-03-06 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
| ES423972A Expired ES423972A1 (en) | 1972-10-23 | 1974-03-06 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES423969A Expired ES423969A1 (en) | 1972-10-23 | 1974-03-06 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
| ES423972A Expired ES423972A1 (en) | 1972-10-23 | 1974-03-06 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Country Status (7)
| Country | Link |
|---|---|
| AT (2) | ATA89375A (en) |
| DE (1) | DE2346743C3 (en) |
| ES (3) | ES423971A1 (en) |
| MX (1) | MX3103E (en) |
| PH (1) | PH13986A (en) |
| PL (2) | PL96274B1 (en) |
| SU (3) | SU517248A3 (en) |
-
1973
- 1973-09-17 DE DE2346743A patent/DE2346743C3/en not_active Expired
- 1973-10-17 AT AT89375*A patent/ATA89375A/en not_active IP Right Cessation
- 1973-10-17 AT AT89075*A patent/ATA89075A/en not_active IP Right Cessation
- 1973-10-22 PL PL1973176692A patent/PL96274B1/en unknown
- 1973-10-22 PL PL1973176689A patent/PL91886B1/en unknown
- 1973-10-22 PH PH15134A patent/PH13986A/en unknown
- 1973-10-23 MX MX003606U patent/MX3103E/en unknown
-
1974
- 1974-03-06 ES ES74423971A patent/ES423971A1/en not_active Expired
- 1974-03-06 ES ES423969A patent/ES423969A1/en not_active Expired
- 1974-03-06 ES ES423972A patent/ES423972A1/en not_active Expired
- 1974-10-10 SU SU2065436A patent/SU517248A3/en active
- 1974-10-10 SU SU2065438A patent/SU520033A3/en active
- 1974-10-10 SU SU2065408A patent/SU519123A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ATA89075A (en) | 1975-07-15 |
| MX3103E (en) | 1980-04-10 |
| ES423969A1 (en) | 1976-06-16 |
| PH13986A (en) | 1980-11-20 |
| PL96274B1 (en) | 1977-12-31 |
| SU520033A3 (en) | 1976-06-30 |
| SU519123A3 (en) | 1976-06-25 |
| DE2346743A1 (en) | 1975-04-03 |
| SU517248A3 (en) | 1976-06-05 |
| ES423972A1 (en) | 1976-06-16 |
| PL91886B1 (en) | 1977-03-31 |
| DE2346743C3 (en) | 1979-07-12 |
| DE2346743B2 (en) | 1978-11-09 |
| ATA89375A (en) | 1975-07-15 |
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