ES424758A1 - 4-oxo-6,7,8,9-tetrahydropyrido-1,2-a-pyrimidine derivatives methods for their preparation and compositions containing them - Google Patents

4-oxo-6,7,8,9-tetrahydropyrido-1,2-a-pyrimidine derivatives methods for their preparation and compositions containing them

Info

Publication number
ES424758A1
ES424758A1 ES424758A ES424758A ES424758A1 ES 424758 A1 ES424758 A1 ES 424758A1 ES 424758 A ES424758 A ES 424758A ES 424758 A ES424758 A ES 424758A ES 424758 A1 ES424758 A1 ES 424758A1
Authority
ES
Spain
Prior art keywords
formula
group
compound
carboxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424758A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES424758A1 publication Critical patent/ES424758A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation procedure for pyrido (1,2a) pyrimidine derivatives and their salts, the derivatives of formula (I) being ** (See formula) ** (in which R1 is hydrogen or alkyl, R2 is hydrogen, halogen, alkyl, aralkyl, amino, alkylamino, acylamino, hydroxy, alkoxy, carboxy or a group derived from carboxylic acid, is hydrogen, carboxy, or a group derived from carboxylic acid, and n = 1 or 2) characterized in that it comprises subjecting to reduction a compound of formula (II) ** (See formula) ** (in which R1 and n have the same meaning as indicated above, R4 is like R2 and can also mean a nitro group and R5 is a carboxy or carboxylic acid derivative group) and, if desired, converted to a compound of the formula (III) ** (See formula) ** thus obtained, the group R5 into a group R3 or, if desired, transform a group R3 into another group R3 and, if desired, convert a compound of formula (I) thus obtained into its acid addition salt or its quaternary salt or release a compound of formula (I) from its acid addition salt or its quaternary salt. (Machine-translation by Google Translate, not legally binding)
ES424758A 1973-03-30 1974-03-29 4-oxo-6,7,8,9-tetrahydropyrido-1,2-a-pyrimidine derivatives methods for their preparation and compositions containing them Expired ES424758A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1361A HU168014B (en) 1973-03-30 1973-03-30

Publications (1)

Publication Number Publication Date
ES424758A1 true ES424758A1 (en) 1976-06-16

Family

ID=10994473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424758A Expired ES424758A1 (en) 1973-03-30 1974-03-29 4-oxo-6,7,8,9-tetrahydropyrido-1,2-a-pyrimidine derivatives methods for their preparation and compositions containing them

Country Status (20)

Country Link
JP (1) JPS505396A (en)
AT (1) AT336624B (en)
BE (1) BE813021A (en)
CA (1) CA1032938A (en)
CH (1) CH605940A5 (en)
CS (1) CS189872B1 (en)
DD (1) DD110661A1 (en)
DE (1) DE2414751A1 (en)
DK (1) DK138327B (en)
ES (1) ES424758A1 (en)
FI (1) FI57949C (en)
FR (1) FR2223036B1 (en)
GB (1) GB1454312A (en)
HU (1) HU168014B (en)
IL (1) IL44417A (en)
NL (1) NL7403901A (en)
NO (1) NO140821C (en)
PL (1) PL93755B1 (en)
SE (1) SE418087B (en)
SU (1) SU566524A3 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173438B (en) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 4-oxo-1,6,7,8-tetrahydro-4h-pyrido-/1,2-a/pyrimidine derivatives with antiinflammatory and anticoagulant activity
HU174693B (en) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing condensed pyrimidine derivatives
HU174901B (en) * 1976-06-25 1980-04-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new pyrido /1,2-a/pyrimidine derivatives
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines
HU185925B (en) * 1977-12-29 1985-04-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing compounds with nitrogen bridge head
HU179143B (en) * 1977-12-29 1982-08-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-hydroxy-groops-containing 6,7-dihydro-pyrido-square bracket-1,2-a-square bracket closed-pyrimidin derivatives and esters thereof
HU180701B (en) * 1977-12-29 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
AT376675B (en) * 1979-05-08 1984-12-27 Erba Farmitalia METHOD FOR PRODUCING NEW SUBSTITUTED PYRIDO (1,2-A) PYRIMIDINES
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
HU201551B (en) * 1988-02-03 1990-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same
WO2009109987A2 (en) * 2008-01-11 2009-09-11 Glenmark Pharmaceuticals, S.A. Fused pyrimidine derivatives as trpv3 modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT299212B (en) * 1966-11-02 1972-06-12 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of new homopyrimidazole derivatives and their salts

Also Published As

Publication number Publication date
CS189872B1 (en) 1979-05-31
CA1032938A (en) 1978-06-13
DD110661A1 (en) 1975-01-05
NL7403901A (en) 1974-10-02
NO140821B (en) 1979-08-13
BE813021A (en) 1974-07-15
ATA252674A (en) 1976-09-15
GB1454312A (en) 1976-11-03
AT336624B (en) 1977-05-10
DK138327B (en) 1978-08-14
HU168014B (en) 1976-02-28
FI57949C (en) 1980-11-10
IL44417A0 (en) 1974-06-30
DE2414751A1 (en) 1974-10-10
CH605940A5 (en) 1978-10-13
DK138327C (en) 1979-01-22
SU566524A3 (en) 1977-07-25
AU6670474A (en) 1975-09-18
FR2223036B1 (en) 1977-05-06
NO140821C (en) 1979-11-21
JPS505396A (en) 1975-01-21
IL44417A (en) 1978-01-31
FI57949B (en) 1980-07-31
PL93755B1 (en) 1977-06-30
FR2223036A1 (en) 1974-10-25
NO741125A (en) 1974-10-01
SE418087B (en) 1981-05-04

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