FI863120A - Nya (4-substituerad-piperazinyl) pyridaziner. - Google Patents
Nya (4-substituerad-piperazinyl) pyridaziner. Download PDFInfo
- Publication number
- FI863120A FI863120A FI863120A FI863120A FI863120A FI 863120 A FI863120 A FI 863120A FI 863120 A FI863120 A FI 863120A FI 863120 A FI863120 A FI 863120A FI 863120 A FI863120 A FI 863120A
- Authority
- FI
- Finland
- Prior art keywords
- pyridaziner
- substituerad
- nya
- piperazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76084585A | 1985-07-31 | 1985-07-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI863120A0 FI863120A0 (fi) | 1986-07-30 |
| FI863120A true FI863120A (fi) | 1987-02-01 |
Family
ID=25060338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI863120A FI863120A (fi) | 1985-07-31 | 1986-07-30 | Nya (4-substituerad-piperazinyl) pyridaziner. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0211457A3 (fi) |
| JP (1) | JPS6229575A (fi) |
| KR (1) | KR870001192A (fi) |
| CN (1) | CN86105558A (fi) |
| AU (1) | AU6073986A (fi) |
| DK (1) | DK363186A (fi) |
| ES (1) | ES8802151A1 (fi) |
| FI (1) | FI863120A (fi) |
| GR (1) | GR862022B (fi) |
| HU (1) | HU195501B (fi) |
| IL (1) | IL79549A0 (fi) |
| NO (1) | NO863083L (fi) |
| NZ (1) | NZ216918A (fi) |
| PH (1) | PH22884A (fi) |
| PT (1) | PT83098B (fi) |
| TN (1) | TNSN86117A1 (fi) |
| ZA (1) | ZA865700B (fi) |
| ZW (1) | ZW14886A1 (fi) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
| MY104343A (en) * | 1987-11-23 | 1994-03-31 | Janssen Pharmaceutica Nv | Novel pyridizinamine deravatives |
| GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| US5070090A (en) * | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
| US5270312A (en) * | 1990-11-05 | 1993-12-14 | Warner-Lambert Company | Substituted piperazines as central nervous system agents |
| BR9813279B1 (pt) * | 1997-10-27 | 2010-11-16 | derivado de homopiperazina, composição farmacêutica, e, uso do derivado de homopiperazina. | |
| AU773830B2 (en) | 1999-04-26 | 2004-06-10 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
| EP2264014A1 (en) | 2001-08-31 | 2010-12-22 | Université Louis Pasteur | Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| EP3042895A1 (en) | 2003-07-30 | 2016-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| KR20060037410A (ko) | 2003-07-30 | 2006-05-03 | 제논 파마슈티칼스 인크. | 피리다진 유도체 및 그의 치료제로서의 용도 |
| US7754711B2 (en) * | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| WO2006034440A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| TW200626139A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| CN101083982A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物 |
| WO2006034441A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CA2589102C (en) | 2004-11-02 | 2013-08-13 | Northwestern University | Pyridazine compounds and methods for using the compounds to treat inflammatory diseases |
| JP5337375B2 (ja) | 2004-11-02 | 2013-11-06 | ノースウェスタン ユニバーシティ | ピリダジン化合物、組成物および方法 |
| AU2016203312B2 (en) * | 2004-11-02 | 2018-05-24 | Centre National De La Recherche Scientifique | Pyridazine compounds, compositions and methods |
| EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| EP2015750A2 (en) | 2006-04-28 | 2009-01-21 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| CN101754762A (zh) | 2006-04-28 | 2010-06-23 | 西北大学 | 用于治疗神经炎症性疾病的包含哒嗪化合物的制剂 |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| WO2008128996A1 (en) | 2007-04-23 | 2008-10-30 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| JP5431305B2 (ja) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体 |
| WO2008145681A2 (en) * | 2007-05-31 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| EP2307374B1 (en) | 2008-07-31 | 2017-01-25 | Janssen Pharmaceutica NV | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| EP2816037A3 (en) | 2011-05-24 | 2015-04-01 | Università degli Studi di Bari "Aldo Moro" | New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof |
| JP6917910B2 (ja) | 2015-07-02 | 2021-08-11 | セントレクシオン セラピューティクス コーポレイション | （４−（（３ｒ，４ｒ）−３−メトキシテトラヒドロ−ピラン−４−イルアミノ）ピペリジン−１−イル）（５−メチル−６−（（（２ｒ，６ｓ）−６−（ｐ−トリル）テトラヒドロ−２ｈ−ピラン−２−イル）メチルアミノ）ピリミジン−４イル）メタノンクエン酸塩 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
-
1986
- 1986-06-25 ES ES556738A patent/ES8802151A1/es not_active Expired
- 1986-07-09 EP EP86201203A patent/EP0211457A3/en not_active Withdrawn
- 1986-07-14 KR KR1019860005671A patent/KR870001192A/ko not_active Application Discontinuation
- 1986-07-21 NZ NZ216918A patent/NZ216918A/xx unknown
- 1986-07-23 JP JP61171940A patent/JPS6229575A/ja active Pending
- 1986-07-28 PH PH34070A patent/PH22884A/en unknown
- 1986-07-28 CN CN198686105558A patent/CN86105558A/zh active Pending
- 1986-07-29 IL IL79549A patent/IL79549A0/xx unknown
- 1986-07-29 TN TNTNSN86117A patent/TNSN86117A1/fr unknown
- 1986-07-30 GR GR862022A patent/GR862022B/el unknown
- 1986-07-30 ZA ZA865700A patent/ZA865700B/xx unknown
- 1986-07-30 PT PT83098A patent/PT83098B/pt unknown
- 1986-07-30 HU HU863248A patent/HU195501B/hu unknown
- 1986-07-30 ZW ZW148/86A patent/ZW14886A1/xx unknown
- 1986-07-30 DK DK363186A patent/DK363186A/da not_active Application Discontinuation
- 1986-07-30 FI FI863120A patent/FI863120A/fi not_active IP Right Cessation
- 1986-07-30 NO NO863083A patent/NO863083L/no unknown
- 1986-07-31 AU AU60739/86A patent/AU6073986A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0211457A2 (en) | 1987-02-25 |
| DK363186A (da) | 1987-02-01 |
| IL79549A0 (en) | 1986-10-31 |
| ZW14886A1 (en) | 1988-02-24 |
| FI863120A0 (fi) | 1986-07-30 |
| NZ216918A (en) | 1988-11-29 |
| NO863083L (no) | 1987-02-02 |
| PT83098A (en) | 1986-08-01 |
| ES8802151A1 (es) | 1988-04-01 |
| HUT41772A (en) | 1987-05-28 |
| AU6073986A (en) | 1987-02-05 |
| HU195501B (en) | 1988-05-30 |
| ES556738A0 (es) | 1988-04-01 |
| TNSN86117A1 (fr) | 1990-01-01 |
| EP0211457A3 (en) | 1987-07-22 |
| GR862022B (en) | 1986-12-24 |
| NO863083D0 (no) | 1986-07-30 |
| KR870001192A (ko) | 1987-03-12 |
| ZA865700B (en) | 1988-03-30 |
| DK363186D0 (da) | 1986-07-30 |
| JPS6229575A (ja) | 1987-02-07 |
| PH22884A (en) | 1989-01-19 |
| CN86105558A (zh) | 1987-01-28 |
| PT83098B (en) | 1988-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: JANSSEN PHARMACEUTICA N.V. |
