FR2139651A1 - 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch - Google Patents

4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch

Info

Publication number
FR2139651A1
FR2139651A1 FR7119501A FR7119501A FR2139651A1 FR 2139651 A1 FR2139651 A1 FR 2139651A1 FR 7119501 A FR7119501 A FR 7119501A FR 7119501 A FR7119501 A FR 7119501A FR 2139651 A1 FR2139651 A1 FR 2139651A1
Authority
FR
France
Prior art keywords
amino
broch
oxepine
antitussive
dioxolan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7119501A
Other languages
French (fr)
Other versions
FR2139651B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7119501A priority Critical patent/FR2139651A1/en
Priority to BE783499A priority patent/BE783499A/en
Priority to LU65380A priority patent/LU65380A1/xx
Priority to GB2391572A priority patent/GB1359951A/en
Priority to ZA723500A priority patent/ZA723500B/en
Priority to IL39496A priority patent/IL39496A/en
Priority to CH757472A priority patent/CH532034A/en
Priority to DE2225245A priority patent/DE2225245C3/en
Priority to US00256655A priority patent/US3845046A/en
Priority to SU1788862A priority patent/SU420174A3/en
Priority to CA143,363A priority patent/CA989404A/en
Priority to SE7206954A priority patent/SE373583B/en
Priority to CS7200003650A priority patent/CS181224B2/en
Priority to AR242209A priority patent/AR192786A1/en
Priority to AU42788/72A priority patent/AU465949B2/en
Priority to IT68696/72A priority patent/IT1052682B/en
Priority to JP47052583A priority patent/JPS5218196B1/ja
Priority to NL7207229A priority patent/NL7207229A/xx
Publication of FR2139651A1 publication Critical patent/FR2139651A1/en
Application granted granted Critical
Publication of FR2139651B1 publication Critical patent/FR2139651B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds have formula: (where Z = H, 1-4C alkoxy or halo, R and R1 = 1-3C alkyl or together with the N atom form a pyrrolidino, piperidino, morpholino, hexamethyleneimino or piperazino gp. which is substd. in the N' position by a 1-3C alkyl gp. (opt. substd by 1 or 2 hydroxyl gps) or by an aminocarbonylmethyl gp. in which the amino gp. is opt. substd. by one or more 1-3 alkyl gps. or forms part of a pyrrolidino, morpholino or hexamethyleneimino gp).
FR7119501A 1971-03-28 1971-05-28 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch Granted FR2139651A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR7119501A FR2139651A1 (en) 1971-05-28 1971-05-28 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch
BE783499A BE783499A (en) 1971-05-28 1972-05-15 N-TERTIAIRE AMINOMETHYL-4 'DIBENZO (B, E) OXEPINE-11-SPIRO- 2'-DIOXOLANNE-1', 3 ', THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
LU65380A LU65380A1 (en) 1971-05-28 1972-05-17
GB2391572A GB1359951A (en) 1971-05-28 1972-05-22 Ny-tertiary-4,-aminomethyl-dibenzo-b,e-11-oxepine-2,-spiro- 1,3,-dioxolanes their process of preparation and their thera peutic application
ZA723500A ZA723500B (en) 1971-05-28 1972-05-22 Dibenzo(b,e)11-oxepine-2'-spiro-1',3-dioxolanes and their preparation and use
IL39496A IL39496A (en) 1971-05-28 1972-05-22 Dibenzo(b,e)oxepine spiro dioxolane derivatives,their preparation and pharmaceutical compositions containing them
CH757472A CH532034A (en) 1971-05-28 1972-05-23 Process for the preparation of substituted dibenzo-oxepine-spiro-dioxolanes
DE2225245A DE2225245C3 (en) 1971-05-28 1972-05-24 (b, e) -Dibenzoxepin-II-spiro-2'-0'3'-dioxolane) derivatives, processes for their preparation and pharmaceuticals containing them
US00256655A US3845046A (en) 1971-05-28 1972-05-25 N-tertiary-4-aminomethyl-dibenzo(b,e)-11-oxepine-2'-spiro-1',3'-dioxolanes
CA143,363A CA989404A (en) 1971-05-28 1972-05-26 N-tertiary aminomethyl-4' dibenzo(b,e)oxepine-11 spiro-2'-dioxolanne-1' ,3', their preparation process and therapeutic application
SE7206954A SE373583B (en) 1971-05-28 1972-05-26 SET TO PREPARE 4' -N- TERTIERAMINO-METHYL-2', 11-SPIRODIBENSO სB,Eს OXEPIN-1',3'- DIOXOLANES
CS7200003650A CS181224B2 (en) 1971-05-28 1972-05-26 Method of production of 4-/n-tertiary aminomethyl/-2-/dibenzo/b,c/oxepine-11-spiro/-1,3-dioxolanes
AR242209A AR192786A1 (en) 1971-05-28 1972-05-26 PROCEDURE FOR THE PREPARATION OF NEW N-AMINE-TERTIARY-METHYL-4'DIBENZO (B, E) OXEPINE-11-SPIRO-2'DIOXOLANOS-1 ', 3'
AU42788/72A AU465949B2 (en) 1971-03-28 1972-05-26 N-TERTIARY-4'-AMINOMETHYL-DIBENZO b,e-11-OXEPINE-2'-SPIRO-1',3'-DIOXOLANES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION
SU1788862A SU420174A3 (en) 1971-05-28 1972-05-26 METHOD FOR PREPARING SPIRO DERIVATIVES (DIBENZO / b, e / OKSEPIN-] 1: 2 '- / 4' AMINOMETYLEDIOXOLANA-] ', 34} 1The invention relates to the method of obtaining new compounds - spiro derivatives (D'ibenzo / b, e / okse1sh-11: '2' - / 4'-a'Minomethyl- D | IO: Xolana-G, 3 '/) of the formula I' 'o' '^ ° LJ_5' C ^ SNR-NRRIhexamethylene '.] The 1st 11th radical; -or their salts. These compounds have valuable physiologically activating properties. 5 The method is based on the reaction of obtaining 4-amH'Nomethyldioxolane-1,3 2-spiranovogo series by the interaction of cycloketones with e-pybromhydryn and subsequent mutually! ! Mode) 1m Education state 4-bromomethylldloxole-1,3 10 2-spiranova series with a-a minim. The proposed method consists in the fact that dibenzo / b, e / oxepin-11-one formulas II where Z is a hydrogen or halogen atom or al - coco-carbon with 1-4 carbon atoms and R and Ri - al'K'IL with 1-3 carbon atoms or R 1 and RI groups together with nitrogen atoms, with which oi) [are bound to form pyrrolidine, iiperi - di-new 1IL'I-morpholium ring, hexam-T | Ilen'IM; inIli'I steraz.inovoy ring, unsubstituted by ui N'-3aMeuieHHoe alkyl with 1-3 carbon atoms, which can be mono- -! or D1I-substituted hydroxyl group or pinherazine ring, N'-3aMemeHnoe aminocarbonylmethyl group, in which the nitrogen atom can be mono- or di-substituent alkylome with 1-3 carbon atoms "occurs in pyrroldium, morpholine or z and .means of the decree] First values, subjected to the interaction with epibibromhydriomy, formed by spiro (dibeiso / b, e / o "Seln-M: 2 '- / 4'- bromomethyl dioxole 11-1", 3 "/) is subjected to interaction with the secondary amine of the formula HIH- NX30 ^ R,
IT68696/72A IT1052682B (en) 1971-05-28 1972-05-27 N TERTIARY AMMINOMETHY 4 DIBENZO B.E, OXEPINA 11 SPIRO 2 DIOSSOLA NO 1, 3, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION INTERAPIA
JP47052583A JPS5218196B1 (en) 1971-05-28 1972-05-29
NL7207229A NL7207229A (en) 1971-05-28 1972-05-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7119501A FR2139651A1 (en) 1971-05-28 1971-05-28 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch

Publications (2)

Publication Number Publication Date
FR2139651A1 true FR2139651A1 (en) 1973-01-12
FR2139651B1 FR2139651B1 (en) 1974-08-30

Family

ID=9077809

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7119501A Granted FR2139651A1 (en) 1971-03-28 1971-05-28 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch

Country Status (2)

Country Link
FR (1) FR2139651A1 (en)
ZA (1) ZA723500B (en)

Also Published As

Publication number Publication date
ZA723500B (en) 1973-03-28
FR2139651B1 (en) 1974-08-30

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