GB1013235A - Method of preparing polyhydric alcohol esters of acetylsalicylic acid - Google Patents
Method of preparing polyhydric alcohol esters of acetylsalicylic acidInfo
- Publication number
- GB1013235A GB1013235A GB195864A GB195864A GB1013235A GB 1013235 A GB1013235 A GB 1013235A GB 195864 A GB195864 A GB 195864A GB 195864 A GB195864 A GB 195864A GB 1013235 A GB1013235 A GB 1013235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetylsalicylate
- polyhydric alcohol
- acetylsalicylic acid
- alcohol esters
- preparing polyhydric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula <FORM:1013235/C2/1> wherein n is an integer not less than 3 and A is an aliphatic residue of valency n, are made by reacting a C1-4 alkyl, phenyl or toluyl salicylate with a polyhydric alcohol having at least 3 OH groups and acetylating the polyhydric alcohol ester of salicylic acid thus obtained. Exemplified products are: (1) diacetylmannitol tetra-acetylsalicylate, (2) trimethylolpropane triacetylsalicylate, (3) inositol hexa-acetylsalicylate, (4) N - methyl - N - 2 - acetoxybenzoylglucamine penta-acetylsalicylate, (5) sorbitol hexa-acetylsalicylate, (6) pentaerythritol tetra-acetylsalicylate. Polyhydric alcohols otherwise specified are arabitol, xylitol, N,N-dimethylglucamine, triethanolamine and polyvinyl alcohol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP220463 | 1963-01-17 | ||
JP220563 | 1963-01-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1013235A true GB1013235A (en) | 1965-12-15 |
Family
ID=26335540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB195864A Expired GB1013235A (en) | 1963-01-17 | 1964-01-16 | Method of preparing polyhydric alcohol esters of acetylsalicylic acid |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH428766A (en) |
GB (1) | GB1013235A (en) |
SE (1) | SE303509B (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0576868A1 (en) * | 1992-07-02 | 1994-01-05 | REHAU AG + Co | Medical articles |
WO1996015809A2 (en) * | 1994-11-22 | 1996-05-30 | Laboratori Alchemia S.R.L. | Process for the preparation of a pharmacologically active chemical combination |
FR2842520A1 (en) * | 2002-07-18 | 2004-01-23 | Inst Superieur D Agriculture D | New saccharide or sugar alcohol derivatives containing O-ortho-salicyloyl group and O-n-alkanoyl group, useful for treating or preventing enterocolitis or intestinal adeno-carcinoma |
EP1461122A2 (en) * | 2001-12-10 | 2004-09-29 | Control Delivery Systems, Inc. | Treatment of genitourinary tract disorders |
WO2005009480A2 (en) * | 2003-06-11 | 2005-02-03 | Control Delivery Systems, Inc. | Implants containing codrugs |
CN114195744A (en) * | 2021-12-17 | 2022-03-18 | 抚顺东科精细化工有限公司 | Preparation method of cosmetic preservative mannitol salicylate dehydrate |
-
1964
- 1964-01-16 GB GB195864A patent/GB1013235A/en not_active Expired
- 1964-01-16 SE SE54964A patent/SE303509B/xx unknown
- 1964-01-16 CH CH45764A patent/CH428766A/en unknown
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0576868A1 (en) * | 1992-07-02 | 1994-01-05 | REHAU AG + Co | Medical articles |
WO1996015809A2 (en) * | 1994-11-22 | 1996-05-30 | Laboratori Alchemia S.R.L. | Process for the preparation of a pharmacologically active chemical combination |
WO1996015809A3 (en) * | 1994-11-22 | 1996-10-17 | Lab Alchemia Srl | Process for the preparation of a pharmacologically active chemical combination |
EP1038534A2 (en) * | 1994-11-22 | 2000-09-27 | Laboratori Alchemia S.R.L. | Process for the preparation of a conjugate of pharmacologically active substances |
EP1038534A3 (en) * | 1994-11-22 | 2001-04-04 | Laboratori Alchemia S.R.L. | Process for the preparation of a conjugate of pharmacologically active substances |
US6369260B1 (en) | 1994-11-22 | 2002-04-09 | Laboratori Alchemica S.R.L. | Process for the preparation of a pharmacologically active chemical combination |
EP1461122A4 (en) * | 2001-12-10 | 2006-08-23 | Control Delivery Sys Inc | Treatment of genitourinary tract disorders |
EP1461122A2 (en) * | 2001-12-10 | 2004-09-29 | Control Delivery Systems, Inc. | Treatment of genitourinary tract disorders |
FR2842520A1 (en) * | 2002-07-18 | 2004-01-23 | Inst Superieur D Agriculture D | New saccharide or sugar alcohol derivatives containing O-ortho-salicyloyl group and O-n-alkanoyl group, useful for treating or preventing enterocolitis or intestinal adeno-carcinoma |
WO2005009480A3 (en) * | 2003-06-11 | 2005-07-14 | Control Delivery Sys Inc | Implants containing codrugs |
WO2005009480A2 (en) * | 2003-06-11 | 2005-02-03 | Control Delivery Systems, Inc. | Implants containing codrugs |
CN114195744A (en) * | 2021-12-17 | 2022-03-18 | 抚顺东科精细化工有限公司 | Preparation method of cosmetic preservative mannitol salicylate dehydrate |
CN114195744B (en) * | 2021-12-17 | 2023-09-29 | 抚顺东科精细化工有限公司 | Preparation method of cosmetic preservative mannitol salicylate |
Also Published As
Publication number | Publication date |
---|---|
SE303509B (en) | 1968-09-02 |
CH428766A (en) | 1967-01-31 |
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