GB2255561B - Lysins from bacteriophages - Google Patents

Lysins from bacteriophages

Info

Publication number
GB2255561B
GB2255561B GB9108498A GB9108498A GB2255561B GB 2255561 B GB2255561 B GB 2255561B GB 9108498 A GB9108498 A GB 9108498A GB 9108498 A GB9108498 A GB 9108498A GB 2255561 B GB2255561 B GB 2255561B
Authority
GB
United Kingdom
Prior art keywords
bacteriophages
lysins
bacteria
specific
tyrobutyrlcum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9108498A
Other versions
GB2255561A (en
GB9108498D0 (en
Inventor
Michael John Gasson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotechnology and Biological Sciences Research Council
Original Assignee
Biotechnology and Biological Sciences Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnology and Biological Sciences Research Council filed Critical Biotechnology and Biological Sciences Research Council
Priority to GB9108498A priority Critical patent/GB2255561B/en
Publication of GB9108498D0 publication Critical patent/GB9108498D0/en
Priority to CA002066387A priority patent/CA2066387C/en
Priority to CA002395688A priority patent/CA2395688A1/en
Priority to US07/877,516 priority patent/US5763251A/en
Priority to EP02079804A priority patent/EP1300082A3/en
Priority to AU15023/92A priority patent/AU650737B2/en
Priority to DE69233152T priority patent/DE69233152T2/en
Priority to AT92303533T priority patent/ATE247169T1/en
Priority to EP92303533A priority patent/EP0510907B1/en
Publication of GB2255561A publication Critical patent/GB2255561A/en
Application granted granted Critical
Publication of GB2255561B publication Critical patent/GB2255561B/en
Priority to US08/870,736 priority patent/US6083684A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/783—Microorganisms; Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Bacteriophages of food-contaminating or pathogenic bacteria or the lysine thereof are used to kill such bacteria. Examples include lysins from bacteriophages of Listeria monocytogenes and Clostridium tyrobutyrlcum. <??>Tests for bacterial contamination can be made specific for specific bacteria by using the appropriate bacteriophage or lysin thereof and determining whether cells are lysed thereby. <IMAGE>
GB9108498A 1991-04-20 1991-04-20 Lysins from bacteriophages Expired - Lifetime GB2255561B (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB9108498A GB2255561B (en) 1991-04-20 1991-04-20 Lysins from bacteriophages
CA002395688A CA2395688A1 (en) 1991-04-20 1992-04-16 Viral products
CA002066387A CA2066387C (en) 1991-04-20 1992-04-16 Viral products
US07/877,516 US5763251A (en) 1991-04-20 1992-04-20 Viral products
EP92303533A EP0510907B1 (en) 1991-04-20 1992-04-21 Bacteriophage lysins and their applications in destroying and testing for bacteria
AU15023/92A AU650737B2 (en) 1991-04-20 1992-04-21 Viral products
DE69233152T DE69233152T2 (en) 1991-04-20 1992-04-21 Bacteriophage lysines and their applications for the destruction and testing for bacteria
AT92303533T ATE247169T1 (en) 1991-04-20 1992-04-21 BACTERIOPHAGEN LYSINES AND THEIR APPLICATIONS FOR DESTROYING AND TESTING FOR BACTERIA
EP02079804A EP1300082A3 (en) 1991-04-20 1992-04-21 Lysin of a bacteriophage of Clostridia spp
US08/870,736 US6083684A (en) 1991-04-20 1997-06-06 Viral products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9108498A GB2255561B (en) 1991-04-20 1991-04-20 Lysins from bacteriophages

Publications (3)

Publication Number Publication Date
GB9108498D0 GB9108498D0 (en) 1991-06-05
GB2255561A GB2255561A (en) 1992-11-11
GB2255561B true GB2255561B (en) 1995-06-21

Family

ID=10693655

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9108498A Expired - Lifetime GB2255561B (en) 1991-04-20 1991-04-20 Lysins from bacteriophages

Country Status (7)

Country Link
US (2) US5763251A (en)
EP (2) EP0510907B1 (en)
AT (1) ATE247169T1 (en)
AU (1) AU650737B2 (en)
CA (1) CA2066387C (en)
DE (1) DE69233152T2 (en)
GB (1) GB2255561B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010136754A1 (en) 2009-05-26 2010-12-02 Plant Bioscience Limited Novel polypeptides having endolysin activity and uses thereof

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0759998A1 (en) * 1994-05-12 1997-03-05 Quest International B.V. Process for the lysis of a culture of lactic acid bacteria by means of a lysin, and uses of the resulting lysed culture
WO1995031562A1 (en) * 1994-05-12 1995-11-23 Quest International B.V. Process for inhibiting the growth of a culture of lactic acid bacteria, and optionally lysing the bacterial cells, and uses of the resulting lysed culture
EP0781349B1 (en) * 1994-09-09 2003-01-15 Biotec Laboratories Limited Decomposition of bacteria cells by phage lysins
US20030129147A1 (en) * 1997-10-31 2003-07-10 Vincent Fischetti Use of bacterial phage associated lysing proteins for treating bacterial dental caries
US6056954A (en) * 1997-10-31 2000-05-02 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6423299B1 (en) 1997-10-31 2002-07-23 Vincent Fischetti Composition for treatment of a bacterial infection of an upper respiratory tract
US6406692B1 (en) * 1997-10-31 2002-06-18 New Horizons Diagnostics Corp Composition for treatment of an ocular bacterial infection
US6399097B1 (en) 1997-10-31 2002-06-04 New Horizons Diagnostics Corporation Composition for treatment of a bacterial infection of the digestive tract
US7232576B2 (en) 1997-10-31 2007-06-19 New Horizons Diagnostics Corp Throat lozenge for the treatment of Streptococcus Group A
US20020136712A1 (en) * 1997-10-31 2002-09-26 Fischetti Vincent Bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of colonization and infections caused by streptococcus pneumoniae
US20030082110A1 (en) * 1997-10-31 2003-05-01 Vincent Fischetti Use of bacterial phage associated lysing proteins for treating bacterial dental caries
US6752988B1 (en) 2000-04-28 2004-06-22 New Horizons Diagnostic Corp Method of treating upper resiratory illnesses
US6432444B1 (en) 1997-10-31 2002-08-13 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymes for treating dermatological infections
US6399098B1 (en) 1997-10-31 2002-06-04 New Horizons Diagnostics Corp Composition for treating dental caries caused by streptococcus mutans
US20030129146A1 (en) * 1997-10-31 2003-07-10 Vincent Fischetti The use of bacterial phage associated lysing proteins for treating bacterial dental caries
US6428784B1 (en) 1997-10-31 2002-08-06 New Horizons Diagnostics Corp Vaginal suppository for treating group B Streptococcus infection
US6277399B1 (en) 1997-10-31 2001-08-21 New Horizon Diagnostics Corporation Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections
US6143551A (en) * 1997-12-29 2000-11-07 Schering Aktiengesellschaft Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria
US6391626B1 (en) 1999-08-23 2002-05-21 3M Innovative Properties Company Culture medium and device using ballasted pH indicators for detection and enumeration of microorganisms
US7063837B2 (en) * 1999-09-14 2006-06-20 New Horizons Diagnostics Corp Syrup composition containing phage associated lytic enzymes
US20020127215A1 (en) * 1999-09-14 2002-09-12 Lawrence Loomis Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
WO2001051027A2 (en) * 2000-01-11 2001-07-19 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
US6436661B1 (en) * 2000-04-13 2002-08-20 3M Innovative Properties Company Bacteria and bacteriophage detection using immobilized enzyme substrates
WO2001082945A2 (en) * 2000-04-28 2001-11-08 New Horizons Diagnostic Corporation The use of bacterial phage associated lysing enzymes for treating various illnesses
US6395504B1 (en) 2000-09-01 2002-05-28 New Horizons Diagnostics Corp. Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants
WO2002102405A1 (en) * 2000-11-02 2002-12-27 New Horizons Diagnostics Corporation The use of bacterial phage associated lytic enzymes to prevent food poisoning
WO2003000010A2 (en) * 2001-06-20 2003-01-03 Mayo Foundation For Medical Education And Research Adenosyl-cobalamin fortified compositions
US20040213765A1 (en) * 2001-07-13 2004-10-28 Vincent Fischetti Use of bacterial phage associated lytic enzymes to prevent food poisoning
AU2002354900A1 (en) 2001-07-18 2003-03-03 Instytut Immunologii I Terapii Doswiadczalnej Pan Methods of polyvalent bacteriophage preparation for the treatment of bacterial infections
JP4849772B2 (en) * 2001-09-27 2012-01-11 ガンガゲン インコーポレーティッド Lysine-deficient bacteriophages with low immunogenicity
WO2004008938A2 (en) * 2001-12-06 2004-01-29 The Rockefeller University A novel method to identify targets for antibiotic development
GB0202556D0 (en) 2002-02-04 2002-03-20 Danisco Novel Protein
US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
JP4490112B2 (en) 2002-04-12 2010-06-23 コロラド・スクール・オブ・マインズ A method for detecting low concentrations of target bacteria using phage to infect target bacterial cells
WO2003103578A2 (en) * 2002-06-05 2003-12-18 Iowa State University Research Foundation, Inc. Bacteriophage and enzymes lytic to salmonellae
WO2004020451A1 (en) * 2002-08-29 2004-03-11 The Uab Research Foundation Group b streptococcal phage lysin
US20050129711A1 (en) * 2002-11-14 2005-06-16 Janakiraman Ramachandran Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression
WO2006105504A1 (en) 2005-03-31 2006-10-05 Microphage Incorporated Apparatus and method for detecting microorganisms using flagged bacteriophage
US20110059514A1 (en) * 2007-01-09 2011-03-10 David Alexander Schofield Yeast Biocatalysts for Degradation of Biowarfare Agents
US8455186B2 (en) 2007-06-15 2013-06-04 MicroPhage™ Incorporated Method of detection of microorganisms with enhanced bacteriophage amplification
NO2185699T3 (en) 2007-08-22 2018-04-21
KR100974185B1 (en) * 2007-08-27 2010-08-05 주식회사 인트론바이오테크놀로지 Bacterial lysates prepared by bacteriophage-derived lytic protein action and vaccine composition for preventing animal diseases comprising the same
WO2009082525A2 (en) 2007-10-01 2009-07-02 Guild Associates, Inc. Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents
US20090104157A1 (en) * 2007-10-05 2009-04-23 E. I. Du Pont De Nemours And Company Utilization of bacteriophage to control bacterial contamination in fermentation processes
CN101220350B (en) * 2007-11-16 2010-05-19 珠海市晋平科技有限公司 Separated Listeria monocytogenes phage and uses thereof
CA2706600A1 (en) * 2007-11-26 2009-06-04 Plant Bioscience Limited Novel polypeptides having endolysin activity and uses thereof
US8697434B2 (en) 2008-01-11 2014-04-15 Colorado School Of Mines Detection of phage amplification by SERS nanoparticles
US9441204B2 (en) 2008-04-03 2016-09-13 Colorado School Of Mines Compositions and methods for detecting Yersinia pestis bacteria
EP2143729A1 (en) * 2008-07-07 2010-01-13 Hyglos Invest GmbH New enzymatic active enzyme against Clostridium
GB0815484D0 (en) * 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
PL215522B1 (en) 2008-09-29 2013-12-31 Inst Immunologii I Terapii Doswiadczalnej Pan New strains of bacteriophages for treatment of bacterial infections, preferably by means of the strains of drug-resistant bacterias of the Enterococcus type
SG177704A1 (en) 2009-06-26 2012-02-28 Lysando Holding Ag Antimicrobial agents
EP2445515B1 (en) 2009-06-26 2016-04-06 Katholieke Universiteit Leuven, K.U. Leuven R&D Antimicrobial agents
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
CN102575240B (en) 2009-08-24 2016-01-13 勒芬天主教大学，K.U.勒芬R&D new endolysin OBPgpLYS
EP2338916A1 (en) 2009-12-23 2011-06-29 Hyglos Invest GmbH Chimeric polypeptides and their use in bacterial decoloniation
EP2397548A1 (en) 2010-06-18 2011-12-21 Hyglos Invest GmbH Methods of generating and screening for lytic chimeric polypeptides
PL212258B1 (en) 2010-06-20 2012-09-28 Inst Immunologii I Terapii Doswiadczalnej Pan New strains of bacteriophages for treating bacterial infections, especially of drug-resistant bacterial strains such as Stenotrophomonas
US8962297B2 (en) * 2010-09-01 2015-02-24 The United States Of America, As Represented By The Secretary Of Agriculture Bacteriophage lytic enzymes as alternative antimicrobials
JP6121057B2 (en) 2013-06-27 2017-04-26 スターバックス・コーポレイション Biological preservation methods for beverages and other foods
EP3372091A1 (en) * 2017-03-07 2018-09-12 Nomad Bioscience GmbH Method of reducing contamination of an object with clostridium

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2243611A (en) * 1988-07-13 1991-11-06 Agricultural & Food Res Use of viral enzymes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3094466A (en) * 1959-07-15 1963-06-18 Warner Lambert Pharmaceutical Preparation for typing of staphylococci and process therefor
US3002892A (en) * 1960-01-20 1961-10-03 Elmo S Dooley Process for preparing bacteriophage-impregnated paper discs for rapid identificationof bacterial strains
US3793151A (en) * 1972-07-10 1974-02-19 J Denney Method of screening for anticapsular substances
US4618576A (en) * 1984-02-27 1986-10-21 Becton Dickinson And Company Diagnostic test for Streptococcus A
IT1197924B (en) * 1986-10-28 1988-12-21 Prodotti Antibiotici Spa PROCEDURE FOR THE PREPARATION OF FOODS OF ANIMAL ORIGIN
GB8710795D0 (en) * 1987-05-07 1987-06-10 Microbial Dev Ltd Antimicrobial preparations
US4859597A (en) * 1987-07-27 1989-08-22 Igene Biotechnology, Inc. Production of phage and phage-associated lysin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2243611A (en) * 1988-07-13 1991-11-06 Agricultural & Food Res Use of viral enzymes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Acta. Medica. Univ. Kagoshima, Vol 14, 1972, pages 91-101 *
Appl.Environ.Microbiol. 1988,54(12),2933-2937 *
Can.J.Microbiol. 1977,23(5),601-606 *
Gene, Vol 94, 1990, pages 61-67 *
J.Bacteriol. 1981,145(1),661-663 *
J.Dairy Research 1985,52,123-138 *
J.Virology 1987,61(8),2573-2580 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010136754A1 (en) 2009-05-26 2010-12-02 Plant Bioscience Limited Novel polypeptides having endolysin activity and uses thereof

Also Published As

Publication number Publication date
EP0510907A2 (en) 1992-10-28
GB2255561A (en) 1992-11-11
ATE247169T1 (en) 2003-08-15
EP1300082A3 (en) 2003-11-19
US5763251A (en) 1998-06-09
AU1502392A (en) 1992-10-22
DE69233152D1 (en) 2003-09-18
EP0510907B1 (en) 2003-08-13
AU650737B2 (en) 1994-06-30
CA2066387A1 (en) 1992-10-21
US6083684A (en) 2000-07-04
CA2066387C (en) 2003-07-01
GB9108498D0 (en) 1991-06-05
EP1300082A2 (en) 2003-04-09
DE69233152T2 (en) 2004-05-27
EP0510907A3 (en) 1993-03-03

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Legal Events

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732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Expiry date: 20110419