GB890749A - Esters of testosterone and 19-nortestosterone, and method for the production thereof - Google Patents
Esters of testosterone and 19-nortestosterone, and method for the production thereofInfo
- Publication number
- GB890749A GB890749A GB911/59A GB91159A GB890749A GB 890749 A GB890749 A GB 890749A GB 911/59 A GB911/59 A GB 911/59A GB 91159 A GB91159 A GB 91159A GB 890749 A GB890749 A GB 890749A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acids
- beta
- alkoxyphenyl
- propionic
- nortestosterone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises 17-esters of testosterone and 19-nortestosterone with beta-(p-alkoxyphenyl)-propionic acids containing 1 to 12 carbon atoms in the alkoxy group, and the preparation thereof by esterifying the free 17-ols with functionally reactive derivatives of the acids, such as chlorides or anhydrides. The reaction is advantageously carried out in the presence of an organic base, such as pyridine. Examples are given. Beta-(p-alkoxyphenyl)-propionic acids are prepared (1) by hydrogenation of the corresponding alkoxy-cinnamic acids; (2) by decarboxylation of p-alkoxybenzyl-malonic acids; or (3) by alkylation of the corresponding beta-(p-hydroxyphenyl)-propionic acids or esters thereof with subsequent hydrolysis. Beta-(p-alkoxyphenyl)-propionyl chlorides are prepared from the acids and thionyl chloride. Beta-p-alkoxyphenyl)-propionic acid anhydrides are prepared from the free acids (1 mol), thionyl chloride (0.5 mol) and pyridine (1 mol) in ether at -10 DEG C.ALSO:An injection solution comprises a 17-ester of testosterone or 19-nortestosterone with a beta-(p-alkoxyphenyl)-propionic acid containing 1 to 12 carbon atoms in the alkoxy group in isopropyl myristate or peanut oil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK890749X | 1958-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB890749A true GB890749A (en) | 1962-03-07 |
Family
ID=8153568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB911/59A Expired GB890749A (en) | 1958-01-14 | 1959-01-09 | Esters of testosterone and 19-nortestosterone, and method for the production thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB890749A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108796021A (en) * | 2017-04-28 | 2018-11-13 | 沈阳药科大学 | A kind of engineering bacteria and its purposes for being used to prepare stosterone |
-
1959
- 1959-01-09 GB GB911/59A patent/GB890749A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108796021A (en) * | 2017-04-28 | 2018-11-13 | 沈阳药科大学 | A kind of engineering bacteria and its purposes for being used to prepare stosterone |
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