GB8923590D0 - Antimuscarinic bronchodilators - Google Patents

Antimuscarinic bronchodilators

Info

Publication number
GB8923590D0
GB8923590D0 GB898923590A GB8923590A GB8923590D0 GB 8923590 D0 GB8923590 D0 GB 8923590D0 GB 898923590 A GB898923590 A GB 898923590A GB 8923590 A GB8923590 A GB 8923590A GB 8923590 D0 GB8923590 D0 GB 8923590D0
Authority
GB
United Kingdom
Prior art keywords
halo
substituents
alkoxy
hydroxy
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB898923590A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER Ltd
Pfizer Ltd Great Britain
Original Assignee
PFIZER Ltd
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER Ltd, Pfizer Ltd Great Britain filed Critical PFIZER Ltd
Priority to GB898923590A priority Critical patent/GB8923590D0/en
Publication of GB8923590D0 publication Critical patent/GB8923590D0/en
Priority to AT90311107T priority patent/ATE102198T1/en
Priority to DE69007009T priority patent/DE69007009T2/en
Priority to EP90311107A priority patent/EP0424021B1/en
Priority to IL96000A priority patent/IL96000A0/en
Priority to KR1019900016425A priority patent/KR930004845B1/en
Priority to US07/598,288 priority patent/US5171744A/en
Priority to PT95610A priority patent/PT95610A/en
Priority to PL28736590A priority patent/PL287365A1/en
Priority to CA002027896A priority patent/CA2027896A1/en
Priority to NZ235750A priority patent/NZ235750A/en
Priority to SU904831482A priority patent/RU2005721C1/en
Priority to NO904523A priority patent/NO174256C/en
Priority to FI905147A priority patent/FI905147A0/en
Priority to ZA908343A priority patent/ZA908343B/en
Priority to AU64726/90A priority patent/AU616362B2/en
Priority to HU906495A priority patent/HU206345B/en
Priority to YU197290A priority patent/YU197290A/en
Priority to CN90108502A priority patent/CN1022488C/en
Priority to JP2281688A priority patent/JPH06780B2/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Feeding And Guiding Record Carriers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds having the formula: <CHEM> wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CR3, C1-C4 alkyl, C1-C4 alkoxy and hydroxy, or (b) a thienyl group; and Y is an imidazolyl, pyrazolyl, triazolyl or tetrazolyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF3, C1-C4 alkoxy, hydroxy and amino; and pharmaceutically acceptable salts thereof, are antimuscarinic bronchodilators useful in the treatment of chronic obstructive airways disease and asthma.
GB898923590A 1989-10-19 1989-10-19 Antimuscarinic bronchodilators Pending GB8923590D0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB898923590A GB8923590D0 (en) 1989-10-19 1989-10-19 Antimuscarinic bronchodilators
AT90311107T ATE102198T1 (en) 1989-10-19 1990-10-10 ANTIMUSCARINE BRONCHODILATORS.
DE69007009T DE69007009T2 (en) 1989-10-19 1990-10-10 Antimuscarine bronchodilators.
EP90311107A EP0424021B1 (en) 1989-10-19 1990-10-10 Antimuscarinic bronchodilators
IL96000A IL96000A0 (en) 1989-10-19 1990-10-15 Antimuscarinic bronchodilator 3-quinuclidinyl propanoates
KR1019900016425A KR930004845B1 (en) 1989-10-19 1990-10-16 Antimuscarinic Bronchodilators
US07/598,288 US5171744A (en) 1989-10-19 1990-10-16 Antimuscarinic bronchodilators
CA002027896A CA2027896A1 (en) 1989-10-19 1990-10-17 Antimuscarinic bronchodilators
PL28736590A PL287365A1 (en) 1989-10-19 1990-10-17 Method of obtaining novel derivatives of 3-quinuclidinyl propinate
PT95610A PT95610A (en) 1989-10-19 1990-10-17 PROCESS FOR THE PREPARATION OF UTILIZED 3-QUINUCLIDINYLS AS ANTIMUSCARINIC BRONCHODILATORS
HU906495A HU206345B (en) 1989-10-19 1990-10-18 Process for producing bronchodilatating quinuclidine derivatives of antimuscaric activity and pharmaceutical compositions containing them as active components
ZA908343A ZA908343B (en) 1989-10-19 1990-10-18 Antimuscarinic bronchodilators
SU904831482A RU2005721C1 (en) 1989-10-19 1990-10-18 Process for preparing 3-quinuclidinyl propionic acid esters
NO904523A NO174256C (en) 1989-10-19 1990-10-18 Analogous method of preparing therapeutically active quinuclidine derivatives
FI905147A FI905147A0 (en) 1989-10-19 1990-10-18 ANTIMUSKARINBRONKODILATORER.
NZ235750A NZ235750A (en) 1989-10-19 1990-10-18 Quinuclidine derivatives, preparation and pharmaceutical compositions thereof, and intermediates therefor
AU64726/90A AU616362B2 (en) 1989-10-19 1990-10-18 Antimuscarinic bronchodilators
YU197290A YU197290A (en) 1989-10-19 1990-10-19 ANTIMUSCARINAL BRONCHODYLATORS
CN90108502A CN1022488C (en) 1989-10-19 1990-10-19 Antimuscainic bronchodilators
JP2281688A JPH06780B2 (en) 1989-10-19 1990-10-19 Antimuscarinic bronchodilator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898923590A GB8923590D0 (en) 1989-10-19 1989-10-19 Antimuscarinic bronchodilators

Publications (1)

Publication Number Publication Date
GB8923590D0 true GB8923590D0 (en) 1989-12-06

Family

ID=10664848

Family Applications (1)

Application Number Title Priority Date Filing Date
GB898923590A Pending GB8923590D0 (en) 1989-10-19 1989-10-19 Antimuscarinic bronchodilators

Country Status (19)

Country Link
US (1) US5171744A (en)
EP (1) EP0424021B1 (en)
JP (1) JPH06780B2 (en)
KR (1) KR930004845B1 (en)
CN (1) CN1022488C (en)
AT (1) ATE102198T1 (en)
AU (1) AU616362B2 (en)
CA (1) CA2027896A1 (en)
DE (1) DE69007009T2 (en)
FI (1) FI905147A0 (en)
GB (1) GB8923590D0 (en)
HU (1) HU206345B (en)
NO (1) NO174256C (en)
NZ (1) NZ235750A (en)
PL (1) PL287365A1 (en)
PT (1) PT95610A (en)
RU (1) RU2005721C1 (en)
YU (1) YU197290A (en)
ZA (1) ZA908343B (en)

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Also Published As

Publication number Publication date
HU906495D0 (en) 1991-04-29
JPH06780B2 (en) 1994-01-05
FI905147A0 (en) 1990-10-18
DE69007009D1 (en) 1994-04-07
NO174256B (en) 1993-12-27
US5171744A (en) 1992-12-15
KR930004845B1 (en) 1993-06-09
HU206345B (en) 1992-10-28
CN1022488C (en) 1993-10-20
ZA908343B (en) 1992-06-24
CN1051041A (en) 1991-05-01
ATE102198T1 (en) 1994-03-15
AU616362B2 (en) 1991-10-24
NZ235750A (en) 1992-03-26
AU6472690A (en) 1991-07-25
DE69007009T2 (en) 1994-06-09
PL287365A1 (en) 1991-06-03
PT95610A (en) 1991-09-13
NO904523L (en) 1991-04-22
NO904523D0 (en) 1990-10-18
HUT56365A (en) 1991-08-28
RU2005721C1 (en) 1994-01-15
CA2027896A1 (en) 1991-04-20
KR910007924A (en) 1991-05-30
EP0424021A1 (en) 1991-04-24
JPH03133980A (en) 1991-06-07
EP0424021B1 (en) 1994-03-02
NO174256C (en) 1994-04-06
YU197290A (en) 1993-10-20

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