GB951653A - Improvements in or relating to 6-pteridinehydrazide and amidrazone derivatives - Google Patents
Improvements in or relating to 6-pteridinehydrazide and amidrazone derivativesInfo
- Publication number
- GB951653A GB951653A GB4001060A GB4001060A GB951653A GB 951653 A GB951653 A GB 951653A GB 4001060 A GB4001060 A GB 4001060A GB 4001060 A GB4001060 A GB 4001060A GB 951653 A GB951653 A GB 951653A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- maximum
- cyano
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/10—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with an aromatic or hetero-aromatic ring directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises compounds of general formula: <FORM:0951653/C2/1> wherein R1, R2, R4 and R5, which may be th same or different, are each hydrogen or an alkyl radical having a maximum of 4 carbon atoms, Ar is an aromatic radical having not more than 8 carbon atoms and R3 is O or NH (including, when only one of R1 and R2 is alkyl, isomers in which it is attached to the nitrogen atom next to the -CR3- group), together with their pharmaceutically acceptable acid addition salts formed with non-toxic acids; and a process for their preparation by reacting a compound of formula: <FORM:0951653/C2/2> in which X is lower carbalkoxy having a maximum of 5 carbon atoms (when R3 is O) or cyano (when R3 is NH), with a compound R1R2N-NH2, the reaction being carried out at elevated temperatures in the presence of a hydroxylated polar organic solvent having less than 6 carbon atoms when X is lower carbalkoxy and in the presence of a lower alcohol having a maximum of 4 carbon atoms when X is cyano. In examples Ar is phenyl, pyridyl, thienyl and phenyl substituted by methyl, amino, hydroxy, methoxy, chloro, fluoro or trifluoromethyl. Specification 951,655 is referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4001060A GB951653A (en) | 1960-11-21 | 1960-11-21 | Improvements in or relating to 6-pteridinehydrazide and amidrazone derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4001060A GB951653A (en) | 1960-11-21 | 1960-11-21 | Improvements in or relating to 6-pteridinehydrazide and amidrazone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB951653A true GB951653A (en) | 1964-03-11 |
Family
ID=10412706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4001060A Expired GB951653A (en) | 1960-11-21 | 1960-11-21 | Improvements in or relating to 6-pteridinehydrazide and amidrazone derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB951653A (en) |
-
1960
- 1960-11-21 GB GB4001060A patent/GB951653A/en not_active Expired
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