HUT54117A - Process for producing substituted chloro-anilines and pharmaceutical compositions containing them - Google Patents

Process for producing substituted chloro-anilines and pharmaceutical compositions containing them

Info

Publication number
HUT54117A
HUT54117A HU89623A HU62389A HUT54117A HU T54117 A HUT54117 A HU T54117A HU 89623 A HU89623 A HU 89623A HU 62389 A HU62389 A HU 62389A HU T54117 A HUT54117 A HU T54117A
Authority
HU
Hungary
Prior art keywords
alkyl
substd
alkylene
opt
atoms
Prior art date
Application number
HU89623A
Other languages
Hungarian (hu)
Inventor
Lawrence Henry Charles Lunts
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878718939A external-priority patent/GB8718939D0/en
Priority to GB878718939A priority Critical patent/GB8718939D0/en
Priority to US07/230,358 priority patent/US4996218A/en
Priority to PT88234A priority patent/PT88234B/en
Priority to DE3882613T priority patent/DE3882613T2/en
Priority to NZ225771A priority patent/NZ225771A/en
Priority to JP63199776A priority patent/JPH01146866A/en
Priority to ZA885875A priority patent/ZA885875B/en
Priority to EP88307398A priority patent/EP0303464B1/en
Priority to AT88307398T priority patent/ATE92048T1/en
Priority to AU20596/88A priority patent/AU609505B2/en
Priority to DK448188A priority patent/DK448188A/en
Priority to CA000574358A priority patent/CA1321199C/en
Priority to HU89623A priority patent/HUT54117A/en
Priority to CN89101634A priority patent/CN1023599C/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to US07/624,337 priority patent/US5149698A/en
Priority claimed from US07/624,337 external-priority patent/US5149698A/en
Publication of HUT54117A publication Critical patent/HUT54117A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Chloraniline derivs. of formula (I) and its physiologically accetpable salts and solvents are new, where Q = Cl or CF3; X = a bond, 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; Y = a bond, 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; the sum total of C atoms in X and Y is not more than 10; Chains XCH2 and CH2Y is opt. substd. by 1 or 2 1-3C alkyl; or when 1C atoms is substd. by two alkyl gps. these may be linked to form alkylene gp.; R = H or 1-3C alkyl; R1, R2 = H or 1-3C alkyl; the sum of total C atoms in R1 and R2 is not more than 4; Met = benzoheteroaryl or monocyclic heteroaryl where the heteroaryl is 5 or 6 membered and contains 1, 2 or 3 heteroatoms one of which is N and the other(s) is (are) N, O or S atmos. The Met. gp. is opt. substd. by one or two gps. selected from 1-4C(alkyl, alkoxy), OH, halogen, -NR3R4 and COR8; R3,R4 = H or 1-4C alkyl; or NR3R4 forms a satd. 5-7 member heterocyclic amino gp. opt. contg. in the ring one or more atoms of -O-, -S-, -NH- or N(CH3)-; R8 = OH, 1-4C alkoxy or -NR3R4; when Hef represents a pyridyl gp. substd. by -NR3R4 or -COR8, Cl = Cl; or when Het represents a pyridyl gp. opt. substd. by one or two halogen, OH, 1-3C alkyl, 1-3C alkoxy and Y = a band, 1-4C alkylene, 2-4C alkenylene 0r 2-4C alkylene, in both cases R = 1-3C alkyl and/or at least one of -XCH2- and -CH2Y- is subtd. by one or two 1-3C alkyl gps..
HU89623A 1987-08-11 1989-02-10 Process for producing substituted chloro-anilines and pharmaceutical compositions containing them HUT54117A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB878718939A GB8718939D0 (en) 1987-08-11 1987-08-11 Chemical compounds
EP88307398A EP0303464B1 (en) 1987-08-11 1988-08-10 Chloroaniline derivatives
DK448188A DK448188A (en) 1987-08-11 1988-08-10 CHLORANILINE DERIVATIVES
DE3882613T DE3882613T2 (en) 1987-08-11 1988-08-10 Chloraniline derivatives.
NZ225771A NZ225771A (en) 1987-08-11 1988-08-10 Heterocyclically-substituted chloroaniline derivatives and pharmaceutical compositions: processes for preparation
JP63199776A JPH01146866A (en) 1987-08-11 1988-08-10 Chloroaniline derivative
ZA885875A ZA885875B (en) 1987-08-11 1988-08-10 Chloroaniline derivatives
US07/230,358 US4996218A (en) 1987-08-11 1988-08-10 Chloroaniline derivatives
AT88307398T ATE92048T1 (en) 1987-08-11 1988-08-10 CHLORANILINE DERIVATIVES.
AU20596/88A AU609505B2 (en) 1987-08-11 1988-08-10 Chloroaniline derivatives
PT88234A PT88234B (en) 1987-08-11 1988-08-10 PROCESS FOR THE PREPARATION OF CHLOROANILINE DERIVATIVES
CA000574358A CA1321199C (en) 1987-08-11 1988-08-10 Chloroaniline derivatives
HU89623A HUT54117A (en) 1987-08-11 1989-02-10 Process for producing substituted chloro-anilines and pharmaceutical compositions containing them
CN89101634A CN1023599C (en) 1987-08-11 1989-02-10 Chloroaniline derivatives
US07/624,337 US5149698A (en) 1987-08-11 1990-12-07 Chloroaniline derivatives

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB878718939A GB8718939D0 (en) 1987-08-11 1987-08-11 Chemical compounds
US07/230,358 US4996218A (en) 1987-08-11 1988-08-10 Chloroaniline derivatives
HU89623A HUT54117A (en) 1987-08-11 1989-02-10 Process for producing substituted chloro-anilines and pharmaceutical compositions containing them
CN89101634A CN1023599C (en) 1987-08-11 1989-02-10 Chloroaniline derivatives
US07/624,337 US5149698A (en) 1987-08-11 1990-12-07 Chloroaniline derivatives

Publications (1)

Publication Number Publication Date
HUT54117A true HUT54117A (en) 1991-01-28

Family

ID=27509641

Family Applications (1)

Application Number Title Priority Date Filing Date
HU89623A HUT54117A (en) 1987-08-11 1989-02-10 Process for producing substituted chloro-anilines and pharmaceutical compositions containing them

Country Status (1)

Country Link
HU (1) HUT54117A (en)

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Legal Events

Date Code Title Description
DFC9 Refusal of application