IL133087A0 - Conjugated peptide nucleic acids having enhanced cellular uptake - Google Patents
Conjugated peptide nucleic acids having enhanced cellular uptakeInfo
- Publication number
- IL133087A0 IL133087A0 IL13308798A IL13308798A IL133087A0 IL 133087 A0 IL133087 A0 IL 133087A0 IL 13308798 A IL13308798 A IL 13308798A IL 13308798 A IL13308798 A IL 13308798A IL 133087 A0 IL133087 A0 IL 133087A0
- Authority
- IL
- Israel
- Prior art keywords
- nucleic acids
- peptide nucleic
- cellular uptake
- enhanced cellular
- conjugated peptide
- Prior art date
Links
- 108091093037 Peptide nucleic acid Proteins 0.000 title 1
- 230000004700 cellular uptake Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Dispersion Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86476597A | 1997-05-28 | 1997-05-28 | |
PCT/US1998/010804 WO1998053801A1 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Publications (1)
Publication Number | Publication Date |
---|---|
IL133087A0 true IL133087A0 (en) | 2001-03-19 |
Family
ID=25344022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13308798A IL133087A0 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1003480A4 (en) |
JP (1) | JP2001501975A (en) |
AU (1) | AU745309B2 (en) |
CA (1) | CA2291839A1 (en) |
IL (1) | IL133087A0 (en) |
NZ (1) | NZ501289A (en) |
WO (1) | WO1998053801A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6723560B2 (en) | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
DE19909373A1 (en) * | 1999-03-03 | 2000-10-05 | Ugichem | New PNA monomers, resulting PNA oligomers and their use |
DE10038169A1 (en) * | 2000-08-04 | 2002-03-07 | November Ag Molekulare Medizin | Synthetic particle for marking a substance |
EP1543019A2 (en) * | 2002-09-11 | 2005-06-22 | Santaris Pharma A/S | Modified pna molecules |
US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
WO2011005761A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc | Novel nucleic acid prodrugs and methods use thereof |
EP2620428B1 (en) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
CN107365339A (en) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | The method for synthesizing functionalization nucleic acid |
CN112007045A (en) | 2012-07-13 | 2020-12-01 | 波涛生命科学有限公司 | Chiral control |
KR101835401B1 (en) | 2012-07-13 | 2018-03-08 | 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. | Chiral nucleic acid adjuvant |
EP2872485B1 (en) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
JPWO2015108047A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant having immunity induction activity and immunity induction activator |
US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
BR112016016400A2 (en) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | COMPOSITIONS OF CHIRALLY CONTROLLED OLIGONUCLEOTIDES, THEIR USE, THEIR PHARMACEUTICAL COMPOSITION, AND METHODS |
DE102014007158A1 (en) * | 2014-05-16 | 2015-11-19 | Ugichem Gmbh | New peptide-nucleic acid monomers and oligomers |
PE20171238A1 (en) | 2014-06-24 | 2017-08-24 | Shire Human Genetic Therapies | STEREOCHEMICALLY ENRICHED COMPOSITIONS FOR NUCLEIC ACIDS ADMINISTRATION |
AU2020315947A1 (en) * | 2019-07-24 | 2022-03-10 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treating cancer using peptide nucleic acid-based agents |
CN114315835B (en) * | 2021-11-30 | 2023-03-03 | 华南农业大学 | A kind of 6-benzyl adenine hapten, artificial antigen, antibody and its preparation method and application |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
DK51092D0 (en) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF |
US5705333A (en) * | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
WO1996011205A1 (en) * | 1994-10-06 | 1996-04-18 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid conjugates |
WO1996019240A1 (en) * | 1994-12-21 | 1996-06-27 | Novartis Ag | Oligonucleotide-dendrimer conjugates |
WO1997014026A2 (en) * | 1995-10-12 | 1997-04-17 | Dako A/S | Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule |
-
1998
- 1998-05-28 IL IL13308798A patent/IL133087A0/en unknown
- 1998-05-28 NZ NZ501289A patent/NZ501289A/en not_active IP Right Cessation
- 1998-05-28 WO PCT/US1998/010804 patent/WO1998053801A1/en not_active Application Discontinuation
- 1998-05-28 CA CA002291839A patent/CA2291839A1/en not_active Abandoned
- 1998-05-28 EP EP98923819A patent/EP1003480A4/en not_active Withdrawn
- 1998-05-28 AU AU76021/98A patent/AU745309B2/en not_active Ceased
- 1998-05-28 JP JP11500871A patent/JP2001501975A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU7602198A (en) | 1998-12-30 |
EP1003480A1 (en) | 2000-05-31 |
EP1003480A4 (en) | 2002-04-17 |
JP2001501975A (en) | 2001-02-13 |
WO1998053801A1 (en) | 1998-12-03 |
NZ501289A (en) | 2001-06-29 |
AU745309B2 (en) | 2002-03-21 |
CA2291839A1 (en) | 1998-12-03 |
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