JP2885868B2 - Supplements for treating or preventing hyperlipidemia - Google Patents
Supplements for treating or preventing hyperlipidemiaInfo
- Publication number
- JP2885868B2 JP2885868B2 JP2092344A JP9234490A JP2885868B2 JP 2885868 B2 JP2885868 B2 JP 2885868B2 JP 2092344 A JP2092344 A JP 2092344A JP 9234490 A JP9234490 A JP 9234490A JP 2885868 B2 JP2885868 B2 JP 2885868B2
- Authority
- JP
- Japan
- Prior art keywords
- corn
- treating
- food
- supplements
- hyperlipidemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- General Preparation And Processing Of Foods (AREA)
- Seeds, Soups, And Other Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は高脂血症治療又は予防用補助食品に関する。The present invention relates to a supplement for treating or preventing hyperlipidemia.
近年食生活の欧風化に伴い、高脂肪や砂糖類の摂取比
率が高まり高脂血症、糖尿病の多発がみられ、これらは
文明病とまで言われるようになった。In recent years, with the westernization of dietary habits, the intake ratio of high fats and sugars has increased and hyperlipidemia and diabetes have frequently occurred, and these have been called civilization diseases.
これを解決するには畜産物などの高脂肪食の摂取を減
少させること、穀類、野菜などをより多く摂取すること
が言われている。To solve this problem, it is said to reduce the intake of high-fat foods such as livestock products and to consume more cereals and vegetables.
〔発明が解決しようとする課題〕 しかし、美食化した現状では、食生活を変更させるこ
とは極めて困難である。[Problems to be Solved by the Invention] However, it is extremely difficult to change the eating habits under the current state of gastronomy.
本発明は現在の食生活に適し、かつ高脂血症の治療及び
予防作用を有する食品の開発を目的とする。An object of the present invention is to develop a food suitable for the current dietary life and having a therapeutic and preventive action for hyperlipidemia.
本発明は、とうもろこしの外皮から得られる食物繊維
及びキトサンを含有する高脂血症治療又は予防用補助食
品に関する。The present invention relates to a supplement for treating or preventing hyperlipidemia, comprising dietary fiber and chitosan obtained from corn hulls.
本発明で使用する食物繊維は、人の消化酵素で消化さ
れない食物中の難消化性炭水化物で、かつとうもろこし
の外皮から得られるものであり、通常とうもろこしの外
皮を酵素処理、化学的処理、物理的処理のいずれか、ま
たは、これらを適宜組合せて処理することにより得られ
る。酵素処理は、例えばα−アミラーゼ、グルコアミラ
ーゼ等の澱粉分解酵素、プロテアーゼ等の蛋白分解酵
素、リパーゼ等の脂質分解酵素、セルラーゼ等の繊維素
分解酵素をpH3〜９、温度30〜100℃の条件下に添加作用
されて処理することにより行われる。化学的処理は、例
えば上記とうもろこしの外皮に鉱酸、有機酸の水溶液を
添加し、pH2〜５の条件下に加熱するかまたは食品用界
面活性剤を添加し、pH3〜８の条件下に熱処理すること
により行われる。物理的処理は、例えば上記とうもろこ
しの外皮をホモジナイザー、ハンマーミル等の粉砕機で
粉砕した後、篩別することにより行われる。Dietary fiber used in the present invention is an indigestible carbohydrate in food that is not digested by human digestive enzymes, and is obtained from corn hulls.Usually, corn hulls are subjected to enzyme treatment, chemical treatment, physical treatment. It is obtained by performing any one of the processes or a combination thereof as appropriate. The enzymatic treatment is performed, for example, under conditions of a starch degrading enzyme such as α-amylase and glucoamylase, a protease such as protease, a lipolytic enzyme such as lipase, and a fibrinolytic enzyme such as cellulase at pH 3 to 9 and a temperature of 30 to 100 ° C. It is performed by adding and acting below. Chemical treatment is performed, for example, by adding an aqueous solution of a mineral acid or an organic acid to the corn hull and heating it under the condition of pH 2 to 5 or adding a surfactant for food and heat treating it under the condition of pH 3 to 8. It is done by doing. The physical treatment is performed, for example, by crushing the corn skin with a crusher such as a homogenizer or a hammer mill and then sieving.
本発明で使用する食物繊維は、これらの製法のうち、
物理的処理により得られるものが好ましく、とうもろこ
しの外皮から得られるものを用いる。このようなものの
例として日食セルファー （日本食品加工（株）製）が
あげられる。このものは、コーンスターチ製造工程で生
産されるとうもろこし外皮から機械と精製水の物理的処
理だけ製造される水不溶性のもので粗蛋白、デンプンの
含量がいずれも６％以下（乾物）であり、又、バンソエ
スト法による植物繊維含量の指標であるNDF（ニュート
ラル・デタージェット・ファイバー）値が85％以上、AD
F（アシッド・デタージェット・ファイバー）値が25％
以下のものである。又その粒度は150メッシュ以下、好
ましくは200メッシュ以下のものが90％以上であるもの
がよい、このようなものとして日食セルファー 200が
あげられる。 Dietary fiber used in the present invention, among these production methods,
Preferably obtained by physical treatment, corn
Use the one obtained from the rind of shin. Of something like this
Eclipse selfie as an example (Made by Japan Food Processing Co., Ltd.)
can give. This product is produced in the corn starch manufacturing process.
The physical treatment of the machine and purified water from the corn hulls produced
Water-insoluble, made only from crude protein and starch
Each content is 6% or less (dry matter).
NDF (Newt)
Ral data jet fiber) value is more than 85%, AD
25% F (Acid Deterjet Fiber)
These are: Also, the particle size is less than 150 mesh, good
Preferably, those with less than 200 mesh are 90% or more
Good, eclipse selfie as such 200 is
can give.
キトサンはカニやエビの殻に含まれるキチンを水酸化
アルカリなどの強アルカリ処理して得られるもので、平
均分子量50万以上、好ましくは100万以上、脱アセチル
化度70％以上好ましくは80〜90％前後のものがよい。又
その粒度は32メッシュ以下、好ましくは48メッシュ以下
のものが、85％以上であるものがよい。このようなもの
として、カヤミック 450（日本化薬（株）製）があげ
られる。 Chitosan hydroxylates chitin in crab and shrimp shells
Obtained by strong alkali treatment such as alkali.
Average molecular weight 500,000 or more, preferably 1,000,000 or more, deacetylated
The degree of chemical conversion is 70% or more, preferably about 80 to 90%. or
The particle size is 32 mesh or less, preferably 48 mesh or less
Should be 85% or more. Something like this
As kayamic 450 (made by Nippon Kayaku Co., Ltd.)
Can be
本発明において、食品中のとうもろこしの外皮から得
られる植物繊維及びキトサンの割合は前者が５〜40％好
ましくは10〜30％さらに好ましくは15〜20％程度後者が
0.1〜７％好ましくは0.5〜５％さらに好ましくは、１〜
３％程度がよい。In the present invention, the ratio of plant fiber and chitosan obtained from corn hulls in food is preferably 5 to 40%, preferably 10 to 30%, more preferably 15 to 20% for the former.
0.1 to 7%, preferably 0.5 to 5%, more preferably 1 to
About 3% is good.
本発明において、食品としては、特に制限なく、例え
ば、パン類やビスケット、キャンデー、チョコレート、
プリンなどの洋菓子類ゼリー、ヨウカンなどの和菓子
類、ポタージュ等のスープ類、アイスクリーム、麺類な
どがあげられる。又顆粒にすることも可能である。In the present invention, the food is not particularly limited, for example, breads and biscuits, candy, chocolate,
Examples include Western confectionery jellies such as pudding, Japanese confectionery such as Yokan, soups such as potage, ice cream, and noodles. It is also possible to make granules.
本発明の食品にはアルギン酸が添加されていてもよ
い。その量は２％以下、好ましくは0.01〜２％さらに好
ましくは0.1〜２％がよい。Alginic acid may be added to the food of the present invention. The amount is 2% or less, preferably 0.01 to 2%, more preferably 0.1 to 2%.
次に本発明の作用について、実験例を基に説明する。 Next, the operation of the present invention will be described based on experimental examples.
実験例 平均年令50才の女性10人および弾性１人の合計11人の
高脂血症患者にコーンファイバー（日食セルファー 20
0）を15％キトサン（カヤミック450）を２％およびアル
ギン酸を0.5％配合したビスケット（商品名ヘルケット
日本化薬（株）製）を１日上記３者の摂取量が総量で25
gとなるように５週間自由に摂取させた。その他の食事
については制限しなかった。調査項目としては、試験前
と試験後の体重、血圧、総コレステロール、HDL−コレ
ステロールおよび中性脂肪を測定した。なお、試験期間
中各患者は通常の内科的治療を継続した。Experimental example A total of 11 women, 10 women 50 years old on average and 1 elastic
Hyperlipidemia for corn fiber 20
0) 15% chitosan (Kayamic 450) 2% and Al
Biscuit containing 0.5% formic acid
Nippon Kayaku Co., Ltd.) has a daily intake of 25
The rats were allowed to freely ingest for 5 weeks to obtain g. Other meals
Was not restricted. Before the test,
And post-test weight, blood pressure, total cholesterol, HDL-core
Sterol and neutral fat were measured. Test period
Middle patients continued their usual medical treatment.
結果を次表に示す。 The results are shown in the following table.
試験期間は平均５週間と短期間であったが、被験者11
人の平均では、体重は平均0.9kg、総コレステロールは
約16mg/dl中性脂肪は約16mg/dlの減少およびHDL−コレ
ステロールは約7mg/dlの増加といずれも高脂血症にとつ
ては好ましい方向に数値が変化した。また、血圧も最大
値および最小値いずれも低下する傾向が観察された。特
に本発明の食品を摂取することにより総合コレステロー
ルと中性脂肪を著しく減少した。一方で善玉コレステロ
ールと謂われるHDL−コレステロール値を上昇させてお
り、これは、高脂血症治療にとっては注目に値する成績
である。 Although the test period was short, averaging 5 weeks,
On average, a person's body weight is 0.9 kg, total cholesterol is about 16 mg / dl, triglyceride is about 16 mg / dl, and HDL-cholesterol is about 7 mg / dl. The numerical value changed in a favorable direction. In addition, the blood pressure also tended to decrease at both the maximum value and the minimum value. In particular, the consumption of the food of the present invention significantly reduced the total cholesterol and neutral fat. On the other hand, it raises the HDL-cholesterol level, which is a so-called good cholesterol, which is a remarkable result for the treatment of hyperlipidemia.
〔効果〕 以上から明らかなように本発明の食品を高脂血症患者
の食品療法の補助として使うことにより、体重の減少お
よび血漿脂質の改善が期待される。[Effects] As is clear from the above, the use of the food of the present invention as a food therapy aid for hyperlipidemia patients is expected to reduce body weight and improve plasma lipids.
〔実施例１〕 ビスケット 小麦粉51g,コーンファイバー（日食セルファー）15g、
砂糖11.3g、オリゴ糖5g,シヨートニング5g、峰蜜5g、キ
トサン2g、ブドウ糖2g、アルギン酸0.5g、食塩0.5g、炭
酸カルシウム0.2g、ベーキングパウダー2.5g、配合比の
ビスケットを製造した。[Example 1] 51 g of biscuit flour, 15 g of corn fiber (eclipse selfie),
Biscuits of 11.3 g of sugar, 5 g of oligosaccharide, 5 g of shyotoning, 5 g of honeybee, 2 g of chitosan, 2 g of glucose, 0.5 g of alginic acid, 0.5 g of salt, 0.2 g of calcium carbonate, 2.5 g of baking powder and 2.5 g of baking powder were produced.
〔実施例２〕 ポタージュ 粒径40μｍ以下、平均粒径20μｍに湿式摩砕したトウ
モロコシの種子の外皮2.5g（日食セルファー）、キトサ
ン0.5g、牛乳15g、脱塩ホエイ2.6g、オリゴ糖2.5g、ス
イートコーン10g、生クリーム1.5g、コーンフレイバー
0.5g食塩0.1g更に調味料、香辛料を適量添加し、水を加
え全体を100gとし、罐に詰めて本発明のポタージュを得
た。[Example 2] Potage 2.5 g of corn seed hulls (solar eclipse) wet milled to a particle size of 40 μm or less and an average particle size of 20 μm, chitosan 0.5 g, milk 15 g, desalted whey 2.6 g, oligosaccharide 2.5 g , Sweet corn 10g, fresh cream 1.5g, corn flavor
0.5 g salt 0.1 g Further, seasonings and spices were added in appropriate amounts, water was added to make the whole 100 g, and the mixture was packed in a can to obtain the potage of the present invention.
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 昭63−185931（ＪＰ，Ａ) 特開 昭63−188355（ＪＰ，Ａ) 特開 平３−262461（ＪＰ，Ａ) 菅野道廣「キチン、キトサンのコレス テロール代謝改善効果と食品への応用 性」食品工業、光琳（1990．９．30）33 （18）Ｐ．20−24 (58)調査した分野(Int.Cl.6，ＤＢ名) A23L 1/308 ──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-63-185931 (JP, A) JP-A-63-188355 (JP, A) JP-A-3-262461 (JP, A) Michihiro Sugano “Kitin , Chitosan Improves Cholesterol Metabolism and Its Applicability to Foods ”, Food Industry, Korin (1990. 9.30) 33 (18) 20-24 (58) Fields surveyed (Int. Cl. 6 , DB name) A23L 1/308
Claims (1)
及びキトサンを含有する高脂血症治療又は予防用補助食
品。1. A supplement for treating or preventing hyperlipidemia, comprising dietary fiber and chitosan obtained from corn hulls.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2092344A JP2885868B2 (en) | 1990-04-09 | 1990-04-09 | Supplements for treating or preventing hyperlipidemia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2092344A JP2885868B2 (en) | 1990-04-09 | 1990-04-09 | Supplements for treating or preventing hyperlipidemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03290170A JPH03290170A (en) | 1991-12-19 |
| JP2885868B2 true JP2885868B2 (en) | 1999-04-26 |
Family
ID=14051783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2092344A Expired - Lifetime JP2885868B2 (en) | 1990-04-09 | 1990-04-09 | Supplements for treating or preventing hyperlipidemia |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2885868B2 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE207363T1 (en) * | 1992-10-30 | 2001-11-15 | Gennady Alexandrovich Markov | COMPOUND FOR BIOLOGICAL STIMULATION AND CORRECTION OF THE PHENOTYPE OF AN ORGANISM AND METHOD FOR PRODUCING IT |
| JPH07327633A (en) * | 1994-06-02 | 1995-12-19 | Matsura:Kk | Chitosan processed food |
| JP3737881B2 (en) * | 1998-04-17 | 2006-01-25 | 株式会社ファンケル | Chitosan composition and method for producing the same |
| JP4532766B2 (en) * | 2001-03-15 | 2010-08-25 | 株式会社東洋新薬 | healthy food |
| JP5026657B2 (en) | 2003-03-11 | 2012-09-12 | 花王株式会社 | Obesity prevention / amelioration agent |
| JP4738165B2 (en) | 2005-02-21 | 2011-08-03 | 松谷化学工業株式会社 | Water-soluble dietary fiber-containing composition and method for producing the same |
| JP5498073B2 (en) | 2009-07-16 | 2014-05-21 | 花王株式会社 | Blood triglyceride level increase inhibitor |
| GB0920633D0 (en) | 2009-11-25 | 2010-01-13 | Rdbiomed Ltd | Inhibition of pancreatic lipase |
| WO2012096108A1 (en) | 2011-01-12 | 2012-07-19 | 花王株式会社 | Suppressor for increase in blood gip level, suppressor for increase in blood insulin level, postprandial blood triglyceride level reducing agent, and suppressor for increase in blood glucose level |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6394948A (en) * | 1986-10-09 | 1988-04-26 | Yakult Honsha Co Ltd | Dietary fiber manufacturing method |
| JPH0761952B2 (en) * | 1987-01-28 | 1995-07-05 | 雪印乳業株式会社 | Manufacturing method of refined wheat flour |
| JPS63188355A (en) * | 1987-01-30 | 1988-08-03 | Snow Brand Milk Prod Co Ltd | Preparation of processed oat effective in improving serum lipid level |
| JPH01196270A (en) * | 1988-01-29 | 1989-08-08 | Snow Brand Milk Prod Co Ltd | Production of processed oats bran effective in improving blood serum lipid |
| JPH0738781B2 (en) * | 1988-04-04 | 1995-05-01 | 株式会社中埜酢店 | New food material manufacturing method |
| JPH03262461A (en) * | 1990-03-14 | 1991-11-22 | Snow Brand Milk Prod Co Ltd | Production of puffed food with high dietary fiber content |
-
1990
- 1990-04-09 JP JP2092344A patent/JP2885868B2/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 菅野道廣「キチン、キトサンのコレステロール代謝改善効果と食品への応用性」食品工業、光琳（１９９０．９．３０）３３（１８）Ｐ．２０−２４ |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03290170A (en) | 1991-12-19 |
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