JP3334725B2 - Accelerator for reducing alcohol in the body, its metabolites and oral freshener - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to a medicament which can exert an excellent effect in preventing unpleasant symptoms such as nausea and other discomforts, nausea, vomiting, hangover, dizziness and bad breath which are adverse effects of excessive drinking. or decrease promoter in the body alcohol and alcohol metabolites as quasi Hinto, also medical
It relates to a mouthwash as a quasi-drug .

[0002]

BACKGROUND ART Unpleasant symptoms such as nausea and other discomforts, nausea, vomiting, hangovers, dizziness or bad breath, which are adverse effects of excessive drinking, are caused by alcohol or alcohol such as ethanol remaining in the body by conventional research. It is believed that the action of metabolites such as acetaldehyde is involved.

[0003] Therefore, in order to prevent or suppress the above-mentioned symptoms, researches on pharmaceuticals for reducing their concentration in the body and non-pharmaceuticals according to them have been conducted. In particular, components extracted from natural plants are particularly attracting attention in terms of safety and the like.

[0004] On the other hand, as for tea, it is disclosed that the saponin component contained in a large amount in the seed has an effect of inhibiting absorption of alcohol (Japanese Patent Laid-Open No. 4-145).
028) There is no disclosure of the action of accelerating the concentration of the above-mentioned in-vivo alcohol or its metabolite.

[0005]

In the case of unpleasant symptoms, especially when drinking excessively, not only is the pharmacological effect and safety excellent, but also the scent and mouthfeel are increased.
Well easy to ingest it is important.

Accordingly, the present inventor has focused on the safety of tea, which is a natural product, which is proven to be consumed on a daily basis, the rich aroma thereof, the refreshing sensation of mouthfeel, or the availability thereof. After conducting research on the extraction method of tea and the pharmacological effects of the extract, we succeeded in finding that the hot water or organic solvent extractables have the effect of promoting the reduction of alcohol in the body, etc. In addition to being capable of being produced, it can exhibit excellent pharmacological effects and is highly safe for the human body, and yet has investigated alcohol that is ingested, an accelerator for lowering its metabolites, and an oral freshener. .

[0007]

Means for Solving the Problems To solve the above-mentioned problems, the present inventor has proposed a component obtained by extracting tea with hot water or an organic solvent or a mixture of hot water and an organic solvent (hereinafter referred to as tea extraction). The present invention has been achieved by successfully obtaining an in-vivo ethanol and acetaldehyde lowering accelerator containing the above-mentioned active ingredient as an active ingredient, and the effectiveness of the in-vivo ethanol and acetaldehyde lowering accelerator has been clarified by animal experiments. We were able to.

In the present invention, tea is a general term used as a raw material for green tea, oolong tea, black tea, etc., and refers to each part of tea leaves, tea seeds, bark, etc., or the whole (Camellia sinennsis). Things.

The above-mentioned tea extract is mainly composed of catechins, and further contains ash, free amino acids, caffeine, sugar, protein, lipid, vitamin C, and other substances. The safety for the human body was confirmed from the composition.

[0010] In order to obtain this tea extract component, for example, tea leaves are processed into crude tea according to a standard method, and this is treated with hot water or an organic solvent such as ethanol or a mixture of hot water and these organic solvents as an extraction solvent. After performing extraction at a predetermined temperature for a predetermined time, the extract may be filtered or centrifuged, and the obtained filtrate or extract may be concentrated and dried.

The thus-obtained tea extract can be used as an active ingredient of the present invention as it is, and it can be used as a medicinal product by subjecting it to dialysis, sterilization filtration, heat treatment, freeze-drying and the like. It can be provided as a quasi-drug or the like.

Further, the tea extract component is adjusted to a predetermined concentration, preferably about 0.1 to 5%, and formed into tablets, capsules, or the like having a round shape, a ring shape, a plate shape, or the like.
Alternatively, make it into a powder or liquid and pack it in a brown bottle container,
It can also be provided as a mouthwash as a quasi-drug .

[0013] It is preferable to provide a sweetener, a flavoring agent, and a preservative in addition to the above-mentioned tea-extracting component, because it becomes easier to ingest.

[0014]

EFFECT OF THE INVENTION Before drinking, when drinking excessively, or when feeling unpleasant due to excessive drinking, etc., the ingestion of the ethanol or acetoaldevit lowering accelerator or the oral freshener in the body according to the present invention is mainly used. By the action of catechins and the like as components, the concentration of ethanol and acetaldehyde in blood and liver is promoted to decrease, and various unpleasant symptoms due to excessive drinking can be prevented or suppressed. In addition, since the safety has been confirmed from the components, it can be taken with confidence.

[0015]

【Example】

(Method of producing tea extract and analysis of its composition) Fresh leaves (Thea
sinensis L.) according to a standard method, and 100 kg of 90 ° C. purified water is added to 10 kg of the dried leaves.
After extraction at 0 ° C. for 10 minutes, the extract is filtered or centrifuged, and further concentrated and dried to 2.5 kg.
A dry powdered tea extract was obtained.

When the composition of the tea extract was analyzed, the water content was 3.7%, the ash content was 8.0%, the free amino acids were 3.9%, and the catechins were 30.0% (EGC 10.0%,
EGCg 14.3%, EC 1.8%, ECG 3.4%,
Others 0.5%), caffeine 5.2%, sugar content 8.3
%, Protein 8.9%, fat 0.2%, vitamin C
It was found that the composition contained 1.0% and 30.8% of other components (crude fiber, organic acid, pigment, flavonoid, volatile odor component).

(Administration test using mice) Then, the crude catechin was dissolved in distilled water, and this was dissolved in an ICR male mouse (n = 3 ×
2 × 3) was orally administered at a dose of 500 mg / kg body weight, and after 1 hour, ethanol was orally administered at a dose of 2 g / kg body weight (20% W / V) using a catheter. As a control, distilled water was orally administered in the same manner. And before ethanol administration and 1 after ethanol administration
After 3 hours, blood and liver were collected, and the concentrations of ethanol, acetaldehyde, acetate and acetone in the blood and liver were measured, respectively.

The measuring method at this time is as follows. First, 0.5 ml of blood and 0.5 g of liver were powdered using liquid nitrogen, and immediately cooled PCA reagent (0.6 N p
erchloric acid, 30mM thiourea, 0.1mM EDTA in salin
e) Mix 2.5 ml and add 1 at 3000 rpm at 4 ° C.
Centrifuge for 0 minutes.

Next, the obtained supernatant sample was bisected, and one (A) was placed in a vial for measuring ethanol, acetaldehyde and acetone, and the other (B) was placed in a vial for measuring acetate. , Methanol 100
μl and 50 μl of sulfuric acid were added for methylation. In addition, 0.0003% t-
0.1 ml of butanol was added, and 0.1 ml was added to the B vial.
Add 0.1 ml of 02% n-butanol. And A
The vial was heated at 65 ° C. for 15 minutes, and the vial of B was heated at 55 ° C. for 30 minutes, and then quantitatively analyzed by GC.

FIGS. 1 to 8 show the results, respectively. FIG. 1 shows the change in the ethanol concentration in the blood when the crude catechin was administered and the control, and FIG. 2 shows the acetaldehyde in the blood. 3 shows the change in the acetate concentration in the blood, FIG. 4 shows the change in the acetone concentration in the blood, FIG. 5 shows the change in the ethanol concentration in the liver, and FIG. 7 shows the change in the acetaldehyde concentration in the liver, FIG. 7 shows the change in the acetate concentration in the liver, and FIG. 8 also shows the change in the acetone concentration in the liver over time.

From these results, it was found that when crude catechin was administered as compared with the control, the concentration of ethanol and acetaldehyde in blood and liver disappeared earlier. On the other hand, the concentrations of acetate and acetone in the blood and liver are higher than those of the control. This also revealed that the administration of crude catechin promoted alcohol metabolism.

Therefore, it can be considered that the above-mentioned tea extract component containing catechins as a main component also acts in the same manner, and the ethanol and acetaldehyde lowering promoters in the body and the mouth freshener according to the present invention include ethanol and acetaldehyde in the body. It was confirmed that it had an effect of lowering the concentration, and at the same time, it was found that it had an effect of promoting the metabolism of alcohol and acetaldehyde in the body.

(Production Example) The tea extract obtained by the above method is adjusted to a concentration of about 0.1 to 5% by weight in terms of dry powder so that the extract is converted into a dry powder so as to be preferable as a drinking concentration. And add flavoring agents, sweetening agents, preservatives, etc.
It can be put into a 00 ml amber bottle container, or made into a capsule or a tablet and commercialized.

[Brief description of the drawings]

FIG. 1 is a graph showing the concentration of ethanol in blood over time.

FIG. 2 is a graph showing acetaldehyde concentration in blood over time.

FIG. 3 is a graph showing the acetate concentration in blood over time.

FIG. 4 is a graph showing the concentration of acetone in blood over time.

FIG. 5 is a graph showing the concentration of ethanol in the liver over time.

FIG. 6 is a graph showing the concentration of acetaldehyde in the liver over time.

FIG. 7 is a graph showing the acetate concentration in the liver over time.

FIG. 8 is a graph showing the acetone concentration in the liver over time.

──────────────────────────────────────────────────続 き Continuing from the front page Examiner Hideki Tsurumi (56) References CHEMICAL ABSTRACT S, 1969, Vol. 70, No. 7, pp 158, 70: 27240 (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 35/78 A61K 7/26 A61K 31/35 BIOSIS (DIALOG) CA (STN) MEDLINE (STN)

Claims (3)

(57) [Claims] The method according to claim 1] Brown, obtained by extracting with hot water or an organic solvent, or a mixed solution of hot water and an organic solvent Kateki
A promoter for lowering alcohol in the body and metabolites of alcohol, which contains as an active ingredient a tea extract component mainly containing carbohydrates. 2. The unpleasantness due to excessive drinking obtained by adjusting the tea extract component according to claim 1 to an appropriate concentration and molding it into tablets or capsules, or obtained as a powder or liquid.
Oral freshener for preventing or suppressing various symptoms . 3. The content of the tea extract component is 0.1 to 5 % by weight.
3. The mouth freshener according to claim 2 , wherein the mouth freshener is used.