JPH0268105A - Filtration membrane having antibiotic action - Google Patents
Filtration membrane having antibiotic actionInfo
- Publication number
- JPH0268105A JPH0268105A JP63218558A JP21855888A JPH0268105A JP H0268105 A JPH0268105 A JP H0268105A JP 63218558 A JP63218558 A JP 63218558A JP 21855888 A JP21855888 A JP 21855888A JP H0268105 A JPH0268105 A JP H0268105A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- filtration membrane
- filtration
- microorganisms
- antibiotic action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 51
- 238000001914 filtration Methods 0.000 title claims abstract description 48
- 230000003115 biocidal effect Effects 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 claims abstract description 17
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 230000001954 sterilising effect Effects 0.000 claims abstract description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 8
- 238000005229 chemical vapour deposition Methods 0.000 claims abstract description 4
- 238000005240 physical vapour deposition Methods 0.000 claims abstract description 4
- 239000004332 silver Substances 0.000 claims abstract description 4
- 229910052709 silver Inorganic materials 0.000 claims abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 8
- 239000007788 liquid Substances 0.000 abstract description 4
- 230000035755 proliferation Effects 0.000 abstract description 3
- 229920001817 Agar Polymers 0.000 description 6
- 239000008272 agar Substances 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000001471 micro-filtration Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910021642 ultra pure water Inorganic materials 0.000 description 2
- 239000012498 ultrapure water Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Filtering Materials (AREA)
Abstract
Description
本発明は一般に液相系あるいは気相系に分散している微
生物を流体中からろ過膜を用いて除去する、いわゆるろ
過滅菌に関するものである。
本発明による抗菌作用を有するろ過膜は、例えば、液相
系においては家庭用浄水器、生ビール、生酒製造用のろ
過装置あるいは超純水製造用の最終ろ過装置等、気相系
においては医薬用アンプルに充填する無菌窒素ガス、超
純水製造装置に陽圧用ガスとして充填する無菌の空気あ
るいは半導体製造工程における空調用・希釈用の無菌の
空気や不活性ガスなどの製造のために適用される。The present invention generally relates to so-called filtration sterilization in which microorganisms dispersed in a liquid phase system or a gas phase system are removed from a fluid using a filtration membrane. The filtration membrane having an antibacterial effect according to the present invention can be used, for example, in liquid phase systems for household water purifiers, filtration devices for producing draft beer and draft sake, or final filtration devices for producing ultrapure water, and in gas phase systems for medical purposes. Applicable for the production of sterile nitrogen gas filled into ampoules, sterile air filled as positive pressure gas in ultrapure water production equipment, sterile air and inert gas for air conditioning and dilution in semiconductor manufacturing processes, etc. .
流体（液体および気体）中の微生物を除去あるいは殺菌
する方法としては、精密ろ過膜や限外ろ過膜を使用する
ろ過滅菌法、紫外線照射法および加熱法等があるが、最
終除菌法としてろ過滅菌法がよ（使用されている。この
方法は加熱処理あるいは薬剤処理等を施すことな（連続
処理することが可能なので、あらゆる分野で広範囲に用
いられている。
膜素材としては、酢酸セルロース、硝酸セルロース、再
生セルロース、テフロン、ポリスルホン、ポリアクリロ
ニトリル、ポリアミド、ポリイミド、ポリエーテルスル
ホンなどの高分子膜や、耐熱性、耐薬品性のある多孔質
焼結体膜などがある。Methods for removing or sterilizing microorganisms in fluids (liquids and gases) include filtration sterilization using microfiltration membranes or ultrafiltration membranes, ultraviolet irradiation, and heating methods, but filtration is the final sterilization method. Sterilization methods are often used. This method does not require heat treatment or chemical treatment (it can be processed continuously), so it is widely used in all fields. Membrane materials include cellulose acetate, Examples include polymer membranes such as cellulose nitrate, regenerated cellulose, Teflon, polysulfone, polyacrylonitrile, polyamide, polyimide, and polyethersulfone, as well as porous sintered membranes with heat resistance and chemical resistance.
本発明者らは、上述した従来技術にあった問題点を解決
すべく鋭意研究を重ねた結果、本発明を為すに至ったも
のである。
本発明の原理は、微生物を含む流体をろ過膜を通過させ
ることにより微生物を除去するとき、ろ過膜の原流体側
面上に、抗菌性を持つとして知られている銀を、物理的
蒸着法あるいは化学的蒸着法により蒸着することにより
、ろ過膜自体に抗菌性を付加することにある。
本発明による抗菌作用を有するろ過膜を用いることによ
り、従来技術の問題点であるろ過膜面上での微生物の増
殖を防止あるいは抑制できるため、微生物の透過流体中
への漏出を防止することができる。
なお本発明に用いるろ過膜の種類は精密ろ過膜、ろ布、
ろ紙など銀蒸着薄膜を形成しうるあらゆるろ過膜を含み
、材質は酢酸セルロース、テフロン、ポリスルホンなと
あらゆる素材を含む。またろ過膜の形状は平膜あるいは
スパイラル型、プリーツ型、管型、中空糸型モジュール
などあらゆる形状を含む。The present inventors have made extensive research to solve the above-mentioned problems in the prior art, and as a result, have accomplished the present invention. The principle of the present invention is that when microorganisms are removed by passing a fluid containing microorganisms through a filtration membrane, silver, which is known to have antibacterial properties, is deposited on the side of the raw fluid of the filtration membrane using physical vapor deposition or The aim is to add antibacterial properties to the filtration membrane itself by depositing it using a chemical vapor deposition method. By using the filtration membrane having an antibacterial effect according to the present invention, it is possible to prevent or suppress the proliferation of microorganisms on the surface of the filtration membrane, which is a problem with the conventional technology, thereby preventing microorganisms from leaking into the permeate fluid. can. The types of filtration membranes used in the present invention include microfiltration membranes, filter cloth,
It includes all types of filtration membranes that can form a silver-deposited thin film, such as filter paper, and includes all kinds of materials such as cellulose acetate, Teflon, and polysulfone. Further, the shape of the filtration membrane includes all shapes such as a flat membrane, a spiral type, a pleated type, a tube type, and a hollow fiber type module.
以下に本発明の実施例、および本発明によらない対照例
を以下に示す。
実施例および対照例はいずれも第１図に示すようなろ過
回路を用いた。第１図において、ｌはろ過滅菌器、２は
無菌的に操作を行うためのエアフィルター、３は菌体を
含む試料、４は銀蒸着あるいは対照（非蒸着）ろ過膜、
５はろ液、６はろ過操作終了時に大気圧に戻すためのリ
ークパルプ、７は吸引ポンプを示す。またろ過操作は次
のようにして行った。すなわち微生物を含む液３を、銀
蒸着ろ過膜あるいは対照ろ過膜（いずれも富士写真フィ
ルム株式会社製精密ろ過膜、三酢酸セルロース膜、公称
孔径０．４５μｍ、直径４７ｍｍ、平膜）４で、吸引ポ
ンプ７を用いてろ液側の圧力を１００ｍｍＨｇとして一
定量（２５０ｍｌ）吸引ろ過し、ろ過に用いたろ過膜４
を第１表に示す組成の寒天培地上で７日間３７°Ｃで培
養した。そして、ろ過膜面上に発生したコロニーの発現
数を計数することにより銀蒸着ろ過膜の抗菌性の度合を
評価した。なおこのときのろ過膜の有効ろ通商積は約１
０ｃｍ”であった。
第１表 大腸菌用寒天培地
実施例１
大腸菌（Ｅ、ｃｏｌ：）の濃度が８６０コ／２となるよ
うに調整した試料２５０ｍｊ！を上述の銀蒸着ろ過膜を
用いて吸引ろ過した。使用済みのろ過膜を寒天培地上で
７日間、３７°Ｃで培養した。この結果を第２表に示す
。
対照例１
大腸菌の濃度が８６０コ／ｌとなるように調整した試料
２５０ｍ１を上述の非蒸着膜を用いて吸引ろ過した。使
用済みのろ過膜を寒天培地上で７日間、３７°Ｃで培養
した。この結果を第２表に示す。
実施例２
大腸菌の濃度が４Ｘ１０’コ／ｌとなるように調整した
試料２５０ｍｌを上述の銀蒸着ろ過膜を用いて吸引ろ過
した。使用済みのろ過膜を寒天培地上で７日間、３７゛
Ｃで培養した。この結果を第２表に示す。
対照例２
大腸菌の濃度が４Ｘ１０’コ／Ｉ！、となるように調整
した試料２５０ｍｊ！を上述の非蒸着膜を用いて吸引ろ
過した。使用済みのろ過膜を寒天培地上で７日間、３７
°Ｃで培養した。この結果を第２表に示す。
第２表
実施例および対照例Examples of the present invention and comparative examples not according to the present invention are shown below. In both Examples and Control Examples, a filtration circuit as shown in FIG. 1 was used. In FIG. 1, l is a filter sterilizer, 2 is an air filter for aseptic operation, 3 is a sample containing bacterial cells, 4 is a silver-deposited or control (non-vapor-deposited) filtration membrane,
5 is a filtrate, 6 is a leak pulp for returning to atmospheric pressure at the end of the filtration operation, and 7 is a suction pump. Further, the filtration operation was performed as follows. That is, the liquid 3 containing microorganisms is sucked through a silver-deposited filtration membrane or a control filtration membrane (both microfiltration membranes manufactured by Fuji Photo Film Co., Ltd., cellulose triacetate membranes, nominal pore size 0.45 μm, diameter 47 mm, flat membrane) 4. Using pump 7, the pressure on the filtrate side was set to 100 mmHg, and a certain amount (250 ml) was suction-filtered, and the filtration membrane 4 used for filtration was
were cultured at 37°C for 7 days on an agar medium with the composition shown in Table 1. Then, the degree of antibacterial properties of the silver-deposited filtration membrane was evaluated by counting the number of colonies generated on the surface of the filtration membrane. The effective filtration volume of the filtration membrane at this time is approximately 1
Table 1 Agar medium for Escherichia coli Example 1 250 mj! of a sample adjusted so that the concentration of Escherichia coli (E, col:) was 860/2 was aspirated using the above-mentioned silver-deposited filtration membrane. The used filtration membrane was cultured on an agar medium at 37°C for 7 days. The results are shown in Table 2. Control Example 1 Sample adjusted to have an E. coli concentration of 860 cells/l. 250 ml was suction filtered using the non-deposited membrane described above. The used filter membrane was cultured on an agar medium at 37°C for 7 days. The results are shown in Table 2. Example 2 The concentration of E. coli was 250 ml of the sample adjusted to 4 x 10'co/l was suction-filtered using the above-mentioned silver-deposited filtration membrane.The used filtration membrane was cultured on an agar medium for 7 days at 37°C.This result was It is shown in Table 2. Comparative Example 2 A sample of 250 mj! adjusted to have an E. coli concentration of 4 x 10'co/I! was suction filtered using the non-deposited membrane described above.The used filtration membrane was placed on an agar medium. 7 days above, 37
Cultured at °C. The results are shown in Table 2. Table 2 Examples and comparative examples
以上のことから銀蒸着ろ過膜は、ろ過滅菌の際にろ過膜
面上に堆積した微生物の増殖を防止あるいは抑制する効
果を存することが確認された。From the above, it was confirmed that the silver-deposited filtration membrane has the effect of preventing or suppressing the growth of microorganisms deposited on the filtration membrane surface during filtration sterilization.
第１図は実施例および対照例を行う際の回路図である。
図中、１はろ過滅凹器、２はエアフィルタ、３は試料、
４は銀蒸着（ある゛いは非薄着）ろ過膜、５はろ液、６
はリークパルプ、７は吸引ポンプである。FIG. 1 is a circuit diagram when carrying out an example and a comparative example. In the figure, 1 is a filter sterilizer, 2 is an air filter, 3 is a sample,
4 is a silver-deposited (or non-thinly deposited) filtration membrane, 5 is a filtrate, 6
is a leak pulp, and 7 is a suction pump.
Claims (1)
法あるいは化学的蒸着法を用い、銀薄膜を形成すること
により、ろ過膜面上に捕捉された微生物の増殖を防止あ
るいは抑制することを特徴とする抗菌作用を有するろ過
膜。When performing filtration sterilization, a thin silver film is formed on the side of the raw fluid of the filtration membrane using physical vapor deposition or chemical vapor deposition to prevent or suppress the growth of microorganisms captured on the filtration membrane surface. A filtration membrane with antibacterial action.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63218558A JPH0268105A (en) | 1988-09-02 | 1988-09-02 | Filtration membrane having antibiotic action |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63218558A JPH0268105A (en) | 1988-09-02 | 1988-09-02 | Filtration membrane having antibiotic action |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0268105A true JPH0268105A (en) | 1990-03-07 |
Family
ID=16721826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63218558A Pending JPH0268105A (en) | 1988-09-02 | 1988-09-02 | Filtration membrane having antibiotic action |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0268105A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06226263A (en) * | 1993-01-29 | 1994-08-16 | Shigetaka Ishikawa | Antimicrobial resinous net and suppressing method for breeding of microorganisms using the same |
| US5490938A (en) * | 1993-12-20 | 1996-02-13 | Biopolymerix, Inc. | Liquid dispenser for sterile solutions |
| US5817325A (en) * | 1996-10-28 | 1998-10-06 | Biopolymerix, Inc. | Contact-killing antimicrobial devices |
| US5849311A (en) * | 1996-10-28 | 1998-12-15 | Biopolymerix, Inc. | Contact-killing non-leaching antimicrobial materials |
| US5869073A (en) * | 1993-12-20 | 1999-02-09 | Biopolymerix, Inc | Antimicrobial liquid compositions and methods for using them |
| US6180584B1 (en) | 1998-02-12 | 2001-01-30 | Surfacine Development Company, Llc | Disinfectant composition providing sustained residual biocidal action |
| US7288264B1 (en) | 1993-12-20 | 2007-10-30 | Surfacine Development Company, L.L.C. | Contact-killing antimicrobial devices |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60261502A (en) * | 1984-06-08 | 1985-12-24 | Mitsubishi Rayon Co Ltd | Porous polyolefin hollow yarn module having germicidal effect |
| JPS6316018A (en) * | 1986-07-07 | 1988-01-23 | Asahi Stainless Kk | Water purifying filter |
-
1988
- 1988-09-02 JP JP63218558A patent/JPH0268105A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60261502A (en) * | 1984-06-08 | 1985-12-24 | Mitsubishi Rayon Co Ltd | Porous polyolefin hollow yarn module having germicidal effect |
| JPS6316018A (en) * | 1986-07-07 | 1988-01-23 | Asahi Stainless Kk | Water purifying filter |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06226263A (en) * | 1993-01-29 | 1994-08-16 | Shigetaka Ishikawa | Antimicrobial resinous net and suppressing method for breeding of microorganisms using the same |
| US5490938A (en) * | 1993-12-20 | 1996-02-13 | Biopolymerix, Inc. | Liquid dispenser for sterile solutions |
| US5869073A (en) * | 1993-12-20 | 1999-02-09 | Biopolymerix, Inc | Antimicrobial liquid compositions and methods for using them |
| US6030632A (en) * | 1993-12-20 | 2000-02-29 | Biopolymerix And Surfacine Development Company | Non-leaching antimicrobial films |
| US6126931A (en) * | 1993-12-20 | 2000-10-03 | Surfacine Development Company, Llc | Contact-killing antimicrobial devices |
| US6264936B1 (en) | 1993-12-20 | 2001-07-24 | Biopolymerix, Inc. | Contact-killing non-leaching antimicrobial materials |
| US7288264B1 (en) | 1993-12-20 | 2007-10-30 | Surfacine Development Company, L.L.C. | Contact-killing antimicrobial devices |
| US5817325A (en) * | 1996-10-28 | 1998-10-06 | Biopolymerix, Inc. | Contact-killing antimicrobial devices |
| US5849311A (en) * | 1996-10-28 | 1998-12-15 | Biopolymerix, Inc. | Contact-killing non-leaching antimicrobial materials |
| US6180584B1 (en) | 1998-02-12 | 2001-01-30 | Surfacine Development Company, Llc | Disinfectant composition providing sustained residual biocidal action |
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