JPH0783806A - Storing device for dry analytical film - Google Patents

Abstract

PURPOSE:To easily keep the humidity of a housing chamber in a prescribed range with a simple structure by arranging an absorptive agent (humidity controlling agent) of water containing a prescribed moisture in the housing chamber of a dry analytical film. CONSTITUTION:A cover 125 is provided on the upper part of the base part 124 of a film storing device 111 to seal a housing chamber 111a, and a cartridge 20 in which a film is housed is inserted to a cartridge housing part 122a from the input port 125b of the cover 125. A humidity controlling agent housing part 127 provided in the center part of the base part 124 is filled with a humidity controlling agent 126 such as silica get containing a fixed quantity of moisture from the input port 125b having an opening and closing lid formed in the center part of the cover 125 to keep the housing chamber 111a in the dried state of low humidity. Namely, the moisture content of the humidity controlling agent 126 is regulated so that the humidity of the housing chamber 111a is lower than a fixed value, and the humidity of the housing chamber 111a is kept in a required humidity range higher than 0%RH.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a dry analysis having a reagent layer which causes an optical density change due to a chemical reaction, a biochemical reaction or an immunoreaction with a predetermined biochemical substance contained in a sample liquid such as blood or urine. The present invention relates to a storage device such as a film supplier of a biochemical analysis device that stores a film.

[0002]

2. Description of the Related Art In recent years, the content of a specific chemical component contained in a sample solution or its activity value, or the content of a tangible component, can be quantitatively analyzed by simply spotting and supplying small drops of the sample solution. A dry-type integrated multi-layer analysis film (also referred to as a multi-layer analysis element or a multi-layer analysis element) that can be used has been developed and put into practical use. In addition, a filter paper type test piece and an improved single-layer or multi-layer test piece have been proposed, and some of them have been put into practical use.

In order to quantitatively analyze chemical components in a sample solution using such a dry analysis film, in the case where the sample solution has a development layer in the dry analysis film,
For those that do not have a spreading layer, after direct spotting on the reagent layer,
This is kept at a constant temperature (incubation) for a predetermined time in an incubator (incubator) to cause a color reaction (dye formation reaction or color change reaction of the indicator dye), and then included in the dry analysis film with a predetermined biochemical substance in the sample solution. The chemical analysis slide is irradiated with irradiation light for measurement containing a wavelength preselected by the combination with the reagent to be measured, and its optical density is measured. The substance concentration (content) or the activity value of a predetermined biochemical substance in the sample solution is obtained by using a calibration curve showing the correspondence with the substance concentration of the substance.

By the way, the integrated multi-layer type dry analysis film has a structure in which at least one reagent layer containing a reagent is provided on a support made of an organic polymer, and more preferably, a development layer is provided on the upper side of the reagent layer. And is formed into a dry analysis film piece having a predetermined shape such as a square or a rectangle. For automatic operation, the dry analysis film piece is put to practical use as a chemical analysis slide held by an organic polymer mount. In addition, the inventors of the present invention have proposed a technique for directly loading a dry analysis film strip having no mount into a cartridge, storing the cartridge in a storage device (film supplier) of a biochemical analysis device, and sequentially taking out the measurement. is suggesting.

In the storage of the dry analysis film, it is necessary to adjust and maintain the humidity in the storage part such as the film supplier within a certain range in order to keep the performance constant and ensure the measurement accuracy.

That is, the dry analytical film contains biochemical materials such as enzymes and antibodies corresponding to the measurement items, and it is generally preferable to store it at low humidity because the reaction does not start. However, some dry analytical films, such as those for measuring total protein (TP), high-density lipoprotein-cholesterol (HDL-C), and albumin (ALB), have a storage atmosphere humidity of 0% or in the vicinity thereof. Humidity causes a problem that their performances are significantly changed and a desired measurement function cannot be obtained.

Therefore, for example, as disclosed in Japanese Utility Model Laid-Open No. 5-33048 (US Pat. No. 5,043,143), the dry analytical film (test element) is communicated with a storage chamber to store water. A first compartment containing water adding means by a sponge impregnated with water and a second compartment containing water removing means by desiccant are provided, and the communication between these two compartments and the storage room is selectively opened and closed. There is known a technique for adjusting humidity. That is, by the control of the control means based on the signal of the humidity sensor provided in the storage room, when the humidity is low, the communication with the first compartment is opened for humidification, and when the humidity is high, the communication with the second compartment is established. It is intended to maintain the specified humidity by opening the to dehumidify.

[0008]

However, in the humidity control of the containment room as in the above-mentioned prior art, the first means for adding water is used.
Two compartments, a compartment and a second compartment for water removing means, are formed separately from the storage compartment, and a control system and mechanism for controlling the opening and closing of the compartments according to the detected humidity are required. However, it is complicated and costly.

Further, in the above-mentioned prior art, when the humidifying operation is performed, a drastic humidity change is brought about, which makes it difficult to stably adjust the humidity. In particular, maintaining the humidity in the storage chamber containing the dry analysis film at a relatively low humidity above 0% (for example, 10% RH or less) requires fine control, and stable humidity cannot be maintained. The performance of the dry analysis film stored and stored may deteriorate and the measurement accuracy may decrease.

The present invention has been made in view of the above circumstances, and is a dry method in which the humidity of a storage chamber accommodating a dry analysis film for biochemical analysis is maintained in a predetermined humidity range with a simple structure. It is an object of the present invention to provide an analytical film storage device.

[0011]

In order to achieve the above object, a storage device for a dry analytical film according to the present invention has a storage chamber for accommodating a dry analytical film for biochemical analysis in a substantially sealed state. A water adsorbent containing water is provided to keep the humidity of the storage chamber in a constant range over 0% RH.

The water adsorbent is preferably a physical desiccant such as silica gel, zeolite, molecular sieve, activated clay and activated alumina.

On the other hand, the water-containing adsorbent may contain a target water content in the whole adsorbent, or a water adsorbent adjusted to a constant water content exceeding the target water content,
You may mix with the water adsorbent which does not contain water at a fixed ratio.

[0014]

In the storage device for the dry analysis film of the present invention, a water adsorbent containing a predetermined amount of water is arranged in the storage chamber accommodating the dry analysis film, and the water content of this water adsorbent is adjusted. Then, the humidity of the storage room is adjusted to a value that does not fall below a certain value, in other words, in the initial stage of installation of water adsorbent, or
When a predetermined time elapses from the time when the humidity changes depending on the storage or removal of the dry analysis film and the dehumidification and humidification by the predetermined water-containing adsorbent are in equilibrium, the humidity inside the storage chamber is desired to be higher than 0% RH. The humidity range is maintained and adjusted.

When the water adsorbent is a physical desiccant such as silica gel, zeolite, molecular sieve, activated clay, activated alumina, etc., it is chemically stable and adversely affects the reaction and equipment of the dry analytical film. Not given and easy to handle.

Further, the adsorbent to be installed in the storage chamber is
An adsorbent adjusted to a constant water content that exceeds the target water content,
When the adsorbent containing no water is mixed at a constant ratio, the water content can be easily controlled when adjusting the adsorbent having a low water content, and the storage chamber can be kept at a low humidity.

[0017]

Embodiments of the present invention will be described below with reference to the accompanying drawings. First, FIG. 1 is a perspective view showing a schematic configuration of a biochemical analyzer including a storage device according to an embodiment of the present invention.

The biochemical analyzer 10 is a film storage device 11 (film supplier) which stores an unused substantially square or rectangular dry analysis film 1 (dry analysis film piece), and the film storage device 11 described above. And an incubator 12 which is disposed on the side of the dry analysis film 1 and keeps the dry analysis film 1 at a constant temperature for a predetermined time, and a film transport means for transporting the dry analysis film 1 from the film storage device 11 to the incubator 12.
13, a sample liquid storage means 14 (sampler) for storing a plurality of sample liquids such as serum and urine, and a dry type until the sample liquid in the sample liquid storage means 14 is transferred to the incubator 12 by the film transfer means 13. The analysis film 1 is provided with a spotting means 15 for spotting, and a measuring means 16 arranged below the incubator 12.

As shown in FIG. 2, the dry analysis film 1 has a reagent layer 3 coated or adhered on a light-transmissive support 2 made of a plastic sheet such as an organic polymer sheet such as polyethylene terephthalate (PET) or polystyrene. A film piece (chip) in which the development layer 4 is laminated thereon by a laminating method or the like and does not have a mount corresponding to a mount in a conventional chemical analysis slide.

In the reagent layer 3, a hydrophilic polymer binder such as gelatin or a porous layer contains a detection reagent which selectively reacts with the analyte and a reagent (chemical analysis reagent or immunoassay reagent) necessary for color reaction. At least 1 included
It consists of two layers.

Further, the spreading layer 4 is a woven fabric or a knitted fabric made of a synthetic fiber such as polyester which is resistant to abrasion with the outside, a woven fabric, a knitted fabric, a non-woven fabric, etc. made of a blend of natural fibers and synthetic fibers, or paper. And the sample liquid spotted on the spreading layer 4 is spread so as to be uniformly supplied onto the reagent layer 3.

This dry analysis film 1 is
As shown in FIG. 2 (A), it is formed in a shape close to a plane. However, since the dry analysis film 1 is arranged in a dry environment (for example, humidity is 20% or less) so as not to cause a chemical reaction or an immunological reaction during storage, the dry analysis film 1 shown in FIG.
(B) or has a characteristic of curling with the spreading layer 4 inside as shown in FIG. 2 (C).

The dry analysis film 1 is housed in a cartridge 20 as shown in FIG. 3 for each measurement item. The cartridge 20 accommodates a large number of dry analysis films 1 in a stacked state with the light-transmitting support 2 facing downward, and is formed into a disk shape of the film storage device 11 as shown in FIG. A plurality of cartridge accommodating portions 22a on the inner peripheral side or the outer peripheral side provided on the frame 22 are loaded in parallel. The frame 22 is rotatably supported by a base 24, and is rotationally driven by a supplier motor (not shown) installed in the base 24.
The predetermined cartridge storage portion 22a is controlled so as to stop at the take-out position corresponding to the film transport means 13.

The outer peripheral portion of the frame 22 is covered.
A storage chamber 11a is provided in which 25 is provided and the inside is hermetically sealed, and the cartridge 20 is provided to be inserted and removed from an insertion opening 25a having an opening / closing lid provided on the upper surface. Further, the humidity control agent accommodating portion 27 is provided at the center of the frame 22.
The humidity control agent storage portion 27 is permeable to the storage chamber 11a, and has an opening / closing lid formed at the center of the upper surface of the cover 25 from the inlet 25b. (Not shown)
11a in which the dry analysis film 1 is loaded
Is kept in a dry state within a predetermined humidity range on the low humidity side.

The humidity control agent is composed of an adsorbent of water containing a predetermined amount of water and keeps the humidity of the storage chamber 11a within a certain range exceeding 0% RH. As the water adsorbent, a physical desiccant such as silica gel, zeolite, molecular sieve, activated clay, activated alumina, etc. is selectively used. Adjusted humidity range is 1-40%
It is RH.

Further, the water adsorbent containing a predetermined amount of water has a target amount of water contained in the whole adsorbent, or a water adsorbent adjusted to a constant amount of water exceeding the target amount of water,
It is formed by mixing a water-free water adsorbent at a constant ratio. That is, for example, when adjusting the adsorbent such that the minimum humidity is 1% RH, it is difficult to control the quality because the amount of water absorption is very small.
It is obtained by mixing a dry adsorbent in a predetermined ratio with an adsorbent containing water.

On the other hand, the cover of the film storage device 11
An opening / closing shutter (not shown) which is opened when a predetermined dry analysis film 1 is taken out from each cartridge 20 is provided at the take-out position on the lower surface of 25, and a sucker 70 for taking out the film transport means 13 inserted through the shutter. Thus, the dry analysis film 1 at the bottom of the cartridge 20 is taken out.

Here, as shown in FIGS. 3A and 3B, the cartridge 20 for accommodating the dry analysis film 1 is shown in detail in FIG. 3A and FIG. A spring member 30 and a pressing member 31 arranged on the side are provided. Further, near the bottom of one side surface 20b of the box body 21, there is formed a first opening 20c through which only one bottom of the dry analysis film 1 can be taken out, and the bottom 20d is provided with the film 1 described above. A substantially U-shaped second opening 20e into which a suction cup 70 (suction cup) for suction holding is formed is formed.

Further, the other side surface 20f of the box body 21 is provided with a magnetic stripe 20g having information representing the characteristics of the contained dry analysis film 1 and the side surface.
20b and the side opposite to this cartridge 20
A rib 20h is provided so as to hold the cartridge in the cartridge accommodating portion 22a and prevent misidentification in the cartridge insertion direction.

Next, in the incubator 12 shown in FIG. 1, a disk-shaped main body 40 is rotatably supported by a rotary drive mechanism 41 at the lower center, and the dry analysis film 1 is provided on the circumference of the main body 40 at predetermined intervals. A plurality of cells 42 for accommodating are arranged, and the dry analysis film 1 is incubated in the cells 42.

The main body 40 of the incubator 12 has a lower metal disc 45 having a flat lower surface and a metallic upper disc (not shown) disposed on the lower disc 45. The upper disc has an outer peripheral portion. Is formed by bulging upward in a ring shape,
A gap is formed between the lower end of the outer periphery and the upper surface of the lower disk 45 to form the side opening 42a of the cell 42. A heater is built in the main body 40, and the dry analysis film 1 is heated and maintained at a predetermined temperature (for example, 37 ° C.).

Although not shown, the lower disc
A photometric window is opened at 45 at a predetermined interval corresponding to the position where the cell 42 is formed, and the dry analysis film 1 inserted in the cell 42.
Is provided with a film retainer for fixing the
Below the main body 40 at the measuring position, the photometric head 95 of the measuring means 16 is arranged.

The transport means 13 for transporting the dry analysis film 1 from the film storage device 11 to the incubator 12 is held by the suction cup 70 for taking out the dry analysis film 1 from the cartridge 20 and this suction cup 70. The dry analysis film 1 is held and received from below with the reagent layer 1b being the upper surface, and the incubator is received.
Horseshoe-shaped transfer member to be inserted into 12 cells 42 from the side opening
73 and a holding suction cup 76 for holding and holding the dry analysis film 1 held by the transfer member 73 in the cell 42 of the incubator 12 from below the cell 42.

The suction cup 70 for taking out is provided to be movable back and forth and up and down by a moving mechanism (not shown), and pulls out the dry analysis film 1 to the outside of the cartridge and conveys it to the spotting position. Further, the holding suction cup 76 is provided so as to be movable up and down by a drive mechanism (not shown), and the cell 42 is opened from the photometric window opened on the bottom surface of the cell 42 of the incubator 12.
Move in and out.

On the other hand, a film discharging means 17 is arranged at the film discharging position of the incubator 12, and a discharging sucker 81 for sucking and lifting the measured dry analysis film 1 in the cell 42, and a discharging sucker 81. The horse-shoe-shaped transfer member 82 for taking out the film, which receives the dry analysis film 1 lifted up by and is carried out of the incubator 12, and the dry analysis film 1 taken out by the transfer member 82, and the waste box 84. It is composed of a suction cup 83 for disposal.

The sample liquid accommodating means 14 has a rotary drive mechanism 86.
A rotary table 85 which is rotated by the rotary table 85 is provided, and a plurality of sample containers 87 containing sample liquid are held on the outer peripheral portion of the rotary table 85, and the sample containers 87 are sequentially moved to the supply position. A nozzle tip 88 mounted on the tip of a spotting nozzle 91 described later is housed on the inner peripheral side.

The spotting means 15 for spotting each sample solution in the sample container 87 onto the dry analysis film 1 conveyed to the incubator 12 has a spotting nozzle 91 for sucking and discharging the sample solution. The pipette-shaped nozzle tip 88 is detachably attached to the tip of the spotting nozzle 91, and the driving mechanism 92
The sample liquid is sucked and moved from the sample liquid accommodating means 14 to be spotted on the dry analysis film 1 held on the transfer member 73. Also,
The nozzle tip 88 at the tip of the spotting nozzle 91 of the spotting means 15 is replaced when the sample liquid is changed.

The spotted dry analysis film 1 is incubated in an incubator 12 and measured by a measuring means 16 arranged below the incubator 12. The measuring means 16 has a photometric head 95 for measuring the optical density due to the color reaction between the dry analysis film 1 and the analyte in the sample solution. The photometric head 95 is used for the support 2 which is transparent to the irradiation light for measurement including light of a predetermined wavelength.
Of the light source 96 (lamp) to the photometric head 95.
Light is incident through the interference filter 97, and the light is irradiated on the reagent layer 3 in the photometric head 95. The filter
A plurality of types of 97 corresponding to inspection items are installed on the disc 98, and the disc 98 is rotated by a motor 99 to select a filter 97 having a predetermined characteristic corresponding to the measurement item. There is.

As the spectroscopic means provided in the optical system for irradiating the photometric head 95 with the measurement light, a diffraction grating may be used instead of the interference filter 97 as described above.

The reflected light from the reagent layer 3 is optical information (specifically, the amount of light) according to the amount of dye produced in the reagent layer 3.
The reflected light carrying the optical information is incident on the photo-detecting element of the photometric head 95, photoelectrically converted, and sent to the determination unit via the amplifier. The determination unit determines the optical density of the dye generated in the reagent layer 3 based on the level of the input electric signal, and determines the concentration (content) or activity value of a predetermined biochemical substance in the sample solution. Calculated according to the principle of colorimetric method.

The measurement by the biochemical analysis device 10 will be described. First, the dry analysis film stored in the film storage device 11 by the take-out suction cup 70 of the transport means 13 from the cartridge 20 corresponding to the measurement item at a predetermined humidity. Take 1 out. The dry analysis film 1 held on the suction cup 70 is transferred to the transfer member 73 with the reagent layer 3 as the upper side as it is, and the sample solution is spotted on the reagent layer 3.

This spotting is performed by the spotting nozzle 91 of the spotting means 15.
After attaching the nozzle tip 88 to the tip of the
Nozzle tip 88 by moving it over 14 predetermined sample containers 87
The tip of is immersed in the sample solution, and a predetermined amount of sample solution is sucked into the nozzle tip 88. Then, the spot wearing nozzle 91 is moved to the center of the dry analysis film 1 on the transfer member 73,
Then, the spotting nozzle 91 is moved downward to drop a predetermined amount of the sample liquid onto the reagent layer 3 of the dry analysis film 1 from the nozzle tip 88. The dropped sample liquid is spread and diffused and mixed with the reagent.

The dry analysis film 1 after the spotting is mounted on the transfer member 73.
Transport of the incubator cell 42 to the side opening 42
Inserted from a. In the incubator cell 42, when the dry analysis film 1 is sealed and heated to a predetermined temperature by a predetermined incubation, the reagent layer 3 causes a color reaction (dye formation reaction). Then, the optical density of the dye generated by this color reaction is measured by the photometric head 95 of the measuring means 16 at every predetermined time or after the lapse of a predetermined time during the color reaction.

Next, FIGS. 4 to 5 show a specific structure of the film storage device 111 in which the number of cartridges 20 accommodated is different from that of FIG.

The illustrated film storage device 111 has substantially the same basic structure as the film storage device 11 described above.
A disk-shaped frame 122 rotatably supported by 124 is provided.
The frame 122 has cartridge storage portions 122a arranged in a line on the outer peripheral surface thereof, and the above-mentioned cartridges 20 are loaded in the respective cartridge storage portions 122a.

A cover 12 is provided on the base 124.
5 is provided to seal the internal storage chamber 111a, and the cartridge 20 is inserted and taken out from the insertion opening 125a having an opening / closing lid provided on the upper surface thereof.
The cover 125 is configured so that it can be removed from the base portion 124, and if some trouble occurs in the film storage device 111 and it is necessary to temporarily transfer the cartridge 20 to another place, the cover 125 is removed. Cartridge 20 can be quickly removed by removing 125.

Further, a humidity control agent accommodating portion 127 is provided in the central portion of the base portion 124, and the humidity control agent accommodating portion 127 is provided with the opening 125b having an opening / closing lid formed in the central portion of the upper surface of the cover. A humidity control agent 126 similar to the above is loaded, and the inside of the storage chamber 111a is kept in a dry state with low humidity.

Further, on the lower surface of the base portion 124, a take-out port 123 for taking out a predetermined dry analysis film 1 from each cartridge 20, and an opening / closing shutter 12 for opening and closing the take-out port 123.
8 are provided. This opening / closing shutter 128 is composed of a spring 12
9 is urged in the direction to close the outlet 123, and when the predetermined dry analysis film 1 is taken out, the outlet 123 is opened by being pressed by the cam 131 which is rotationally driven by the shutter motor 130. Has been done. Further, a tooth portion 122b that meshes with the rotary gear 121a of the frame motor 121 is formed on the lower portion of the outer peripheral surface of the frame 122, and the frame 122 is rotationally driven by the frame motor 121 and a predetermined cartridge The storage portion 122a is controlled so as to stop at the position of the outlet 123.

Here, the storage chamber 111a containing the humidity control agent 126 is used.
An example of the humidity adjustment experiment will be described. First, in the first experimental example, silica gel was used as an adsorbent, and the silica gel containing 12% by weight of water was added to the silica gel.
The moisture content as a whole of the humidity control agent 126 is adjusted by variously changing the mixing ratio with dry silica gel having a water content of 0%, and the prepared humidity control agent 126 is stored in the film storage device 111. Table 1 shows the relationship between the mixing ratio and the humidity of the storage chamber 111a in the equilibrium state when the humidity control agent storage unit 127 is loaded from the charging port 125b.

[0050]

[Table 1]

Next, as a second experimental example, activated clay was used as an adsorbent, and a predetermined amount of water was added to this activated clay to prepare humidity control agents 126 having various water contents. Table 2 shows the relationship between the water content and the humidity of the storage chamber 111a in the equilibrium state when the humidity control agent storage portion 127 of the storage device 111 is loaded from the input port 125b.

[0052]

[Table 2]

As described above, the humidity of the storage chamber 111a can be stably maintained at a relatively low humidity by adjusting the type of adsorbent and the water content, and the dry analysis stored in the inside can be performed. The film 1 can be stored in a good condition without deteriorating its performance.

After a long time, the water content of the adsorbent fluctuates according to the inflow of moisture from the outside or the release of moisture to the outside as the storage chamber 111a is opened and closed. The humidity of the storage room 111a in an equilibrium state fluctuates,
The humidity range is maintained by exchanging the adsorbent or adjusting the amount of water every time a predetermined time elapses or by detecting the humidity condition.

As the dry analysis film which can be accommodated in the film storage device of the present invention, a dry analysis film piece having no mount as described in the above embodiment, a slide type dry analysis film having a mount, and a filter paper are used. A type of dry analysis film or the like can be applied.

Further, as a film storage device, a dry analysis film is installed in the biochemical analysis device as in the embodiment and the dry analysis film is sequentially taken out in correspondence with the measurement, and only the dry analysis film is provided separately from the biochemical analysis device. May be stored.

[0057]

DETAILED DESCRIPTION OF THE INVENTION

(1) The storage device for a dry analysis film according to claim 1, wherein the adsorbent is a physical desiccant such as silica gel, zeolite, molecular sieve, activated clay and activated alumina.

(2) The water-containing adsorbent contains a target water content in the whole adsorbent.
Storage device for the dry analysis film described.

(3) The water-containing adsorbent is a mixture of an adsorbent adjusted to a water content exceeding a target water content and an adsorbent containing no water at a constant ratio. The dry analysis film storage device according to 1.

[0060]

According to the storage device for a dry analysis film of the present invention, a water adsorbent containing a predetermined amount of water is arranged in the storage chamber accommodating the dry analysis film. The humidity can be stably adjusted to a humidity range in which the humidity in the storage chamber does not become a certain value or less in accordance with the water content of the simple configuration.

[Brief description of drawings]

FIG. 1 is a perspective view showing the outline of a biochemical analysis device equipped with a storage device according to an embodiment of the present invention.

FIG. 2 is a perspective view showing the outline of a dry analysis film.

FIG. 3 is a partially cutaway perspective view showing a cartridge containing a dry analysis film.

FIG. 4 is a vertical sectional view showing a schematic configuration of a film storage device.

FIG. 5 is a bottom view showing the film storage device shown in FIG. 4 with a part thereof cut away.

[Explanation of symbols]

 1 Dry analysis film 10 Biochemical analysis device 11,111 Film storage device 11a, 111a Storage room 12 Incubator 13 Film transfer means 14 Sample liquid storage means 15 Pointing means 16 Measuring means 20 Cartridge 22,122 Frame 22a, 122a Cartridge storage section 24,124 Base section 25,125 Cover 27,127 Humidity agent housing 113 Film removal means 121 Body motor 126 Humidity agent

Claims (1)

[Claims] 1. A storage device for storing a dry analysis film incorporated in a biochemical analysis device, wherein a predetermined moisture is contained in a storage chamber which stores the dry analysis film in a substantially closed state. A storage device for a dry analysis film, characterized by being provided with a water adsorbent to maintain the humidity of the storage chamber within a certain range exceeding 0% RH.