JPS557255A - Thiazolidine derivative - Google Patents

Thiazolidine derivative

Info

Publication number
JPS557255A
JPS557255A JP8111678A JP8111678A JPS557255A JP S557255 A JPS557255 A JP S557255A JP 8111678 A JP8111678 A JP 8111678A JP 8111678 A JP8111678 A JP 8111678A JP S557255 A JPS557255 A JP S557255A
Authority
JP
Japan
Prior art keywords
group
formula
removal
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8111678A
Other languages
Japanese (ja)
Other versions
JPS6141357B2 (en
Inventor
Junichi Iwao
Masayuki Ooya
Toshio Baba
Tadashi Iso
Takehisa Chiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to JP8111678A priority Critical patent/JPS557255A/en
Priority to AU45444/79A priority patent/AU528115B2/en
Priority to US05/023,397 priority patent/US4430344A/en
Priority to SE7902910A priority patent/SE434943B/en
Priority to GB7911642A priority patent/GB2018248B/en
Priority to CH3226/79A priority patent/CH649293A5/en
Priority to IT21666/79A priority patent/IT1115158B/en
Priority to ES479410A priority patent/ES479410A1/en
Priority to CA325,022A priority patent/CA1127157A/en
Priority to DE2914059A priority patent/DE2914059C2/en
Priority to NL7902710A priority patent/NL7902710A/en
Priority to FR7908829A priority patent/FR2421889A1/en
Priority to AT0311479A priority patent/AT367414B/en
Publication of JPS557255A publication Critical patent/JPS557255A/en
Priority to US06/239,601 priority patent/US4386096A/en
Priority to US06/239,602 priority patent/US4356183A/en
Priority to US06/239,600 priority patent/US4423054A/en
Priority to US06/239,599 priority patent/US4457935A/en
Publication of JPS6141357B2 publication Critical patent/JPS6141357B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A thiazolidine derivative of formula I: [R<1> is phenyl, cycloalkyl, higher alkyl, R<2>-S-lower alkyl (phenyl group may be substituted by lower alkyl- substituted amino, lower alkylenedioxy, carboxyl, or a group after removal of the group R<1> from formula I); R<2> is H, acyl, aralkyl, or a group after removal of the group R<2> from formula I; Z is 1-13C straight or branched chain alkylene group)] and its salt. EXAMPLE:(4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-2-(3,4-methylenedio xyphenyl)-4-thiazolidine carboxylic acid. USE:Hypotensive agents. PROCESS:A compound of formula II: (R<3> is acyl or aralkyl group; X is halogen) is reacted with a compound of formula III: (R<4> is the same as R<1>; however, -COZSR<2> is substituted by H when R<1> is a group after removal of R<1> from formula I) to give the compound of formula I.
JP8111678A 1978-04-08 1978-07-03 Thiazolidine derivative Granted JPS557255A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP8111678A JPS557255A (en) 1978-07-03 1978-07-03 Thiazolidine derivative
AU45444/79A AU528115B2 (en) 1978-04-08 1979-03-23 Antihypertensive 4-thiazolidine/carboxylic acids
US05/023,397 US4430344A (en) 1978-04-08 1979-03-23 Antihypertensive 4-thiazolidinecarboxylic acids
SE7902910A SE434943B (en) 1978-04-08 1979-04-02 4-thiazolidin carboxylic acid
GB7911642A GB2018248B (en) 1978-04-08 1979-04-03 Antihypertensive 4 thiazolidine carboxylic acids
CH3226/79A CH649293A5 (en) 1978-04-08 1979-04-05 DERIVATIVES OF 4-THIAZOLIDINE CARBONIC ACID AND ITS SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
CA325,022A CA1127157A (en) 1978-04-08 1979-04-06 Antihypertensive 4-thiazolidinecarboxylic acids
FR7908829A FR2421889A1 (en) 1978-04-08 1979-04-06 NEW DERIVATIVES OF THIAZOLIDINECARBOXYLIC-4 ACID USEFUL AS ANTIHYPERTENSIVE MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION
ES479410A ES479410A1 (en) 1978-04-08 1979-04-06 Antihypertensive 4-thiazolidinecarboxylic acids (pyridyl derivatives)
IT21666/79A IT1115158B (en) 1978-04-08 1979-04-06 ANTI-HYPERTENTION 4-THIAZOLIDINI-CARBOXYLIC ACIDS
DE2914059A DE2914059C2 (en) 1978-04-08 1979-04-06 4-Thiazolidinecarboxylic acids, processes for their preparation and pharmaceutical compositions containing them
NL7902710A NL7902710A (en) 1978-04-08 1979-04-06 PROCESS FOR PREPARING A MEDICINAL PRODUCT WITH ANTI-HYPERTENSIVE ACTION, FORMATED MEDICINAL PRODUCT AND PROCEDURE FOR PREPARING THE MEDICINAL 4-THIAZOLIDINE CARBON ACID DERIVATE.
AT0311479A AT367414B (en) 1978-04-25 1979-04-25 PROCESS FOR THE PREPARATION OF NEW 4-THIAZOLIDINE CARBONIC ACID DERIVATIVES AND THEIR SALTS AND STEREOISOMERS
US06/239,601 US4386096A (en) 1978-04-08 1981-03-02 Antihypertensive 4-thiazolidinecarboxylic acids (furyl and thienyl derivatives)
US06/239,599 US4457935A (en) 1978-04-08 1981-03-02 Antihypertensive 4-thiazolidinecarboxylic acids (substituted phenyl derivatives)
US06/239,602 US4356183A (en) 1978-04-08 1981-03-02 Antihypertensive 4-thiazolidinecarboxylic acids (pyridyl derivatives)
US06/239,600 US4423054A (en) 1978-04-08 1981-03-02 Antihypertensive 4-thiazolidinecarboxylic acids (substituted alkyl derivatives)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8111678A JPS557255A (en) 1978-07-03 1978-07-03 Thiazolidine derivative

Publications (2)

Publication Number Publication Date
JPS557255A true JPS557255A (en) 1980-01-19
JPS6141357B2 JPS6141357B2 (en) 1986-09-13

Family

ID=13737400

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8111678A Granted JPS557255A (en) 1978-04-08 1978-07-03 Thiazolidine derivative

Country Status (1)

Country Link
JP (1) JPS557255A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982002200A1 (en) * 1980-12-29 1982-07-08 Iwao Jun Ichi Heterocyclic 5-membered ring compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5382778A (en) * 1976-12-03 1978-07-21 Squibb & Sons Inc Thiazolidinecarboxylate derivative and related compounds thereof process for preparing same and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5382778A (en) * 1976-12-03 1978-07-21 Squibb & Sons Inc Thiazolidinecarboxylate derivative and related compounds thereof process for preparing same and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982002200A1 (en) * 1980-12-29 1982-07-08 Iwao Jun Ichi Heterocyclic 5-membered ring compounds

Also Published As

Publication number Publication date
JPS6141357B2 (en) 1986-09-13

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