JPS56125325A - Preparation of omega-hydroxy coenzyme q1 derivative - Google Patents

Preparation of omega-hydroxy coenzyme q1 derivative

Info

Publication number
JPS56125325A
JPS56125325A JP2799780A JP2799780A JPS56125325A JP S56125325 A JPS56125325 A JP S56125325A JP 2799780 A JP2799780 A JP 2799780A JP 2799780 A JP2799780 A JP 2799780A JP S56125325 A JPS56125325 A JP S56125325A
Authority
JP
Japan
Prior art keywords
formula
coenzyme
compound
hydroxy
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2799780A
Other languages
Japanese (ja)
Other versions
JPS631930B2 (en
Inventor
Kikumasa Sato
Seiichi Inoue
Michiya Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP2799780A priority Critical patent/JPS56125325A/en
Publication of JPS56125325A publication Critical patent/JPS56125325A/en
Publication of JPS631930B2 publication Critical patent/JPS631930B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain an ω-hydroxy coenzyme Q1 derivative useful as an intermediate for coenzymes Q industrially advantageously, by reacting a Grignard compound corresponding to the desired compound with 1,2-epoxy-2-methyl-3-butene.
CONSTITUTION: A compound shown by the formula I (X is halogen; Z is protecting group) is reacted with 1,2-epoxy-2-methyl-3-butene shown by the formula II under usual Grignard reaction conditions, to give an ω-hydroxy coenzyme Q1 derivative shown by the formula III useful as an intermediate for coenzymes Q having activities in organisms, especially coenzyme Q10. The compound shown by the formula I is obtained by treating a compound shown by the formula IV by a common Grignard reagent preparation, and the resulting compound is used directly as the raw material without isolating is from the reaction solution. The compound shown by the formula II can be synthesized from isoprene by a well-known method.
COPYRIGHT: (C)1981,JPO&Japio
JP2799780A 1980-03-07 1980-03-07 Preparation of omega-hydroxy coenzyme q1 derivative Granted JPS56125325A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2799780A JPS56125325A (en) 1980-03-07 1980-03-07 Preparation of omega-hydroxy coenzyme q1 derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2799780A JPS56125325A (en) 1980-03-07 1980-03-07 Preparation of omega-hydroxy coenzyme q1 derivative

Publications (2)

Publication Number Publication Date
JPS56125325A true JPS56125325A (en) 1981-10-01
JPS631930B2 JPS631930B2 (en) 1988-01-14

Family

ID=12236456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2799780A Granted JPS56125325A (en) 1980-03-07 1980-03-07 Preparation of omega-hydroxy coenzyme q1 derivative

Country Status (1)

Country Link
JP (1) JPS56125325A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008837A1 (en) * 1996-08-28 1998-03-05 Farmacon, Inc. Phenylbutanol derivatives, methods for their preparation and pharmaceutical compositions thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008837A1 (en) * 1996-08-28 1998-03-05 Farmacon, Inc. Phenylbutanol derivatives, methods for their preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
JPS631930B2 (en) 1988-01-14

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