LU82236A1 - 9-aminoalkylfluorenes, leur preparation et leur utilisation therapeutique - Google Patents

9-aminoalkylfluorenes, leur preparation et leur utilisation therapeutique Download PDF

Info

Publication number
LU82236A1
LU82236A1 LU82236A LU82236A LU82236A1 LU 82236 A1 LU82236 A1 LU 82236A1 LU 82236 A LU82236 A LU 82236A LU 82236 A LU82236 A LU 82236A LU 82236 A1 LU82236 A1 LU 82236A1
Authority
LU
Luxembourg
Prior art keywords
formula
compound
group
alkyl
isopropylaminopropyl
Prior art date
Application number
LU82236A
Other languages
English (en)
French (fr)
Inventor
William Bryant Lacefield
Richard Lee Simon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LU82236A1 publication Critical patent/LU82236A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/10—Impermeable to liquids, e.g. waterproof; Liquid-repellent
    • A41D31/102—Waterproof and breathable
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/18—Elastic
    • A41D31/185—Elastic using layered materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Textile Engineering (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU82236A 1979-03-12 1980-03-10 9-aminoalkylfluorenes, leur preparation et leur utilisation therapeutique LU82236A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1953379A 1979-03-12 1979-03-12
US1953379 1979-03-12

Publications (1)

Publication Number Publication Date
LU82236A1 true LU82236A1 (fr) 1980-06-06

Family

ID=21793707

Family Applications (1)

Application Number Title Priority Date Filing Date
LU82236A LU82236A1 (fr) 1979-03-12 1980-03-10 9-aminoalkylfluorenes, leur preparation et leur utilisation therapeutique

Country Status (40)

Country Link
US (1) US4277495A (da)
EP (1) EP0018076B1 (da)
JP (1) JPS55124743A (da)
KR (2) KR840000279B1 (da)
AR (6) AR228851A1 (da)
AT (4) AT370407B (da)
AU (1) AU527992B2 (da)
BE (1) BE882166A (da)
CA (1) CA1136624A (da)
CH (1) CH643234A5 (da)
CS (4) CS214696B2 (da)
CY (1) CY1345A (da)
DD (1) DD149511A5 (da)
DE (1) DE3064872D1 (da)
DK (1) DK158658C (da)
EG (1) EG14592A (da)
ES (5) ES489470A0 (da)
FI (3) FI67211C (da)
FR (2) FR2460287A1 (da)
GB (1) GB2046257B (da)
GR (1) GR68035B (da)
GT (1) GT198062477A (da)
HK (1) HK101086A (da)
HU (1) HU179837B (da)
IE (1) IE49553B1 (da)
IL (1) IL59558A (da)
IT (1) IT1140772B (da)
LU (1) LU82236A1 (da)
MA (1) MA18763A1 (da)
MY (1) MY8700080A (da)
NZ (1) NZ193078A (da)
OA (1) OA06486A (da)
PH (1) PH15594A (da)
PL (1) PL122643B1 (da)
PT (1) PT70927A (da)
RO (2) RO79822A (da)
SG (1) SG72286G (da)
SU (2) SU1022656A3 (da)
YU (1) YU65680A (da)
ZA (1) ZA801422B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212337A (en) * 1978-03-31 1980-07-15 Union Carbide Corporation Closure fastening device
US4452745A (en) * 1981-02-06 1984-06-05 Eli Lilly And Company 9-Aminoalkylfluorenes
US4484352A (en) * 1983-02-07 1984-11-20 Katzin Lawrence F Reclosable plastic bag
US4552982A (en) * 1983-08-01 1985-11-12 Eli Lilly And Company Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes
US4508735A (en) * 1983-09-21 1985-04-02 Eli Lilly And Company Anti-arrhythmic N-alkanoylaminoalkyl fluorenes
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
US4486592A (en) * 1983-10-19 1984-12-04 Eli Lilly And Company 9-Carbamoylfluorene derivatives
FI844067L (fi) * 1983-10-19 1985-04-20 Lilly Co Eli Foerfarande foer framstaellning av 9-karbamoylfluorenderivat.
DE3444837A1 (de) * 1984-12-08 1986-06-12 Basf Ag, 6700 Ludwigshafen 10,11-dihydro-5h-dibenzo(a,d)cycloheptadien- derivate, ihre herstellung und verwendung
GB9304189D0 (en) * 1993-03-02 1993-04-21 Sturmey Archer Ltd Epicyclic change speed gear hubs
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5631203A (en) * 1995-05-04 1997-05-20 Phillips Petroleum Company Metallocene compounds and preparation thereof containing terminal alkynes
AU716729B2 (en) * 1996-01-16 2000-03-02 Bristol-Myers Squibb Company Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB736372A (en) * 1953-05-06 1955-09-07 Miles Lab Fluorene derivatives
GB960758A (en) 1962-12-21 1964-06-17 Boehringer & Soehne Gmbh Basic fluorene derivatives
FR1345419A (fr) * 1962-12-21 1963-12-06 Boehringer & Soehne Gmbh Procédé pour la préparation de dérivés basiques du fluorène et des sels de ces dérivés
DE1203253B (de) * 1963-02-09 1965-10-21 Boehringer & Soehne Gmbh Verfahren zur Herstellung basischer Fluorenderivate und ihrer Salze
FR1482727A (fr) * 1965-06-10 1967-05-26 Upjohn Co 9-(2-amino-1-méthyléthyl) fluoren-9-ols et leur procédé de fabrication
GB1211459A (en) * 1967-05-10 1970-11-04 Abbott Lab Hydroxy amines
US3660485A (en) * 1970-10-05 1972-05-02 Searle & Co Fluorene-9-carboxylic acid hydrazides
US3843657A (en) * 1972-12-08 1974-10-22 Searle & Co 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides

Also Published As

Publication number Publication date
ES8201945A1 (es) 1982-01-01
ES497301A0 (es) 1982-01-01
MA18763A1 (fr) 1980-10-01
SU1022656A3 (ru) 1983-06-07
DE3064872D1 (en) 1983-10-27
ATA114081A (de) 1982-01-15
FI840920A0 (fi) 1984-03-07
AU527992B2 (en) 1983-03-31
ES497303A0 (es) 1982-01-01
IE800494L (en) 1980-09-12
EP0018076A1 (en) 1980-10-29
CS214696B2 (en) 1982-05-28
HU179837B (en) 1982-12-28
DK158658C (da) 1990-12-31
FI69299B (fi) 1985-09-30
EG14592A (en) 1985-03-31
MY8700080A (en) 1987-12-31
CS214700B2 (en) 1982-05-28
ATA134480A (de) 1982-08-15
GB2046257B (en) 1983-10-19
EP0018076B1 (en) 1983-09-21
ES8201947A1 (es) 1982-01-01
PH15594A (en) 1983-02-28
AT370407B (de) 1983-03-25
FR2457278A1 (fr) 1980-12-19
AR225526A1 (es) 1982-03-31
GB2046257A (en) 1980-11-12
JPS55124743A (en) 1980-09-26
ES497300A0 (es) 1982-01-01
PT70927A (en) 1980-04-01
DK103380A (da) 1980-09-13
FI67211C (fi) 1985-02-11
BE882166A (fr) 1980-09-11
NZ193078A (en) 1981-11-19
GR68035B (da) 1981-10-27
ATA113981A (de) 1982-01-15
ATA114181A (de) 1982-01-15
US4277495A (en) 1981-07-07
FI69299C (fi) 1986-01-10
FI70006C (fi) 1986-09-12
AT368130B (de) 1982-09-10
ES8104186A1 (es) 1981-04-16
KR840001836B1 (ko) 1984-10-22
JPS6314702B2 (da) 1988-04-01
FI70006B (fi) 1986-01-31
FI840921A (fi) 1984-03-07
ES489470A0 (es) 1981-04-16
AR228851A1 (es) 1983-04-29
FI840921A0 (fi) 1984-03-07
PL222600A1 (da) 1980-12-15
AT368131B (de) 1982-09-10
RO79822A (ro) 1983-02-01
KR840000279B1 (ko) 1984-03-13
IT1140772B (it) 1986-10-10
ES8201943A1 (es) 1982-01-01
AR228059A1 (es) 1983-01-14
FI840920A (fi) 1984-03-07
CH643234A5 (fr) 1984-05-30
IT8020502A0 (it) 1980-03-11
HK101086A (en) 1987-01-02
RO85074A (ro) 1984-08-17
FI67211B (fi) 1984-10-31
PL122643B1 (en) 1982-08-31
IE49553B1 (en) 1985-10-30
ES497302A0 (es) 1982-01-01
YU65680A (en) 1983-02-28
ZA801422B (en) 1981-10-28
FI800735A (fi) 1980-09-13
SG72286G (en) 1987-03-27
DD149511A5 (de) 1981-07-15
SU1015820A3 (ru) 1983-04-30
GT198062477A (es) 1981-09-02
CS214698B2 (en) 1982-05-28
AR230983A1 (es) 1984-08-31
AT368125B (de) 1982-09-10
OA06486A (fr) 1981-07-31
CA1136624A (en) 1982-11-30
FR2460287A1 (fr) 1981-01-23
AU5630180A (en) 1980-09-18
CS214699B2 (en) 1982-05-28
ES8201946A1 (es) 1982-01-01
FR2457278B1 (da) 1984-06-29
CY1345A (en) 1987-01-16
AR229402A1 (es) 1983-08-15
AR227318A1 (es) 1982-10-15
DK158658B (da) 1990-07-02
FR2460287B1 (da) 1983-03-11
IL59558A0 (en) 1980-06-30
IL59558A (en) 1984-05-31
KR830001860A (ko) 1983-05-19

Similar Documents

Publication Publication Date Title
LU82387A1 (fr) Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters
LU82236A1 (fr) 9-aminoalkylfluorenes, leur preparation et leur utilisation therapeutique
EP0745586A1 (fr) Nouveaux aryl(alkyl) propylamides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0506532A1 (fr) Nouveaux dérivés de l'indole, procédé de préparation et médicaments les contenant
EP0125195B1 (fr) Nouveaux acides flavonecarboxyliques-4', leur méthode de préparation et leur application thérapeutique
EP0062596B1 (fr) Nouveaux dérivés d'aminoéthoxy-4 isopropyl-5 méthyl-2 phénol, leur méthode de préparation et leur emploi en tant que médicaments
EP0077427B1 (fr) Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique
EP0063084B1 (fr) Dérivés de phénéthanolamine, leur préparation et leur application en thérapeutique
EP0745584A1 (fr) Composés arylalkyl(thio) carboxamides ayant une affinité pour des récepteurs mélatoninergiques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
US4658061A (en) 9-aminoalkylfluorenes
EP0138714B1 (fr) Dérivés de 1-(acétylaminophényl)-2-amino-propanone, leur utilisation en thérapeutique et leur procédé de préparation
CH622795A5 (da)
EP0201400A1 (fr) Dérivés du 4-phénylpropyl indole et leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
EP0002401B1 (fr) Dérivés de naphtalène, leur préparation et leur application en thérapeutique
FR652M (fr) Nouveau médicament, contenant comme composé actif un dérivé de l’indole ou un de ses sels.
CH658786A5 (fr) Medicaments qui contiennent d'alpha-(n-pyrrolyl)-acides ou de leurs sels ou esters.
EP0275762B1 (fr) Dérivés de l'indole carboxamide ainsi que leurs sels, procédé et intermédiaires de préparation, application à titre de médicaments de ces dérivés et compositions les renfermant
EP0709371B1 (fr) O-arylméthyl N-(thio)acyl hydroxylamines comme ligands des récepteurs de la mélatonine, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
LU82237A1 (fr) (1,1-biphenyl-2-yl)-propyl- et butylamines, leur preparatin et leur utilisation therapeutique
CH620678A5 (en) Process for the preparation of a derivative of piperidine
BE897281A (fr) Le 2 (hexahydroazepine)-n-(2,6-dimethylphenyle)-acetamide son derive chlorhydrate, procede pour leur obtention et compositions pharmaceutique les contenant
CH618970A5 (en) Process for the preparation of 4-amido-trans-decahydroquinoline derivatives
BE822193A (fr) Nouveaux composes aromatiques amines
FR2610931A1 (fr) Application a titre de medicaments de derives de la dihydroquinidine, nouveaux derives et procede de preparation
FR2503142A1 (en) N-Substd. 4-aminoethoxy-2-methyl-5-isopropyl-phenol derivs. - useful as alpha blockers and platelet aggregation inhibitors