NZ508392A - Multiparticulate delayed release pharmaceutical form comprising at least two independent polymers with different permeability rates - Google Patents

Multiparticulate delayed release pharmaceutical form comprising at least two independent polymers with different permeability rates

Info

Publication number
NZ508392A
NZ508392A NZ508392A NZ50839299A NZ508392A NZ 508392 A NZ508392 A NZ 508392A NZ 508392 A NZ508392 A NZ 508392A NZ 50839299 A NZ50839299 A NZ 50839299A NZ 508392 A NZ508392 A NZ 508392A
Authority
NZ
New Zealand
Prior art keywords
coating
polymer
active material
composition
multiparticulate
Prior art date
Application number
NZ508392A
Inventor
Edouard Gendrot
Gerard Cousin
Francoise Ragot
Marie-Christine Clee-Bouvet
Original Assignee
Prographarm Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prographarm Lab filed Critical Prographarm Lab
Publication of NZ508392A publication Critical patent/NZ508392A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described is a delayed and timed release multiparticulate pharmaceutical composition which liberates the active material after 4-8 hours, gives controlled release of all active material over the next 8-20 hours, and is free from organic acids. The composition is in the form of spheroids having a neutral spherical support with a first coating in which particles of the active material are uniformly distributed, and a second coating. The first coating comprises a water soluble polymer and a water-insoluble polymer. The second coating comprises two pH independent polymers having different degrees of permeability with respect to gastric and intestinal environments, and optionally a pH dependent polymer, a plasticizer, and a filler uniformly distributed in the coating. In the first coating, the weight ratio of water soluble to water insoluble polymers is preferably 0.1-0.9, preferably 0.45-0.55. In the second coating the weight ratio of less permeable polymer to more permeable is 97/3 to 80/20. Suitable fillers include talc, colloidal silica, magnesium stearate and/or glyceryl monostearate. Also described is a method for the preparation of the composition.
NZ508392A 1998-05-20 1999-05-20 Multiparticulate delayed release pharmaceutical form comprising at least two independent polymers with different permeability rates NZ508392A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9806384A FR2778848B1 (en) 1998-05-20 1998-05-20 MULTIPARTICULATE PHARMACEUTICAL FORMULA WITH PULSED RELEASE AND ITS PREPARATION METHOD
PCT/FR1999/001201 WO1999059557A1 (en) 1998-05-20 1999-05-20 Multiparticulate pharmaceutical form with programmed and timed release and preparation method

Publications (1)

Publication Number Publication Date
NZ508392A true NZ508392A (en) 2002-09-27

Family

ID=9526556

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ508392A NZ508392A (en) 1998-05-20 1999-05-20 Multiparticulate delayed release pharmaceutical form comprising at least two independent polymers with different permeability rates

Country Status (25)

Country Link
EP (1) EP1077687B1 (en)
JP (1) JP2002515423A (en)
KR (1) KR100583065B1 (en)
CN (1) CN1186014C (en)
AT (1) ATE214598T1 (en)
AU (1) AU758299B2 (en)
BG (1) BG64764B1 (en)
BR (1) BR9910606A (en)
CA (1) CA2333188C (en)
DE (1) DE69901062T2 (en)
DK (1) DK1077687T3 (en)
ES (1) ES2173739T3 (en)
FR (1) FR2778848B1 (en)
GE (1) GEP20022750B (en)
HK (1) HK1033271A1 (en)
HU (1) HU224193B1 (en)
IL (1) IL139774A (en)
MX (1) MXPA00011364A (en)
NO (1) NO330501B1 (en)
NZ (1) NZ508392A (en)
PL (1) PL192950B1 (en)
PT (1) PT1077687E (en)
TR (1) TR200100107T2 (en)
WO (1) WO1999059557A1 (en)
ZA (1) ZA200006768B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
EP2417969A1 (en) 2004-10-21 2012-02-15 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
AU2013273835B2 (en) * 2005-05-02 2016-07-07 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
WO2008136016A1 (en) * 2007-05-08 2008-11-13 Medreich Limited A stable controlled release oral solid dosage form composition and a process thereof
TWI471146B (en) 2009-12-02 2015-02-01 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
FR2999432B1 (en) 2012-12-17 2014-12-12 Ethypharm Sa ORODISPERSIBLE COMPRESSES OBTAINED BY COMPRESSION MOLDING

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2558396B2 (en) * 1990-06-28 1996-11-27 田辺製薬株式会社 Controlled release formulation
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
FR2754710B1 (en) * 1996-10-22 1998-12-31 Prographarm Lab PROCESS FOR THE PREPARATION OF A MULTIPARTICULAR PHARMACEUTICAL FORM WITH CONTROLLED RELEASE PLURISEQUENTIELLE

Also Published As

Publication number Publication date
PL344314A1 (en) 2001-10-22
HU224193B1 (en) 2005-06-28
GEP20022750B (en) 2002-08-26
NO330501B1 (en) 2011-05-02
AU758299B2 (en) 2003-03-20
CN1186014C (en) 2005-01-26
IL139774A0 (en) 2002-02-10
BG104963A (en) 2001-07-31
ATE214598T1 (en) 2002-04-15
KR100583065B1 (en) 2006-06-08
DE69901062T2 (en) 2002-10-31
DE69901062D1 (en) 2002-04-25
HUP0102027A3 (en) 2002-12-28
JP2002515423A (en) 2002-05-28
NO20005838D0 (en) 2000-11-17
FR2778848B1 (en) 2001-11-23
HUP0102027A2 (en) 2002-03-28
TR200100107T2 (en) 2001-06-21
PT1077687E (en) 2002-09-30
CA2333188A1 (en) 1999-11-25
WO1999059557A1 (en) 1999-11-25
IL139774A (en) 2005-09-25
AU3830299A (en) 1999-12-06
ZA200006768B (en) 2001-11-20
EP1077687B1 (en) 2002-03-20
PL192950B1 (en) 2006-12-29
ES2173739T3 (en) 2002-10-16
CA2333188C (en) 2010-07-06
KR20010052370A (en) 2001-06-25
MXPA00011364A (en) 2008-09-09
HK1033271A1 (en) 2001-08-24
FR2778848A1 (en) 1999-11-26
NO20005838L (en) 2001-01-10
BG64764B1 (en) 2006-03-31
EP1077687A1 (en) 2001-02-28
BR9910606A (en) 2001-10-02
CN1305371A (en) 2001-07-25
DK1077687T3 (en) 2002-06-17

Similar Documents

Publication Publication Date Title
NZ508392A (en) Multiparticulate delayed release pharmaceutical form comprising at least two independent polymers with different permeability rates
Milojevic et al. Amylose as a coating for drug delivery to the colon: Preparation and in vitro evaluation using 5-aminosalicylic acid pellets
AU2256495A (en) Sustained-release matrix pellets and method for preparing them
WO2004022031A3 (en) Stable probiotic microsphere compositions and their methods of preparation
CA2332922A1 (en) Enteric coated pharmaceutical composition and method of manufacturing
JP2001522876A (en) Low temperature coating
CA2500390A1 (en) Compositions having an inner core and at least two surrounding layers
CA2191178A1 (en) Long-lasting release nifedipine preparation
AU1010500A (en) Controlled Release Tramadol Preparations Having a Storage- stable Release Profile and Process for the Production Thereof
GB1593062A (en) Coatings
CA2121038A1 (en) Oral preparation for release in lower digestive tracts
KR900011451A (en) New Pharmaceutical Formulations
WO2000020017A3 (en) Controlled-release garlic formulations
WO2005077420A1 (en) Composition for oral administration of tamsulosin hydrochloride and controlled release granule formulation comprising same
DK1417960T3 (en) Sustained-release micropellets and methods for making them
EP1095651A3 (en) Multipor food protection
NZ601969A (en) Taste-masked multiparticulate pharmaceutical compositions comprising a drug-containing core particle and a solvent-coacervated membrane
CA2651696A1 (en) Modified release tablets comprising tramadol
KR970032869A (en) Sustained-release pellet formulation of diltiazem
CA2298951A1 (en) System and method for producing a pigmented cement composition

Legal Events

Date Code Title Description
PSEA Patent sealed
ASS Change of ownership

Owner name: ETHYPHARM, FR

Free format text: OLD OWNER(S): LABORATOIRES PROGRAPHARM

RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
EXPY Patent expired