PE45195A1 - Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene - Google Patents

Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene

Info

Publication number
PE45195A1
PE45195A1 PE1995262061A PE26206195A PE45195A1 PE 45195 A1 PE45195 A1 PE 45195A1 PE 1995262061 A PE1995262061 A PE 1995262061A PE 26206195 A PE26206195 A PE 26206195A PE 45195 A1 PE45195 A1 PE 45195A1
Authority
PE
Peru
Prior art keywords
preparation
amino acid
derivative
procedure
pharmaceutical composition
Prior art date
Application number
PE1995262061A
Other languages
English (en)
Inventor
Gerd Schnorrenberg
Frank Esser
Georg Speck
Horst Dollinger
Birgit Jung
Erich Burger
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944406885 external-priority patent/DE4406885A1/de
Priority claimed from DE4406884A external-priority patent/DE4406884A1/de
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of PE45195A1 publication Critical patent/PE45195A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I: R1-CO-A-R2, DONDE: 1) R1 ES VINILO, ARILO, HETEROARILO, ARALQUILO, HETEROARALALQUILO, ARILVINILO, HETEROARILVINILO, ARILOXIALQUILO, ARILALQUILOXI, CICLOALQUILO C3-C8, Y OTROS; DE PREFERENCIA INDOLILO OPCIONALMENTE SUSTITUIDO POR UN METILO A NIVEL DEL ATOMO DE NITROGENO; 2) A ES ALANINA, VALINA, LEUCINA, ISOLEUCINA, SERINA, TREONINA, ALOTREONINA, CISTEINA, METIONINA, FENILALANINA, TRIPTOFANO, TIROSINA, PROLINA Y OTROS; DE PREFERENCIA ES PROLINA o 4-HIDROXIPROLINA; 3) R2 REPRESENTA UNA AMINA DE FORMULA II DONDE: A) G ES FLUOR, CLORO, BROMO, ETILO; B) m VARIA DE 1 A 5; C) Y y Z SON HIDROGENO, ALQUILO C1-C5, ALCOXI C1-C5, BENCILOXI, Y OTROS; DE PREFERENCIA METOXI, HIDROGENO o SIGNIFICAN EN COMUN -OCH2O- o Y ES HIDROGENO Y Z ES CLORO; EL CUAL ES ANTAGONISTA DE NEUROQUININA, UNIENDOSE AL RECEPTOR NK1 PARA LA SUSTANCIA P (TAQUIQUININA), Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS, ENFERMEDADES INFLAMATORIAS Y PARA EL TRATAMIENTO DE ESTADOS DOLOROSOS COMO JAQUECA o MIGRANA
PE1995262061A 1994-03-03 1995-02-16 Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene PE45195A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19944406885 DE4406885A1 (de) 1994-03-03 1994-03-03 Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4406884A DE4406884A1 (de) 1994-03-03 1994-03-03 Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
PE45195A1 true PE45195A1 (es) 1996-01-17

Family

ID=25934302

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995262061A PE45195A1 (es) 1994-03-03 1995-02-16 Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene

Country Status (18)

Country Link
US (1) US5712397A (es)
EP (1) EP0802922B1 (es)
JP (1) JP2801087B2 (es)
KR (1) KR970701727A (es)
CN (1) CN1142228A (es)
AT (1) ATE206135T1 (es)
AU (1) AU1812795A (es)
CA (1) CA2182396A1 (es)
CZ (1) CZ254296A3 (es)
DE (1) DE59509647D1 (es)
FI (1) FI963440A0 (es)
HU (1) HUT75527A (es)
MX (1) MX9603272A (es)
NO (1) NO963655L (es)
NZ (1) NZ281240A (es)
PE (1) PE45195A1 (es)
PL (1) PL316114A1 (es)
WO (1) WO1995023810A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
US6635632B1 (en) * 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
ATE279407T1 (de) * 1998-08-07 2004-10-15 Applied Research Systems Fsh mimetika zur behandlung von infertilität
HUP0401154A2 (hu) * 2001-07-20 2004-10-28 Pfizer Products Inc. NK-1 receptor antagonisták használata kutyák, macskák és lovak nemkívánatos viselkedésének módosítására
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
CA2110514A1 (en) * 1991-07-05 1993-01-21 Raymond Baker Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
NZ255380A (en) * 1992-09-03 1997-06-24 Boehringer Ingelheim Int Amino acid derivatives having neurokinin (tachykinin) antagonistic properties, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CZ254296A3 (en) 1997-06-11
ATE206135T1 (de) 2001-10-15
EP0802922B1 (de) 2001-09-26
US5712397A (en) 1998-01-27
NZ281240A (en) 1997-09-22
CN1142228A (zh) 1997-02-05
DE59509647D1 (de) 2001-10-31
EP0802922A1 (de) 1997-10-29
HU9602402D0 (en) 1996-10-28
NO963655D0 (no) 1996-09-02
HUT75527A (en) 1997-05-28
JPH09505317A (ja) 1997-05-27
WO1995023810A1 (de) 1995-09-08
PL316114A1 (en) 1996-12-23
NO963655L (no) 1996-11-01
FI963440A (fi) 1996-09-03
JP2801087B2 (ja) 1998-09-21
CA2182396A1 (en) 1995-09-08
AU1812795A (en) 1995-09-18
FI963440A0 (fi) 1996-09-03
KR970701727A (ko) 1997-04-12
MX9603272A (es) 1997-03-29

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed