PT2268646E - Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase - Google Patents

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase Download PDF

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Publication number
PT2268646E
PT2268646E PT97295968T PT09729596T PT2268646E PT 2268646 E PT2268646 E PT 2268646E PT 97295968 T PT97295968 T PT 97295968T PT 09729596 T PT09729596 T PT 09729596T PT 2268646 E PT2268646 E PT 2268646E
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Prior art keywords
yloxy
phenyl
thiazolopyrazin
thiazolopyridin
modulators
Prior art date
Application number
PT97295968T
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Portuguese (pt)
Inventor
Cheryl A Grice
Xiaohu Deng
Jimmy T Liang
Neelakandha S Mani
Genesis M Bacani
Diego Broggini
Eugene Y Cheung
Christa C Chrovian
Anne M Fourine
Laurent Gomez
Aaron M Kearney
Adrienne M Landry-Bayle
Alice Lee-Dutra
Susanne Lochner
Virginia M Tanis
Alvah T Wickboldt
Hartmut Zinser
Alejandro Santillan
Kathleen C Sappey
Kia Sepassi
John J M Wiener
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT2268646E publication Critical patent/PT2268646E/en

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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

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  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Neurology (AREA)
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  • Hematology (AREA)
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  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
PT97295968T 2008-04-11 2009-04-09 Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase PT2268646E (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4434908P 2008-04-11 2008-04-11
US14912909P 2009-02-02 2009-02-02

Publications (1)

Publication Number Publication Date
PT2268646E true PT2268646E (en) 2013-12-10

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PT97295968T PT2268646E (en) 2008-04-11 2009-04-09 Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
PT111592366T PT2336125E (en) 2008-04-11 2009-04-09 Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase

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US (3) US7939527B2 (en)
EP (2) EP2336125B1 (en)
JP (2) JP5530423B2 (en)
KR (1) KR101228378B1 (en)
CN (1) CN102056933B (en)
AR (1) AR072353A1 (en)
AU (1) AU2009234140B2 (en)
BR (1) BRPI0911336A2 (en)
CA (1) CA2721099C (en)
CL (1) CL2009000877A1 (en)
CO (1) CO6260069A2 (en)
CY (1) CY1114628T1 (en)
DK (2) DK2268646T3 (en)
EA (1) EA018802B1 (en)
EC (1) ECSP10010558A (en)
ES (2) ES2440746T3 (en)
HK (2) HK1152041A1 (en)
HN (1) HN2010002074A (en)
HR (2) HRP20130278T1 (en)
IL (2) IL208480A (en)
JO (1) JO2911B1 (en)
MX (1) MX2010011154A (en)
MY (1) MY157597A (en)
NI (1) NI201000168A (en)
NZ (2) NZ588341A (en)
PE (1) PE20091779A1 (en)
PH (1) PH12013500094A1 (en)
PL (2) PL2268646T3 (en)
PT (2) PT2268646E (en)
RS (2) RS52712B (en)
SI (2) SI2268646T1 (en)
SV (1) SV2010003694A (en)
TW (2) TW201420100A (en)
UY (1) UY31760A (en)
WO (1) WO2009126806A2 (en)
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