SE8702654D0 - A PROCESS FOR PREPARING A MERCAPTOACYLPROLINE - Google Patents

A PROCESS FOR PREPARING A MERCAPTOACYLPROLINE

Info

Publication number
SE8702654D0
SE8702654D0 SE8702654A SE8702654A SE8702654D0 SE 8702654 D0 SE8702654 D0 SE 8702654D0 SE 8702654 A SE8702654 A SE 8702654A SE 8702654 A SE8702654 A SE 8702654A SE 8702654 D0 SE8702654 D0 SE 8702654D0
Authority
SE
Sweden
Prior art keywords
formula
salts
acid addition
resulting
addition salts
Prior art date
Application number
SE8702654A
Other languages
Swedish (sv)
Other versions
SE8702654L (en
SE462751B (en
Inventor
J Fischer
T Fodor
L Dobay
B Stefko
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE8702654D0 publication Critical patent/SE8702654D0/en
Publication of SE8702654L publication Critical patent/SE8702654L/en
Publication of SE462751B publication Critical patent/SE462751B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to a process for the preparation of 1-[3'-{mercapto}-(2'S)-{methyl}-propionyl]-pyrrolidine-(2S)-carboxylic acid of the formula <IMAGE> or its salts by reacting compounds of the general formula <IMAGE> in which X stands for a halogen atom, or their salts with thiourea and subsequent hydrolysis, in which the reaction of the compounds of the general formula III or their salts with the thiourea is carried out in organic dipolar aprotic solvents and the resulting isothiuronium compound of the formula <IMAGE> if appropriate in the form of its internal salt, or resulting acid addition salts thereof with hydrohalic acids, are hydrolysed, if appropriate after their isolation, and the resulting compound of the formula I is optionally converted in a manner known per se into acid addition salts and/or the resulting acid addition salts of the compound of the formula I are converted into the free 1-[3'-{mercapto}-(2'S)-{methyl}-propionyl]-pyrrolidine-(2S)-carboxylic acid of the formula I and/or into other acid addition salts.
SE8702654A 1986-06-27 1987-06-26 SET FOR MANUFACTURE OF A BRAND CAPACYL PROLINE SE462751B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862689A HU196959B (en) 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives

Publications (3)

Publication Number Publication Date
SE8702654D0 true SE8702654D0 (en) 1987-06-26
SE8702654L SE8702654L (en) 1987-12-28
SE462751B SE462751B (en) 1990-08-27

Family

ID=10960651

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8702654A SE462751B (en) 1986-06-27 1987-06-26 SET FOR MANUFACTURE OF A BRAND CAPACYL PROLINE

Country Status (21)

Country Link
JP (1) JPS6327475A (en)
KR (1) KR900007217B1 (en)
CN (1) CN87104388A (en)
AR (1) AR243159A1 (en)
AT (2) AT395012B (en)
CH (1) CH673279A5 (en)
CS (1) CS276394B6 (en)
DD (1) DD263757A5 (en)
DE (1) DE3721430A1 (en)
DK (1) DK329787A (en)
ES (1) ES2004451A6 (en)
FI (1) FI87770C (en)
GR (1) GR871012B (en)
HU (1) HU196959B (en)
IT (1) IT1206792B (en)
NO (1) NO168941C (en)
PL (1) PL153449B1 (en)
PT (1) PT85190B (en)
SE (1) SE462751B (en)
SU (1) SU1650007A3 (en)
YU (1) YU46319B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE421551B (en) * 1980-03-26 1982-01-04 Sandvik Ab DRILLING TOOL FOR ROTATION AND / OR DRILLING
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
JPS62125081A (en) * 1985-11-21 1987-06-06 キングプリンテイング株式会社 Printing method
ATE222758T1 (en) * 1996-09-26 2002-09-15 Meditor Pharmaceuticals Ltd PHARMACEUTICAL COMPOSITIONS CONTAINING S-ALKYLISOTHIOURONIUM DERIVATIVES
CN103086939A (en) * 2011-10-28 2013-05-08 华中药业股份有限公司 Recrystallization method of 1-(3-bromo-2-D-methyl propionyl)pyrrolidine-2-carboxylic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
IE54551B1 (en) * 1982-01-22 1989-11-22 Ici Plc Amide derivatives
KR860001391B1 (en) * 1984-07-23 1986-09-22 보령제약 주식회사 Method for preparing pyrrolidine derivative

Also Published As

Publication number Publication date
CS479487A3 (en) 1992-01-15
IT1206792B (en) 1989-05-03
CS276394B6 (en) 1992-05-13
YU46319B (en) 1993-05-28
KR900007217B1 (en) 1990-10-05
HUT44490A (en) 1988-03-28
NO872690L (en) 1987-12-28
SU1650007A3 (en) 1991-05-15
DK329787A (en) 1987-12-28
SE8702654L (en) 1987-12-28
ATA162087A (en) 1988-06-15
FI87770B (en) 1992-11-13
FI872859A (en) 1987-12-28
CN87104388A (en) 1988-03-02
NO168941B (en) 1992-01-13
AT387381B (en) 1989-01-10
DE3721430A1 (en) 1988-01-28
GR871012B (en) 1987-11-02
IT8721085A0 (en) 1987-06-26
FI872859A0 (en) 1987-06-26
ES2004451A6 (en) 1989-01-01
FI87770C (en) 1993-02-25
AT395012B (en) 1992-08-25
DK329787D0 (en) 1987-06-26
PL266478A1 (en) 1988-06-09
PL153449B1 (en) 1991-04-30
PT85190B (en) 1990-03-30
NO168941C (en) 1992-04-29
PT85190A (en) 1987-07-01
KR880000392A (en) 1988-03-25
SE462751B (en) 1990-08-27
DD263757A5 (en) 1989-01-11
CH673279A5 (en) 1990-02-28
AR243159A1 (en) 1993-07-30
YU118187A (en) 1988-04-30
HU196959B (en) 1989-02-28
ATA91186A (en) 1992-01-15
NO872690D0 (en) 1987-06-26
JPS6327475A (en) 1988-02-05

Similar Documents

Publication Publication Date Title
DE69330853D1 (en) Process for the preparation of aryl-piperazinyl-heterocyclic derivatives
DE69126350D1 (en) Process for the preparation of chlorothiazole derivatives
ATE27273T1 (en) PROCESSES FOR THE PREPARATION OF OPTICALLY ACTIVE CARBAZOLE DERIVATIVES, NOVEL R- AND S-CARBAZOLE DERIVATIVES, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS.
MX9427A (en) SUBSTITUTED ALCANDIFOSFONICOS ACIDS AND PROCEDURE FOR ITS PREPARATION
PT69823A (en) 2- (2-ALKOXYETHYL) -2&#39;-HYDROXY-6,7-BENZOMORPHANES OF THE ACIDIC ACID SALT THEREOF AND THE METHOD FOR THE PRODUCTION THEREOF
DK154831C (en) PROCEDURE FOR THE PREPARATION OF 1-DESOXY-NOJIRIMYCINE DERIVATIVES OR SALTS THEREOF
ATE43344T1 (en) NEW 1-HYDROXY-1,1-DIPHOSPHONIC ACID COMPOUNDS, REF. FOR THEIR PRODUCTION AND PHARMACOLOGICAL PREPARATIONS, ESPECIALLY. FOR TREATMENT OF BONE TUMORS.
HUT34166A (en) Process for producing of imidazol-ethanol esthers
DE3861173D1 (en) HYDROXYALKYL-AZOLYL DERIVATIVES.
SE8702654D0 (en) A PROCESS FOR PREPARING A MERCAPTOACYLPROLINE
KR880701231A (en) N- (2-substituted alkyl) -N &#39;-((imidazol-4-yl) alkyl) guanidine
ATE74598T1 (en) OPTICALLY ACTIVE SALTS OF A SUBSTITUTED THIAZOLIDINE-4-CARBOXYLATE AND 3-CHLORO-2HYDROXYPROPYLTRIMETHYLAMMONIUM, THEIR PREPARATION AND USE.
SU649318A3 (en) Method of obtaining thiazolines or salts thereof
DE3885115D1 (en) Process for the preparation of thiols.
ATE101391T1 (en) PROCESS FOR THE PREPARATION OF CYCLOPROPANECARBONIC ACID DERIVATIVES SUBSTITUTED IN POSITION 3 BY A HALOGENATED SATURATED CHAIN.
ES532098A0 (en) A PROCEDURE FOR PREPARING SUBSTITUTED DERIVATIVES IN POSITION 1 OF AZETIDIN-3-OL
ES500980A0 (en) PROCEDURE FOR PREPARING ALCOXI PROPANOLAMINES
DE3278160D1 (en) Process for the preparation of b-û(2-methylpropoxy)-methyl¨-n-phenyl-n-(phenylmethyl)-1-pyrrolidineethanamine
ATE10844T1 (en) QUINOLINECARBONIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND BACTERICIDES CONTAINING IT.
SE8205563D0 (en) PROCESS FOR THE PREPARATION OF VINCAMINIC ACID ESTERS
GB2001062A (en) Preparation of Pyridinecarboxylic acid piperazides
ATE9152T1 (en) PROCESS FOR THE PREPARATION OF HYDRAZIDINS.
DE3469527D1 (en) Nortropine derivative, process for its preparation and its use
YU211180A (en) Process for preparing 2-(2-chloro-4-cyclopropyl-phenylimino)-imidazolidine
CS247588B1 (en) Method of 2-(2,6-dimethyl-phenylamino)-4h-5,6-dihydro-1,3-thiazine&#39;s hydrochloride&#39;s monohydrate production

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8702654-8

Effective date: 19950110

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8702654-8

Format of ref document f/p: F