US3789841A - Disposable guide wire - Google Patents

Disposable guide wire Download PDF

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US3789841A
US3789841A US00180810A US3789841DA US3789841A US 3789841 A US3789841 A US 3789841A US 00180810 A US00180810 A US 00180810A US 3789841D A US3789841D A US 3789841DA US 3789841 A US3789841 A US 3789841A
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guide wire
coil spring
core wire
wire
inner core
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US00180810A
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W Antoshkiw
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Becton Dickinson and Co
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Becton Dickinson and Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M25/09016—Guide wires with mandrils
    • A61M25/09033—Guide wires with mandrils with fixed mandrils, e.g. mandrils fixed to tip; Tensionable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09083—Basic structures of guide wires having a coil around a core

Definitions

  • catherization procedure is the percutaneous technique described in 1953 by Sven Ivar Seldinger.
  • an area of the skin is antiseptically prepared and a local anthestic is applied after which a nick is made in the skin over the site of a vessel to be catherized.
  • An arterial needle assembly, (inner needle, stylet) is then introduced into the vessel and its introduction is indicated by a back flow of blood to the inner needle.
  • the inner needle is then withdrawn and replaced with a guide wire which is then introduced through the cannula for a distance of approximately 6 to 10 inches.
  • External pressure is then applied to hold the guide wire in place while the cannula is withdrawn after which the guide wire is fed into the vessel to the selected area by fluoroscopy or some other similar technique. Considerable manipulation is required of the guide line to direct it to the desired area. Once the guide wire reaches the selected area, the catheter is passed over the guide wire to the selected area after which the guide wire is withdrawn from the catheter.
  • guide wires were formed of closely wound stainless steel forming a continuous coil spring having an inner bore which is sealed at the distal end with arounded cap or tip.
  • an inner core wire is placed within the coil bore, said wire terminating a short distance from the distal tip to provide flexibility at the distal tip and rigidity throughout the remainder of the wire.
  • the proximal portion having the core wire was too rigid while the distal tip was so flexible it was practically uncontrollable.
  • U. S. Pat. No. 3,528,406 taught the use of two core wires, one extending to the distal tip and the other terminating a distance therefrom.
  • Another embodiment taught by the previously mentioned patent included a heavy gauge core wire throughout the proximal portion, the heavy gauge wire being reduced to a uniform thinner diameter at the distal tip portion to provide greater flexibility.
  • All the devices heretofore provided had a coil spring extending throughout their entire length and were therefore subject to coil breakage or breakage of the core wire.
  • the coil spring and the core wire were not usually in contact and therefore did not provide mutual support for each other.
  • the coil spring did not provide for good torque transmission because the spring would tend to bend and turn rather than transmit torque from the proximal portion to the distal tip of the guide wire. This feature made manipulation more difficult and time consuming.
  • the coil spring also had many other disadvantages, one being the high friction presented between the coils of the spring and the inner surface of the vessel.
  • the spring coils tended to collect blood and were more difflcult to clean causing clot formation on the coils.
  • the spring also presented an electrical hazard during cardiovascular catheterization.
  • the present invention contemplates a flexible guide wire for use in vascular manipulations.
  • the guide wire is disposable and comprises a stainless steel core wire having a portion of uniform diameter and a tapered portion.
  • the uniform diameter portion is coated with a plastic jacket to form a proximal portion and the tapered portion is enclosed in a stainless steel coil spring to form a distal portion.
  • the spring is fixed at both ends to the inner core by soldering, the solder at the end forming a rounded distal tip.
  • the stainless steel spring closing the distal portion provides the required flexibility and resiliency while permitting introduction of the guide wire through a stainless steel cannula without the danger of skiving during introduction of the wire.
  • the danger of spring coil breakage is greatly reduced by reducing the spring length and by connecting it to the inner core at both ends.
  • the tapered core wire at the distal portion provides for uniform increase in flexibility between the proximal portion and the distal tip.
  • the use of the plastic jacket around the proximal portion of the center of core wire provides several advantages.
  • the use of the plastic jacket reduces the length of spring coil required and thereby greatly reduces the cost of the guide wire.
  • Stainless steel spring material is the most expensive component of the guide wire and elimination of substantial length of spring material greatly reduces the cost.
  • the plastic material provides a smooth low friction surface and thereby facilitates the movement of the guide wire through a vessel.
  • the plastic jacket is easier to clean than the spring coil and prevents clotting between the coils of the spring.
  • the plastic jacket is in direct contact with the inner core wire and therefore supports the wire and reduces the possibility of wire breakage while also providing for excellent torque transmission to the distal portion to facilitate manipulation of the guide wire.
  • Use of an insulated plastic jacket eliminates the electrical hazard which was present during cardiovascular catheterization when devices of the prior art were used.
  • the primary objective of the present invention is to provide a disposable guide wire that need not be cleaned and sterilized after each use.
  • Another objective of the present invention is to provide a guide wire having better manipulative characteristics than guide wires heretofore provided.
  • Another objective of the present invention is to provide a guide wire having a low coefficient of friction and good torque transmitting ability.
  • Another objective of the present invention is to provide a guide wire that prevents clot formation.
  • Another objective of the present invention is to provide a guide wire that is not prone to breakage.
  • FIG. 1 is a plan view of a flexible guide wire constructed in accordance with the present invention.
  • FIG. 2 is a sectional view taken along lines 22 of FIG. 1.
  • a stainless steel wire having a portion 12 of uniform thickness and a tapered portion 14. Portion 12 is covered by a jacket 16 made of a plastic material such as Teflon which has a smooth low friction outer surface.
  • the plastic coated portion 12 forms a proximal portion of a guide wire.
  • a stainless steel coil spring 18 extends over tapered portion 14 and is soldered or otherwise connected to wire 10 at a point indicated by numeral 20 which is adjacent the end of jacket 16. Spring 18 also connected by soldering or otherwise to the end of the tapered portion 14 to form a distal tip 22 having a rounded outer surface.
  • outer diameters of spring 18 and jacket 16 are substantially equal and vary from 0.021 to 0.047 of an inch. However, other diameters are contemplated and must be considered to be within the teachings of the present invention.
  • the guide wire may be manufactured from standard plastic coated stainless steel wire cut to any desired length such as 120 centimeters after which the plastic coating is stripped from the distal portion.
  • the distal portion is then tapered by either a grinding procedure or by the application of a tension force to neck down the distal portion.
  • the stainless steel spring is then positioned over the distal portion and soldered to the stainless steel core wire to form the disposable guide wire.
  • the flexible guide wire may be used following the standard techniques taught by Seldinger and as previously explained in the background of the invention.
  • the distal portion has a rounded tip 22 and an increased amount of flexibility provided by the tapered core wire 14 while the proximal portion has a greater degree of rigidity provided by the uniform diameter of the core wire and the plastic jacket 16.
  • the plastic jacket provides a smooth surface with a low coefficient of friction to facilitate insertion of the guide wire into a vessel while the Teflon jacket provides for excellent torque transmission making the guide wire exceptionally maneuverable.
  • the use of a plastic jacket eliminates the need for the coil spring to extend over the entire length of the guide wire and thus reduces the amount of spring material it required.
  • the cost of the guide wire is substantially reduced as a result of the reduced amount of extensive stainless steel spring material required for the guide wire.
  • the tendency towards clot formation is greatly reduced by the smooth surface of the plastic jacket.
  • the possibility of core wire breakage is greatly reduced by the use of the plastic jacket which is in contact with the proximal portion of the core wire and provides reinforcement.
  • the tendency towards spring coil breakage is also reduced by the use of a shorter spring than in those devices heretofore provided.
  • the plastic jacket also provides an additional advantage in that it eliminates the electrical hazard associated with devices of the prior art during cardiovascular catheterization.
  • a flexible guide wire comprising:
  • an elongated inner core wire having a proximal portion and a distal portion
  • a coil spring enclosing the distal portion and fixably attached thereto the coil spring including a proximal end and distal end;
  • a plastic jacket enclosing and engaging the proximal portion the jacket including a proximal end and a distal end, the jacket distal end terminating at the coil spring proximal end and being substantially equal in diameter to the coil spring such that the jacket forms an extension of the coil spring.
  • a flexible guide wire comprising:
  • an elongated inner core wire having a proximal portion and a tapered distal portion
  • a flexible guide wire comprising:
  • an elongated inner core wire having a proximal portion and a distal portion the proximal portion of the inner core wire being of uniform diameter and the distal portion is tapered;

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

A stainless steel core wire has a tapered portion at one end and a portion of uniform thickness at another end. A Teflon jacket encloses the portion having uniform thickness to form a proximal end and a flexible stainless steel spring encloses the tapered portion forming a distal end. The spring is secured at both ends to the stainless steel core wire.

Description

United States Patent Antoshkiw 45 F b, 5 1974 DISPOSABLE GUIDE WIRE 3,547,103 12/1970 Cook 128/205 R Inventor: William T. Antoshkiw y, NJ 3,612,058 10/1971 Ackerman 128/348 [73] Assignee: Becton, Dickinson 8!. Company, East Primary Examiner-Lucie H. Laudenslager Rutherford, NJ. Attorney, Agent, or Firm-Kane, Dalsimer, Kane, Sul- 22 Filed: Sept. 15, 1971 and [2]] Appl. No.: 180,810 57 ABSTRACT A stainless steel core wire has a tapered portion at one [52] U.S. Cl ..128/2.05 R end and a portion of uniform thickness at another end. [51] Int. Cl A61b 5/02 A Teflon jacket encloses the portion having uniform [58] Field of Search... 128/205 R, DIG. 9, 341, 348 thickness to form a proximal end and a flexible stainv less steel spring encloses the tapered portion forming a [56] References Cited distal end. The spring is secured at both ends to the UNITED STATES PATENTS stainless steel core wire. 3,452,740 7/1969 Muller 128/DIG. 9 UX 10 Claims, 2 Drawing Figures DISPOSABLE GUIDE WIRE BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to guide wires for vascular manipulations and more particularly to a disposable guide wire having added strength in the proximal portion and flexibility in the distal portion.
2. Description of the Prior Art The requirements for diagnostic studies of the vascular systems of the human body have increased considerably in recent years with the marked advances in the cardiac and vascular surgery. This increased requirement has led to extensive use of cardiac and vascular catheters that must be inserted over a relatively long distance into internal sites in the body. Extensive manipulation is required to maneuver a relatively long catheter into branch vessels that extend at sharp angles relative to the feeding direction of the catheter.
The most common catherization procedure is the percutaneous technique described in 1953 by Sven Ivar Seldinger. In the practice of this catherization procedure, an area of the skin is antiseptically prepared and a local anthestic is applied after which a nick is made in the skin over the site of a vessel to be catherized. An arterial needle assembly, (inner needle, stylet) is then introduced into the vessel and its introduction is indicated by a back flow of blood to the inner needle. The inner needle is then withdrawn and replaced with a guide wire which is then introduced through the cannula for a distance of approximately 6 to 10 inches. External pressure is then applied to hold the guide wire in place while the cannula is withdrawn after which the guide wire is fed into the vessel to the selected area by fluoroscopy or some other similar technique. Considerable manipulation is required of the guide line to direct it to the desired area. Once the guide wire reaches the selected area, the catheter is passed over the guide wire to the selected area after which the guide wire is withdrawn from the catheter.
Heretofore, guide wires were formed of closely wound stainless steel forming a continuous coil spring having an inner bore which is sealed at the distal end with arounded cap or tip. Usually an inner core wire is placed within the coil bore, said wire terminating a short distance from the distal tip to provide flexibility at the distal tip and rigidity throughout the remainder of the wire. In most cases, the proximal portion having the core wire was too rigid while the distal tip was so flexible it was practically uncontrollable.
In order to overcome the problems of the devices of the prior art, U. S. Pat. No. 3,528,406 taught the use of two core wires, one extending to the distal tip and the other terminating a distance therefrom. Another embodiment taught by the previously mentioned patent included a heavy gauge core wire throughout the proximal portion, the heavy gauge wire being reduced to a uniform thinner diameter at the distal tip portion to provide greater flexibility.
All the devices heretofore provided had a coil spring extending throughout their entire length and were therefore subject to coil breakage or breakage of the core wire. The coil spring and the core wire were not usually in contact and therefore did not provide mutual support for each other. The coil spring did not provide for good torque transmission because the spring would tend to bend and turn rather than transmit torque from the proximal portion to the distal tip of the guide wire. This feature made manipulation more difficult and time consuming.
The coil spring also had many other disadvantages, one being the high friction presented between the coils of the spring and the inner surface of the vessel. The spring coils tended to collect blood and were more difflcult to clean causing clot formation on the coils. The spring also presented an electrical hazard during cardiovascular catheterization.
SUMMARY OF THE INVENTION The present invention contemplates a flexible guide wire for use in vascular manipulations. The guide wire is disposable and comprises a stainless steel core wire having a portion of uniform diameter and a tapered portion. The uniform diameter portion is coated with a plastic jacket to form a proximal portion and the tapered portion is enclosed in a stainless steel coil spring to form a distal portion. The spring is fixed at both ends to the inner core by soldering, the solder at the end forming a rounded distal tip.
The stainless steel spring closing the distal portion provides the required flexibility and resiliency while permitting introduction of the guide wire through a stainless steel cannula without the danger of skiving during introduction of the wire. The danger of spring coil breakage is greatly reduced by reducing the spring length and by connecting it to the inner core at both ends. The tapered core wire at the distal portion provides for uniform increase in flexibility between the proximal portion and the distal tip.
The use of the plastic jacket around the proximal portion of the center of core wire provides several advantages. The use of the plastic jacket reduces the length of spring coil required and thereby greatly reduces the cost of the guide wire. Stainless steel spring material is the most expensive component of the guide wire and elimination of substantial length of spring material greatly reduces the cost. The plastic material provides a smooth low friction surface and thereby facilitates the movement of the guide wire through a vessel. The plastic jacket is easier to clean than the spring coil and prevents clotting between the coils of the spring. The plastic jacket is in direct contact with the inner core wire and therefore supports the wire and reduces the possibility of wire breakage while also providing for excellent torque transmission to the distal portion to facilitate manipulation of the guide wire. Use of an insulated plastic jacket eliminates the electrical hazard which was present during cardiovascular catheterization when devices of the prior art were used.
The primary objective of the present invention is to provide a disposable guide wire that need not be cleaned and sterilized after each use.
Another objective of the present invention is to provide a guide wire having better manipulative characteristics than guide wires heretofore provided.
Another objective of the present invention is to provide a guide wire having a low coefficient of friction and good torque transmitting ability.
Another objective of the present invention is to provide a guide wire that prevents clot formation.
Another objective of the present invention is to provide a guide wire that is not prone to breakage.
The foregoing objectives and advantages of the invention will appear more fully hereinafter from a consideration of the detailed description which follows, taken together with the accompanying drawing wherein one embodiment of the invention is illustrated by way of example. It is to be expressly understood, however, that the drawing is for illustrative purposes only and is not to be considered as defining the limits of the invention.
DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of a flexible guide wire constructed in accordance with the present invention.
FIG. 2 is a sectional view taken along lines 22 of FIG. 1.
DESCRIPTION OF THE INVENTION Referring to the drawings, there is shown a stainless steel wire having a portion 12 of uniform thickness and a tapered portion 14. Portion 12 is covered by a jacket 16 made of a plastic material such as Teflon which has a smooth low friction outer surface. The plastic coated portion 12 forms a proximal portion of a guide wire.
A stainless steel coil spring 18 extends over tapered portion 14 and is soldered or otherwise connected to wire 10 at a point indicated by numeral 20 which is adjacent the end of jacket 16. Spring 18 also connected by soldering or otherwise to the end of the tapered portion 14 to form a distal tip 22 having a rounded outer surface.
The outer diameters of spring 18 and jacket 16 are substantially equal and vary from 0.021 to 0.047 of an inch. However, other diameters are contemplated and must be considered to be within the teachings of the present invention.
The guide wire may be manufactured from standard plastic coated stainless steel wire cut to any desired length such as 120 centimeters after which the plastic coating is stripped from the distal portion. The distal portion is then tapered by either a grinding procedure or by the application of a tension force to neck down the distal portion. The stainless steel spring is then positioned over the distal portion and soldered to the stainless steel core wire to form the disposable guide wire.
The flexible guide wire may be used following the standard techniques taught by Seldinger and as previously explained in the background of the invention. The distal portion has a rounded tip 22 and an increased amount of flexibility provided by the tapered core wire 14 while the proximal portion has a greater degree of rigidity provided by the uniform diameter of the core wire and the plastic jacket 16. The plastic jacket provides a smooth surface with a low coefficient of friction to facilitate insertion of the guide wire into a vessel while the Teflon jacket provides for excellent torque transmission making the guide wire exceptionally maneuverable.
The use of a plastic jacket eliminates the need for the coil spring to extend over the entire length of the guide wire and thus reduces the amount of spring material it required. The cost of the guide wire is substantially reduced as a result of the reduced amount of extensive stainless steel spring material required for the guide wire. Likewise, the tendency towards clot formation is greatly reduced by the smooth surface of the plastic jacket. The possibility of core wire breakage is greatly reduced by the use of the plastic jacket which is in contact with the proximal portion of the core wire and provides reinforcement. The tendency towards spring coil breakage is also reduced by the use of a shorter spring than in those devices heretofore provided. The plastic jacket also provides an additional advantage in that it eliminates the electrical hazard associated with devices of the prior art during cardiovascular catheterization.
It is to be understood that the teachings of the invention are not strictly limited to the materials recited above, but that other compatible materials may be used which are familiar to those skilled in the art.
What is claimed is:
1. A flexible guide wire, comprising:
an elongated inner core wire having a proximal portion and a distal portion;
a coil spring enclosing the distal portion and fixably attached thereto the coil spring including a proximal end and distal end; and
a plastic jacket enclosing and engaging the proximal portion the jacket including a proximal end and a distal end, the jacket distal end terminating at the coil spring proximal end and being substantially equal in diameter to the coil spring such that the jacket forms an extension of the coil spring.
2. A guide wire as described in claim 1, wherein the proximal portion is of uniform diameter.
3. A guide wire as described in claim 1, wherein the coil spring is attached to the inner core wire at both ends of the distal portion.
4. A guide wire as described in claim 1, wherein the inner core wire is made of stainless steel.
5. A guide wire as described in claim 1, wherein the coil spring is made of stainless steel.
6. A flexible guide wire, comprising:
an elongated inner core wire having a proximal portion and a tapered distal portion;
a coil spring enclosing the distal portion and fixably attached thereto; and
a plastic jacket enclosing and engaging the proximal portion.
7. A flexible guide wire, comprising:
an elongated inner core wire having a proximal portion and a distal portion the proximal portion of the inner core wire being of uniform diameter and the distal portion is tapered;
a coil spring enclosing the distal portion and fixably attached thereto; and
a plastic jacket enclosing and engaging the proximal portion.
8. A guide wire as described in claim 7, wherein the coil spring is attached to the inner core wire at both ends of the distal portion.
9. A guide wire as described in claim 8, wherein the inner core wire and the coil spring are formed of stainless steel.
10. A guide wire as described in claim 9, wherein the coil spring is attached to the inner core wire by soldering and the solder forms a distal tip at one end of the coil spring.

Claims (10)

1. A flexible guide wire, comprising: an elongated inner core wire having a proximal portion and a distal portion; a coil spring enclosing the distal portion and fixably attached thereto the coil spring including a proximal end and distal end; and a plastic jacket enclosing and engaging the proximal portion the jacket including a proximal end and a distal end, the jacket distal end terminating at the coil spring proximal end and being substantially equal in diameter to the coil spring such that the jacket forms an extension of the coil spring.
2. A guide wire as described in claim 1, wherein the proximal portion is of uniform diameter.
3. A guide wire as described in claim 1, wherein the coil spring is attached to the inner core wire at both ends of the distal portion.
4. A guide wire as described in claim 1, wherein the inner core wire is made of stainless steel.
5. A guide wire as described in claim 1, wherein the coil spring is made of stainless steel.
6. A flexible guide wire, comprising: an elongated inner core wire having a proximal portion and a tapered distal portion; a coil spring enclosing the distal portion and fixably attached thereto; and a plastic jacket enclosing and engaging the proximal portion.
7. A flexible guide wire, comprising: an elongated inner core wire having a proximal portion and a distal portion the proximal portion of the inner core wire being of uniform diameter and the distal portion is tapered; a coil spring enclosing the distal portion and fixably attached thereto; and a plastic jacket enclosing and engaging the proximal portion.
8. A guide wire as described in claim 7, wherein the coil spring is attached to the inner core wire at both ends of the distal portion.
9. A guide wire as described in claim 8, wherein the inner core wire and the coil spring are formed of stainless steel.
10. A guide wire as described in claim 9, wherein the coil spring is attached to the inner core wire by soldering and the solder forms a distal tip at one end of the coil spring.
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Cited By (189)

* Cited by examiner, † Cited by third party
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US4003369A (en) * 1975-04-22 1977-01-18 Medrad, Inc. Angiographic guidewire with safety core wire
EP0014424A1 (en) * 1979-02-08 1980-08-20 Toray Monofilament Company Limited Medical vascular guide wire and self-guiding type catheter
US4402307A (en) * 1980-10-31 1983-09-06 Datascope Corp. Balloon catheter with rotatable energy storing support member
DE3334174A1 (en) * 1982-09-22 1984-03-22 C.R. Bard, Inc., 07974 Murray Hill, N.J. STEERABLE GUIDE WIRE FOR BALLONDILATION
US4456017A (en) * 1982-11-22 1984-06-26 Cordis Corporation Coil spring guide with deflectable tip
JPS607862A (en) * 1983-06-27 1985-01-16 テルモ株式会社 Guide wire for catheter
JPS6063066A (en) * 1983-09-16 1985-04-11 テルモ株式会社 Guide wire for catheter
JPS6063065A (en) * 1983-09-16 1985-04-11 テルモ株式会社 Guide wire for catheter
JPS60168466A (en) * 1983-11-10 1985-08-31 アドヴアンスド　カ−デイオヴアスキユラ−　システムズ　インコ−ポレ−テツド Guide wire for catheter
US4548206A (en) * 1983-07-21 1985-10-22 Cook, Incorporated Catheter wire guide with movable mandril
US4554929A (en) * 1983-07-13 1985-11-26 Advanced Cardiovascular Systems, Inc. Catheter guide wire with short spring tip and method of using the same
EP0200430A1 (en) * 1985-04-18 1986-11-05 Advanced Cardiovascular Systems, Inc. Torsional guide wire with attenuated diameter
EP0200919A1 (en) * 1985-05-04 1986-11-12 ANGIOMED Aktiengesellschaft Guide wire
DE3528876A1 (en) * 1985-08-12 1987-02-19 Schubert Werner Guiding wire
EP0223179A2 (en) * 1985-11-21 1987-05-27 Sarcem Sa Remotely controlled catheter guide
US4721117A (en) * 1986-04-25 1988-01-26 Advanced Cardiovascular Systems, Inc. Torsionally stabilized guide wire with outer jacket
US4757827A (en) * 1987-02-17 1988-07-19 Versaflex Delivery Systems Inc. Steerable guidewire with deflectable tip
US4811743A (en) * 1987-04-21 1989-03-14 Cordis Corporation Catheter guidewire
US4813434A (en) * 1987-02-17 1989-03-21 Medtronic Versaflex, Inc. Steerable guidewire with deflectable tip
US4815478A (en) * 1987-02-17 1989-03-28 Medtronic Versaflex, Inc. Steerable guidewire with deflectable tip
US4830023A (en) * 1987-11-27 1989-05-16 Medi-Tech, Incorporated Medical guidewire
WO1989006985A1 (en) * 1988-01-27 1989-08-10 Advanced Biomedical Devices, Inc. Steerable guidewire for vascular system
US4867173A (en) * 1986-06-30 1989-09-19 Meadox Surgimed A/S Steerable guidewire
US4867174A (en) * 1987-11-18 1989-09-19 Baxter Travenol Laboratories, Inc. Guidewire for medical use
WO1989010088A1 (en) * 1988-04-18 1989-11-02 Target Therapeutics Catheter guide wire
EP0340304A1 (en) * 1987-01-07 1989-11-08 Terumo Kabushiki Kaisha Guide wire for catheters and method of manufacturing same
US4922924A (en) * 1989-04-27 1990-05-08 C. R. Bard, Inc. Catheter guidewire with varying radiopacity
US4925445A (en) * 1983-09-16 1990-05-15 Fuji Terumo Co., Ltd. Guide wire for catheter
US4934380A (en) * 1987-11-27 1990-06-19 Boston Scientific Corporation Medical guidewire
US4971490A (en) * 1988-03-01 1990-11-20 National Standard Company Flexible guide wire with improved mounting arrangement for coil spring tip
US4976690A (en) * 1989-08-10 1990-12-11 Scimed Life Systems, Inc. Variable stiffness angioplasty catheter
US4984581A (en) * 1988-10-12 1991-01-15 Flexmedics Corporation Flexible guide having two-way shape memory alloy
US4991588A (en) * 1986-07-21 1991-02-12 Pfizer Hospital Products Group, Inc. Doppler guide wire
JPH0351060A (en) * 1989-06-29 1991-03-05 Cook Inc Wire guide
EP0157862B1 (en) * 1983-10-04 1991-03-20 MÄRZ, Peter, Dr. Guiding mandrel for catheter and similar instruments and manufacturing process thereof
US5003918A (en) * 1989-12-28 1991-04-02 Interventional Technologies, Inc. Apparatus for manufacturing atherectomy torque tubes
US5054501A (en) * 1990-05-16 1991-10-08 Brigham & Women's Hospital Steerable guide wire for cannulation of tubular or vascular organs
US5059176A (en) * 1989-12-21 1991-10-22 Winters R Edward Vascular system steerable guidewire with inflatable balloon
US5067489A (en) * 1988-08-16 1991-11-26 Flexmedics Corporation Flexible guide with safety tip
US5095915A (en) * 1990-03-19 1992-03-17 Target Therapeutics Guidewire with flexible distal tip
US5102390A (en) * 1985-05-02 1992-04-07 C. R. Bard, Inc. Microdilatation probe and system for performing angioplasty in highly stenosed blood vessels
USRE33911E (en) * 1983-07-13 1992-05-05 Advanced Cardiovascular Systems, Inc. Catheter guide wire with short spring tip and method of using the same
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