USRE46363E1 - Dial-down mechanism for wind-up pen - Google Patents

Dial-down mechanism for wind-up pen Download PDF

Info

Publication number
USRE46363E1
USRE46363E1 US14/091,774 US200514091774A USRE46363E US RE46363 E1 USRE46363 E1 US RE46363E1 US 200514091774 A US200514091774 A US 200514091774A US RE46363 E USRE46363 E US RE46363E
Authority
US
United States
Prior art keywords
dial
cam
key
down mechanism
engage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US14/091,774
Inventor
Claus Schmidt Moeller
Christian Peter Enggaard
Bo Radmer
Tom Hede Markussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34928586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=USRE46363(E1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to US14/091,774 priority Critical patent/USRE46363E1/en
Application granted granted Critical
Publication of USRE46363E1 publication Critical patent/USRE46363E1/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

  • the present invention relates to a dial-down mechanism for automatic wind-up pens.
  • the present invention relates to integrated axial and radial dial-down mechanisms for wind-up pens.
  • US 2004/199117 discloses a medication delivery pen including an arrangement where incorrect dosage settings may be corrected by a user via a dial-back feature that enables the user to reset the dose amount without expelling medication and without having to dial a dose knob to an extended, reset position.
  • the medication delivery pen of US 2004/199117 is a so-called manual pen where the injection of a medicament from the pen is driven by a force purely provided by the user of the pen.
  • the injection of a medicament is not assisted by any resilient member, such as a spring, and the dial-down arrangement disclosed in US 2004/199117 is not arranged to maintain a resilient member in a given strained position.
  • Automatic wind-up pens are here to be understood as pens having a resilient member, such as a spring, to assist injecting a medicament from an injection device.
  • a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising
  • the dial-down mechanism may be implemented as a radial dial-down mechanism or as an axial dial-down mechanism.
  • the dial-down key or keys are arranged to move in the radial direction of the mechanism. This may also be the radial direction of the injection device.
  • the dial-down key or keys are arranged to move in the axial direction of the injection device.
  • dial-up key or keys, and the dial-down key or keys may be different keys—i.e. physically separated keys.
  • dial-up and dial-down key is constituted by the same key.
  • the mechanism according to the present invention comprises only a single key which is used for both dial-up and dial down.
  • the dial-up and dial-down cams may be arranged as openings or indentations in an outer surface part of a disc-shaped cam member.
  • the cam member may, alternatively, also be shaped as a substantially cylindrical member.
  • the dial-up and dial-down cams may be arranged in a substantially plane surface part of the cam member. This substantially plane surface part may be substantially perpendicular to an axial direction of the disc or cylindrical shaped cam member.
  • the cam member may be a hollow construction, or alternatively, the cam member may be a solid construction.
  • the dial-up cam may form a curved track, such as part of a circular, elliptical or parabolic track.
  • the dial-down cam may form part of a V-shaped track, or alternative, it may have a rectangular shape.
  • the dial-down mechanism may comprise a first and a second dial-up cam. Furthermore, the dial-down mechanism may comprise a first and a second dial-up key, wherein the first dial-up key may be adapted to engage and cooperate with the first dial-up cam, and wherein the second dial-up key may be adapted to engage and cooperate with the second dial-up cam.
  • the dial-down mechanism may further comprise a first and a second dial-down cam, and a first and a second dial-down key.
  • the first dial-down key may be adapted to engage and cooperate with the first dial-down cam, whereas the second dial-down key may be adapted to engage and cooperate with the second dial-down cam.
  • dial-up and dial-down cams form part of regions of the same track.
  • dial-up and dial-down keys may be constituted by the same key, said key being adapted to engage and cooperate with dial-up and dial-down cams of the same track.
  • the dial-up and dial-down cams may be arranged as cams having an axial component parallel to an axial direction of the injection device.
  • the dial-up and dial-down cams may be arranged on an outer and curved surface part of a substantially cylindrical cam member.
  • This substantially cylindrical cam member may be the dose setting member of the injection device, or it may be a separate component cooperating with the dose setting member of the injection device.
  • the dial-up cam may be substantially parallel to an axial direction of the injection device.
  • the dial-down cam may form an angle, such as around 45 degrees, to the dial-up cam.
  • the present invention relates to an axially arranged dial-down mechanism for an injection device, the dial-down mechanism comprising
  • dial-up and dial-down cams may form part of regions of the same track.
  • the dial-up and dial-down keys may be constituted by the same key, said key being adapted to engage and cooperate with dial-up and dial-down cams of the same track.
  • the present invention relates to a medication delivery device, such as a handheld medication delivery device, comprising a dial-down mechanism according to the first aspect of the present invention.
  • FIG. 1 shows the principle of a radial dial-up and dial-down mechanism where the keys on the flexible arm are used for both dial-up and dial-down,
  • FIG. 2 shows FIGS. 2A and 2B show a radial dial-up/dial down mechanism with separate keys for dial-up and dial-down, where FIG. 2A shows torsion spring 18 and disc 14 over ratchet 13 (not labeled) and adjacent to nut 10 (not labeled), and FIG. 2B also shows ratchet 13 adjacent nut 10.
  • FIG. 3 shows a radial dial-up/dial down mechanism with separate keys for dial-up and dial-down where the movements of the dial-down key is determined by a track in the nut
  • FIG. 4 shows an injection device having an integrated radial dial-down mechanism
  • FIG. 5 shows FIGS. 5A and 5B show an injection device having an integrated axial dial-down mechanism, where FIG. 5A shows a cross-section of an injection device, and FIG. 5B shows a partial front or side elevation view of the same injection device.
  • the dial-down mechanism according to the present invention may be implemented as an axial or a radial mechanism. Both of these mechanisms may be integrated into an injection device, such as an injection pen.
  • FIG. 1a shows a rotatable inner part 2 biased against a fixed outer part 1 .
  • the biasing force is provided by a torsion spring (not shown) in the counter-clockwise direction.
  • the inner part 2 which is rotatable around a center axis 6 , has one or more flexible arms 3 adapted to engage with the edges 5 in the fixed outer part 1 .
  • FIG. 1b shows the arrangement of FIG. 1a with a rotatable disc 7 (hatched region) placed on top of the inner part 2 and outer part 1 .
  • the disc 7 has an opening 8 .
  • the edges defining the opening 8 constitute dial-up and dial-down cams.
  • a pick-up key 4 attached to, or integrated with, the flexible arm 3 operates as a cam follower when the disc 7 is rotated relative to the outer part 1 .
  • the system illustrated in FIG. 1 is operated in the following manner:
  • the inner part 2 When a dose is to be set (dial-up), the inner part 2 is rotated in the clockwise direction whereby the flexible arm 3 will move from one edge 5 to the neighboring edge or edges—depending on the angle of rotation.
  • the inner part 2 is driven by disc 7 —thus, when disc 7 is rotated the inner part 2 rotates with it.
  • the pick-up key 4 moves in and out along the radial direction.
  • the pick-up key 4 When the disc 7 is rotated in the counter clockwise direction (dial-down direction) the pick-up key 4 , and thereby the flexible arm 3 , is lifted out of its engaging position with the edge 5 of the outer part 1 . When the arm 3 is fully disengaged from the edge 5 the inner part 2 may be rotated in the counter clockwise direction relative to the outer part 1 . It is a characteristic of the system shown in FIG. 1 that the pick-up key 4 is used for both dial-up (increasing a dose) and dial-down (resetting or reducing a dose).
  • dial-up is achieved by rotating the inner portion 2 in the counter clockwise direction.
  • dial-down could be achieved by rotating disc 7 in the clockwise direction.
  • FIG. 2 shows FIGS. 2A and 2B show an exploded drawing of the radial embodiment of the dial-down mechanism according to the present invention.
  • the main difference compared to the embodiment shown in FIG. 1 is that the embodiment of FIG. 2 FIGS. 2A and 2B applies different pick-up keys for dial-up (pick-up key 11 ) and dial-down (pick-up key 12 ).
  • the dial-up key 11 engages with track 15 of the disc 14
  • dial-down key 12 engages with track 16 of the disc 14 .
  • Tracks 15 and 16 are formed as through-going openings or indentations in a planar surface of the disc 14 .
  • the dial-up tracks 15 take the form of curved tracks whereas the dial-down tracks 16 are V-shaped.
  • V-shape An obvious alternative to the V-shape is a rectangular shape. It should be noted that the general idea is that the dial-up tracks 15 should be capable of transferring a momentum to a torsion spring 18 . In the same manner, the dial-down tracks 16 should be capable of releasing the dial-down keys (and thereby release energy) in case the disc 14 is rotated just a few degrees relative to the nut 10 .
  • the dial-down keys 12 are integrated with the flexible arms 19 . These arms are fabricated of a resilient material such as for example plastic.
  • the flexible arms 19 with integrated dial-down keys 12 form an integral part of the ratchet 13 .
  • the ratchet including arms and dial-down keys may preferably be fabricated of the same material, such as of plastic.
  • a torsion spring 18 is arranged coaxially with the ratchet 13 .
  • An opening 21 is provided in the center part of the nut 10 .
  • the side wall of this opening is provided with threads 22 which are adapted to engage with a threaded outer surface of a piston rod (not shown).
  • FIG. 3 shows another radial embodiment according to the present invention.
  • the movement of the arm 26 is controlled by a track 23 in the nut 27 .
  • the track 23 is engaged by the track/cam follower 24 which precisely guides the dial-down key 28 from one tooth to the neighboring tooth during dial-down.
  • the opening 25 in the center of the nut 27 is provided with a track follower 29 .
  • This track follower is adapted to engage with a track in the outer surface of a piston rod (not shown).
  • FIG. 4 shows an injection device having a radial dial-down mechanism according to the present invention.
  • the injection device shown in FIG. 4 shows a dose setting member 30 , a piston rod 31 having a threaded outer surface and a drive track arranged in the axial direction of the piston rod, a nut 32 , a torsion spring 35 , a drive member 33 , the threaded portion 34 of the housing, a lease mechanism 36 , a toothing mechanism 37 , and ratchet 38 .
  • a dose is set by rotating the dose setting member 30 and the nut 32 whereby the torsion spring 35 is strained.
  • the dose setting member 30 is prevented from returning to its initial position due the toothing mechanism 37 positioned between the nut 32 and the drive member 33 .
  • the dose setting member 30 is simply rotated in the opposite direction. The interaction between ratchet 38 and nut 32 during dial-down is described in connection with FIG. 2 .
  • FIG. 5 shows FIGS. 5A and 5B show an injection device having an axial dial-down mechanism according to the present invention.
  • the injection device shown in FIG. 5 5B comprising a dose setting member 40 , an opening 41 defining dial-up and dial-down cam surfaces, a cam follower 42 , a torsion spring 43 , a ratchet 44 , and a piston rod 45 .
  • the general idea behind the axial dial-down mechanism is to use the torsion spring 43 to both drive and rotate the piston rod 45 and to ensure that the upper and lower parts of the toothing 48 remain together.
  • the cam follower 42 engages with cam surface 46 .
  • the torsion spring 43 is strained because the ratchet 44 is prevented from reversing due to the toothing 48 .
  • the ratchet 44 will move up and down along cam surface 46 as the upper and lower parts of the toothing 48 rotate relative to each other.
  • the cam surface 47 will lift and thereby release the upper part of the toothing from the lower part of the toothing thereby the ratchet 44 is allowed to rotate an angle corresponding to one tooth.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pens And Brushes (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Push-Button Switches (AREA)

Abstract

The present invention relates to a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising dial-up cam arranged to receive and engage with a dial-up key, wherein the dial-up cam and the dial-up key are adapted to, upon rotation of a dose setting member in a first direction, cooperate to strain the torsion spring of the injection device, and a dial-down cam arranged to receive and engage with a dial-down key, wherein the dial-down cam and the dial-down key are adapted to, upon rotation of the dose setting member in a second direction, cooperate to release the torsion spring of the injection device, the second rotation direction being opposite to the first rotation direction.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 35 U.S.C. § 371 national stage application of International Patent Application PCT/EP2005/011285 (published as WO 2006/045526), filed Oct. 20, 2005, which claimed priority of European Patent Application 04077900.1, filed Oct. 21, 2004; this application further claims priority under 35 U.S.C. § 119 of U.S. Provisional Application 60/626,270, filed Nov. 9, 2004. This application is a Divisional Reissue of U.S. application Ser. No. 13/431,019, filed Mar. 27, 2012, which is an Application for Reissue of U.S. Pat. No. 7,686,786, issued Mar. 30, 2010 (U.S. application Ser. No. 11/665,486, filed Oct. 11, 2007), which is a 35 U.S.C. §371 national stage application of International Patent Application PCT/EP2005/011285 (published as WO2006/045526), filed Oct. 20, 2005, which claimed priority of European Patent Application 04077900.1, filed Oct. 21, 2004; this application further claims priority under 35 U.S.C. §119 of U.S. Provisional Application 60/626,270, filed Nov. 9, 2004, incorporated herein by reference.
FIELD OF THE INVENTION
The present invention relates to a dial-down mechanism for automatic wind-up pens. In particular, the present invention relates to integrated axial and radial dial-down mechanisms for wind-up pens.
BACKGROUND OF THE INVENTION
In known injection devices, such as wind-up pens, based on torsion springs, the use of dial-down mechanisms rely on that the user of the injection device applies a force to a rotatable dose setting member of the injection device. The force must be applied in order to axially withdraw the dose setting member a certain distance to release the dose setting member from a toothing mechanism or ratchet positioned within the body of the injection device. By releasing the dose setting member from this toothing mechanism the dose setting member can be reversed by rotation and set at a new and lower dose.
An example of a known wind-up pen applying a torsion spring may for example be found in U.S. Pat. No. 5,104,380. However, the pen suggested in U.S. Pat. No. 5,104,380 does not offer a dial-down mechanism. A dial-down mechanism is provided in WO 02/053214. However, the proposed solution in WO 02/053214 involves a linear spring.
It is a disadvantage of known torsion spring-based dial-down systems that the user must apply a force to withdraw the dose setting member a certain axial distance and, at the same time, adjust the angular position of the dose setting member. Especially for persons having reduced motoric skills or reduced finger strength, such as children, elderly people or disabled people this is a rather complicated procedure.
US 2004/199117 discloses a medication delivery pen including an arrangement where incorrect dosage settings may be corrected by a user via a dial-back feature that enables the user to reset the dose amount without expelling medication and without having to dial a dose knob to an extended, reset position. The medication delivery pen of US 2004/199117 is a so-called manual pen where the injection of a medicament from the pen is driven by a force purely provided by the user of the pen. Thus, the injection of a medicament is not assisted by any resilient member, such as a spring, and the dial-down arrangement disclosed in US 2004/199117 is not arranged to maintain a resilient member in a given strained position.
It is an object of the present invention to provide a dial-down mechanism for automatic wind-up pens. Automatic wind-up pens are here to be understood as pens having a resilient member, such as a spring, to assist injecting a medicament from an injection device.
SUMMARY OF THE INVENTION
The above-mentioned object is complied with by providing, in a first aspect, a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising
    • dial-up cam arranged to receive and engage with a dial-up key, wherein the dial-up cam and the dial-up key are adapted to, upon rotation of a dose setting member in a first direction, cooperate to strain the torsion spring of the injection device, and
    • a dial-down cam arranged to receive and engage with a dial-down key, wherein the dial-down cam and the dial-down key are adapted to, upon rotation of the dose setting member in a second direction, cooperate to release the torsion spring of the injection device, the second rotation direction being opposite to the first rotation direction.
Generally speaking the dial-down mechanism may be implemented as a radial dial-down mechanism or as an axial dial-down mechanism. In the radial dial-down mechanism the dial-down key or keys are arranged to move in the radial direction of the mechanism. This may also be the radial direction of the injection device. In the axial dial-down mechanism, the dial-down key or keys are arranged to move in the axial direction of the injection device.
Also it should be noted that the dial-up key or keys, and the dial-down key or keys may be different keys—i.e. physically separated keys. However, it may also be that the dial-up and dial-down key is constituted by the same key. Thus, it may be that the mechanism according to the present invention comprises only a single key which is used for both dial-up and dial down.
The dial-up and dial-down cams may be arranged as openings or indentations in an outer surface part of a disc-shaped cam member. The cam member may, alternatively, also be shaped as a substantially cylindrical member. In particular, the dial-up and dial-down cams may be arranged in a substantially plane surface part of the cam member. This substantially plane surface part may be substantially perpendicular to an axial direction of the disc or cylindrical shaped cam member. The cam member may be a hollow construction, or alternatively, the cam member may be a solid construction.
In both the radial and the axial mechanism, the dial-up cam may form a curved track, such as part of a circular, elliptical or parabolic track. The dial-down cam may form part of a V-shaped track, or alternative, it may have a rectangular shape.
The dial-down mechanism may comprise a first and a second dial-up cam. Furthermore, the dial-down mechanism may comprise a first and a second dial-up key, wherein the first dial-up key may be adapted to engage and cooperate with the first dial-up cam, and wherein the second dial-up key may be adapted to engage and cooperate with the second dial-up cam.
The dial-down mechanism may further comprise a first and a second dial-down cam, and a first and a second dial-down key. The first dial-down key may be adapted to engage and cooperate with the first dial-down cam, whereas the second dial-down key may be adapted to engage and cooperate with the second dial-down cam.
It may also be that the dial-up and dial-down cams form part of regions of the same track. Furthermore, the dial-up and dial-down keys may be constituted by the same key, said key being adapted to engage and cooperate with dial-up and dial-down cams of the same track.
In the axial mechanism, the dial-up and dial-down cams may be arranged as cams having an axial component parallel to an axial direction of the injection device. The dial-up and dial-down cams may be arranged on an outer and curved surface part of a substantially cylindrical cam member. This substantially cylindrical cam member may be the dose setting member of the injection device, or it may be a separate component cooperating with the dose setting member of the injection device.
In the axial mechanism, the dial-up cam may be substantially parallel to an axial direction of the injection device. In order to be able to release an associated ratchet from a toothing the dial-down cam may form an angle, such as around 45 degrees, to the dial-up cam.
In a second aspect, the present invention relates to an axially arranged dial-down mechanism for an injection device, the dial-down mechanism comprising
    • a rotatable member adapted to be rotated when a dose to be injected from the injection device is set, the rotatable member comprising a dial-up cam and a dial-down cam, wherein the dial-up cam is adapted to receive and engage with a key of a ratchet of the injection device during dose setting during dial-up, and wherein the dial-down cam is adapted to receive and engage with the key during dial-down,
      wherein the dial-up cam is substantially parallel to an axial direction of the injection device.
In this second aspect of the present invention the dial-up and dial-down cams may form part of regions of the same track. The dial-up and dial-down keys may be constituted by the same key, said key being adapted to engage and cooperate with dial-up and dial-down cams of the same track.
In a third aspect, the present invention relates to a medication delivery device, such as a handheld medication delivery device, comprising a dial-down mechanism according to the first aspect of the present invention.
BRIEF DESCRIPTION OF THE DRAWINGS
The present invention will now be described in further details with reference to the accompanying figures, wherein
FIG. 1 shows the principle of a radial dial-up and dial-down mechanism where the keys on the flexible arm are used for both dial-up and dial-down,
FIG. 2 shows FIGS. 2A and 2B show a radial dial-up/dial down mechanism with separate keys for dial-up and dial-down, where FIG. 2A shows torsion spring 18 and disc 14 over ratchet 13 (not labeled) and adjacent to nut 10 (not labeled), and FIG. 2B also shows ratchet 13 adjacent nut 10.
FIG. 3 shows a radial dial-up/dial down mechanism with separate keys for dial-up and dial-down where the movements of the dial-down key is determined by a track in the nut,
FIG. 4 shows an injection device having an integrated radial dial-down mechanism, and
FIG. 5 shows FIGS. 5A and 5B show an injection device having an integrated axial dial-down mechanism, where FIG. 5A shows a cross-section of an injection device, and FIG. 5B shows a partial front or side elevation view of the same injection device.
While the invention is susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.
DETAILED DESCRIPTION OF THE INVENTION
The dial-down mechanism according to the present invention may be implemented as an axial or a radial mechanism. Both of these mechanisms may be integrated into an injection device, such as an injection pen.
A radial solution is shown in FIG. 1. FIG. 1a shows a rotatable inner part 2 biased against a fixed outer part 1. The biasing force is provided by a torsion spring (not shown) in the counter-clockwise direction. The inner part 2, which is rotatable around a center axis 6, has one or more flexible arms 3 adapted to engage with the edges 5 in the fixed outer part 1. FIG. 1b shows the arrangement of FIG. 1a with a rotatable disc 7 (hatched region) placed on top of the inner part 2 and outer part 1. The disc 7 has an opening 8. The edges defining the opening 8 constitute dial-up and dial-down cams. A pick-up key 4 attached to, or integrated with, the flexible arm 3 operates as a cam follower when the disc 7 is rotated relative to the outer part 1.
The system illustrated in FIG. 1 is operated in the following manner:
When a dose is to be set (dial-up), the inner part 2 is rotated in the clockwise direction whereby the flexible arm 3 will move from one edge 5 to the neighboring edge or edges—depending on the angle of rotation. The inner part 2 is driven by disc 7—thus, when disc 7 is rotated the inner part 2 rotates with it. During rotation in the clockwise direction, the pick-up key 4 moves in and out along the radial direction.
When the disc 7 is rotated in the counter clockwise direction (dial-down direction) the pick-up key 4, and thereby the flexible arm 3, is lifted out of its engaging position with the edge 5 of the outer part 1. When the arm 3 is fully disengaged from the edge 5 the inner part 2 may be rotated in the counter clockwise direction relative to the outer part 1. It is a characteristic of the system shown in FIG. 1 that the pick-up key 4 is used for both dial-up (increasing a dose) and dial-down (resetting or reducing a dose).
It should be noted that the directions of rotation could be reversed so that dial-up is achieved by rotating the inner portion 2 in the counter clockwise direction. In such a configuration dial-down could be achieved by rotating disc 7 in the clockwise direction.
FIG. 2 shows FIGS. 2A and 2B show an exploded drawing of the radial embodiment of the dial-down mechanism according to the present invention. The main difference compared to the embodiment shown in FIG. 1 is that the embodiment of FIG. 2 FIGS. 2A and 2B applies different pick-up keys for dial-up (pick-up key 11) and dial-down (pick-up key 12). The dial-up key 11 engages with track 15 of the disc 14, whereas dial-down key 12 engages with track 16 of the disc 14. Tracks 15 and 16 are formed as through-going openings or indentations in a planar surface of the disc 14. The dial-up tracks 15 take the form of curved tracks whereas the dial-down tracks 16 are V-shaped. An obvious alternative to the V-shape is a rectangular shape. It should be noted that the general idea is that the dial-up tracks 15 should be capable of transferring a momentum to a torsion spring 18. In the same manner, the dial-down tracks 16 should be capable of releasing the dial-down keys (and thereby release energy) in case the disc 14 is rotated just a few degrees relative to the nut 10.
The dial-down keys 12 are integrated with the flexible arms 19. These arms are fabricated of a resilient material such as for example plastic. The flexible arms 19 with integrated dial-down keys 12 form an integral part of the ratchet 13. Thus, the ratchet including arms and dial-down keys may preferably be fabricated of the same material, such as of plastic. In order to bias the dial-down keys 12 against the teeth 20 of the nut 10 a torsion spring 18 is arranged coaxially with the ratchet 13. An opening 21 is provided in the center part of the nut 10. The side wall of this opening is provided with threads 22 which are adapted to engage with a threaded outer surface of a piston rod (not shown).
FIG. 3 shows another radial embodiment according to the present invention. In this embodiment, the movement of the arm 26 is controlled by a track 23 in the nut 27. The track 23 is engaged by the track/cam follower 24 which precisely guides the dial-down key 28 from one tooth to the neighboring tooth during dial-down. In contrast to FIG. 2 the opening 25 in the center of the nut 27 is provided with a track follower 29. This track follower is adapted to engage with a track in the outer surface of a piston rod (not shown).
FIG. 4 shows an injection device having a radial dial-down mechanism according to the present invention. Among other components the injection device shown in FIG. 4 shows a dose setting member 30, a piston rod 31 having a threaded outer surface and a drive track arranged in the axial direction of the piston rod, a nut 32, a torsion spring 35, a drive member 33, the threaded portion 34 of the housing, a lease mechanism 36, a toothing mechanism 37, and ratchet 38.
A dose is set by rotating the dose setting member 30 and the nut 32 whereby the torsion spring 35 is strained. The dose setting member 30 is prevented from returning to its initial position due the toothing mechanism 37 positioned between the nut 32 and the drive member 33. In case the user wants to reduce a preset dose, the dose setting member 30 is simply rotated in the opposite direction. The interaction between ratchet 38 and nut 32 during dial-down is described in connection with FIG. 2.
FIG. 5 shows FIGS. 5A and 5B show an injection device having an axial dial-down mechanism according to the present invention. Among other components the injection device shown in FIG. 5 5B comprising a dose setting member 40, an opening 41 defining dial-up and dial-down cam surfaces, a cam follower 42, a torsion spring 43, a ratchet 44, and a piston rod 45. The general idea behind the axial dial-down mechanism is to use the torsion spring 43 to both drive and rotate the piston rod 45 and to ensure that the upper and lower parts of the toothing 48 remain together.
When a dose is to be set, the cam follower 42 engages with cam surface 46. As a result the torsion spring 43 is strained because the ratchet 44 is prevented from reversing due to the toothing 48. During dial-up the ratchet 44 will move up and down along cam surface 46 as the upper and lower parts of the toothing 48 rotate relative to each other. In case of dial-down the cam surface 47 will lift and thereby release the upper part of the toothing from the lower part of the toothing thereby the ratchet 44 is allowed to rotate an angle corresponding to one tooth.

Claims (11)

The invention clamed is:
1. A dial-down mechanism for an injection device comprising a torsion spring (18) for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising
dial-up cam (15) arranged to receive and engage with a dial-up key (11), wherein the dial-up cam (15) and the dial-up key (11) are adapted to, upon rotation of a dose setting member in a first direction, cooperate to strain the torsion spring (18) of the injection device, and
a dial-down cam (16) arranged to receive and engage with a dial-down key (12), wherein the dial-down cam (16) and the dial-down key (12) are adapted to, upon rotation of the dose setting member in a second direction, cooperate to release the torsion spring (18) of the injection device, the second rotation direction being opposite to the first rotation direction,
wherein the dial-up and dial-down cams form part of regions of the same track,
further comprising an arm wherein the dial-up and dial-down keys are both located on the same arm, said keys being adapted to engage and cooperate with dial-up and dial-down cams of the same track.
2. A dial-down mechanism according to claim 1, wherein the dial-up cam (15) forms part of a curved track.
3. A dial-down mechanism according to claim 2, wherein the curved dial-up cam (15) forms part of a circular, elliptical or parabolic track.
4. A dial-down mechanism according to claim 1 comprising a first and a second dial-up cam.
5. A dial-down mechanism according to claim 4 comprising a first and a second dial-up key, wherein the first dial-up key is adapted to engage and cooperate with the first dial-up cam, and wherein the second dial-up key is adapted to engage and cooperate with the second dial-up cam.
6. A dial-down mechanism according to claim 1, wherein the dial-down cam (16) forms part of a V-shaped track.
7. A dial-down mechanism according to claim 1 comprising a first and a second dial-down cam.
8. A dial-down mechanism according to claim 7 comprising a first and a second dial-down key, wherein the first dial-down key is adapted to engage and cooperate with the first dial-down cam, and wherein the second dial-down key is adapted to engage and cooperate with the second dial-down cam.
9. A medication delivery device comprising a dial-down mechanism according to claim 1.
10. A medication delivery device according to claim 9, wherein the medication delivery device is a handheld medication injection pen.
11. A method for using a wind up injection pen, the method comprising the steps of
rotating a first element in a first direction, the direction being a dial up direction;
causing a second element to be rotated in the same direction as the first element;
straining a torsional spring;
moving an arm that is in engagement with one edge to a neighboring edge, wherein when the arm is engaged with an edge it prevents the torsional spring from unwinding;
rotating the first element in a second direction opposite the first direction;
moving a pick-up key and radially lifting the arm out of engagement with an edge and when the arm is fully disengaged from an edge allowing the second rotatable element to rotate in the second direction and allowing the strain on the spring to be decreased.
US14/091,774 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen Active 2026-08-03 USRE46363E1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/091,774 USRE46363E1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP04077900 2004-10-21
EP04077900 2004-10-21
US62627004P 2004-11-09 2004-11-09
US11/665,486 US7686786B2 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen
US14/091,774 USRE46363E1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen
PCT/EP2005/011285 WO2006045526A1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen
US201213431019A 2012-03-27 2012-03-27

Publications (1)

Publication Number Publication Date
USRE46363E1 true USRE46363E1 (en) 2017-04-11

Family

ID=34928586

Family Applications (2)

Application Number Title Priority Date Filing Date
US14/091,774 Active 2026-08-03 USRE46363E1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen
US11/665,486 Ceased US7686786B2 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11/665,486 Ceased US7686786B2 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen

Country Status (16)

Country Link
US (2) USRE46363E1 (en)
EP (1) EP1804865B1 (en)
JP (1) JP4698677B2 (en)
KR (1) KR101300496B1 (en)
CN (1) CN100571804C (en)
AT (1) ATE444090T1 (en)
AU (1) AU2005298944B2 (en)
CA (1) CA2584760C (en)
DE (1) DE602005016952D1 (en)
DK (1) DK1804865T3 (en)
ES (1) ES2334046T3 (en)
IL (1) IL182613B (en)
PL (1) PL1804865T3 (en)
RU (1) RU2389514C2 (en)
WO (1) WO2006045526A1 (en)
ZA (1) ZA200703707B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12233110B2 (en) 2024-02-16 2025-02-25 I20 Therapeutics, Inc. Compositions comprising pharmaceutically acceptable salts of glucagon-like peptide-1 analogs and uses thereof

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
KR101300496B1 (en) 2004-10-21 2013-09-02 노보 노르디스크 에이/에스 Dial-down mechanism for wind-up pen
EP1819382B2 (en) 2004-10-21 2024-09-04 Novo Nordisk A/S Injection device with torsion spring and rotatable display
PL208660B1 (en) * 2005-05-25 2011-05-31 Kappa Medilab Społka Z Ograniczoną Odpowiedzialnością Automatic applicator, particularly for application of the insulin
ATE499962T1 (en) 2005-07-27 2011-03-15 Novo Nordisk As DOSE MECHANISM FOR AN INJECTION DEVICE FOR LIMITING A DOSE SETTING ACCORDING TO THE REMAINING AMOUNT OF DRUG
PL1909871T5 (en) 2005-07-27 2014-05-30 Novo Nordisk As Syringe device with a dose limiting mechanism and an additional safety mechanism
DE102005060929A1 (en) * 2005-09-14 2007-03-15 Tecpharma Licensing Ag Product e.g. insulin, injecting device, has housing and operating knob with locking units that are formed such that movement of operating knob in one direction has smaller resistance in contrast to movement in other direction
GB0524604D0 (en) * 2005-12-02 2006-01-11 Owen Mumford Ltd Injection method and apparatus
RU2433840C2 (en) 2006-05-18 2011-11-20 Ново Нордиск А/С Injection device with means for blocking function
WO2007137930A1 (en) * 2006-05-29 2007-12-06 Novo Nordisk A/S Mechanism for injection device
CN101939035B (en) * 2008-02-07 2013-04-03 诺沃-诺迪斯克有限公司 Injection device having mode defining elements
BRPI0919925B8 (en) 2008-10-24 2021-06-22 Novo Nordisk As down selector mechanism for injection device
GB2465390A (en) 2008-11-17 2010-05-19 Owen Mumford Ltd Syringe needle cover remover
EP2266647A1 (en) * 2009-06-25 2010-12-29 Sanofi-Aventis Deutschland GmbH Drive mechanism for drug delivery device
JP5309261B2 (en) * 2009-08-24 2013-10-09 エス・ホー・エル・グループ・アクチボラゲット Dose reset mechanism
PL215310B1 (en) * 2009-10-30 2013-11-29 Kappa Medilab Spolka Z Ograniczona Odpowiedzialnoscia Automatic applicator, especially for insulin
EP2329857A1 (en) * 2009-12-03 2011-06-08 Sanofi-Aventis Deutschland GmbH A drug delivery device
GB0921295D0 (en) * 2009-12-04 2010-01-20 Owen Mumford Ltd Injection appaeratus
US9138542B2 (en) 2010-02-17 2015-09-22 Sanofi-Aventis Deutschland Gmbh Automatic injection device with torsional spring
DK2536458T3 (en) * 2010-02-18 2018-01-29 Sanofi Aventis Deutschland CLUTCH MECHANISM
WO2011114343A1 (en) * 2010-03-19 2011-09-22 Pawan Trilokchand Agrawal Multi dose parental drug delivery system with exchangeable glass cartridge
EP2959877B2 (en) 2010-05-27 2020-11-25 J&J Solutions, Inc. Closed fluid transfer system
GB201018827D0 (en) * 2010-11-08 2010-12-22 Owen Mumford Ltd Injection device
US9072839B2 (en) * 2010-11-29 2015-07-07 Sanofi-Aventis Deutschland Gmbh Automatic delivery device with triggering mechanism
USD729930S1 (en) 2011-03-08 2015-05-19 Novo Nordisk A/S Injection device
BR122021000311B1 (en) * 2011-03-16 2022-03-22 Becton, Dickinson And Company Medication injection pens and methods
EP2686042B1 (en) * 2011-03-18 2021-10-27 Becton, Dickinson and Company End of injection indicator for injection pen
WO2012130705A1 (en) * 2011-03-25 2012-10-04 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism and injection device
US9283325B2 (en) 2011-05-12 2016-03-15 Shl Group Ab Medicament delivery device with dose re-setting
USD734450S1 (en) 2011-11-01 2015-07-14 Novo Nordisk A/S Injection device
MX2014007375A (en) 2011-12-29 2014-08-22 Novo Nordisk As Torsion- spring based wind-up autoinjector pen with dial - up/dial - down dosing mechanism.
PL220720B1 (en) * 2012-02-08 2015-12-31 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Injection device with a reset mechanism of the dose
EP3527245A1 (en) * 2012-03-15 2019-08-21 Becton, Dickinson and Company Multiple use disposable injection pen
GB2501897B (en) * 2012-05-09 2014-09-03 Owen Mumford Ltd Injection devices
CH706567A2 (en) * 2012-05-16 2013-11-29 Tecpharma Licensing Ag Improved device to set a dose a limiting mechanism for an apparatus for administering a product.
MX2014013842A (en) 2012-05-31 2015-02-18 Novo Nordisk As Dial-down mechanism for wind-up pen.
EP2692379B1 (en) * 2012-08-01 2014-07-16 TecPharma Licensing AG Injection device with a coupling
JP6416126B2 (en) 2013-02-01 2018-10-31 ノボ・ノルデイスク・エー／エス Non-axially actuated internal volume termination mechanism and injection device equipped with the same
DE202013001350U1 (en) * 2013-02-08 2014-05-09 Haselmeier Gmbh injection device
US11291774B2 (en) * 2013-04-10 2022-04-05 Sanofi Drive mechanism for a drug delivery device
BR112015025703A2 (en) * 2013-04-10 2017-07-18 Sanofi Sa injection device
DK3003439T3 (en) * 2013-05-27 2021-09-13 Sanofi Aventis Deutschland UNIT FOR A Drug Administration
WO2014198858A1 (en) * 2013-06-14 2014-12-18 Novo Nordisk A/S Drug delivery device with dual layer spring
HUE052236T2 (en) * 2013-09-23 2021-04-28 Sanofi Aventis Deutschland Assembly for a drug delivery device and drug delivery device
WO2015055640A1 (en) * 2013-10-16 2015-04-23 Novo Nordisk A/S Drug delivery device with improved dose reset mechanism
AU2014336333B2 (en) * 2013-10-18 2018-08-02 Sanofi-Aventis Deutschland Gmbh Injection device
RU2674085C1 (en) * 2013-11-22 2018-12-04 Санофи-Авентис Дойчланд Гмбх Spring assisted drug delivery mechanism
EP3071265B1 (en) * 2013-11-22 2023-04-26 Sanofi-Aventis Deutschland GmbH Spring assisted drug delivery device
MX2016006673A (en) 2013-11-22 2016-09-06 Sanofi Aventis Deutschland Spring assisted drug delivery device.
TWI644696B (en) 2013-12-09 2018-12-21 德商賽諾菲阿凡提斯德意志有限公司 Operation member and mechanism for a drug delivery device, and drug delivery device
DE202014001135U1 (en) * 2014-02-05 2015-05-06 Haselmeier Gmbh injection device
ES2731642T3 (en) * 2014-02-20 2019-11-18 Medirio Sa Rotor for medical flow regulation devices
CN107073199B (en) * 2014-09-05 2020-08-18 魏民 Automatic injection device for variable dose of medication
CN106794311A (en) 2014-10-08 2017-05-31 诺和诺德股份有限公司 Torque spring for injection device and the injection device including this torque spring
US10576212B2 (en) * 2014-12-08 2020-03-03 Sanofi Dose setting mechanism and drug delivery device herewith
DE102014225687B3 (en) * 2014-12-12 2016-01-21 Vetter Pharma-Fertigung GmbH & Co. KG injection device
ES2727163T3 (en) 2015-02-27 2019-10-14 Novo Nordisk As Drug delivery device with dose reset mechanism
US10441722B2 (en) 2015-04-29 2019-10-15 Novo Nordisk A/S Drug delivery device with spring mechanism
CN108025138A (en) * 2015-10-01 2018-05-11 诺和诺德股份有限公司 Torque spring in automatic drug delivery apparatus is fixed
US11458251B2 (en) 2015-10-09 2022-10-04 Novo Nordisk A/S Drug delivery device with slim drive mechanism
PL414383A1 (en) 2015-10-15 2017-04-24 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Setting mechanism, in particular for dosing pharmaceuticals
PL414382A1 (en) * 2015-10-15 2017-04-24 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Setting mechanism, in particular for dosing
PL227678B1 (en) 2015-12-22 2018-01-31 Copernicus Spolka Z Ograniczona Odpowiedzialnoscia Control and drive system for the device intended for injection and the device for making injections equipped with such a system
EP3429665A1 (en) * 2016-03-15 2019-01-23 Sanofi Dosing mechanism for multi-shot injection device comprising flexible ratchet element
EP3108914B1 (en) 2016-07-07 2019-02-27 Copernicus SP. Z O.O. Injection device for delivering a defined number of equal doses of a liquid substance
EP3506969A1 (en) 2016-08-31 2019-07-10 Novo Nordisk A/S Drug delivery device with over-torque protection mechanism
GB201615439D0 (en) 2016-09-12 2016-10-26 Norton Healthcare Ltd Dose setting mechanism
GB201615442D0 (en) 2016-09-12 2016-10-26 Norton Healthcare Ltd Dose setting mechanism
WO2018057977A1 (en) 2016-09-23 2018-03-29 Delpor, Inc. Stable compositions for incretin mimetic compounds
RU2653688C1 (en) * 2017-01-19 2018-05-11 Бектон, Дикинсон Энд Компани Disposable syringe-pen for several doses
WO2019002020A1 (en) 2017-06-27 2019-01-03 Novo Nordisk A/S A torsion spring driven injection device
US10688247B2 (en) * 2017-07-13 2020-06-23 Haselmeier Ag Injection device with flexible dose selection
PL232651B1 (en) 2017-07-18 2019-07-31 Copernicus Spolka Z Ograniczona Odpowiedzialnoscia Coupling with locking system for the medical injecting device
WO2019046593A1 (en) 2017-08-30 2019-03-07 Pirouette Medical LLC Compact auto-injector
WO2019071129A1 (en) 2017-10-05 2019-04-11 Pirouette Medical LLC Protective case for an auto-injector
AU2019283460A1 (en) * 2018-06-06 2020-11-19 Datamars Sa Improvements in, or relating to, applicators
US11969583B2 (en) 2018-07-17 2024-04-30 Medmix Switzerland Ag Injection device with dose interruption fail safe
USD926973S1 (en) 2019-09-05 2021-08-03 Novo Nordisk A/S Injection device

Citations (424)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US854390A (en) 1906-08-16 1907-05-21 Twitchell Co S Apparatus for carbonating liquids.
US2392196A (en) 1945-02-24 1946-01-01 Arthur E Smith Syringe
GB574705A (en) 1940-04-26 1946-01-17 Boulton Aircraft Ltd Improvements in and relating to machine guns
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3144178A (en) 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3556099A (en) 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3729003A (en) 1971-02-11 1973-04-24 Ampoules Inc Variable dosage ampoule applicator
US3880162A (en) 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US3944843A (en) 1973-03-09 1976-03-16 Filinto Vaz Martins Impedance responsive touch actuated circuit
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
EP0015617A1 (en) 1979-03-06 1980-09-17 Stamicarbon B.V. Device for mixing two fluids
EP0017318A1 (en) 1979-02-12 1980-10-15 American Hospital Supply Corporation Capacitive switching circuit for energizing remote controlled device
US4231368A (en) 1978-03-23 1980-11-04 Michael Becker Device for intramuscular injections, especially of insulin
US4275727A (en) 1980-01-07 1981-06-30 Keeri Szanto Michael Device for monitoring and controlling self-administered intravenous drug dosage
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4300554A (en) 1979-02-22 1981-11-17 Intermedicat Gmbh Portable infusion apparatus
JPS56163486A (en) 1980-05-21 1981-12-16 Citizen Watch Co Ltd Electronic timepiece
JPS5733A (en) 1980-05-28 1982-01-05 Sanyo Electric Co Charger for battery
US4313439A (en) 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
DE3048135A1 (en) 1980-12-19 1982-07-15 Imed Corp., 92131 San Diego, Calif. Intravenous liquid administration by pump - with external pressure sensing cartridge regulating discharge pressure
GB2091107A (en) 1981-01-15 1982-07-28 Colombo Americo Dental syringe
EP0064858A1 (en) 1981-05-07 1982-11-17 Merck & Co. Inc. Dose adjustable delivery system for semi-solid medicaments
US4368731A (en) 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
USRE31315E (en) 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4430079A (en) 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
DE3236374A1 (en) 1982-10-01 1984-04-05 Brown, Boveri & Cie Ag, 6800 Mannheim Security paper
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
US4470317A (en) 1982-02-06 1984-09-11 Eppendorf Geratebau Netheler & Hinz Gmbh Pipetting device
US4493704A (en) 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
US4498904A (en) 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
WO1985002256A1 (en) 1983-11-15 1985-05-23 Kamen Dean L Volumetric pump with replaceable reservoir assembly
GB2153445A (en) 1984-01-25 1985-08-21 Fernandez Tresguerres Hernande Delivery and dosage device
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4584439A (en) 1983-12-01 1986-04-22 Floating Membranes, Inc. Audio transducer with controlled flexibility diaphragm
US4585439A (en) 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
FR2583291A1 (en) 1985-06-14 1986-12-19 Hazon Bernard Device for step-by-step advance of syringe plungers by means of a double coaxial screw with control of the injection rate. Application to repetitive intradermic medicinal injections
US4634431A (en) 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
WO1987002895A1 (en) 1985-11-08 1987-05-21 Disetronic Ag Injection instrument
US4676122A (en) 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
DE3609555A1 (en) 1986-03-21 1987-09-24 Josef Porner Blood-collecting syringe
DE3638984A1 (en) 1986-11-14 1988-05-26 Haselmeier Wilhelm Fa Injection appliance
US4749109A (en) 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
EP0295075A1 (en) 1987-06-12 1988-12-14 Hypoguard (Uk) Limited Measured dose syringe
US4812724A (en) 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
JPH01100495A (en) 1987-10-13 1989-04-18 Seiko Epson Corp Stopwatch
FR2622457A1 (en) 1987-11-03 1989-05-05 Piccinali Eric Mesotherapeutic injector with microprocessor
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
JPH0135671B2 (en) 1982-11-29 1989-07-26 Terumo Corp
EP0327910A2 (en) 1988-02-10 1989-08-16 D.C.P. Af 1988 A/S A dosage unit for dosing a number of measured quantities of a liquid, such as an insulin preparation, from a cartridge
EP0327810A2 (en) 1988-02-09 1989-08-16 WEGU Gummi- und Kunststoffwerke Walter Dräbing KG Rubber bearing for springs, axles and similar parts of motor vehicles
US4871351A (en) 1984-09-28 1989-10-03 Vladimir Feingold Implantable medication infusion system
EP0338806A2 (en) 1988-04-18 1989-10-25 Turner, Robert Charles Syringes
US4893291A (en) 1987-08-29 1990-01-09 Jet-R Limited Devices for aiding resynchronization of body clocks
US4898578A (en) 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
EP0362484A2 (en) 1988-10-05 1990-04-11 B. Braun Melsungen AG Injection device
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4924737A (en) 1989-03-20 1990-05-15 Gummow Tool Company Positive drive ratchet
JPH02126184A (en) 1988-11-04 1990-05-15 Casio Comput Co Ltd Stop watch device
JPH02182267A (en) 1989-01-06 1990-07-16 Oriental Kiden Kk Drip monitor apparatus
US4950246A (en) 1987-05-08 1990-08-21 Spruyt-Hillen B.V. Injection pen
WO1990009202A1 (en) 1989-02-14 1990-08-23 Novo Nordisk A/S Injection pen
EP0387854A2 (en) 1989-03-17 1990-09-19 Siemens Aktiengesellschaft Circuit arrangement and device for the contactless setting of a target value for an integrated circuit enveloped by a non-magnetic material
GB2229497A (en) 1989-03-10 1990-09-26 Graseby Medical Ltd Infusion pump safety device
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
DE3923079A1 (en) 1989-07-13 1991-01-24 Fresenius Ag Measuring level of electrically conducting liquid - has measuring of infusion liquid or blood from change in capacitance of electrodes in measurement liquid
US4988337A (en) 1988-08-10 1991-01-29 Terumo Kabushiki Kaisha Syringe pump apparatus
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US4998922A (en) 1990-02-23 1991-03-12 Kuracina Thomas C Safety syringe cap minimizing needle-stick probability
US5000744A (en) 1989-10-23 1991-03-19 Gte Products Corporation Hypodermic syringe
US5002537A (en) 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
EP0422482A2 (en) 1989-10-07 1991-04-17 KG CATTS GESELLSCHAFT FÜR ERKENNUNGS- & SICHERHEITSTECHNOLOGIE MBH & CO. Coding device for ulteriorly coding electrically conductive code arrangements
US5011479A (en) 1989-10-06 1991-04-30 Son Le Cover and connector for hypodermic needle
WO1991010677A1 (en) 1990-01-18 1991-07-25 Basf Aktiengesellschaft Process for enriching or cleaning biomolecules
WO1991010460A1 (en) 1990-01-22 1991-07-25 Novo Nordisk A/S A process and apparatus for mixing and injecting a medicine
WO1991014467A1 (en) 1990-03-29 1991-10-03 Bernard Sams Dispensing device
EP0454331A1 (en) 1990-04-16 1991-10-30 Minimed Inc., doing business as Minimed Technologies Infusionssystem für die Medikation
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
US5078698A (en) 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5104388A (en) 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5112317A (en) 1988-01-22 1992-05-12 Nosta Ag Injection device
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5122317A (en) 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
EP0498737A1 (en) 1991-02-07 1992-08-12 Terumo Kabushiki Kaisha Dosing means for an injector
JPH04224764A (en) 1990-04-04 1992-08-14 Eli Lilly & Co Injector
JPH04256757A (en) 1991-02-07 1992-09-11 Terumo Corp Quantitative dispenser
US5154698A (en) 1990-10-19 1992-10-13 Patrizio Compagnucci Single use syringe incorporating a sliding protection cap for the needle
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
US5176646A (en) 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
WO1993001573A1 (en) 1991-07-02 1993-01-21 Mallinckrodt Medical, Inc. Syringe pressure monitor
DE4223958A1 (en) 1991-07-24 1993-01-28 Medico Dev Investment Co INJECTOR
WO1993003780A1 (en) 1991-08-27 1993-03-04 Johnson Thomas R Injection syringe
WO1993007922A1 (en) 1991-10-18 1993-04-29 Novo Nordisk A/S Large dose pen
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5226342A (en) 1989-02-07 1993-07-13 Agence Spatiale Europeenne Linear or circular rachet-type locking device with automatic unlocking and self-locking
EP0554996A1 (en) 1992-02-04 1993-08-11 Becton, Dickinson and Company Medication delivery pen with improved dosage setting
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
JPH0634825A (en) 1992-07-20 1994-02-10 Shiyoudenshiya:Kk Optical fiber connection box
JPH0655644A (en) 1992-08-07 1994-03-01 Sekisui Chem Co Ltd Resin liquid spray nozzle for plate molded body manufacturing device
US5292976A (en) 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
EP0594349A1 (en) 1992-10-20 1994-04-27 Eli Lilly And Company Device to prevent refilling of a hypodermic syringe
FR2697434A1 (en) 1992-11-02 1994-05-06 Godillon Jean Francois Surgical syringe plunger withdrawal attachment - has lever and transmission member which allow plunger to be withdrawn with one hand, leaving other one free
US5314412A (en) 1991-04-17 1994-05-24 Novo Nordisk A S Manifold for a two barrel syringe
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
WO1994012228A1 (en) 1992-12-03 1994-06-09 A/S Dumex (Dumex Ltd.). A liquid dispenser
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
EP0615762A1 (en) 1993-03-15 1994-09-21 Eli Lilly And Company Dosing seringe
US5368572A (en) 1993-01-06 1994-11-29 Shirota Denki Rozai Kabushiki Kaisha Injection device for dental anesthetic or like
US5370629A (en) 1992-02-21 1994-12-06 Medimpex Ets. Injection device
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
JPH07502678A (en) 1992-10-15 1995-03-23 ザ　ゼネラル　ホスピタル　コーポレーション Infusion pump with electronically loadable drug library
US5408387A (en) 1991-11-30 1995-04-18 Meitaku System Co., Ltd. Edge light panel and its production
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
WO1995021645A1 (en) 1994-02-14 1995-08-17 Genentech, Inc. Self administered injection pen apparatus and method
US5447150A (en) 1990-12-01 1995-09-05 Norton Healthcare Limited Medicament dispensing device
WO1995024233A1 (en) 1994-03-09 1995-09-14 Castellano Thomas P Medication delivery device with a microprocessor and characteristic monitor
EP0673482A1 (en) 1992-12-18 1995-09-27 SAMS, Bernard Incrementing dosage mechanism
EP0679440A1 (en) 1994-04-27 1995-11-02 Eppendorf-Netheler-Hinz Gmbh Repeater pipette
DE4419235A1 (en) 1994-06-01 1995-12-07 Thomas Braeger Injection syringe
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5496286A (en) 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
WO1996007443A1 (en) 1994-09-08 1996-03-14 Owen Mumford Limited Improvements relating to injection devices
EP0702970A2 (en) 1994-09-19 1996-03-27 Becton, Dickinson and Company Medication delivery pen with variable increment dose scale
EP0704225A2 (en) 1994-09-28 1996-04-03 Becton, Dickinson and Company Retractable needle syringe
US5505697A (en) 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5505704A (en) 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
EP0708179A2 (en) 1994-10-18 1996-04-24 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
DE19503230A1 (en) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Syringe with a damping and pressure measuring device integrated in the piston and method for uniform and pressure-controlled injection by means of this syringe
US5546932A (en) 1992-03-25 1996-08-20 Tebro Sa Powder jet dispenser for medicament inhalation therapies
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
WO1996026754A2 (en) 1995-02-28 1996-09-06 Bernard Sams Incrementing mechanism in particular for use with a membral syringe
WO1996032973A1 (en) 1995-04-19 1996-10-24 Eli Lilly And Company Multi-cartridge medication injection device
WO1996038190A1 (en) 1995-06-02 1996-12-05 Novo Nordisk A/S Automatic withdrawal of piston rod
EP0747391A2 (en) 1995-06-07 1996-12-11 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (en) 1995-08-21 1997-01-02 Adamaszek, Franz-Heinz, 70193 Stuttgart Dosing and automatic injection system
US5591136A (en) 1991-04-15 1997-01-07 Medico Development Investment Company Injection device
US5599314A (en) 1992-09-19 1997-02-04 Hypoguard (Uk) Limited Syringe with incrementally actuated plunger
WO1997007841A2 (en) 1995-08-25 1997-03-06 Medrad, Inc. Front load pressure jacket system with syringe holder
US5611784A (en) 1993-06-30 1997-03-18 Hamilton Company Manual dispensing aid for a syringe
US5611783A (en) 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
WO1997010865A1 (en) 1995-09-19 1997-03-27 Becton Dickinson And Company Medication delivery pen with cap actuated dose delivery clutch
FR2740345A1 (en) 1995-10-26 1997-04-30 Neftel Frederic AUTOMATION DEVICE
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
JPH09166474A (en) 1995-12-19 1997-06-24 Omron Corp Residual-quantity sensor
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
GB2309644A (en) 1995-05-22 1997-08-06 Wolfgang Wagner Device for diagnosis/therapy of a metabolic disturbance
WO1997030742A1 (en) 1996-02-23 1997-08-28 Novo Nordisk A/S Syringe with electronic representation of parameters
US5662612A (en) 1993-11-24 1997-09-02 Liebel Flarsheim Company Controlling plunger drives for fluid injections in animals
WO1997033638A1 (en) 1996-03-12 1997-09-18 Novo Nordisk A/S Injection device with electronic presentation of set doses
WO1997034919A1 (en) 1996-03-15 1997-09-25 Novo Nordisk A/S Method for purification of a protein from a protein containing solution
WO1997036626A1 (en) 1996-04-02 1997-10-09 Disetronic Licensing Ag Injection device
US5679111A (en) 1993-04-30 1997-10-21 Pharmacia & Upjohn Aktiebolag Device for dosing a liquid preparation
US5685864A (en) 1993-11-22 1997-11-11 Interventional Research Technologies Locking device for aspirator, syringe or like instrument
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US5720733A (en) 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5728559A (en) 1993-07-09 1998-03-17 Novo Nordisk A/S Separation of proteins
WO1998010813A1 (en) 1996-09-13 1998-03-19 Novo Nordisk A/S Dose display for an injection syringe
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
RU2111019C1 (en) 1997-05-22 1998-05-20 Сергей Александрович Хворостов General-purpose injector
US5755692A (en) 1994-09-28 1998-05-26 Manicom; Anthony William Method and apparatus for administering a drug to a patient
US5782633A (en) 1996-04-10 1998-07-21 Muehlbauer; Ernst Applicator for a dental compound
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US5820602A (en) 1995-09-08 1998-10-13 Visionary Medical Products, Inc. Pen-type injector drive mechanism
US5823998A (en) 1994-08-24 1998-10-20 Eli Lilly Japan Kabushiki Kaisha Injection apparatus
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5830194A (en) 1996-09-20 1998-11-03 Azam Anwar Power syringe
EP0879610A2 (en) 1995-03-07 1998-11-25 Eli Lilly And Company Recyclable medication dispensing divice
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
WO1998056439A1 (en) 1997-06-09 1998-12-17 Novo Nordisk A/S A displacement device for controlled dispensing of a dose of a liquid contained in a cartridge
WO1998056436A1 (en) 1997-06-09 1998-12-17 Novo Nordisk A/S A dose setting mechanism and an injection syringe having such a dose setting mechanism
WO1998057688A1 (en) 1997-06-17 1998-12-23 Novo Nordisk A/S Dose setting device
DE19723647C1 (en) 1997-06-05 1998-12-24 Disetronic Licensing Ag Fluid dosing unit indicator for e.g. insulin or for pipetting laboratory fluids
WO1999007425A1 (en) 1997-08-06 1999-02-18 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
EP0897728A1 (en) 1997-08-11 1999-02-24 Becton Dickinson and Company Medication delivery pen
FR2767479A1 (en) 1997-08-22 1999-02-26 Aguettant Lab Medication injection syringe
US5879630A (en) 1996-03-04 1999-03-09 Motorola, Inc. Semiconductor chemical sensor device and method of forming a thermocouple for a semiconductor chemical sensor device
US5879360A (en) 1994-01-21 1999-03-09 The University Of Melbourne Syringe pumps
US5882718A (en) 1994-09-20 1999-03-16 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation and composition thereof
WO1999015214A1 (en) 1997-09-25 1999-04-01 Disetronic Licensing Ag Delivery device with a sensing unit
WO1999016487A1 (en) 1997-09-29 1999-04-08 Becton Dickinson And Company Disposable, pre-filled drug cartridge
EP0908273A2 (en) 1997-10-09 1999-04-14 Chicago Pneumatic Tool Company Ratchet wrench head
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
WO1999021598A1 (en) 1997-10-29 1999-05-06 Azam Anwar Power syringe
US5928201A (en) 1996-07-05 1999-07-27 Novo Nordisk A/S Dose setting device
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
WO1999038554A1 (en) 1998-01-30 1999-08-05 Novo Nordisk A/S An injection syringe
EP0937471A2 (en) 1998-02-20 1999-08-25 Becton Dickinson and Company Medication delivery pen
EP0937472A2 (en) 1998-02-20 1999-08-25 Becton Dickinson and Company Repeat-dose medication delivery pen
EP0937476A2 (en) 1998-02-23 1999-08-25 Becton, Dickinson and Company Low-cost medication delivery pen
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
US5951530A (en) 1996-04-24 1999-09-14 Novo Nordisk A/S Injection needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
WO1999048546A1 (en) 1998-03-23 1999-09-30 Elan Corporation, Plc Drug delivery device
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US5971963A (en) 1998-08-18 1999-10-26 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
US5980491A (en) 1996-07-05 1999-11-09 Novo Nordisk A/S Automatic needle insertion mechanism
US5984900A (en) 1991-11-29 1999-11-16 Novo Nordisk A/S Automatic pen-shaped syringe
EP0956873A2 (en) 1998-05-15 1999-11-17 Disetronic Licensing AG Automatic injection device
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US5998989A (en) 1993-12-22 1999-12-07 Itt Automotive Europe Gmbh Device including magnet-biased magnetoresistive sensor and rotatable, magnetized encoder for detecting rotary movements
WO1999065548A1 (en) 1998-06-15 1999-12-23 Medrad, Inc. Encoding of syringe information
US6010485A (en) 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
US6019745A (en) 1993-05-04 2000-02-01 Zeneca Limited Syringes and syringe pumps
JP3017167B2 (en) 1998-05-20 2000-03-06 インターナショナル・ビジネス・マシーンズ・コーポレイション Method and apparatus for binarizing a read signal from a data storage medium
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6033377A (en) 1997-02-04 2000-03-07 Novo Nordisk A/S Device for the administration of a liquid medicament suspension
US6036675A (en) 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
WO2000015224A1 (en) 1998-09-17 2000-03-23 Eli Lilly And Company Protein formulations
US6048336A (en) 1997-03-03 2000-04-11 Medico Injection device
DE19838760A1 (en) 1998-08-26 2000-04-20 Bauer Jlona Injection unit, especially for injecting medicines such as insulin, consists of a housing with a chamber for holding a needle, a cartridge and a release mechanism.
WO2000037098A1 (en) 1998-12-22 2000-06-29 Eli Lilly And Company Shelf-stable formulation of glucagon-like peptide-1
WO2000037129A1 (en) 1998-12-22 2000-06-29 Alcor Medical Instruments Method and device for monitoring fluid level
US6083197A (en) 1995-12-19 2000-07-04 Umbaugh; Jerald C. Spring-actuated needleless injector
CA2359375A1 (en) 1999-01-14 2000-07-20 B D Medico S.A.R.L. Injection device
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
JP2000237308A (en) 1999-02-22 2000-09-05 Ckd Corp Infusion pump
WO2000051668A1 (en) 1999-03-05 2000-09-08 Accumed Systems, Inc. High pressure syringe
US6129080A (en) 1997-01-27 2000-10-10 Medic-Aid Limited Atomizer
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US6161364A (en) 1996-08-02 2000-12-19 Scherring Aktiengesellschaft Terminal sterilization process for filled syringes under an auxiliary pressure
EP1074273A1 (en) 1999-08-06 2001-02-07 Becton Dickinson and Company Improved medication delivery pen
WO2001010484A1 (en) 1999-08-05 2001-02-15 Becton, Dickinson And Company Medication delivery pen
US6193698B1 (en) 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
WO2001019434A1 (en) 1999-09-16 2001-03-22 Novo Nordisk A/S Dose setting limiter
WO2001026710A2 (en) 1999-10-12 2001-04-19 Novo Nordisk A/S Air shot mechanism for electronic injection devices
EP1095668A1 (en) 1999-11-01 2001-05-02 Becton Dickinson and Company Electronic medication delivery pen having a multifunction actuator
WO2001030425A1 (en) 1999-10-22 2001-05-03 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6231540B1 (en) 1997-07-14 2001-05-15 Novo Nordisk A/S Injection member
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
US6268722B1 (en) 1998-03-17 2001-07-31 Unisia Jecs Corporation Rotation angle sensor having improved magnetic leakage effect prevention and reduction in parts
US6277097B1 (en) 1997-03-25 2001-08-21 Novo Nordisk A/S Injection system
US20010016571A1 (en) 1996-03-13 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. N-[ (R) -1-{3- (4- piperidyl) propionyl } -3-piperidylcarbonyl] -2 (S) -acetylamino-beta -alanine as fibrinogen receptor antagonist
DE10103287A1 (en) 2000-02-16 2001-08-23 B D Medico Gmbh Mies Unit for reconstitution of injection liquids and their subsequent injection comprises a slidable stop and an element which is slidable relative to this stop and is attached to the piston of the unit
US6281225B1 (en) 1998-06-11 2001-08-28 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
US6283941B1 (en) 1994-02-14 2001-09-04 Univec Inc. Single-use syringe with aspirating mechanism
US6287283B1 (en) 1997-07-11 2001-09-11 Novo Nordisk A/S Apparatus for the registration of the setting of a medical device
WO2001072361A1 (en) 2000-03-24 2001-10-04 Bernard Sams One-way clutch mechanisms and injector devices
US6302869B1 (en) 1996-07-05 2001-10-16 Novo Nordisk A/S Syringe having a flexible piston rod
US20010034506A1 (en) 1998-06-15 2001-10-25 Hirschman Alan D. Encoding of syringe information
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
WO2001095959A1 (en) 2000-06-16 2001-12-20 Novo Nordisk A/S An injection device with a gearbox
US20010053893A1 (en) 2000-05-18 2001-12-20 Andre Larsen Injection device
US20020002354A1 (en) 2000-04-15 2002-01-03 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Syringe for medical purposes
US20020002326A1 (en) 1998-08-18 2002-01-03 Causey James D. Handheld personal data assistant (PDA) with a medical device and method of using the same
US20020007154A1 (en) 2000-05-04 2002-01-17 Steffen Hansen Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
WO2002005876A2 (en) 2000-07-14 2002-01-24 Novo Nordisk A/S A liquid medication delivery device and a method of delivering an intended dose
US20020020654A1 (en) 2000-08-10 2002-02-21 Michael Eilersen Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
WO2002024257A1 (en) 2000-09-22 2002-03-28 Novo Nordisk A/S A medication delivery device
US20020049415A1 (en) 2000-10-03 2002-04-25 Nemoto Kyorindo Co., Ltd. Automatic injection device
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US6383167B2 (en) 1996-04-02 2002-05-07 Disetronic Licensing Ag Injection device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
EP1216719A1 (en) 2000-12-21 2002-06-26 Lin Wang Safety syringe
EP1216717A1 (en) 2000-12-21 2002-06-26 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
WO2002050214A2 (en) 2000-12-21 2002-06-27 Future Energy Resources Corporation Biomass gasification system and method
WO2002053214A1 (en) 2001-01-05 2002-07-11 Novo Nordisk A/S Automatic injection device with reset feature
US6419661B1 (en) 1999-03-05 2002-07-16 Roche Diagnostics Gmbh Device for withdrawing blood for diagnostic applications
US20020107486A1 (en) 2000-10-05 2002-08-08 Munk Jens Aage Medication delivery system with improved dose accuracy
WO2002064196A1 (en) 2001-02-14 2002-08-22 Novo Nordisk A/S Electronically controlled injection or infusion device
WO2002076536A1 (en) 2001-03-27 2002-10-03 Dca Design International Limited Improvements in and relating to an injection device
WO2002076535A1 (en) 2001-03-27 2002-10-03 Dca Design International Limited Improvements in and relating to an injection device
WO2002076537A1 (en) 2001-03-27 2002-10-03 Dca Design International Limited Improvements in and relating to an injection device
US20020165500A1 (en) 1994-05-30 2002-11-07 Herbert Bechtold Injection device
WO2002092153A2 (en) 2001-05-16 2002-11-21 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
US20020188250A1 (en) 2001-06-08 2002-12-12 Sergio Landau Durable hypodermic jet injector apparatus and method
US20030009133A1 (en) 2001-04-13 2003-01-09 Kirk Ramey Drive system for an infusion pump
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US20030039679A1 (en) 1998-02-13 2003-02-27 Duirs Graham Francois Drug delivery system
US20030040715A1 (en) 2001-08-21 2003-02-27 D'antonio Nicholas F. Hypodermic jet injection kit
US6537251B2 (en) 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6547755B1 (en) 1997-08-06 2003-04-15 Pharmacia Ab Automated delivery device and method for its operation
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US20030073954A1 (en) 2000-03-29 2003-04-17 Minimed Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
DE20209051U1 (en) 2001-12-21 2003-04-24 Disetronic Licensing Ag, Burgdorf Medicament administration device has dosage adjuster mounted on piston rod and end stop mounted at end of its path, locking system preventing adjuster from rotating and pressing against stop
US6562011B1 (en) 1998-07-08 2003-05-13 Novo Nordisk A/S Medication delivery device
DE10201875C1 (en) 2002-01-18 2003-05-22 Austriamicrosystems Ag Magnetic or electrical field sensor system has modulators with non-inverting and inverting conditions providing for different sensor configurations
US6569126B1 (en) 1997-07-14 2003-05-27 Novo Nordisk A/S Cylinder ampoule
US20030114800A1 (en) 2001-12-18 2003-06-19 Dca Design International Limited Medicament injection apparatus
WO2003057286A1 (en) 2001-12-13 2003-07-17 Matsushita Electric Industrial Co., Ltd. Administration instrument for medical use
WO2003057283A1 (en) 2002-01-12 2003-07-17 Dca Design International Limited Improvements in and relating to medicament injection apparatus
WO2003057285A2 (en) 2002-01-10 2003-07-17 Owen Mumford Limited Improvements relating to medical injection devices
US6599272B1 (en) 1999-05-12 2003-07-29 Pharmacia Ab Injection device and method for its operation
WO2003063680A2 (en) 2002-01-25 2003-08-07 Inotech Medical Systems, Inc. Tissue monitoring system for intravascular infusion
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
US20030176871A1 (en) 2000-08-10 2003-09-18 Paul Pavlov Device for the introduction of medical items
US20030172924A1 (en) 2002-03-07 2003-09-18 Staniforth John Nicholas Medicament storage and delivery devices
RU2212254C2 (en) 1999-01-12 2003-09-20 Дизетроник Лайсенсинг Аг Device for administering injection product
WO2003080160A1 (en) 2002-03-18 2003-10-02 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
JP2003284777A (en) 2002-03-28 2003-10-07 Suugan Kk Medical tube open and close device
WO2003099357A1 (en) 2002-05-24 2003-12-04 Eli Lilly And Company Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
US20030233075A1 (en) 2002-06-14 2003-12-18 Serge Huegli Piston stopper for injection device, product container and injection device
US6666849B1 (en) 1998-06-11 2003-12-23 Owen Munford Limited Dose setting device for medical injectors
US6673033B1 (en) 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
WO2004002556A1 (en) 2002-06-28 2004-01-08 Tecpharma Licensing Ag Product distribution device with rapid piston rod resetting
WO2004004825A2 (en) 2002-07-04 2004-01-15 Inovio As Electroporation device and injection apparatus
US20040010204A1 (en) 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
WO2004007002A1 (en) 2002-07-10 2004-01-22 Novo Nordisk A/S An injection device
US20040024361A1 (en) 2002-08-02 2004-02-05 Mallinckrodt Inc. Injector
US20040054326A1 (en) 2002-08-30 2004-03-18 Edgar Hommann Device for controlled delivery of an injectable liquid
DE10237258A1 (en) 2002-08-14 2004-03-18 Disetronic Licensing Ag injection device
US20040051368A1 (en) 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
WO2004024218A1 (en) 2002-08-30 2004-03-25 Disetronic Licensing Ag Device for the dosed discharge of a liquid agent and infusion pump
WO2004028598A1 (en) 2002-09-24 2004-04-08 Shl Medical Ab Injecting device
WO2004035113A2 (en) 2002-10-15 2004-04-29 Eli Lilly And Company Medication dispensing apparatus with squeezable actuator
US20040108339A1 (en) 2002-08-29 2004-06-10 Hansen Michael Ejstrup Frontloaded injection device
US6752798B2 (en) 2000-07-28 2004-06-22 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
WO2004054644A1 (en) 2002-12-17 2004-07-01 Safe-T Limited Hollow needle applicators
US20040158304A1 (en) 2000-11-24 2004-08-12 Ckm Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
US20040171983A1 (en) 2003-02-24 2004-09-02 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
WO2004078239A1 (en) 2003-03-03 2004-09-16 Dca Design International Ltd. Drive mechanish for drug delivery devices
WO2004078242A2 (en) 2003-03-03 2004-09-16 Dca Design International Ltd. Improvements in and relating to a pen-type injector
US20040186431A1 (en) 2001-07-30 2004-09-23 Roney Graf Administering apparatus comprising a dosing device
WO2004080306A1 (en) 2003-03-06 2004-09-23 Lifescan, Inc. System and method for piercing dermal tissue
US20040199117A1 (en) 2003-04-03 2004-10-07 Becton, Dickinson And Company Medication delivery pen
WO2004084795A1 (en) 2003-03-24 2004-10-07 Novo Nordisk A/S Transparent electronic marking of a medication cartridge
US20040207385A1 (en) 2001-07-09 2004-10-21 Simone Gafner Position detection
WO2004095379A1 (en) 2003-04-23 2004-11-04 Vasogen Ireland Limited Dispensing systems
JP2004533285A (en) 2001-03-27 2004-11-04 ディーシーエー デザイン インターナショナル リミテッド Drive mechanism for injection device
US20040230157A1 (en) 2003-05-16 2004-11-18 Perry Stephen J. Fluid delivery system and related methods of use
US20040236282A1 (en) 2001-06-07 2004-11-25 Philip Braithwaite Unit dosage powder container
US20040249348A1 (en) 2003-03-22 2004-12-09 Steven Wimpenny Dose dial and drive mechanisms suitable for use in drug delivery devices
US20040260247A1 (en) 2003-03-03 2004-12-23 Robert Frederick Veasey Drive mechanisms suitable for use in drug delivery devices
US20050004529A1 (en) 2003-04-10 2005-01-06 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
FR2857654A1 (en) 2003-07-16 2005-01-21 Prodonta Ejector for liquid or paste product e.g. for medical use has through bore containing toothed thrust cylinder actuated by lever and pawls
US20050019400A1 (en) 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US6852404B2 (en) 2002-03-29 2005-02-08 Tdk Corporation Magnetic recording medium
WO2005018721A1 (en) 2003-08-12 2005-03-03 Eli Lilly And Company Medication dispensing apparatus with triple screw threads for mechanical advantage
DE20317377U1 (en) 2003-11-03 2005-03-17 B D Medico S A R L injection device
WO2005037352A2 (en) 2003-10-16 2005-04-28 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
US6887238B2 (en) 2000-04-27 2005-05-03 Medtronic, Inc. Suction stabilized epicardial ablation devices
DK200500116U1 (en) 2005-05-23 2005-06-10 Novo Nordisk As Motor-powered injection apparatus
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism
EP1557163A1 (en) 2002-09-26 2005-07-27 Japan Science and Technology Agency Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
WO2005089835A1 (en) 2004-03-18 2005-09-29 Smiths Group Plc Infusion apparatus comprising radio-frequency readable coded markers
WO2005097240A1 (en) 2004-03-30 2005-10-20 Eli Lilly And Company Medication dispensing apparatus with gear set having drive member accommodating opening
WO2005097233A2 (en) 2004-03-30 2005-10-20 Eli Lilly And Company Medication dispensing apparatus with spring-driven locking feature enabled by administration of final dose
WO2005102421A1 (en) 2004-04-23 2005-11-03 Tecpharma Licensing Ag Injection device comprising a dosing unit with multiple anti-twist protection
US20050268915A1 (en) 2004-06-07 2005-12-08 Willem Wassenaar Nasal adaptation of an oral inhaler device
WO2006003130A1 (en) 2004-07-05 2006-01-12 Novo Nordisk A/S A credit card sized injection device
WO2006026754A2 (en) 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
DE102004046003A1 (en) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmaceutical package, as a syringe or vial or capsule, has an integrated microchip and antenna to give a unique and tamper-proof identity
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
WO2006037434A1 (en) 2004-10-04 2006-04-13 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
WO2006039930A1 (en) 2004-10-14 2006-04-20 Novo Nordisk A/S Syringe with dosis mechanism
WO2006045529A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with internal dose indicator
WO2006045525A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with a processor for collecting ejection information
WO2006045425A1 (en) 2004-10-25 2006-05-04 Componenti Vending S.P.A. Selector, particularly but not exclusively, for beverage vending machines
WO2006045528A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with torsion spring and rotatable display
WO2006045526A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Dial-down mechanism for wind-up pen
WO2006069454A1 (en) 2004-12-31 2006-07-06 Tecpharma Licensing Ag Device for the dosed administration of a fluid product, provided with decoupling means for the replacement of a container
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
WO2006076921A1 (en) 2005-01-21 2006-07-27 Novo Nordisk A/S An automatic injection device with a top release mechanism
US7104972B2 (en) 2002-07-10 2006-09-12 Novo Nordisk A/S Injection device with a dose setting limiter
JP2006250582A (en) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd Rfid tag with load sensor
US7133329B2 (en) 2002-07-23 2006-11-07 Novo Nordisk A/S Device with time indicating means
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
EP1723977A1 (en) 2004-03-03 2006-11-22 Nemoto Kyorindo Co., Ltd. Medical solution injection system
EP1728529A1 (en) 2005-06-01 2006-12-06 SHL Medical AB Device for delivering medicament
WO2006128794A2 (en) 2005-05-31 2006-12-07 Novo Nordisk A/S Injection device with visual end-of-content indication
WO2007021195A1 (en) 2005-08-18 2007-02-22 Rolls-Royce Marine As System to guide a wire, chain, cable etc., onboard a vessel
WO2007030957A1 (en) 2005-09-14 2007-03-22 Tecpharma Licensing Ag Injection device with two-way slip clutch
WO2007041843A1 (en) 2005-10-11 2007-04-19 Podaima Blake Smart medical compliance method and system
EP1782853A1 (en) 2004-07-14 2007-05-09 Nemoto Kyorindo Co., Ltd. Medical liquid injection system
WO2007063342A1 (en) 2005-12-02 2007-06-07 Owen Mumford Limited Injection method and apparatus
US20070167916A1 (en) 2006-01-16 2007-07-19 Linfair Engineering (Hk) Co., Ltd. Outer barrel for a syringe
WO2007104636A1 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
WO2007107558A2 (en) 2006-03-20 2007-09-27 Novo Nordisk A/S Determination of cartridge content by capacitive means
WO2007107561A2 (en) 2006-03-20 2007-09-27 Novo Nordisk A/S Determination of position of injection needle
US20070265568A1 (en) 2004-11-04 2007-11-15 Izrail Tsals Automatic Injector
WO2007134954A1 (en) 2006-05-18 2007-11-29 Novo Nordisk A/S An injection device with mode locking means
WO2008003130A1 (en) 2006-07-05 2008-01-10 Kaliopi Papantoniou A method and composition for treating the scalp
WO2008031239A1 (en) 2006-09-15 2008-03-20 Tecpharma Licensing Ag Injection device comprising several coupling mechanisms
WO2008037801A1 (en) 2006-09-29 2008-04-03 Novo Nordisk A/S An injection device with electronic detecting means
EP1909871A1 (en) 2005-07-27 2008-04-16 Novo Nordisk A/S Syringe device with a dose limiting mechanism and an additional safety mechanism
WO2008057223A2 (en) 2006-10-26 2008-05-15 Mallinckrodt Inc. Medical fluid injector having a thermo-mechanical drive
JP2008196696A (en) 2007-02-14 2008-08-28 Shimano Inc Multi-stage internal transmission hub assembly for bicycle
US20080221530A1 (en) 2005-04-24 2008-09-11 Novo Nordisk A/S Injection Device With A GearBox
EP2000161A1 (en) 2007-06-06 2008-12-10 Mallinckrodt, Inc. Medical fluid injector having wireless pressure monitoring feature
US20080312592A1 (en) 2004-05-28 2008-12-18 Tim Barrow-Williams Injection Device
EP2019701A1 (en) 2006-05-16 2009-02-04 Novo Nordisk A/S A gearing mechanism for an injection device
US20090043264A1 (en) 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
US20090062748A1 (en) 2006-03-10 2009-03-05 Novo Nordisk A/S Injection Device Having a Gearing Arrangement
WO2010046394A1 (en) 2008-10-24 2010-04-29 Novo Nordisk A/S Dial-down mechanism for wind-up pen
JP2010523183A (en) 2007-04-05 2010-07-15 テクファーマ・ライセンシング・アクチェンゲゼルシャフト Method of administering a liquid reactive substance from a multi-chamber ampoule
WO2010089418A2 (en) 2009-10-30 2010-08-12 Copernicus Sp. Z O.O. Automatic applicator for liquid pharmaceutical preparations, particularly for insulin
US20110046565A1 (en) 2008-01-23 2011-02-24 Novo Nordisk A/S Device for injecting apportioned doses of liquid drug
WO2011025448A1 (en) 2009-08-24 2011-03-03 Shl Group Ab Dose reset mechanism
US20110125100A1 (en) 2008-06-16 2011-05-26 Pharma Consult Ges.M.B.H. & Co Nfg Kg Injection device
PL208660B1 (en) 2005-05-25 2011-05-31 Kappa Medilab Społka Z Ograniczoną Odpowiedzialnością Automatic applicator, particularly for application of the insulin
WO2011136718A1 (en) 2010-04-26 2011-11-03 Shl Group Ab Medicament delivery device
US20130204197A1 (en) 2010-10-12 2013-08-08 Owen Mumford Limited Needle shield arrangement
US20130274676A1 (en) 2010-10-08 2013-10-17 Sanofi-Aventis Deutschland Gmbh Auto-injector with a torsion spring
WO2013178372A1 (en) 2012-05-31 2013-12-05 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US20140350478A1 (en) 2011-12-29 2014-11-27 Novo Nordisk A/S Torsion-Spring Based Wind-Up Auto Injector Pen with Dial-Up/Dial-Down Mechanism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5404380A (en) * 1992-08-25 1995-04-04 Alcatel Network Systems, Inc. Desynchronizer for adjusting the read data rate of payload data received over a digital communication network transmitting payload data within frames

Patent Citations (573)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US854390A (en) 1906-08-16 1907-05-21 Twitchell Co S Apparatus for carbonating liquids.
GB574705A (en) 1940-04-26 1946-01-17 Boulton Aircraft Ltd Improvements in and relating to machine guns
US2392196A (en) 1945-02-24 1946-01-01 Arthur E Smith Syringe
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3144178A (en) 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3556099A (en) 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3729003A (en) 1971-02-11 1973-04-24 Ampoules Inc Variable dosage ampoule applicator
US3944843A (en) 1973-03-09 1976-03-16 Filinto Vaz Martins Impedance responsive touch actuated circuit
US3880162A (en) 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
US4634431A (en) 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
US4231368A (en) 1978-03-23 1980-11-04 Michael Becker Device for intramuscular injections, especially of insulin
US4430079A (en) 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
EP0017318A1 (en) 1979-02-12 1980-10-15 American Hospital Supply Corporation Capacitive switching circuit for energizing remote controlled device
US4300554A (en) 1979-02-22 1981-11-17 Intermedicat Gmbh Portable infusion apparatus
EP0015617A1 (en) 1979-03-06 1980-09-17 Stamicarbon B.V. Device for mixing two fluids
USRE31315E (en) 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
US4275727A (en) 1980-01-07 1981-06-30 Keeri Szanto Michael Device for monitoring and controlling self-administered intravenous drug dosage
US4275727B1 (en) 1980-01-07 1985-11-05
US4368731A (en) 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4313439A (en) 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
JPS56163486A (en) 1980-05-21 1981-12-16 Citizen Watch Co Ltd Electronic timepiece
JPS5733A (en) 1980-05-28 1982-01-05 Sanyo Electric Co Charger for battery
DE3048135A1 (en) 1980-12-19 1982-07-15 Imed Corp., 92131 San Diego, Calif. Intravenous liquid administration by pump - with external pressure sensing cartridge regulating discharge pressure
GB2091107A (en) 1981-01-15 1982-07-28 Colombo Americo Dental syringe
SU1528330A3 (en) 1981-02-12 1989-12-07 Turner Robert Charles Metering device to syringe
US4498904A (en) 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
EP0064858A1 (en) 1981-05-07 1982-11-17 Merck & Co. Inc. Dose adjustable delivery system for semi-solid medicaments
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4470317A (en) 1982-02-06 1984-09-11 Eppendorf Geratebau Netheler & Hinz Gmbh Pipetting device
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
DE3236374A1 (en) 1982-10-01 1984-04-05 Brown, Boveri & Cie Ag, 6800 Mannheim Security paper
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
US4493704A (en) 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
JPH0135671B2 (en) 1982-11-29 1989-07-26 Terumo Corp
US4585439A (en) 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
WO1985002256A1 (en) 1983-11-15 1985-05-23 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4749109A (en) 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4584439A (en) 1983-12-01 1986-04-22 Floating Membranes, Inc. Audio transducer with controlled flexibility diaphragm
GB2153445A (en) 1984-01-25 1985-08-21 Fernandez Tresguerres Hernande Delivery and dosage device
US4676122A (en) 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
US4871351A (en) 1984-09-28 1989-10-03 Vladimir Feingold Implantable medication infusion system
US4812724A (en) 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
FR2583291A1 (en) 1985-06-14 1986-12-19 Hazon Bernard Device for step-by-step advance of syringe plungers by means of a double coaxial screw with control of the injection rate. Application to repetitive intradermic medicinal injections
US4883472A (en) 1985-11-08 1989-11-28 Disetronic Ag. Injection device
WO1987002895A1 (en) 1985-11-08 1987-05-21 Disetronic Ag Injection instrument
DE3609555A1 (en) 1986-03-21 1987-09-24 Josef Porner Blood-collecting syringe
US5114406A (en) 1986-11-14 1992-05-19 Wilhelm Haselmeier Gmbh & Co. Injection device for injection, especially self-administered injection, of medicament, including mechanisms for nulling and for selecting dosage, especially for use with multi-dose ampules
DE3638984A1 (en) 1986-11-14 1988-05-26 Haselmeier Wilhelm Fa Injection appliance
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US4950246A (en) 1987-05-08 1990-08-21 Spruyt-Hillen B.V. Injection pen
EP0295075A1 (en) 1987-06-12 1988-12-14 Hypoguard (Uk) Limited Measured dose syringe
US4936833A (en) 1987-06-12 1990-06-26 Hypoguard (Uk) Limited Cartridge-holder assembly for medication dispensing unit
US4865591A (en) 1987-06-12 1989-09-12 Hypoguard (Uk) Limited Measured dose dispensing device
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
US4893291A (en) 1987-08-29 1990-01-09 Jet-R Limited Devices for aiding resynchronization of body clocks
JPH01100495A (en) 1987-10-13 1989-04-18 Seiko Epson Corp Stopwatch
FR2622457A1 (en) 1987-11-03 1989-05-05 Piccinali Eric Mesotherapeutic injector with microprocessor
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
US5112317A (en) 1988-01-22 1992-05-12 Nosta Ag Injection device
US4898578A (en) 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
EP0327810A2 (en) 1988-02-09 1989-08-16 WEGU Gummi- und Kunststoffwerke Walter Dräbing KG Rubber bearing for springs, axles and similar parts of motor vehicles
WO1989007463A1 (en) 1988-02-10 1989-08-24 D.C.P. Af 1988 A/S A dosage unit for dosing a number of measured quantities of a liquid, such as an insulin preparation, from a cartridge
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
EP0327910A2 (en) 1988-02-10 1989-08-16 D.C.P. Af 1988 A/S A dosage unit for dosing a number of measured quantities of a liquid, such as an insulin preparation, from a cartridge
JPH0271758A (en) 1988-04-18 1990-03-12 Turner Robert Charles Syringe
US5104380A (en) 1988-04-18 1992-04-14 Robert Charles Turner Syringe with dose metering device
EP0338806A2 (en) 1988-04-18 1989-10-25 Turner, Robert Charles Syringes
US4988337A (en) 1988-08-10 1991-01-29 Terumo Kabushiki Kaisha Syringe pump apparatus
EP0362484A2 (en) 1988-10-05 1990-04-11 B. Braun Melsungen AG Injection device
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
JPH02126184A (en) 1988-11-04 1990-05-15 Casio Comput Co Ltd Stop watch device
JPH02182267A (en) 1989-01-06 1990-07-16 Oriental Kiden Kk Drip monitor apparatus
US5226342A (en) 1989-02-07 1993-07-13 Agence Spatiale Europeenne Linear or circular rachet-type locking device with automatic unlocking and self-locking
WO1990009202A1 (en) 1989-02-14 1990-08-23 Novo Nordisk A/S Injection pen
US5244461A (en) 1989-03-10 1993-09-14 Graseby Medical Limited Infusion pump with occlusion sensitive shutoff
GB2229497A (en) 1989-03-10 1990-09-26 Graseby Medical Ltd Infusion pump safety device
EP0387854A2 (en) 1989-03-17 1990-09-19 Siemens Aktiengesellschaft Circuit arrangement and device for the contactless setting of a target value for an integrated circuit enveloped by a non-magnetic material
US4924737A (en) 1989-03-20 1990-05-15 Gummow Tool Company Positive drive ratchet
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5308340A (en) 1989-06-05 1994-05-03 Eli Lilly And Company Multiple dose injection pen
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
DE3923079A1 (en) 1989-07-13 1991-01-24 Fresenius Ag Measuring level of electrically conducting liquid - has measuring of infusion liquid or blood from change in capacitance of electrodes in measurement liquid
US5011479A (en) 1989-10-06 1991-04-30 Son Le Cover and connector for hypodermic needle
EP0422482A2 (en) 1989-10-07 1991-04-17 KG CATTS GESELLSCHAFT FÜR ERKENNUNGS- & SICHERHEITSTECHNOLOGIE MBH & CO. Coding device for ulteriorly coding electrically conductive code arrangements
US5000744A (en) 1989-10-23 1991-03-19 Gte Products Corporation Hypodermic syringe
US5002537A (en) 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US5122317A (en) 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
WO1991010677A1 (en) 1990-01-18 1991-07-25 Basf Aktiengesellschaft Process for enriching or cleaning biomolecules
EP0513128A1 (en) 1990-01-22 1992-11-19 Novo Nordisk As Apparatus for mixing and injecting a medicine.
WO1991010460A1 (en) 1990-01-22 1991-07-25 Novo Nordisk A/S A process and apparatus for mixing and injecting a medicine
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
US4998922A (en) 1990-02-23 1991-03-12 Kuracina Thomas C Safety syringe cap minimizing needle-stick probability
US5304152A (en) 1990-03-29 1994-04-19 Bernard Sams Dispensing device
WO1991014467A1 (en) 1990-03-29 1991-10-03 Bernard Sams Dispensing device
JPH04507059A (en) 1990-03-29 1992-12-10 サムス，バーナード distribution device
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5295976A (en) 1990-04-04 1994-03-22 Eli Lilly And Company Dose indicating injection pen
JPH04224764A (en) 1990-04-04 1992-08-14 Eli Lilly & Co Injector
EP0454331A1 (en) 1990-04-16 1991-10-30 Minimed Inc., doing business as Minimed Technologies Infusionssystem für die Medikation
US5104388A (en) 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5154698A (en) 1990-10-19 1992-10-13 Patrizio Compagnucci Single use syringe incorporating a sliding protection cap for the needle
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
US5447150A (en) 1990-12-01 1995-09-05 Norton Healthcare Limited Medicament dispensing device
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
EP0498737A1 (en) 1991-02-07 1992-08-12 Terumo Kabushiki Kaisha Dosing means for an injector
JPH04256757A (en) 1991-02-07 1992-09-11 Terumo Corp Quantitative dispenser
US5078698A (en) 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5176646A (en) 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
US5591136A (en) 1991-04-15 1997-01-07 Medico Development Investment Company Injection device
US5314412A (en) 1991-04-17 1994-05-24 Novo Nordisk A S Manifold for a two barrel syringe
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
WO1993001573A1 (en) 1991-07-02 1993-01-21 Mallinckrodt Medical, Inc. Syringe pressure monitor
DE4223958A1 (en) 1991-07-24 1993-01-28 Medico Dev Investment Co INJECTOR
US5480387A (en) 1991-07-24 1996-01-02 Medico Development Investment Company Injection device
WO1993003780A1 (en) 1991-08-27 1993-03-04 Johnson Thomas R Injection syringe
US5626566A (en) 1991-10-18 1997-05-06 Novo Nordisk A/S Large dose pen
RU2091087C1 (en) 1991-10-18 1997-09-27 Ново Нордиск А/С Pencil-shaped syringe for large medication doses
JPH07500039A (en) 1991-10-18 1995-01-05 ノボ　ノルディスク　アクティーゼルスカブ pen-shaped syringe
WO1993007922A1 (en) 1991-10-18 1993-04-29 Novo Nordisk A/S Large dose pen
EP0608343A1 (en) 1991-10-18 1994-08-03 Novo Nordisk A/S Large dose pen
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
US5611783A (en) 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
US5984900A (en) 1991-11-29 1999-11-16 Novo Nordisk A/S Automatic pen-shaped syringe
US5408387A (en) 1991-11-30 1995-04-18 Meitaku System Co., Ltd. Edge light panel and its production
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5445606A (en) 1991-12-11 1995-08-29 Alza Corporation Indicator for iontophoresis system
EP0554995A1 (en) 1992-02-04 1993-08-11 Becton, Dickinson and Company Reusable medication delivery pen
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
EP0554996A1 (en) 1992-02-04 1993-08-11 Becton, Dickinson and Company Medication delivery pen with improved dosage setting
US5279585A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
JPH05337179A (en) 1992-02-04 1993-12-21 Becton Dickinson & Co Pen type medication device with improved medicating function
US5370629A (en) 1992-02-21 1994-12-06 Medimpex Ets. Injection device
US5546932A (en) 1992-03-25 1996-08-20 Tebro Sa Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
JPH0634825A (en) 1992-07-20 1994-02-10 Shiyoudenshiya:Kk Optical fiber connection box
JPH0655644A (en) 1992-08-07 1994-03-01 Sekisui Chem Co Ltd Resin liquid spray nozzle for plate molded body manufacturing device
US5599314A (en) 1992-09-19 1997-02-04 Hypoguard (Uk) Limited Syringe with incrementally actuated plunger
US20020077852A1 (en) 1992-10-15 2002-06-20 The General Hospital, Massachusetts Corporation Infusion pump with an electronically loadable drug library and a user interface for loading the library
JPH07502678A (en) 1992-10-15 1995-03-23 ザ　ゼネラル　ホスピタル　コーポレーション Infusion pump with electronically loadable drug library
US6269340B1 (en) 1992-10-15 2001-07-31 The General Hospital Infusion pump with an electronically loadable drug library and a user interface for loading the library
US5681285A (en) 1992-10-15 1997-10-28 Baxter International Inc. Infusion pump with an electronically loadable drug library and a user interface for loading the library
EP0594349A1 (en) 1992-10-20 1994-04-27 Eli Lilly And Company Device to prevent refilling of a hypodermic syringe
FR2697434A1 (en) 1992-11-02 1994-05-06 Godillon Jean Francois Surgical syringe plunger withdrawal attachment - has lever and transmission member which allow plunger to be withdrawn with one hand, leaving other one free
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
WO1994012228A1 (en) 1992-12-03 1994-06-09 A/S Dumex (Dumex Ltd.). A liquid dispenser
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
EP0673482A1 (en) 1992-12-18 1995-09-27 SAMS, Bernard Incrementing dosage mechanism
US5743889A (en) 1992-12-18 1998-04-28 Sams; Bernard Incrementing dosage mechanism for syringe
US5368572A (en) 1993-01-06 1994-11-29 Shirota Denki Rozai Kabushiki Kaisha Injection device for dental anesthetic or like
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
JPH06296691A (en) 1993-03-15 1994-10-25 Eli Lilly & Co Injection device and method for resetting injection set amount
EP0615762A1 (en) 1993-03-15 1994-09-21 Eli Lilly And Company Dosing seringe
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
US5505704A (en) 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
US5292976A (en) 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
US5679111A (en) 1993-04-30 1997-10-21 Pharmacia & Upjohn Aktiebolag Device for dosing a liquid preparation
US6019745A (en) 1993-05-04 2000-02-01 Zeneca Limited Syringes and syringe pumps
US5611784A (en) 1993-06-30 1997-03-18 Hamilton Company Manual dispensing aid for a syringe
US5728559A (en) 1993-07-09 1998-03-17 Novo Nordisk A/S Separation of proteins
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
US5685864A (en) 1993-11-22 1997-11-11 Interventional Research Technologies Locking device for aspirator, syringe or like instrument
US5662612A (en) 1993-11-24 1997-09-02 Liebel Flarsheim Company Controlling plunger drives for fluid injections in animals
US5998989A (en) 1993-12-22 1999-12-07 Itt Automotive Europe Gmbh Device including magnet-biased magnetoresistive sensor and rotatable, magnetized encoder for detecting rotary movements
US5505697A (en) 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5879360A (en) 1994-01-21 1999-03-09 The University Of Melbourne Syringe pumps
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5514097A (en) 1994-02-14 1996-05-07 Genentech, Inc. Self administered injection pen apparatus and method
WO1995021645A1 (en) 1994-02-14 1995-08-17 Genentech, Inc. Self administered injection pen apparatus and method
US6283941B1 (en) 1994-02-14 2001-09-04 Univec Inc. Single-use syringe with aspirating mechanism
WO1995024233A1 (en) 1994-03-09 1995-09-14 Castellano Thomas P Medication delivery device with a microprocessor and characteristic monitor
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5593390A (en) 1994-03-09 1997-01-14 Visionary Medical Products, Inc. Medication delivery device with a microprocessor and characteristic monitor
US5728074A (en) 1994-03-09 1998-03-17 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5573729A (en) 1994-04-27 1996-11-12 Eppendorf-Netheler-Hinz Gmbh Repetition pipette
EP0679440A1 (en) 1994-04-27 1995-11-02 Eppendorf-Netheler-Hinz Gmbh Repeater pipette
US20020165500A1 (en) 1994-05-30 2002-11-07 Herbert Bechtold Injection device
DE4419235A1 (en) 1994-06-01 1995-12-07 Thomas Braeger Injection syringe
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5720733A (en) 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5496286A (en) 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
US5823998A (en) 1994-08-24 1998-10-20 Eli Lilly Japan Kabushiki Kaisha Injection apparatus
WO1996007443A1 (en) 1994-09-08 1996-03-14 Owen Mumford Limited Improvements relating to injection devices
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
EP0702970A2 (en) 1994-09-19 1996-03-27 Becton, Dickinson and Company Medication delivery pen with variable increment dose scale
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
US5882718A (en) 1994-09-20 1999-03-16 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation and composition thereof
US5755692A (en) 1994-09-28 1998-05-26 Manicom; Anthony William Method and apparatus for administering a drug to a patient
EP0704225A2 (en) 1994-09-28 1996-04-03 Becton, Dickinson and Company Retractable needle syringe
EP0708179A2 (en) 1994-10-18 1996-04-24 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
DE19503230A1 (en) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Syringe with a damping and pressure measuring device integrated in the piston and method for uniform and pressure-controlled injection by means of this syringe
WO1996026754A2 (en) 1995-02-28 1996-09-06 Bernard Sams Incrementing mechanism in particular for use with a membral syringe
EP0879610A2 (en) 1995-03-07 1998-11-25 Eli Lilly And Company Recyclable medication dispensing divice
US6221046B1 (en) 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
EP1304129A2 (en) 1995-03-07 2003-04-23 Eli Lilly And Company Recyclable medication dispensing device
US5938642A (en) 1995-03-07 1999-08-17 Eli Lilly And Company Multiple dose medication dispensing device
WO1996032973A1 (en) 1995-04-19 1996-10-24 Eli Lilly And Company Multi-cartridge medication injection device
GB2309644A (en) 1995-05-22 1997-08-06 Wolfgang Wagner Device for diagnosis/therapy of a metabolic disturbance
WO1996038190A1 (en) 1995-06-02 1996-12-05 Novo Nordisk A/S Automatic withdrawal of piston rod
EP0747391A2 (en) 1995-06-07 1996-12-11 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (en) 1995-08-21 1997-01-02 Adamaszek, Franz-Heinz, 70193 Stuttgart Dosing and automatic injection system
WO1997007841A2 (en) 1995-08-25 1997-03-06 Medrad, Inc. Front load pressure jacket system with syringe holder
US5820602A (en) 1995-09-08 1998-10-13 Visionary Medical Products, Inc. Pen-type injector drive mechanism
WO1997010865A1 (en) 1995-09-19 1997-03-27 Becton Dickinson And Company Medication delivery pen with cap actuated dose delivery clutch
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
JPH11511364A (en) 1995-09-19 1999-10-05 ベクトン・ディキンソン・アンド・カンパニー Pen syringe with cartridge loading mechanism
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
FR2740345A1 (en) 1995-10-26 1997-04-30 Neftel Frederic AUTOMATION DEVICE
US6083197A (en) 1995-12-19 2000-07-04 Umbaugh; Jerald C. Spring-actuated needleless injector
JPH09166474A (en) 1995-12-19 1997-06-24 Omron Corp Residual-quantity sensor
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US6248090B1 (en) 1996-02-23 2001-06-19 Novo Nordisk A/S Syringe with electronic representation of parameters
WO1997030742A1 (en) 1996-02-23 1997-08-28 Novo Nordisk A/S Syringe with electronic representation of parameters
US5879630A (en) 1996-03-04 1999-03-09 Motorola, Inc. Semiconductor chemical sensor device and method of forming a thermocouple for a semiconductor chemical sensor device
WO1997033638A1 (en) 1996-03-12 1997-09-18 Novo Nordisk A/S Injection device with electronic presentation of set doses
US6277098B1 (en) 1996-03-12 2001-08-21 Novo Nordisk A/S Injection device with electronic presentation of set doses
US20010016571A1 (en) 1996-03-13 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. N-[ (R) -1-{3- (4- piperidyl) propionyl } -3-piperidylcarbonyl] -2 (S) -acetylamino-beta -alanine as fibrinogen receptor antagonist
WO1997034919A1 (en) 1996-03-15 1997-09-25 Novo Nordisk A/S Method for purification of a protein from a protein containing solution
US6086567A (en) 1996-04-02 2000-07-11 Disetronic Licensing Ag Injection device
US6383167B2 (en) 1996-04-02 2002-05-07 Disetronic Licensing Ag Injection device
WO1997036626A1 (en) 1996-04-02 1997-10-09 Disetronic Licensing Ag Injection device
US5782633A (en) 1996-04-10 1998-07-21 Muehlbauer; Ernst Applicator for a dental compound
US5951530A (en) 1996-04-24 1999-09-14 Novo Nordisk A/S Injection needle
US6340357B1 (en) 1996-07-05 2002-01-22 Novo Nordisk A/S Dose setting device
US5928201A (en) 1996-07-05 1999-07-27 Novo Nordisk A/S Dose setting device
US5980491A (en) 1996-07-05 1999-11-09 Novo Nordisk A/S Automatic needle insertion mechanism
US6302869B1 (en) 1996-07-05 2001-10-16 Novo Nordisk A/S Syringe having a flexible piston rod
US6161364A (en) 1996-08-02 2000-12-19 Scherring Aktiengesellschaft Terminal sterilization process for filled syringes under an auxiliary pressure
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
WO1998010813A1 (en) 1996-09-13 1998-03-19 Novo Nordisk A/S Dose display for an injection syringe
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US6010485A (en) 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
US5830194A (en) 1996-09-20 1998-11-03 Azam Anwar Power syringe
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
US6129080A (en) 1997-01-27 2000-10-10 Medic-Aid Limited Atomizer
US6033377A (en) 1997-02-04 2000-03-07 Novo Nordisk A/S Device for the administration of a liquid medicament suspension
EP1000631A2 (en) 1997-03-03 2000-05-17 Medico Development Investment Company Injection device
US6048336A (en) 1997-03-03 2000-04-11 Medico Injection device
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6277097B1 (en) 1997-03-25 2001-08-21 Novo Nordisk A/S Injection system
RU2111019C1 (en) 1997-05-22 1998-05-20 Сергей Александрович Хворостов General-purpose injector
US6364860B1 (en) 1997-06-05 2002-04-02 Disetronic Licensing Ag Resettable display of a device for metered administration of a fluid drug
DE19723647C1 (en) 1997-06-05 1998-12-24 Disetronic Licensing Ag Fluid dosing unit indicator for e.g. insulin or for pipetting laboratory fluids
WO1998056439A1 (en) 1997-06-09 1998-12-17 Novo Nordisk A/S A displacement device for controlled dispensing of a dose of a liquid contained in a cartridge
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
WO1998056436A1 (en) 1997-06-09 1998-12-17 Novo Nordisk A/S A dose setting mechanism and an injection syringe having such a dose setting mechanism
US6074372A (en) 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
JP2002503122A (en) 1997-06-09 2002-01-29 ノボ ノルディスク アクティーゼルスカブ Moving device for controlling and dispensing an appropriate amount of liquid contained in a container
WO1998057688A1 (en) 1997-06-17 1998-12-23 Novo Nordisk A/S Dose setting device
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US6287283B1 (en) 1997-07-11 2001-09-11 Novo Nordisk A/S Apparatus for the registration of the setting of a medical device
US6569126B1 (en) 1997-07-14 2003-05-27 Novo Nordisk A/S Cylinder ampoule
US6231540B1 (en) 1997-07-14 2001-05-15 Novo Nordisk A/S Injection member
US6193698B1 (en) 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US6547755B1 (en) 1997-08-06 2003-04-15 Pharmacia Ab Automated delivery device and method for its operation
WO1999007425A1 (en) 1997-08-06 1999-02-18 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
EP0897729A2 (en) 1997-08-11 1999-02-24 Becton, Dickinson and Company Medication delivery pen having a controlling means of the torque applied to the dosing elements
EP0897728A1 (en) 1997-08-11 1999-02-24 Becton Dickinson and Company Medication delivery pen
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
FR2767479A1 (en) 1997-08-22 1999-02-26 Aguettant Lab Medication injection syringe
WO1999015214A1 (en) 1997-09-25 1999-04-01 Disetronic Licensing Ag Delivery device with a sensing unit
WO1999016487A1 (en) 1997-09-29 1999-04-08 Becton Dickinson And Company Disposable, pre-filled drug cartridge
EP0908273A2 (en) 1997-10-09 1999-04-14 Chicago Pneumatic Tool Company Ratchet wrench head
CN1214292A (en) 1997-10-09 1999-04-21 芝加哥气动工具公司 Ratchet wrench head
WO1999021598A1 (en) 1997-10-29 1999-05-06 Azam Anwar Power syringe
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
WO1999038554A1 (en) 1998-01-30 1999-08-05 Novo Nordisk A/S An injection syringe
US6004297A (en) 1998-01-30 1999-12-21 Novo Nordisk A/S Injection syringe
US6235004B1 (en) 1998-01-30 2001-05-22 Novo Nordisk A/S Injection syringe
EP1003581A1 (en) 1998-01-30 2000-05-31 Novo Nordisk A/S An injection syringe
US20030039679A1 (en) 1998-02-13 2003-02-27 Duirs Graham Francois Drug delivery system
US6770288B2 (en) 1998-02-13 2004-08-03 Pfizer Products Inc. Drug delivery system
EP0937471A2 (en) 1998-02-20 1999-08-25 Becton Dickinson and Company Medication delivery pen
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6096010A (en) 1998-02-20 2000-08-01 Becton, Dickinson And Company Repeat-dose medication delivery pen
EP0937472A2 (en) 1998-02-20 1999-08-25 Becton Dickinson and Company Repeat-dose medication delivery pen
EP0937476A2 (en) 1998-02-23 1999-08-25 Becton, Dickinson and Company Low-cost medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US6268722B1 (en) 1998-03-17 2001-07-31 Unisia Jecs Corporation Rotation angle sensor having improved magnetic leakage effect prevention and reduction in parts
WO1999048546A1 (en) 1998-03-23 1999-09-30 Elan Corporation, Plc Drug delivery device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
EP0956873A2 (en) 1998-05-15 1999-11-17 Disetronic Licensing AG Automatic injection device
JP3017167B2 (en) 1998-05-20 2000-03-06 インターナショナル・ビジネス・マシーンズ・コーポレイション Method and apparatus for binarizing a read signal from a data storage medium
US6281225B1 (en) 1998-06-11 2001-08-28 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
US6666849B1 (en) 1998-06-11 2003-12-23 Owen Munford Limited Dose setting device for medical injectors
WO1999065548A1 (en) 1998-06-15 1999-12-23 Medrad, Inc. Encoding of syringe information
US20010034506A1 (en) 1998-06-15 2001-10-25 Hirschman Alan D. Encoding of syringe information
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
US6562011B1 (en) 1998-07-08 2003-05-13 Novo Nordisk A/S Medication delivery device
US5971963A (en) 1998-08-18 1999-10-26 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
US20020002326A1 (en) 1998-08-18 2002-01-03 Causey James D. Handheld personal data assistant (PDA) with a medical device and method of using the same
DE19838760A1 (en) 1998-08-26 2000-04-20 Bauer Jlona Injection unit, especially for injecting medicines such as insulin, consists of a housing with a chamber for holding a needle, a cartridge and a release mechanism.
WO2000015224A1 (en) 1998-09-17 2000-03-23 Eli Lilly And Company Protein formulations
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
WO2000037129A1 (en) 1998-12-22 2000-06-29 Alcor Medical Instruments Method and device for monitoring fluid level
WO2000037098A1 (en) 1998-12-22 2000-06-29 Eli Lilly And Company Shelf-stable formulation of glucagon-like peptide-1
RU2212254C2 (en) 1999-01-12 2003-09-20 Дизетроник Лайсенсинг Аг Device for administering injection product
US6699224B2 (en) 1999-01-12 2004-03-02 Disetronic Licensing Ag Device for administering an injectable product
CA2359375A1 (en) 1999-01-14 2000-07-20 B D Medico S.A.R.L. Injection device
DE29907880U1 (en) 1999-01-14 2000-09-14 Medico Development Investment Co., Davos Dorf Injection device with exchangeable cartridge
EP1557189A1 (en) 1999-01-14 2005-07-27 Haselmeier Sàrl Injection device
US6036675A (en) 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
JP2000237308A (en) 1999-02-22 2000-09-05 Ckd Corp Infusion pump
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
WO2000051668A1 (en) 1999-03-05 2000-09-08 Accumed Systems, Inc. High pressure syringe
US6419661B1 (en) 1999-03-05 2002-07-16 Roche Diagnostics Gmbh Device for withdrawing blood for diagnostic applications
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
US6599272B1 (en) 1999-05-12 2003-07-29 Pharmacia Ab Injection device and method for its operation
WO2001010484A1 (en) 1999-08-05 2001-02-15 Becton, Dickinson And Company Medication delivery pen
EP1074273A1 (en) 1999-08-06 2001-02-07 Becton Dickinson and Company Improved medication delivery pen
RU2254878C2 (en) 1999-09-16 2005-06-27 Ново Нордиск А/С Apparatus for injections with dose setting restrictor
US6582404B1 (en) 1999-09-16 2003-06-24 Nna/S Dose setting limiter
WO2001019434A1 (en) 1999-09-16 2001-03-22 Novo Nordisk A/S Dose setting limiter
US6726661B2 (en) 1999-10-12 2004-04-27 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
WO2001026710A2 (en) 1999-10-12 2001-04-19 Novo Nordisk A/S Air shot mechanism for electronic injection devices
WO2001030425A1 (en) 1999-10-22 2001-05-03 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
EP1095668A1 (en) 1999-11-01 2001-05-02 Becton Dickinson and Company Electronic medication delivery pen having a multifunction actuator
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6673033B1 (en) 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
US20020173752A1 (en) * 2000-02-16 2002-11-21 Polzin U1F Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
DE10103287A1 (en) 2000-02-16 2001-08-23 B D Medico Gmbh Mies Unit for reconstitution of injection liquids and their subsequent injection comprises a slidable stop and an element which is slidable relative to this stop and is attached to the piston of the unit
US20030050609A1 (en) 2000-03-24 2003-03-13 Bernard Sams One-way clutch mechanisms and injector devices
US6899698B2 (en) 2000-03-24 2005-05-31 Bernard Sams One-way clutch mechanisms and injector devices
WO2001072361A1 (en) 2000-03-24 2001-10-04 Bernard Sams One-way clutch mechanisms and injector devices
US20030073954A1 (en) 2000-03-29 2003-04-17 Minimed Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US20020002354A1 (en) 2000-04-15 2002-01-03 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Syringe for medical purposes
US6887238B2 (en) 2000-04-27 2005-05-03 Medtronic, Inc. Suction stabilized epicardial ablation devices
US20020007154A1 (en) 2000-05-04 2002-01-17 Steffen Hansen Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6692472B2 (en) 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US20010053893A1 (en) 2000-05-18 2001-12-20 Andre Larsen Injection device
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US20040059299A1 (en) 2000-06-16 2004-03-25 Moller Claus Schmidt Injection device
US20020052578A1 (en) 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US8267899B2 (en) 2000-06-16 2012-09-18 Novo Nordisk A/S Injection device
WO2001095959A1 (en) 2000-06-16 2001-12-20 Novo Nordisk A/S An injection device with a gearbox
EP1568389A1 (en) 2000-06-16 2005-08-31 Novo Nordisk A/S Injection device
US20050209570A1 (en) 2000-06-16 2005-09-22 Novo Nordisk A/S Injection device
US8206361B2 (en) 2000-06-16 2012-06-26 Novo Nordisk A/S Injection device
US8202256B2 (en) 2000-06-16 2012-06-19 Novo Nordisk A/S Injection device
US20080281275A1 (en) 2000-06-16 2008-11-13 Novo Nordisk A/S Injection Device
US20080065026A1 (en) 2000-06-16 2008-03-13 Novo Nordisk A/S Injection Device
US20070244445A1 (en) 2000-06-16 2007-10-18 Novo Nordisk A/S Injection Device
JP2004503303A (en) 2000-06-16 2004-02-05 ノボ　ノルディスク　アクティーゼルスカブ Injection device with gearbox
US7241278B2 (en) 2000-06-16 2007-07-10 Novo Nordisk A/S Injection device
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
WO2002005876A2 (en) 2000-07-14 2002-01-24 Novo Nordisk A/S A liquid medication delivery device and a method of delivering an intended dose
US6613019B2 (en) 2000-07-14 2003-09-02 Novo Nordisk A/S Liquid medication delivery device and a method of delivering an intended dose
US6752798B2 (en) 2000-07-28 2004-06-22 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
US20030176871A1 (en) 2000-08-10 2003-09-18 Paul Pavlov Device for the introduction of medical items
US20020020654A1 (en) 2000-08-10 2002-02-21 Michael Eilersen Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
WO2002024257A1 (en) 2000-09-22 2002-03-28 Novo Nordisk A/S A medication delivery device
US6893415B2 (en) 2000-09-22 2005-05-17 Novo Nordisk A/S Medication delivery device
US20020049415A1 (en) 2000-10-03 2002-04-25 Nemoto Kyorindo Co., Ltd. Automatic injection device
US6537251B2 (en) 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
US20020107486A1 (en) 2000-10-05 2002-08-08 Munk Jens Aage Medication delivery system with improved dose accuracy
US20040158304A1 (en) 2000-11-24 2004-08-12 Ckm Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
WO2002050214A2 (en) 2000-12-21 2002-06-27 Future Energy Resources Corporation Biomass gasification system and method
EP1216719A1 (en) 2000-12-21 2002-06-26 Lin Wang Safety syringe
EP1216717A1 (en) 2000-12-21 2002-06-26 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
EP1351732A1 (en) 2001-01-05 2003-10-15 Novo Nordisk A/S Automatic injection device with reset feature
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
US20050055011A1 (en) 2001-01-05 2005-03-10 Christian Enggaard Automatic injection device with reset feature
US20020120235A1 (en) 2001-01-05 2002-08-29 Christian Enggaard Automatic injection device with reset feature
JP2004516895A (en) 2001-01-05 2004-06-10 ノボ ノルディスク アクティーゼルスカブ Automatic syringe with reset characteristics
WO2002053214A1 (en) 2001-01-05 2002-07-11 Novo Nordisk A/S Automatic injection device with reset feature
WO2002064196A1 (en) 2001-02-14 2002-08-22 Novo Nordisk A/S Electronically controlled injection or infusion device
US7008399B2 (en) 2001-02-14 2006-03-07 Novo Nordisk A/S Electronically controlled device
US20040097879A1 (en) 2001-03-27 2004-05-20 Robert Woolston Injection device
WO2002076535A1 (en) 2001-03-27 2002-10-03 Dca Design International Limited Improvements in and relating to an injection device
JP2004533285A (en) 2001-03-27 2004-11-04 ディーシーエー デザイン インターナショナル リミテッド Drive mechanism for injection device
WO2002076537A1 (en) 2001-03-27 2002-10-03 Dca Design International Limited Improvements in and relating to an injection device
WO2002076536A1 (en) 2001-03-27 2002-10-03 Dca Design International Limited Improvements in and relating to an injection device
US20030009133A1 (en) 2001-04-13 2003-01-09 Kirk Ramey Drive system for an infusion pump
US7195616B2 (en) 2001-05-16 2007-03-27 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
US7704238B2 (en) 2001-05-16 2010-04-27 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
WO2002092153A2 (en) 2001-05-16 2002-11-21 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
US20040210199A1 (en) 2001-05-16 2004-10-21 Atterbury William Goodwin Medication injector apparatus with drive assembly that facilitates reset
US20040236282A1 (en) 2001-06-07 2004-11-25 Philip Braithwaite Unit dosage powder container
US20020188250A1 (en) 2001-06-08 2002-12-12 Sergio Landau Durable hypodermic jet injector apparatus and method
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
US20040207385A1 (en) 2001-07-09 2004-10-21 Simone Gafner Position detection
US20040186431A1 (en) 2001-07-30 2004-09-23 Roney Graf Administering apparatus comprising a dosing device
US20030040715A1 (en) 2001-08-21 2003-02-27 D'antonio Nicholas F. Hypodermic jet injection kit
EP1462134A1 (en) 2001-12-13 2004-09-29 Matsushita Electric Industrial Co., Ltd. Administration instrument for medical use
WO2003057286A1 (en) 2001-12-13 2003-07-17 Matsushita Electric Industrial Co., Ltd. Administration instrument for medical use
US20030114800A1 (en) 2001-12-18 2003-06-19 Dca Design International Limited Medicament injection apparatus
DE20209051U1 (en) 2001-12-21 2003-04-24 Disetronic Licensing Ag, Burgdorf Medicament administration device has dosage adjuster mounted on piston rod and end stop mounted at end of its path, locking system preventing adjuster from rotating and pressing against stop
WO2003057285A2 (en) 2002-01-10 2003-07-17 Owen Mumford Limited Improvements relating to medical injection devices
US20050090782A1 (en) * 2002-01-10 2005-04-28 Owen Mumford Limited Medical injection devices
WO2003057283A1 (en) 2002-01-12 2003-07-17 Dca Design International Limited Improvements in and relating to medicament injection apparatus
DE10201875C1 (en) 2002-01-18 2003-05-22 Austriamicrosystems Ag Magnetic or electrical field sensor system has modulators with non-inverting and inverting conditions providing for different sensor configurations
WO2003063680A2 (en) 2002-01-25 2003-08-07 Inotech Medical Systems, Inc. Tissue monitoring system for intravascular infusion
US20030216663A1 (en) 2002-01-25 2003-11-20 Inotech Medical Systems, Inc. Tissue monitoring system for intravascular infusion
US20050205083A1 (en) 2002-03-07 2005-09-22 Vectura Limited Medicament storage and delivery devices
US20030172924A1 (en) 2002-03-07 2003-09-18 Staniforth John Nicholas Medicament storage and delivery devices
WO2003080160A1 (en) 2002-03-18 2003-10-02 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US7678084B2 (en) 2002-03-18 2010-03-16 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US20040010204A1 (en) 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
JP2003284777A (en) 2002-03-28 2003-10-07 Suugan Kk Medical tube open and close device
US6852404B2 (en) 2002-03-29 2005-02-08 Tdk Corporation Magnetic recording medium
WO2003099357A1 (en) 2002-05-24 2003-12-04 Eli Lilly And Company Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
US7195609B2 (en) 2002-06-14 2007-03-27 Disetronic Licensing Ag Piston stopper for injection device, product container and injection device
US20030233075A1 (en) 2002-06-14 2003-12-18 Serge Huegli Piston stopper for injection device, product container and injection device
AU2003232576A1 (en) 2002-06-28 2004-01-19 Tecpharma Licensing Ag Product distribution device with rapid piston rod resetting
DE10229122A1 (en) 2002-06-28 2004-02-05 Disetronic Licensing Ag Administration device with resettable actuation lock
WO2004002556A1 (en) 2002-06-28 2004-01-08 Tecpharma Licensing Ag Product distribution device with rapid piston rod resetting
US7500966B2 (en) 2002-06-28 2009-03-10 Tecpharma Licensing Ag Administering apparatus with a resettable activating block
WO2004004825A2 (en) 2002-07-04 2004-01-15 Inovio As Electroporation device and injection apparatus
US7104972B2 (en) 2002-07-10 2006-09-12 Novo Nordisk A/S Injection device with a dose setting limiter
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
WO2004007002A1 (en) 2002-07-10 2004-01-22 Novo Nordisk A/S An injection device
US7133329B2 (en) 2002-07-23 2006-11-07 Novo Nordisk A/S Device with time indicating means
US20040024361A1 (en) 2002-08-02 2004-02-05 Mallinckrodt Inc. Injector
DE10237258A1 (en) 2002-08-14 2004-03-18 Disetronic Licensing Ag injection device
JP2005536300A (en) 2002-08-29 2005-12-02 ノボ・ノルデイスク・エー／エス Forward retractable injection device
US20040108339A1 (en) 2002-08-29 2004-06-10 Hansen Michael Ejstrup Frontloaded injection device
US7175055B2 (en) 2002-08-29 2007-02-13 Novo Nordisk, A/S Frontloaded injection device
US20040054326A1 (en) 2002-08-30 2004-03-18 Edgar Hommann Device for controlled delivery of an injectable liquid
WO2004024218A1 (en) 2002-08-30 2004-03-25 Disetronic Licensing Ag Device for the dosed discharge of a liquid agent and infusion pump
US20050197625A1 (en) 2002-08-30 2005-09-08 Ulrich Haueter Device for the dosed discharging of a liquid agent and infusion pump
US20040051368A1 (en) 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
WO2004028598A1 (en) 2002-09-24 2004-04-08 Shl Medical Ab Injecting device
EP1557163A1 (en) 2002-09-26 2005-07-27 Japan Science and Technology Agency Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set
WO2004035113A2 (en) 2002-10-15 2004-04-29 Eli Lilly And Company Medication dispensing apparatus with squeezable actuator
WO2004054644A1 (en) 2002-12-17 2004-07-01 Safe-T Limited Hollow needle applicators
US20050019400A1 (en) 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US20040171983A1 (en) 2003-02-24 2004-09-02 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
US20040260247A1 (en) 2003-03-03 2004-12-23 Robert Frederick Veasey Drive mechanisms suitable for use in drug delivery devices
US20040267207A1 (en) 2003-03-03 2004-12-30 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
WO2004078241A1 (en) 2003-03-03 2004-09-16 Dca Design International Ltd. Pen-type injector with dose dial sleeve
WO2004078239A1 (en) 2003-03-03 2004-09-16 Dca Design International Ltd. Drive mechanish for drug delivery devices
US20040267208A1 (en) 2003-03-03 2004-12-30 Veasey Robert Frederick Pen-type injector
US7094221B2 (en) 2003-03-03 2006-08-22 Dca Design International Ltd. Drive mechanisms suitable for use in drug delivery devices
US20070093761A1 (en) 2003-03-03 2007-04-26 Dca Design International Ltd. Drive mechanisms suitable for use in drug delivery devices
WO2004078240A2 (en) 2003-03-03 2004-09-16 Dca Design International Ltd. Improvements in and relating to drive mechanisms suitable for use in drug delivery devices
US20050033244A1 (en) 2003-03-03 2005-02-10 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
WO2004078242A2 (en) 2003-03-03 2004-09-16 Dca Design International Ltd. Improvements in and relating to a pen-type injector
WO2004080306A1 (en) 2003-03-06 2004-09-23 Lifescan, Inc. System and method for piercing dermal tissue
US7090662B2 (en) 2003-03-22 2006-08-15 Dca Design International Ltd. Dose dial and drive mechanisms suitable for use in drug delivery devices
US20040249348A1 (en) 2003-03-22 2004-12-09 Steven Wimpenny Dose dial and drive mechanisms suitable for use in drug delivery devices
US20060118612A1 (en) 2003-03-24 2006-06-08 Novo Nordisk A/S Electronic marking of a medication cartridge
WO2004084795A1 (en) 2003-03-24 2004-10-07 Novo Nordisk A/S Transparent electronic marking of a medication cartridge
WO2004093940A2 (en) 2003-04-03 2004-11-04 Becton, Dickinson And Company Medication delivery pen
US20040199117A1 (en) 2003-04-03 2004-10-07 Becton, Dickinson And Company Medication delivery pen
US20050004529A1 (en) 2003-04-10 2005-01-06 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
WO2004095379A1 (en) 2003-04-23 2004-11-04 Vasogen Ireland Limited Dispensing systems
US20040230157A1 (en) 2003-05-16 2004-11-18 Perry Stephen J. Fluid delivery system and related methods of use
FR2857654A1 (en) 2003-07-16 2005-01-21 Prodonta Ejector for liquid or paste product e.g. for medical use has through bore containing toothed thrust cylinder actuated by lever and pawls
US20060264838A1 (en) 2003-07-16 2006-11-23 Jean-Claude Volckmann Device for expelling a liquid or pasty substance
WO2005018721A1 (en) 2003-08-12 2005-03-03 Eli Lilly And Company Medication dispensing apparatus with triple screw threads for mechanical advantage
WO2005037352A2 (en) 2003-10-16 2005-04-28 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
JP2007509662A (en) 2003-11-03 2007-04-19 ハーゼルマイアー エス．アー．エル．エル． Injection device
DE20317377U1 (en) 2003-11-03 2005-03-17 B D Medico S A R L injection device
EP1610848A1 (en) 2003-11-03 2006-01-04 Haselmeier Sàrl Injection device
US20060258988A1 (en) 2003-11-03 2006-11-16 Joachim Keitel Injection device
WO2005046770A1 (en) 2003-11-03 2005-05-26 Haselmeier S.A.R.L. Injection device
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism
EP1723977A1 (en) 2004-03-03 2006-11-22 Nemoto Kyorindo Co., Ltd. Medical solution injection system
WO2005089835A1 (en) 2004-03-18 2005-09-29 Smiths Group Plc Infusion apparatus comprising radio-frequency readable coded markers
WO2005097233A2 (en) 2004-03-30 2005-10-20 Eli Lilly And Company Medication dispensing apparatus with spring-driven locking feature enabled by administration of final dose
WO2005097240A1 (en) 2004-03-30 2005-10-20 Eli Lilly And Company Medication dispensing apparatus with gear set having drive member accommodating opening
WO2005102421A1 (en) 2004-04-23 2005-11-03 Tecpharma Licensing Ag Injection device comprising a dosing unit with multiple anti-twist protection
US7771399B2 (en) 2004-04-23 2010-08-10 Tecpharma Licensing Ag Injection device with dose metering mechanism with multiple anti-rotation locking system
US20080312592A1 (en) 2004-05-28 2008-12-18 Tim Barrow-Williams Injection Device
US20050268915A1 (en) 2004-06-07 2005-12-08 Willem Wassenaar Nasal adaptation of an oral inhaler device
EP1768725A1 (en) 2004-07-05 2007-04-04 Novo Nordisk A/S A credit card sized injection device
WO2006003130A1 (en) 2004-07-05 2006-01-12 Novo Nordisk A/S A credit card sized injection device
EP1782853A1 (en) 2004-07-14 2007-05-09 Nemoto Kyorindo Co., Ltd. Medical liquid injection system
WO2006026754A2 (en) 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
DE102004046003A1 (en) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmaceutical package, as a syringe or vial or capsule, has an integrated microchip and antenna to give a unique and tamper-proof identity
WO2006037434A1 (en) 2004-10-04 2006-04-13 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
WO2006040296A2 (en) 2004-10-11 2006-04-20 Novo Nordisk A/S Injection device
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
WO2006039930A1 (en) 2004-10-14 2006-04-20 Novo Nordisk A/S Syringe with dosis mechanism
WO2006045528A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with torsion spring and rotatable display
EP1819382A1 (en) 2004-10-21 2007-08-22 Novo Nordisk A/S Injection device with torsion spring and rotatable display
WO2006045525A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with a processor for collecting ejection information
US20080147005A1 (en) 2004-10-21 2008-06-19 Novo Nordisk A/A Dial-Down Mechanism for Wind-Up Pen
US7686786B2 (en) 2004-10-21 2010-03-30 Novo Nordiks A/S Dial-down mechanism for wind-up pen
EP1804865A1 (en) 2004-10-21 2007-07-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
WO2006045526A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Dial-down mechanism for wind-up pen
WO2006045529A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with internal dose indicator
WO2006045425A1 (en) 2004-10-25 2006-05-04 Componenti Vending S.P.A. Selector, particularly but not exclusively, for beverage vending machines
US20070265568A1 (en) 2004-11-04 2007-11-15 Izrail Tsals Automatic Injector
WO2006069454A1 (en) 2004-12-31 2006-07-06 Tecpharma Licensing Ag Device for the dosed administration of a fluid product, provided with decoupling means for the replacement of a container
JP2008528071A (en) 2005-01-21 2008-07-31 ノボ・ノルデイスク・エー／エス Automatic injection device with release mechanism on top
WO2006076921A1 (en) 2005-01-21 2006-07-27 Novo Nordisk A/S An automatic injection device with a top release mechanism
JP2006250582A (en) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd Rfid tag with load sensor
US20080221530A1 (en) 2005-04-24 2008-09-11 Novo Nordisk A/S Injection Device With A GearBox
US20090043264A1 (en) 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
DK200500116U1 (en) 2005-05-23 2005-06-10 Novo Nordisk As Motor-powered injection apparatus
PL208660B1 (en) 2005-05-25 2011-05-31 Kappa Medilab Społka Z Ograniczoną Odpowiedzialnością Automatic applicator, particularly for application of the insulin
WO2006128794A2 (en) 2005-05-31 2006-12-07 Novo Nordisk A/S Injection device with visual end-of-content indication
EP1728529A1 (en) 2005-06-01 2006-12-06 SHL Medical AB Device for delivering medicament
BRPI0613926A2 (en) 2005-07-27 2011-02-15 Novo Nordisk As syringe device to eject a dose of medicine
EP1909871A1 (en) 2005-07-27 2008-04-16 Novo Nordisk A/S Syringe device with a dose limiting mechanism and an additional safety mechanism
WO2007021195A1 (en) 2005-08-18 2007-02-22 Rolls-Royce Marine As System to guide a wire, chain, cable etc., onboard a vessel
EP1926514A1 (en) 2005-09-14 2008-06-04 Tecpharma Licensing AG Injection device with two-way slip clutch
US20080306445A1 (en) 2005-09-14 2008-12-11 Stefan Burren Injection device with a two-way slip coupling
WO2007030957A1 (en) 2005-09-14 2007-03-22 Tecpharma Licensing Ag Injection device with two-way slip clutch
WO2007041843A1 (en) 2005-10-11 2007-04-19 Podaima Blake Smart medical compliance method and system
WO2007063342A1 (en) 2005-12-02 2007-06-07 Owen Mumford Limited Injection method and apparatus
US20070167916A1 (en) 2006-01-16 2007-07-19 Linfair Engineering (Hk) Co., Ltd. Outer barrel for a syringe
WO2007104636A1 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
US20090062748A1 (en) 2006-03-10 2009-03-05 Novo Nordisk A/S Injection Device Having a Gearing Arrangement
WO2007107558A2 (en) 2006-03-20 2007-09-27 Novo Nordisk A/S Determination of cartridge content by capacitive means
WO2007107561A2 (en) 2006-03-20 2007-09-27 Novo Nordisk A/S Determination of position of injection needle
EP2019701A1 (en) 2006-05-16 2009-02-04 Novo Nordisk A/S A gearing mechanism for an injection device
US20090209920A1 (en) 2006-05-18 2009-08-20 Novo Nordisk A/S Injection Device with Mode Locking Means
WO2007134954A1 (en) 2006-05-18 2007-11-29 Novo Nordisk A/S An injection device with mode locking means
WO2008003130A1 (en) 2006-07-05 2008-01-10 Kaliopi Papantoniou A method and composition for treating the scalp
WO2008031239A1 (en) 2006-09-15 2008-03-20 Tecpharma Licensing Ag Injection device comprising several coupling mechanisms
US8048037B2 (en) 2006-09-15 2011-11-01 Tecpharma Licensing Ag Injection device comprising several coupling mechanisms
WO2008037801A1 (en) 2006-09-29 2008-04-03 Novo Nordisk A/S An injection device with electronic detecting means
WO2008057223A2 (en) 2006-10-26 2008-05-15 Mallinckrodt Inc. Medical fluid injector having a thermo-mechanical drive
JP2008196696A (en) 2007-02-14 2008-08-28 Shimano Inc Multi-stage internal transmission hub assembly for bicycle
JP2010523183A (en) 2007-04-05 2010-07-15 テクファーマ・ライセンシング・アクチェンゲゼルシャフト Method of administering a liquid reactive substance from a multi-chamber ampoule
US20130310739A1 (en) 2007-04-05 2013-11-21 Tecpharma Licensing Ag Method for administering a fluid active substance from a multi-chamber ampoule
EP2000161A1 (en) 2007-06-06 2008-12-10 Mallinckrodt, Inc. Medical fluid injector having wireless pressure monitoring feature
US20110046565A1 (en) 2008-01-23 2011-02-24 Novo Nordisk A/S Device for injecting apportioned doses of liquid drug
US20110125100A1 (en) 2008-06-16 2011-05-26 Pharma Consult Ges.M.B.H. & Co Nfg Kg Injection device
JP2011524212A (en) 2008-06-16 2011-09-01 ファーマ コンサルト ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー エンエフゲー コマンディトゲゼルシャフト Injection device
US20120095410A1 (en) 2008-10-24 2012-04-19 Novo Nordisk A/S Dial-Down Mechanism for Wind-Up Pen
WO2010046394A1 (en) 2008-10-24 2010-04-29 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US9132239B2 (en) 2008-10-24 2015-09-15 Novo Nordisk A/S Dial-down mechanism for wind-up pen
EP2373361A1 (en) 2008-10-24 2011-10-12 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US8870831B2 (en) 2009-08-24 2014-10-28 Shl Group Ab Dose reset mechanism
WO2011025448A1 (en) 2009-08-24 2011-03-03 Shl Group Ab Dose reset mechanism
US20120209208A1 (en) 2009-10-30 2012-08-16 Copernicus Sp. Z O.O. Automatic applicator for liquid pharmaceutical preparations, particularly for insulin
WO2010089418A2 (en) 2009-10-30 2010-08-12 Copernicus Sp. Z O.O. Automatic applicator for liquid pharmaceutical preparations, particularly for insulin
WO2011136718A1 (en) 2010-04-26 2011-11-03 Shl Group Ab Medicament delivery device
US20130274676A1 (en) 2010-10-08 2013-10-17 Sanofi-Aventis Deutschland Gmbh Auto-injector with a torsion spring
US20130204197A1 (en) 2010-10-12 2013-08-08 Owen Mumford Limited Needle shield arrangement
US20140350478A1 (en) 2011-12-29 2014-11-27 Novo Nordisk A/S Torsion-Spring Based Wind-Up Auto Injector Pen with Dial-Up/Dial-Down Mechanism
WO2013178372A1 (en) 2012-05-31 2013-12-05 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US20150148750A1 (en) 2012-05-31 2015-05-28 Novo Nordisk A/S Dial-Down Mechanism for Wind-Up Pen

Non-Patent Citations (40)

* Cited by examiner, † Cited by third party
Title
Advisory Action mailed on Mar. 23, 2010 in U.S. Appl. No. 11/122,289 filed on May 4, 2005 by Moller et al.
Annersten, M. et al., Insulin Pens Dribble From the Tip of the Needle After Injection, Practical Diabetes Int., vol. 17(4), pp. 109-111 (2000).
Answer in Novo Nordisk A/S v. Sanofi-Aventis U.S. LLC and Sanofi-Aventis downloaded from Pacer on Feb. 29, 2008.
Beckmann, Sensors, Memory, Circuits, Polyapply Newsletter, vol. 1(3), (2006).
Chia Kai Su et al, Process Biochemistry, 2006, vol. 41, Part 2, pp. 257-263.
Common Insulin Injection Challenges: http://www.bd.com/us/diabetes/page.aspx?cat=7001&id=7265.
Complaint in Novo Nordisk A/S v. Sanofi-Aventis U.S. LLC and Sanofi-Aventis downloaded from Pacer on Feb. 29, 2008.
Declaration of Benard Sams in Novo Nordisk A/S v. Sanofi-Aventis U.S. LLC and Sanofi-Aventis downloaded from Pacer on Feb. 29, 2008.
Dennison, Clive et al, Protein Expression and Purification, 1997, vol. 11, Part 2, pp. 149-161.
File history of U.S. Appl. No. 10/610,926 which is owned by the same assignee as U.S. Appl. No. 11/122,289 and U.S. Appl. No. 11/765,789.
File history of U.S. Appl. No. 10/610,926, which is owned by the same assignee as U.S. Appl. No. 11/765,789.
Fransson et al, Pharmaceutical Research, 1997, vol. 14, Part 5, pp. 606-612.
Gnanalingham, M.G. et al., Accuracy and Reproducibility of Low Dose Insulin Administration Using Pen-Injectors and Syringes, Downloaded From adc.bmj.com on Jan. 9, 2008.
International Search Report and Written Opinion issued in connection with counterpart PCT Application No. PCT/EP2006/061747, mailed Sep. 29, 2006.
International Search Report and Written Opinion issued in connection with counterpart PCT Application No. PCT/EP2006/061748 mailed Aug. 10, 2006.
Leonil et al, Enzyme and Microbiol Technology, 1994, vol. 16, Part 7, pp. 591-595.
May 17, 2002 Office Action in U.S. Appl. No. 09/768,760 and accompanying 892 and 1149 forms.
Notice of Opposition by Genentech (USA).
Notice of Opposition by Owen Mumford (UK).
Notice of Opposition by Techpharma (CH) Including English Translation.
Opinion of US District Court for the District of NJ in Novo Nordisk A/S v. Sanofi-Aventis U.S. LLC and Sanofi-Aventis Denying motion of a preliminary injunction entered Feb. 20, 2008.
Opposition in Related European Patent Application EP 02711784.5 of Sep. 19, 2008.
Owen Mumford Product Range.
Paule, B.J.A. et al, Protein Expression and Purification, 2004, vol. 34, Part 2, pp. 311-316.
Reissue U.S. Appl. No. 10/442,855 File History.
Reissue U.S. Appl. No. 10/960,900 File History.
Reissue U.S. Appl. No. 11/121,331 File History.
Reissue U.S. Appl. No. 11/640,610 File History.
Rose, Keith et al., Bioconjugate Chemistry, "Natural Peptides as Building Blocks for the Synthesis of Large Protein-Like Molecules With Hydrazone and Oxime Linkages", 1996, vol. 7, 2, pp. 552-556.
Search Report issued in connection with counterpart Danish Application No. PA 2005 00588, mailed Feb. 13, 2006.
Search Report issued in connection with counterpart Danish Application No. PA 2005 00589, mailed Feb. 16, 2006.
Search Report issued in connection with European Application No. 06005599.3, mailed Oct. 4, 2006.
Search Report Issued in Connection With European Appln No. 06005602.5, Mailed Oct. 16, 2006.
Search Report issued in connection with PCT Application No. PCT/EP2007/052633, mailed Feb. 20, 2008.
Search Report Issued in Connection With PCT Appln. No. PCT/EP2007/052630, Mailed Nov. 12, 2007.
Trankler, Hans-Rolf, R. Oldenbourg, Verlag, Munchen, Wien, Taschenbuch Der Messtechnik, 1996.
Validity Opinion by the UK PTO.
Written Opinion issued in connection with counterpart PCT Application No. PCT/EP2006/061747, mailed Nov. 8, 2006.
Written Opinion issued in connection with counterpart PCT Application No. PCT/EP2006/061748, mailed Nov. 8, 2006.
Yurkovetskiy, A. et al., Biomacromolecules., "Fully Degradable Hydrophilic Polyals for Protein Modification", 2005, vol. 6, 5, pp. 2648-2658.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12233110B2 (en) 2024-02-16 2025-02-25 I20 Therapeutics, Inc. Compositions comprising pharmaceutically acceptable salts of glucagon-like peptide-1 analogs and uses thereof
US12233111B2 (en) 2024-02-16 2025-02-25 I2O Therapeutics, Inc. Compositions comprising pharmaceutically acceptable salts of glucagon-like peptide-1 analogs and uses thereof
US12233112B2 (en) 2024-02-16 2025-02-25 I20 Therapeutics, Inc. Compositions comprising pharmaceutically acceptable salts of amylin analogs and uses thereof

Also Published As

Publication number Publication date
CA2584760C (en) 2013-12-24
EP1804865B1 (en) 2009-09-30
JP4698677B2 (en) 2011-06-08
AU2005298944B2 (en) 2010-12-23
DK1804865T3 (en) 2010-02-01
KR20070084393A (en) 2007-08-24
WO2006045526A1 (en) 2006-05-04
ATE444090T1 (en) 2009-10-15
EP1804865A1 (en) 2007-07-11
RU2007114761A (en) 2008-11-27
IL182613A0 (en) 2007-07-24
ES2334046T3 (en) 2010-03-04
DE602005016952D1 (en) 2009-11-12
CA2584760A1 (en) 2006-05-04
CN101060874A (en) 2007-10-24
ZA200703707B (en) 2009-02-25
RU2389514C2 (en) 2010-05-20
CN100571804C (en) 2009-12-23
AU2005298944A1 (en) 2006-05-04
PL1804865T3 (en) 2010-03-31
KR101300496B1 (en) 2013-09-02
US7686786B2 (en) 2010-03-30
US20080147005A1 (en) 2008-06-19
IL182613B (en) 2019-09-26
JP2008516712A (en) 2008-05-22

Similar Documents

Publication Publication Date Title
USRE46363E1 (en) Dial-down mechanism for wind-up pen
JP7426431B2 (en) Dose setting mechanism and injection device
JP5451641B2 (en) Injection device with mode defining element
EP2470245B1 (en) Dose reset mechanism
ES2749395T3 (en) Injection device without the need for a gear
JP4954091B2 (en) Dose setting element for an injection device having a dose setting limiting mechanism
AU2009306387A1 (en) Dial-down mechanism for wind-up pen
US20160228651A1 (en) Drug Delivery Device with Improved Dose Reset Mechanism
US20220379034A1 (en) Fixed dose injection device
EP3645084A1 (en) A torsion spring driven injection device
PT2346552E (en) Drug delivery device and method of manufacturing a drug delivery device
JP6961681B2 (en) Drug delivery device with overtorque protection mechanism
JP6637062B2 (en) Drug delivery device with dose reset mechanism
JP7042826B2 (en) Drug delivery device with torsion spring characteristics
WO2017098460A1 (en) Drive-control system for an injection device
JP2018514303A (en) Drug delivery device having spring mechanism
WO2018100124A1 (en) Drug delivery device with clutch feature
EP4076599A1 (en) Fixed dose injection device

Legal Events

Date Code Title Description
FPAY Fee payment

Year of fee payment: 8

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 12TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1553); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 12