ZA896205B - Annelated tetrahydropyridine acetic acid derivatives,the preparation and use thereof - Google Patents

Annelated tetrahydropyridine acetic acid derivatives,the preparation and use thereof

Info

Publication number
ZA896205B
ZA896205B ZA896205A ZA896205A ZA896205B ZA 896205 B ZA896205 B ZA 896205B ZA 896205 A ZA896205 A ZA 896205A ZA 896205 A ZA896205 A ZA 896205A ZA 896205 B ZA896205 B ZA 896205B
Authority
ZA
South Africa
Prior art keywords
annelated
tetrahydropyridine
preparation
acetic acid
acid derivatives
Prior art date
Application number
ZA896205A
Inventor
Walter Loesel
Loesel Walter
Otto Roos
Roos Otto
Gerd Schnorrenberg
Schnorrenberg Gerd
Dietrich Arndts
Arndts Dietrich
Georg Speck
Speck Georg
Ilse Streller
Streller Ilse
Werner Traunecker
Traunecker Werner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA896205B publication Critical patent/ZA896205B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA896205A 1988-08-16 1989-08-15 Annelated tetrahydropyridine acetic acid derivatives,the preparation and use thereof ZA896205B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3827727A DE3827727A1 (en) 1988-08-16 1988-08-16 ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE OF SUCH CONNECTIONS FOR CARDIRO PROTECTION

Publications (1)

Publication Number Publication Date
ZA896205B true ZA896205B (en) 1991-04-24

Family

ID=6360928

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA896205A ZA896205B (en) 1988-08-16 1989-08-15 Annelated tetrahydropyridine acetic acid derivatives,the preparation and use thereof

Country Status (16)

Country Link
EP (1) EP0358957A1 (en)
JP (1) JPH02160767A (en)
KR (1) KR900003129A (en)
AU (1) AU637767B2 (en)
DD (3) DD285595A5 (en)
DE (1) DE3827727A1 (en)
DK (1) DK399789A (en)
FI (1) FI893832A (en)
HU (1) HU208434B (en)
IL (1) IL91301A0 (en)
NO (1) NO893270L (en)
PH (1) PH27356A (en)
PL (1) PL161521B1 (en)
PT (1) PT91451A (en)
YU (1) YU160189A (en)
ZA (1) ZA896205B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162336A (en) * 1990-06-21 1992-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
DE9017900U1 (en) * 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 55218 Ingelheim 3,4-Dihydro-1-benzyl-6,7-dimethoxy-α-[di-2-(2,3,4-trimethoxyphenyl)ethyl] aminocarbonyl-isoquinoline
DE4104257A1 (en) * 1991-02-13 1992-08-20 Boehringer Ingelheim Kg USE OF ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL ILLNESSES
KR100291706B1 (en) * 1992-06-22 2001-10-24 베링거 인겔하임 카게 Closed dihydropyridine, preparation method thereof and pharmaceutical composition comprising the same
US5643919A (en) * 1992-06-22 1997-07-01 Boehringer Ingelheim Kg Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
DE4343641A1 (en) * 1993-12-21 1995-06-29 Boehringer Ingelheim Kg Anellated dihydropyridines and their use for the preparation of pharmaceutical preparations
DE4343683A1 (en) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellated dihydropyridines and their use for the preparation of pharmaceutical preparations
PT736012E (en) * 1993-12-21 2001-03-30 Boehringer Ingelheim Pharma CYCLED DI-HYDROPYRIDINES AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS
JP2002538151A (en) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Compounds useful as reversible inhibitors of cathepsin
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
NZ533358A (en) 2001-12-19 2007-05-31 Lundbeck & Co As H 3,4-Dihydro-1H-isoquinolin-2-yl-derivatives for use as NK2 receptor antagonists
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
CN111560025A (en) 2009-12-04 2020-08-21 桑诺维恩药品公司 Polycyclic compounds and methods of use thereof
SG10202100751YA (en) 2016-07-29 2021-03-30 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
EA201990400A1 (en) 2016-07-29 2019-07-31 Суновион Фармасьютикалз, Инк. COMPOUNDS AND COMPOSITIONS AND THEIR APPLICATION
IL268694B2 (en) 2017-02-16 2023-10-01 Sunovion Pharmaceuticals Inc Treatment of schizophrenia
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
CN112135827B (en) 2018-02-16 2024-01-12 赛诺维信制药公司 Salts, crystal forms and preparation methods thereof
CA3130849A1 (en) 2019-03-14 2020-09-17 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
JP2023523569A (en) 2020-04-14 2023-06-06 サノビオン ファーマシューティカルズ インク Methods of treating neurological and psychiatric disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
DE2361390A1 (en) * 1973-12-10 1975-06-19 Merck Patent Gmbh ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
HU174697B (en) * 1976-12-30 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolin-acetamide derivatives
FR2447921A1 (en) * 1979-02-05 1980-08-29 Synthelabo IMIDAZO AND PYRIMIDO-PYRIDO-INDOLES AND THEIR APPLICATION IN THERAPEUTICS
FR2455044A1 (en) * 1979-04-26 1980-11-21 Synthelabo PYRIDO-INDOLES AND THEIR APPLICATION IN THERAPEUTICS
DE3013906A1 (en) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim SUBSTITUTED (ALPHA) -AMINOCARBONYL-L-BENZYL-3,4-DIHYDRO-ISOCHINOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3229215A1 (en) * 1982-08-05 1984-02-09 Basf Ag, 6700 Ludwigshafen 1- (HALOGENALKYL) -1,2,3,4-TETRAHYDRO-SS-CARBOLINE, THEIR PRODUCTION AND USE
DE3309596A1 (en) * 1982-08-05 1984-04-05 Basf Ag, 6700 Ludwigshafen 2-SUBSTITUTED 1- (3'-AMINOALKYL) -1,2,3,4-TETRAHYDRO-SS-CARBOLINE, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCT
DE3621413A1 (en) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg USE OF CARBOCYCLIC AND HETEROCYCLICALLY FURNISHED DIHYDROPYRIDINE AS A CARDIOPROTECTIVE AGENT AND NEW HETEROCYCLIC AND CARBOCYCLICALLY FURNISHED DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND ITS ADDITIONAL PRODUCTS
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK399789A (en) 1990-02-17
DK399789D0 (en) 1989-08-15
DE3827727A1 (en) 1990-02-22
IL91301A0 (en) 1990-03-19
PH27356A (en) 1993-06-22
HUT51277A (en) 1990-04-28
AU3992589A (en) 1990-02-22
FI893832A0 (en) 1989-08-15
NO893270D0 (en) 1989-08-15
JPH02160767A (en) 1990-06-20
FI893832A (en) 1990-02-17
DD295379A5 (en) 1991-10-31
KR900003129A (en) 1990-03-23
DD285595A5 (en) 1990-12-19
YU160189A (en) 1992-09-07
DD297640A5 (en) 1992-01-16
NO893270L (en) 1990-02-19
EP0358957A1 (en) 1990-03-21
PL161521B1 (en) 1993-07-30
HU208434B (en) 1993-10-28
AU637767B2 (en) 1993-06-10
PT91451A (en) 1990-03-08

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