acute

Rarer side effects include acute gallstone disease and pancreatitis, and the NHS warns that there is also a risk of hypoglycaemia, which happens when your blood sugar level drops too low.

Neither were they privy to the days when she tackled the most acute personal struggles, alone behind closed doors.

"I remember getting a leaflet and it said without plasma exchange there is a 90% mortality rate from an acute TTP episode," she said.

The centre in the grounds of Belfast City Hospital provides 74 acute mental health en-suite bedrooms, including six psychiatric intensive care beds.

And the problems are becoming more acute each year.