doomed

They do not surrender to their circumstances; they do not accept their doomed fate.

Musselman sits behind a microphone, frustrated after a fourth straight defeat — this one doomed, the coach says, by “the worst defense I’ve ever had a team play in my college tenure.”

"I have served my country and now I'm useless. That job has doomed me," he said.

Those who fail to learn from history, as Salon contributor Mike Lofgren said to me recently, are doomed to repeat famous quotations.

Some people will respond to good science with bad, or prove so hostile that any efforts at conversation are doomed to failure.