modifiable

"Both of those things can be difficult for people to stop or to reverse, but they are probably the most modifiable ones," says Dr McCartney.

Targeting modifiable lifestyle factors -- mainly prevention of obesity via a healthy, balanced diet and adequate exercise -- has been the mainstay of initial management for knee osteoarthritis, Dr. Akkaya noted.

For the study, the researchers focused on the link between modifiable lifestyle-related factors, such as obesity, body fat distribution and metabolic aspects, and Alzheimer's disease pathology.

"We really need to study fathers as a unique population and track men's health outcomes as they become fathers. Cardiovascular health is especially important since the health behaviors and factors are all modifiable."

The results show great potential in terms of modifiable risk factors in type 1 diabetes.