Entry
Name
N-acetylneuraminate 9-O-acetyltransferase;
N-acetylneuraminate 7(8)-O-acetyltransferase;
sialate O-acetyltransferase;
N-acetylneuraminate 7,8-O-acetyltransferase;
acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase;
acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase;
glycoprotein 7(9)-O-acetyltransferase;
acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase;
N-acetylneuraminate O7-(or O9-)acetyltransferase;
acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase;
CASD1;
acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase;
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:CMP-N-acetyl-beta-neuraminate 9-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + CMP-N-acetyl-beta-neuraminate = CoA + CMP-N-acetyl-9-O-acetyl-beta-neuraminate [RN:
R13416 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
CMP-N-acetyl-beta-neuraminate [CPD:
C00128 ]
Product
CoA [CPD:
C00010 ];
CMP-N-acetyl-9-O-acetyl-beta-neuraminate [CPD:
C22979 ]
Comment
The enzyme, found in animals, is essential for the formation of acetylated sialoglycans. The acetyl group has been shown to spontaneously move between the 9-O, 8-O, and 7-O positions of the neuraminate, with 9-O acetylation being most favoured.
History
EC 2.3.1.45 created 1972, modified 2024
Orthology
K03377 N-acetylneuraminate 9-O-acetyltransferase
Genes
MMMA : 107144455(Casd1) 107153746
ACOE : 138106363(CASD1) 138106410
XLA : 108718841(casd1.L) 108719904(casd1.S)
SANH : 107665666 107669810
SGH : 107591593 107593528(casd1)
CCAR : 109063401(casd1) 109103049
CAUA : 113062053 113119366
CGIB : 127935140 127979361
MASI : 127421308 127425294
BPEC : 110153169 110153991 110171387 110174112 110174113
SASA : 106570464 106588938(casd1)
STRU : 115174016 115175522
OMY : 110488018 110496631(casd1)
OCLA : 139373780 139392287
SALP : 111955427 112068426
CCLU : 121572091 121585875(casd1)
PSPA : 121313555 121315032
ARUT : 117394176(casd1) 117400447
PMRN : 116938526(CASD1) 116941006
BFO : 118404490 118404773 118405701
BBEL : 109465441 109479493 109479494
LPIC : 129260400 129262011
APLC : 110978315 110990869
ARUN : 117291808 117300975
AAMU : 139939736 139949560
AFIL : 140147790 140149309 140154954
PFLL : 139116411 139132898 139144021
DSI : Dsimw501_GD16317(Dsim_GD16317)
AALB : 109405957 115266519
CFEL : 113367454 113367520
DPX : DAPPUDRAFT_112080 DAPPUDRAFT_48914
PTRU : 123503038 123516093
RSAN : 119379495 119383519
CSCU : 111616063 111624874
LGI : LOTGIDRAFT_180023 LOTGIDRAFT_63982
PVUL : 126825228 126832596
PCAN : 112561411 112572535
LSAX : 138959943 138980917
HASI : 137277877 137297739
HCRA : 139459869 139465732
MMER : 123538121 123540969
RPHI : 132716463 132733003
DPOL : 127846961 127847875
MAEA : 128206382 128240674
LAK : 106153362 106165798 106179615
OVI : T265_04091 T265_04747 T265_13408
LLON : 135499515 135500844 135500856
NVE : 5509630 5514202 5521358
EPA : 110234291 110234783 110234784 110248915
ATEN : 116288719 116295492 116305786
ADF : 107334174 107334211 107345509 107346916
AMIL : 114958250 114968014 114972240 122950875
MCAZ : 138049160 138051933 138058959
MFOO : 137972160 137996707 137997441
PDAM : 113676799 113678173 113684346
SPIS : 111332105 111334033 111335710
HMG : 100207689 100209243 101234927
HSY : 130612359 130640925 130641091
RES : 135681389 135687959 135688115
ATH : AT1G29890(RWA4) AT2G34410(RWA3) AT3G06550(RWA2) AT5G46340(RWA1)
ALY : 9299483 9315564 9320657 9329649
CRB : 17875446 17888082 17891108
CSAT : 104724746 104744825 104763061 104764349 104772900 104781829 104786122 104792196
EUS : EUTSA_v10000847mg EUTSA_v10016486mg EUTSA_v10020460mg
BRP : 103827737 103849876 103857534 103865335 103870737
BNA : 106346085 106352885 106401717 106402059 106405646 106410799 106432784 106437821 106452994 125599308 125599757 125608297
BOE : 106301625 106328582 106334752 106341685 106343472
RSZ : 108812424 108847969 108848011 108854432 108857151 130507399
THJ : 104806119 104814284 104818874 104820639
CPAP : 110819772 110824470
CIC : CICLE_v10004685mg CICLE_v10014824mg
MINC : 123193761 123219584 123221726
GRA : 105769404 105773829 105777227 105781621 105797619
GHI : 107890014 107896405 107905864 107916221 107960252 121229385 121230869
GAB : 108453689 108454094 108461000 108489526
HSYR : 120119913 120146903 120196010 120203590 120213093
DZI : 111278100 111280042 111280934 111306947
RARG : 115734445 115753006
GMX : 100787763 100794337 100808555 100817430
GSJ : 114393735 114412652 114419942 114421463
CCAJ : 109811002 109813218
APRC : 113846572 113857403
TPRA : 123913669 123921152
PSAT : 127073139 127106373
AHF : 112703000 112723197 112734555 112792343
LANG : 109330139 109350977 109362826
PCIN : 129286810 129295901 129297477 129306654
QSA : O6P43_012913 O6P43_021889
AANS : 126789545 126790371
PMUM : 103323215 103325014
PAVI : 110752075 110766620
PDUL : 117622749 117625964
MDM : 103403516 103434974 103446209 103452661
MSYL : 126585557 126596427 126608217 126624063
PXB : 103945048 103951249 103961277
PCOX : 137725584 137729111 137730725 137736890
CSAV : 115697492 115722746
CSV : 101207939 101212512 101215014 116405538
CMO : 103484388 103487174 103487648 103497777
BHJ : 120068241 120074616 120083773 120090902
MCHA : 111009596 111010951 111012417
CMAX : 111478893 111490405 111494498 111495552 111497102 111499243
CMOS : 111433270 111433520 111434120 111436966 111457318 111460219
CPEP : 111778476 111782319 111783109 111786134 111801804 111804549 111806932
MEAN : 126669223 126680953
HBR : 110638191 110661841 110669412 110672960
MESC : 110602757 110604525 110612009
POP : 7471096 7471833 7485844 7496813
PEU : 105113161 105115586 105117268
PALZ : 118036568 118036927 118045932 118062434
PNZ : 133697850 133702592 133704779 133705732
JRE : 108990224 109006915 109010783 109010797
CILL : 122275998 122279146 122317677
CAVE : 132166104 132166861 132170838
AGLU : 133868686 133879647 133879657
QSU : 112017450 112021180 112037120
TWL : 120001724 120011761 120014888 120015536
VRI : 117905942 117914818 117923686
SLY : 101254052 101266694 101268423
SPEN : 107008039 107011597 107014681
SOT : 102579887 102593707 102595580
SSTN : 125843338 125847987 125858121
SDUL : 129873044 129887380 129895629
CANN : 107840448 107859135 107868432 107878312
LBB : 132616807 132621711 132626746
NTA : 107773919 107783485 107800019 107810649
NSY : 104213118 104231599 104248744
NAU : 109212493 109229287 109232051
INI : 109165476 109170180 109173420
ITR : 116016209 116032607 116033659
SIND : 105167311 105175677 105178870
OEU : 111370903 111376809 111397120 111408284 111412215
EGT : 105951101 105951391 105968967
SSPL : 121741933 121744980 121758555 121786073 121796054 121799781 121804531 121808145
SMIL : 130985255 131013585
SHIS : 125190780 125193893 125194172 125194481 125200304 125210731
APAN : 127247616 127254490
HAN : 110876314 110891530 110924148 110937277
ECAD : 122581567 122590533
LSV : 111908066 111909205 111909394
CCAV : 112505391 112519076 112526788
DCR : 108196538 108197008 108197172
CSIN : 114255796 114299829 114300037
AEW : 130755888 130756614 130772076 130778414
DLT : 127794101 127798906 127808720
CQI : 110690356 110697312 110706312 110728616
ATRI : 130814512 130823609 130825265
NNU : 104587693 104607047 104610624
MING : 122072139 122072314 122073626
TSS : 122640923 122651531 122670999
PSOM : 113289923 113295712 113308113 113311841 113334786 113358045
OSA : 4326670 4332646 4339732
DOSA : Os01g0631100 Os03g0314200 Os05g0582100
OBR : 102704130 102715306 102719434
OGL : 127765953 127774364 127774698
ATS : 109752464 109764228 109778378
TDC : 119285486 119290643 119293742 119294137 119349720
TAES : 123069721 123085692 123089478 123092312 123097651 123100529 123148401 123183263
TUA : 125528377 125551247 125551882
LPER : 127295550 127327779
LRD : 124698240 124702354 124706972 124707008
ZMA : 100384114 103630788 103646881 109941464
MFLO : 136493324 136500135 136512693 136516230
SITA : 101762407 101763687 101772145 101783429
SVS : 117837239 117850390 117856626 117863031
PVIR : 120639595 120664508 120689810 120697730
PHAI : 112877093 112887008 112899637
PAUA : 133885128 133908302 133912371 133916228 133916362 133923830 133929490
PDA : 103703356 103709671 103712694 103715762 103719307
EGU : 105039974 105040999 105047196 105048749 105052613 105057317
MUS : 103978928 103993318 135598439 135615488
ZOF : 121982338 121986222 121991688 121995576 122016849 122036345 122036738 122042803 122048468 122051262 122055820
DCT : 110093788 110098720 110100877 110102076 110107575
PEQ : 110019961 110022780 110027581 110027583
AOF : 109831895 109834206 109841118 109842208
MSIN : 131224831 131227617 131231059 131231700
ACAK : 137957178 137958467 137962003 137965405
NCOL : 116255057 116262494
SMO : SELMODRAFT_114335 SELMODRAFT_146620
PPP : 112277916 112280032 112290747
MPP : MICPUCDRAFT_23866 MICPUCDRAFT_54912
YLI : 2909191(YALI2_C01209g)
FGR : FGSG_03124 FGSG_07886 FGSG_10575 FGSG_11677
FPU : FPSE_00749 FPSE_02099 FPSE_05486 FPSE_10078 FPSE_11039
FPOA : FPOAC1_000079 FPOAC1_003738 FPOAC1_005481 FPOAC1_011676
FVN : FVRRES_00189 FVRRES_04089 FVRRES_06042 FVRRES_06599 FVRRES_12730
FVR : FVEG_08869 FVEG_10849 FVEG_12060
FOX : FOXG_03797 FOXG_09591 FOXG_12275
NHE : NECHADRAFT_86689 NECHADRAFT_88136
FMU : J7337_007243 J7337_013441
PLJ : 28889875(PLICBS_008712)
VAL : VDBG_06818 VDBG_09239
VDA : VDAG_00572 VDAG_05880 VDAG_07397
CDET : 87937242(CDEST_00739)
CDEP : 91089992(L203_105783)
KMG : 30162983(I203_101976)
KNE : 92180258(IAR55_003000)
CCAC : CcaHIS019_0604450(CcaverHIS019_0604450)
ABP : AGABI1DRAFT66224(AGABI1DRAFT_66224)
ABV : AGABI2DRAFT198117(AGABI2DRAFT_198117)
SCM : SCHCO_02744701(SCHCODRAFT_02744701)
EHX : EMIHUDRAFT_450249 EMIHUDRAFT_455633 EMIHUDRAFT_97935
» show all
Taxonomy
Reference
Authors
Schauer R.
Title
[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]
Journal
Hoppe Seylers Z Physiol Chem 351:595-602 (1970)
Reference
Authors
Schauer R.
Title
[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]
Journal
Hoppe Seylers Z Physiol Chem 351:749-58 (1970)
Reference
Authors
Baumann AM, Bakkers MJ, Buettner FF, Hartmann M, Grove M, Langereis MA, de Groot RJ, Muhlenhoff M
Title
9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.45
ExPASy - ENZYME nomenclature database: 2.3.1.45
LinkDB
All DBs