REACTION: R13416
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Entry
R13416 Reaction
Name
acetyl-CoA:CMP-N-acetyl-beta-neuraminate 9-O-acetyltransferase
Definition
Acetyl-CoA + CMP-N-acetylneuraminate <=> CoA + CMP-N-acetyl-9-O-acetyl-beta-neuraminate
Equation
C00024
+
C00128
<=>
C00010
+
C22979
Reaction class
RC00041
C00128_C22979
Enzyme
2.3.1.45
Brite
Enzymatic reactions [BR:
br08201
]
2. Transferase reactions
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.45
R13416 Acetyl-CoA + CMP-N-acetylneuraminate <=> CoA + CMP-N-acetyl-9-O-acetyl-beta-neuraminate
BRITE hierarchy
Orthology
K03377
N-acetylneuraminate 9-O-acetyltransferase [EC:
2.3.1.45
]
Reference
1 [PMID:
26169044
]
Authors
Baumann AM, Bakkers MJ, Buettner FF, Hartmann M, Grove M, Langereis MA, de Groot RJ, Muhlenhoff M
Title
9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate.
Journal
Nat Commun 6:7673 (2015)
DOI:
10.1038/ncomms8673
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