| Entry |
|
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| Name |
Colchicine (JP18/USP);
Colchicine (TN) |
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| Product |
COLCHICINE (A-S Medication Solutions), COLCHICINE (American Health Packaging), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Coupler LLC), COLCHICINE (Hikma Pharmaceuticals USA), COLCHICINE (Major Pharmaceuticals), COLCHICINE (direct rx), COLCRYS (Proficient Rx LP), COLCRYS (Takeda Pharmaceuticals America), GLOPERBA (Scilex Pharmaceuticals), LODOCO (AGEPHA Pharma USA), MITIGARE (Hikma Specialty USA) |
|---|
| Generic |
COLCHICINE (A-S Medication Solutions), COLCHICINE (Actavis Pharma), COLCHICINE (American Health Packaging), COLCHICINE (Amneal Pharmaceuticals LLC), COLCHICINE (Aphena Pharma Solutions - Tennessee), COLCHICINE (Ascend Laboratories), COLCHICINE (Aurobindo Pharma Limited), COLCHICINE (Aurobindo Pharma Limited), COLCHICINE (AvPAK), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Bryant Ranch Prepack), COLCHICINE (Camber Pharmaceuticals), COLCHICINE (Camber Pharmaceuticals), COLCHICINE (Chartwell RX), COLCHICINE (Direct Rx), COLCHICINE (Dr.Reddys Laboratories), COLCHICINE (Endo USA), COLCHICINE (Endo USA), COLCHICINE (Golden State Medical Supply), COLCHICINE (Granules Pharmaceutical), COLCHICINE (Granules Pharmaceuticals), COLCHICINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), COLCHICINE (Major Pharmaceuticals), COLCHICINE (Mylan Institutional), COLCHICINE (Mylan Pharmaceuticals), COLCHICINE (Northstar Rx LLC.), COLCHICINE (NuCare Pharmaceuticals), COLCHICINE (Proficient Rx LP), COLCHICINE (Proficient Rx LP), COLCHICINE (REMEDYREPACK), COLCHICINE (REMEDYREPACK), COLCHICINE (RedPharm Drug), COLCHICINE (Strides Pharma Science Limited), COLCHICINE (Zydus Pharmaceuticals USA) |
|---|
| Formula |
C22H25NO6
|
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| Exact mass |
399.1682
|
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| Mol weight |
399.44
|
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| Structure |
|
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| Simcomp |
|
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| Source |
Colchicum autumnale [TAX: 45005]
|
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| Class |
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Transporter substrate
DG01665 ABCB1 substrate
|
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| Remark |
| Therapeutic category: | 3941 |
| Product (mixture): | D11574<US> |
|
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| Efficacy |
Gout suppressant, Leukocyte (neutrophil) migration inhibitor, Tubulin polymerization inhibitor |
|---|
| Disease |
Gout flares [DS: H01532] Familial mediterranean fever [DS: H00288] |
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
Transporter: ABCB1 [HSA: 5243]
|
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| Interaction |
|
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| Other map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M04 ANTIGOUT PREPARATIONS
M04A ANTIGOUT PREPARATIONS
M04AC Preparations with no effect on uric acid metabolism
M04AC01 Colchicine
D00570 Colchicine (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antigout Agents
Colchicine
D00570 Colchicine (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
394 Gout preparations
3941 Colchicines
D00570 Colchicine (JP18/USP)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00570 Colchicine
Transporter substrate
DG01665 ABCB1 substrate
D00570 Colchicine
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D00570 Colchicine (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00570 Colchicine
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00570
Drug transporters
D00570
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 C1x C 24.2475 -17.8137
2 C8y C 23.4044 -16.6895
3 C8y C 23.7557 -15.3545
4 C1x C 25.6528 -17.8137
5 C2y C 26.2852 -15.4247
6 C1y C 26.5662 -16.7597
7 C8y C 22.7018 -14.3708
8 C8y C 21.3668 -14.7924
9 C8y C 21.0155 -16.1274
10 C8x C 22.0695 -17.1111
11 O2a O 22.9829 -12.9655
12 O2a O 20.3832 -13.8087
13 O2a O 19.6805 -16.5489
14 C2y C 25.0493 -14.7557
15 C2x C 24.7813 -13.3322
16 C2x C 25.7259 -12.3957
17 C2y C 27.1392 -12.3715
18 C5x C 27.9503 -13.5297
19 C2x C 27.5618 -14.8375
20 C1a C 18.6440 -15.6000
21 C1a C 20.7468 -12.4513
22 C1a C 24.3140 -12.5152
23 O5x O 29.3583 -13.5117
24 O2a O 27.7924 -11.1650
25 C1a C 29.1660 -11.1268
26 N1b N 27.9266 -17.1119
27 C5a C 29.1058 -16.3874
28 C1a C 30.3325 -17.0465
29 O5a O 29.1329 -14.9842
BOND 31
1 1 4 1
2 2 3 1
3 4 6 1
4 1 2 1
5 5 6 1
6 3 7 2
7 7 8 1
8 8 9 2
9 9 10 1
10 2 10 2
11 7 11 1
12 8 12 1
13 9 13 1
14 16 17 2
15 17 18 1
16 15 16 1
17 5 19 2
18 14 15 2
19 18 19 1
20 3 14 1
21 14 5 1
22 13 20 1
23 12 21 1
24 11 22 1
25 18 23 2
26 17 24 1
27 24 25 1
28 6 26 1 #Up
29 26 27 1
30 27 28 1
31 27 29 2
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