| Entry |
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| Symbol |
TUBB2A, CDCBM5, TUBB, TUBB2
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| Name |
(RefSeq) tubulin beta 2A class IIa
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| KO |
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| Organism |
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| Pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Network |
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| Element |
| N00976 | Retrograde axonal transport |
| N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
| N00978 | Anterograde axonal transport |
| N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
| N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
| N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
| N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
| N01285 | Microtubule-RHOA signaling pathway |
| N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
| N01295 | Rab7-regulated microtubule minus-end directed transport |
| N01297 | Arl8-regulated microtubule plus-end directed transport |
| N01298 | Salmonella SifA to microtubule plus-end directed transport |
| N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
| N01403 | Zn to anterograde axonal transport |
| N01414 | Iron to anterograde axonal transport |
| N01535 | Kinetochore microtubule attachment |
| N01547 | Kinetochore fiber organization |
| N01549 | Branching microtubule nucleation |
| N01553 | Promotion of microtubule growth |
| N01561 | Microtubule depolymerization |
| N01562 | Microtubule depolymerization at the minus ends |
| N01832 | NTN1-MAP1B axon guidance signaling |
| N01833 | DRAXIN-MAP1B axon guidance signaling |
| N01834 | SEMA3A-MAP1B axon guidance signaling |
| N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
| N01836 | Microtubule plus end regulation network |
| N01837 | Regulation of neurite extension, NAV1-TRIO |
| N01838 | Regulation of synaptic plasticity, p140Cap |
| N01839 | Severing of microtubule, SPAST/KATN |
| N01840 | Severing of microtubule, KIF2A |
| N01841 | Anterograde axonal transport, Kinesin-2 |
| N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
| N01843 | Anterograde dendrite transport, Kinesin-4 |
| N01844 | Anterograde dendrite transport, Kinesin-6 |
| N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
| N01846 | Retrograde axonal/dendrite transport, Dynein |
| N01857 | SEMA3A-DCX axon guidance signaling |
| N01858 | EFNB1-MAPT axon guidance signaling |
| N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
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| Disease |
| H01881 | Complex cortical dysplasia with other brain malformations |
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| Drug target |
| Brentuximab vedotin: | D09587<JP/US> |
| Denintuzumab mafodotin: | D11232 |
| Enfortumab vedotin: | D11525<JP/US> |
| Farletuzumab ecteribulin: | D12183 |
| Lorvotuzumab mertansine: | D09927 |
| Mirvetuximab soravtansine: | D10954<US> |
| Tasidotin hydrochloride: | D06009 |
| Trastuzumab emtansine: | D09980<JP/US> |
| Tusamitamab ravtansine: | D12310 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
7280 (TUBB2A)
09142 Cell motility
04814 Motor proteins
7280 (TUBB2A)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
7280 (TUBB2A)
09164 Neurodegenerative disease
05010 Alzheimer disease
7280 (TUBB2A)
05012 Parkinson disease
7280 (TUBB2A)
05014 Amyotrophic lateral sclerosis
7280 (TUBB2A)
05016 Huntington disease
7280 (TUBB2A)
05020 Prion disease
7280 (TUBB2A)
05022 Pathways of neurodegeneration - multiple diseases
7280 (TUBB2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
7280 (TUBB2A)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
7280 (TUBB2A)
04147 Exosome [BR:hsa04147]
7280 (TUBB2A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
7280 (TUBB2A)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
7280 (TUBB2A)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
7280 (TUBB2A)
Exosomal proteins of colorectal cancer cells
7280 (TUBB2A)
Exosomal proteins of bladder cancer cells
7280 (TUBB2A)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
6:complement(3153666..3157544)
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| AA seq |
445 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA |
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| NT seq |
1338 nt +upstreamnt +downstreamnt
atgcgcgagatcgtgcacatccaggcgggccagtgcggcaaccagatcggcgccaagttt
tgggaggtcatcagcgatgagcatgggatcgaccccacaggcagttaccatggagacagt
gacttgcagctggagagaatcaacgtgtactacaatgaggctgctggtaacaaatatgta
cctcgggccatcctggtggatctggagcctggcaccatggactctgtcaggtctggaccc
ttcggccagatcttcagaccagacaacttcgtgttcggccagagtggagccgggaataac
tgggccaagggccactacacagagggagccgagctggtcgactcggtcctggatgtggtg
aggaaggagtcagagagctgtgactgtctccagggcttccagctgacccactctctgggg
ggcggcacggggtccgggatgggcaccctgctcatcagcaagatccgggaagagtaccca
gaccgcatcatgaacaccttcagcgtcatgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccaccctctctgtccaccagctggtggaaaacacagatgaaacctac
tccattgataacgaggccctgtatgacatctgcttccgcaccctgaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgcagacctgcgcaagctggcggtgaacatggtgcccttc
cctcgcctgcacttcttcatgcccggcttcgcgcccctgaccagccggggcagccagcag
taccgggcgctcacggtgcccgagctcacccagcagatgttcgactccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggctgccatcttccggggccgc
atgtccatgaaggaggtggacgagcagatgctcaacgtgcagaacaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatgtcggccaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgacgaacaaggggagttcgaggaggaggag
ggcgaggacgaggcttaa |
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