KEGG   DRUG: Tisotumab vedotin
Entry
D11814                      Drug                                   
Name
Tisotumab vedotin (USAN/INN);
Tisotumab vedotin (genetical recombination) (JAN);
Tisotumab vedotin-tftv;
Tivdak (TN)
Product
Formula
C6418H9906N1710O2022S44.(C68H106N11O15)n
Remark
Therapeutic category: 4291
ATC code: L01FX23
Product: D11814<US>
Efficacy
Antineoplastic
  Disease
Cervical cancer [DS:H00030]
  Type
Antibody-drug conjugate
Target
F3 (CD142, TF) [HSA:2152] [KO:K03901]
TUBB [HSA:10381 10382 10383 203068 347688 347733 7280 81027 84617] [KO:K07375]
  Pathway
hsa04540  Gap junction
hsa04610  Complement and coagulation cascades
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FX Other monoclonal antibodies and antibody drug conjugates
     L01FX23 Tisotumab vedotin
      D11814  Tisotumab vedotin (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Anti-Tissue Factor Antibodies
    Tisotumab Vedotin
     D11814  Tisotumab vedotin (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11814  Tisotumab vedotin (USAN/INN); Tisotumab vedotin (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F3 (CD142, TF)
     D11814  Tisotumab vedotin (USAN/INN) <US>
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D11814  Tisotumab vedotin (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11814
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11814
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11814
Other DBs
CAS: 1418731-10-8
PubChem: 405226679
LinkDB

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