KEGG   NETWORK: N01833
Entry
N01833                      Network                                
Name
DRAXIN-MAP1B axon guidance signaling
Definition
DRAXIN -> DCC -| AKT -| GSK3B -> MAP1B == (TUBA+TUBB)
  Expanded
374946 -> 1630 -| (207,208,10000) -| 2932 -> 4131 == ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06541 Cytoskeleton in neurons
Type
Reference
Gene
374946  DRAXIN; dorsal inhibitory axon guidance protein
1630  DCC; DCC netrin 1 receptor
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2932  GSK3B; glycogen synthase kinase 3 beta
4131  MAP1B; microtubule associated protein 1B
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Reference
PMID:34924953
  Authors
Sanchez-Huertas C, Herrera E
  Title
With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding.
  Journal
Front Mol Neurosci 14:759404 (2021)
DOI:10.3389/fnmol.2021.759404
Reference
PMID:25775433
  Authors
Meli R, Weisova P, Propst F
  Title
Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3beta (GSK-3beta) and microtubule-associated protein 1B.
  Journal
PLoS One 10:e0119524 (2015)
DOI:10.1371/journal.pone.0119524
Reference
PMID:34899198
  Authors
Ahmed G, Shinmyo Y
  Title
Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain.
  Journal
Front Neuroanat 15:766911 (2021)
DOI:10.3389/fnana.2021.766911
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