| Entry |
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| Name |
Hydrocortisone butyrate (JP18/USP);
Locoid (TN) |
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| Product |
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| Generic |
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| Formula |
C25H36O6
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| Exact mass |
432.2512
|
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| Mol weight |
432.55
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2646 |
| Product (DG00012): | D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP> D02288<US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
Atopic dermatitis [DS: H01358] Seborrheic dermatitis [DS: H01652] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
D07AB Corticosteroids, moderately potent (group II)
D07AB02 Hydrocortisone butyrate
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Medium Potency
Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D01619 Hydrocortisone butyrate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01619 Hydrocortisone butyrate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D01619 Hydrocortisone butyrate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone butyrate
D01619 Hydrocortisone butyrate (JP18/USP)
Second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone butyrate
D01619 Hydrocortisone butyrate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D01619 Hydrocortisone butyrate
Dermatological agent
DG03243 Atopic dermatitis agent
D01619 Hydrocortisone butyrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D01619 Hydrocortisone butyrate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01619 Hydrocortisone butyrate
Dermatological agent
DG03243 Atopic dermatitis agent
D01619 Hydrocortisone butyrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01619 Hydrocortisone butyrate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01619 Hydrocortisone butyrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01619
Topical steroids potency [br08317.html]
Classification in the USA
D01619
Classification in Japan
D01619
Rx-to-OTC switch list in Japan [br08314.html]
D01619
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 31
1 C1z C 23.4455 -15.4741
2 C1y C 23.4632 -16.8359
3 C1z C 24.6253 -14.7814
4 C1x C 22.2892 -14.7991
5 C1y C 22.3069 -17.5227
6 C1x C 25.8286 -16.8824
7 C1x C 25.8169 -15.4506
8 C5a C 24.6136 -13.4138
9 O7a O 25.9754 -14.4939
10 C1y C 21.0976 -15.4918
11 C1y C 21.1036 -16.8476
12 C1x C 22.3069 -18.8845
13 C1b C 25.8581 -12.7564
14 O5a O 23.3868 -12.7035
15 O1a O 19.8767 -14.7874
16 C1z C 19.9472 -17.5285
17 C1x C 21.1270 -19.5712
18 O1a O 27.0672 -13.5018
19 C2y C 19.9590 -18.8963
20 C1x C 18.7614 -16.8594
21 C2x C 18.7732 -19.5889
22 C1x C 17.5758 -17.5402
23 C5x C 17.5581 -18.9783
24 O5x O 16.3665 -19.6182
25 C7a C 27.1852 -15.1923
26 C1b C 28.3980 -14.4902
27 C1b C 29.6109 -15.1923
28 C1a C 30.8237 -14.4902
29 O6a O 27.1860 -16.5967
30 C1a C 23.3905 -14.2074
31 C1a C 19.9850 -16.2632
BOND 34
1 3 8 1 #Up
2 3 9 1 #Down
3 4 10 1
4 5 11 1
5 5 12 1
6 8 13 1
7 8 14 2
8 10 15 1 #Up
9 11 16 1
10 12 17 1
11 13 18 1
12 16 19 1
13 16 20 1
14 19 21 2
15 20 22 1
16 21 23 1
17 23 24 2
18 6 7 1
19 10 11 1
20 17 19 1
21 22 23 1
22 9 25 1
23 1 2 1
24 25 26 1
25 1 3 1
26 26 27 1
27 1 4 1
28 27 28 1
29 2 5 1
30 25 29 2
31 2 6 1
32 1 30 1 #Up
33 3 7 1
34 16 31 1 #Up
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