KEGG T01001: 2908

Homo sapiens (human): 2908

Entry

2908              CDS       T01001

Symbol

NR3C1, GCCR, GCR, GCRST, GR, GRL

Name

(RefSeq) nuclear receptor subfamily 3 group C member 1

K05771

glucocorticoid receptor

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Network

nt06310 CRH-ACTH-cortisol signaling

Element

N00924

Glucocorticoid receptor signaling pathway

Disease

H01702

Glucocorticoid resistance syndrome

Drug target

Alclometasone (DG00415):

D01820<JP/US> D07116

Amcinonide:

D01387<JP/US>

Beclometasone (DG00097):

D00689<JP/US> D07495 D11572<US>

Betamethasone (DG00095):

D00244<JP> D00972<JP> D01357<JP/US> D01402 D01637<JP/US> D02032<JP> D02286

Budesonide:

D00246<JP/US>

Ciclesonide:

D01703<JP/US>

Clobetasol (DG00422):

D01272<JP/US> D07715

Clobetasone (DG00411):

D01273<JP> D07717

Clocortolone (DG00416):

D02287<US> D03541 D07719

Cloprednol:

D03561

Cortisone (DG00509):

D00973<JP/US> D07749

Cortivazol:

D03594

Dagrocorat:

D10617

Dazucorilant:

D12638

Deflazacort:

D03671<US>

Deprodone propionate:

D01434<JP>

Descinolone acetonide:

D03691

Desonide:

D03696<US>

Desoximetasone:

D03697<US>

Dexamethasone (DG00011):

D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D02174 D02591 D02592 D07073<JP> D07796 D07797 D07798 D07799 D07800 D07801 D07802

Dichlorisone (DG02936):

D07814 D07815

Diflorasone (DG00418):

D01327<JP/US> D07827

Diflucortolone (DG00417):

D01764<JP> D03812 D03813

Difluprednate:

D01266<JP/US>

Exicorilant:

D11665

Fluclorolone:

D04201

Fludroxycortide:

D00328<JP/US>

Flumetasone (DG00412):

D01464 D04208

Flunisolide (DG01040):

D00324<US> D04214

Fluocinolone acetonide:

D01825<JP/US>

Fluocinonide:

D00325<JP/US>

Fluocortin (DG00413):

D04217 D07972

Fluocortolone (DG00295):

D04218 D04219 D07973

Fluorometholone (DG00294):

D01367<JP/US> D04221<US>

Flupamesone:

D07975

Fluprednidene (DG00414):

D07201 D07980

Fluprednisolone (DG02888):

D04227 D04228

Fluticasone (DG00420):

D01708<JP/US> D06315<JP/US> D07981

Formocortal:

D04244

Fosdagrocorat:

D10634

Halcinonide:

D01308<US>

Halometasone:

D07202

Halopredone (DG01376):

D01743 D08036

Hydrocortisone (DG00012):

D00088<JP/US> D00165<US> D00976 D00977<JP> D00978<JP/US> D01442 D01619<JP/US> D01886<JP> D02288<US> D04467 D06876 D09796

Loteprednol (DG01127):

D01689<US> D08147

Mapracorat:

D10136

Medrysone:

D02289

Meprednisone:

D06673

Methylprednisolone (DG00410):

D00407<JP/US> D00751<JP/US> D00979<JP/US> D05000 D05001 D05002 D07203

Mifepristone:

D00585<US>

Miricorilant:

D11667

Mometasone (DG00419):

D00690<JP/US> D03325<JP/US> D08227

Nivazol:

D05194

Paramethasone (DG00508):

D01229 D07464

Prednicarbate:

D05601

Prednisolone (DG00093):

D00472<JP/US> D00980<JP/US> D00981<JP/US> D00982 D01239<JP> D01998 D02156 D03301<JP> D08412 D08413 D08414 D08415

Prednisone (DG00094):

D00473<US> D08416

Prednival:

Prednylidene:

Proligestone:

Relacorilant:

Resocortol (DG01545):

D05719 D08476

Rimexolone:

D05729

Ticabesone propionate:

D06135

Tipredane:

D06161

Tixocortol (DG00096):

D06171 D08610

Tralonide:

D06201

Triamcinolone (DG00010):

D00385<JP> D00983<JP/US> D00984 D00985 D06216

Ulobetasol (DG00421):

D04409<US> D08660

Vamorolone:

D11000<US>

Velsecorat:

D11937

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2908 (NR3C1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2908 (NR3C1)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2908 (NR3C1)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    2908 (NR3C1)
Nuclear receptors [BR:hsa03310]
3. Estrogen like
  3C. 3-Ketosteroid receptor
   2908 (NR3C1)

SSDB

Motif

Pfam:

GCR Hormone_recep zf-C4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

5:complement(143277931..143435512)

AA seq 777 aa
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

NT seq 2334 nt +upstreamnt +downstreamnt
atggactccaaagaatcattaactcctggtagagaagaaaaccccagcagtgtgcttgct
caggagaggggagatgtgatggacttctataaaaccctaagaggaggagctactgtgaag
gtttctgcgtcttcaccctcactggctgtcgcttctcaatcagactccaagcagcgaaga
cttttggttgattttccaaaaggctcagtaagcaatgcgcagcagccagatctgtccaaa
gcagtttcactctcaatgggactgtatatgggagagacagaaacaaaagtgatgggaaat
gacctgggattcccacagcagggccaaatcagcctttcctcgggggaaacagacttaaag
cttttggaagaaagcattgcaaacctcaataggtcgaccagtgttccagagaaccccaag
agttcagcatccactgctgtgtctgctgcccccacagagaaggagtttccaaaaactcac
tctgatgtatcttcagaacagcaacatttgaagggccagactggcaccaacggtggcaat
gtgaaattgtataccacagaccaaagcacctttgacattttgcaggatttggagttttct
tctgggtccccaggtaaagagacgaatgagagtccttggagatcagacctgttgatagat
gaaaactgtttgctttctcctctggcgggagaagacgattcattccttttggaaggaaac
tcgaatgaggactgcaagcctctcattttaccggacactaaacccaaaattaaggataat
ggagatctggttttgtcaagccccagtaatgtaacactgccccaagtgaaaacagaaaaa
gaagatttcatcgaactctgcacccctggggtaattaagcaagagaaactgggcacagtt
tactgtcaggcaagctttcctggagcaaatataattggtaataaaatgtctgccatttct
gttcatggtgtgagtacctctggaggacagatgtaccactatgacatgaatacagcatcc
ctttctcaacagcaggatcagaagcctatttttaatgtcattccaccaattcccgttggt
tccgaaaattggaataggtgccaaggatctggagatgacaacttgacttctctggggact
ctgaacttccctggtcgaacagttttttctaatggctattcaagccccagcatgagacca
gatgtaagctctcctccatccagctcctcaacagcaacaacaggaccacctcccaaactc
tgcctggtgtgctctgatgaagcttcaggatgtcattatggagtcttaacttgtggaagc
tgtaaagttttcttcaaaagagcagtggaaggacagcacaattacctatgtgctggaagg
aatgattgcatcatcgataaaattcgaagaaaaaactgcccagcatgccgctatcgaaaa
tgtcttcaggctggaatgaacctggaagctcgaaaaacaaagaaaaaaataaaaggaatt
cagcaggccactacaggagtctcacaagaaacctctgaaaatcctggtaacaaaacaata
gttcctgcaacgttaccacaactcacccctaccctggtgtcactgttggaggttattgaa
cctgaagtgttatatgcaggatatgatagctctgttccagactcaacttggaggatcatg
actacgctcaacatgttaggagggcggcaagtgattgcagcagtgaaatgggcaaaggca
ataccaggtttcaggaacttacacctggatgaccaaatgaccctactgcagtactcctgg
atgtttcttatggcatttgctctggggtggagatcatatagacaatcaagtgcaaacctg
ctgtgttttgctcctgatctgattattaatgagcagagaatgactctaccctgcatgtac
gaccaatgtaaacacatgctgtatgtttcctctgagttacacaggcttcaggtatcttat
gaagagtatctctgtatgaaaaccttactgcttctctcttcagttcctaaggacggtctg
aagagccaagagctatttgatgaaattagaatgacctacatcaaagagctaggaaaagcc
attgtcaagagggaaggaaactccagccagaactggcagcggttttatcaactgacaaaa
ctcttggattctatgcatgaagtggttgaaaatctccttaactattgcttccaaacattt
ttggataagaccatgagtattgaattccccgagatgttagctgaaatcatcaccaatcag
ataccaaaatattcaaatggaaatatcaaaaaacttctgtttcatcaaaagtga

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