| Entry |
|
|---|
| Name |
Dexamethasone 21-acetate;
Dexamethasone acetate anhydrous;
Decaject-L.A. (TN) |
|---|
| Formula |
C24H31FO6
|
|---|
| Exact mass |
434.2105
|
|---|
| Mol weight |
434.50
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
|
|---|
| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07796 Dexamethasone 21-acetate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07796 Dexamethasone 21-acetate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07796 Dexamethasone 21-acetate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07796 Dexamethasone 21-acetate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07796 Dexamethasone 21-acetate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07796 Dexamethasone 21-acetate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07796 Dexamethasone 21-acetate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07796 Dexamethasone 21-acetate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07796 Dexamethasone 21-acetate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07796 Dexamethasone 21-acetate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07796 Dexamethasone 21-acetate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07796 Dexamethasone 21-acetate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07796 Dexamethasone 21-acetate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07796 Dexamethasone 21-acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07796 Dexamethasone 21-acetate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07796
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 31
1 C2x C 22.2600 -21.7000
2 C5x C 22.2600 -23.1000
3 C2x C 23.4500 -23.7300
4 C2y C 24.5700 -23.1000
5 C1z C 24.5700 -21.7000
6 C2x C 23.4500 -21.0700
7 C1x C 25.7600 -23.7300
8 C1x C 26.9500 -23.1000
9 C1y C 26.9500 -21.7000
10 C1z C 25.7600 -21.0700
11 C1y C 28.1400 -21.0700
12 C1z C 28.1400 -19.6700
13 C1x C 26.9500 -19.0400
14 C1y C 25.7600 -19.6700
15 C1x C 30.4500 -21.0700
16 C1y C 30.4500 -19.6700
17 C1z C 29.3300 -19.0400
18 C1a C 24.5700 -20.3700
19 O1a O 24.6400 -19.0400
20 C1a C 28.1400 -18.3400
21 C1a C 31.6400 -19.0400
22 C5a C 29.3300 -17.2900
23 X F 25.7600 -22.4000
24 O1a O 30.4500 -18.1300
25 O5x O 21.0700 -23.7300
26 O5a O 30.4500 -16.6600
27 C1b C 28.1400 -16.6600
28 O7a O 26.9500 -17.2900
29 C7a C 25.7600 -16.5900
30 C1a C 24.5700 -17.2900
31 O6a O 25.7600 -15.1900
BOND 34
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 5 18 1 #Up
22 14 19 1 #Up
23 12 20 1 #Up
24 16 21 1 #Down
25 17 22 1 #Up
26 10 23 1 #Down
27 17 24 1 #Down
28 2 25 2
29 22 26 2
30 22 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 29 31 2
|
|---|
