| Entry |
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| Name |
Methylprednisolone sodium phosphate (USAN) |
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| Formula |
C22H29O8P. 2Na
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| Exact mass |
498.1395
|
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| Mol weight |
498.41
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG00410): | D00407<JP/US> D00751<JP/US> D00979<JP/US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA01 Methylprednisolone
D05001 Methylprednisolone sodium phosphate (USAN)
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA02 Methylprednisolone
D05001 Methylprednisolone sodium phosphate (USAN)
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB04 Methylprednisolone
D05001 Methylprednisolone sodium phosphate (USAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
D05001 Methylprednisolone sodium phosphate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
D05001 Methylprednisolone sodium phosphate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D05001 Methylprednisolone sodium phosphate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05001
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 C2x C 26.6700 -18.6900
2 C5x C 26.6700 -20.0900
3 C2x C 27.8600 -20.7900
4 C2y C 29.1200 -20.0900
5 C1z C 29.1200 -18.6900
6 C2x C 27.8600 -17.9900
7 C1y C 30.3100 -20.7900
8 C1x C 31.5000 -20.0900
9 C1y C 31.5000 -18.6900
10 C1y C 30.3100 -17.9900
11 C1y C 32.7600 -17.9900
12 C1z C 32.7600 -16.5900
13 C1x C 31.5000 -15.8900
14 C1y C 30.3100 -16.5900
15 C1x C 35.1400 -17.9900
16 C1x C 35.1400 -16.5900
17 C1z C 33.9500 -15.8900
18 O5x O 25.4800 -20.7900
19 C1a C 29.1200 -17.2900
20 O1a O 29.1200 -15.8900
21 C1a C 32.7600 -15.1900
22 C5a C 33.9500 -14.2100
23 C1a C 30.3100 -22.1900
24 O1a O 35.1400 -15.1900
25 C1b C 35.1400 -13.5100
26 O5a O 32.7600 -13.5100
27 O2b O 36.3300 -14.2100
28 P1b P 37.5200 -13.5100
29 O1c O 38.7324 -12.8100 #-
30 O1c O 36.8151 -12.3004
31 O1c O 38.2249 -14.7196 #-
32 Z Na 40.1800 -12.8800 #+
33 Z Na 39.7600 -14.7700 #+
BOND 34
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 17 22 1 #Up
26 7 23 1 #Down
27 17 24 1 #Down
28 22 25 1
29 22 26 2
30 25 27 1
31 27 28 1
32 28 29 1
33 28 30 2
34 28 31 1
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