| Entry |
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| Name |
Dexamethasone phenylpropionate;
Dexafort [veterinary] (TN) |
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| Formula |
C31H37FO6
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| Exact mass |
524.2574
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| Mol weight |
524.62
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07801 Dexamethasone phenylpropionate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07801 Dexamethasone phenylpropionate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07801 Dexamethasone phenylpropionate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07801 Dexamethasone phenylpropionate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07801 Dexamethasone phenylpropionate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07801 Dexamethasone phenylpropionate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07801 Dexamethasone phenylpropionate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07801 Dexamethasone phenylpropionate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07801 Dexamethasone phenylpropionate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07801 Dexamethasone phenylpropionate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07801 Dexamethasone phenylpropionate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07801 Dexamethasone phenylpropionate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07801 Dexamethasone phenylpropionate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07801 Dexamethasone phenylpropionate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07801 Dexamethasone phenylpropionate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07801
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 38
1 C2x C 18.4100 -23.8700
2 C5x C 18.4100 -25.2000
3 C2x C 19.6700 -25.9000
4 C2y C 20.8600 -25.2000
5 C1z C 20.8600 -23.8700
6 C2x C 19.6700 -23.2400
7 C1x C 21.9800 -25.9000
8 C1x C 23.1700 -25.2000
9 C1y C 23.1700 -23.8700
10 C1z C 21.9800 -23.2400
11 C1y C 24.3600 -23.2400
12 C1z C 24.3600 -21.8400
13 C1x C 23.1700 -21.2100
14 C1y C 21.9800 -21.8400
15 C1x C 26.7400 -23.2400
16 C1y C 26.7400 -21.8400
17 C1z C 25.5500 -21.2100
18 O1a O 26.5300 -20.2300
19 X F 21.9800 -24.5000
20 O5x O 17.2900 -25.9000
21 C1a C 24.3600 -20.5100
22 C1a C 20.8600 -22.5400
23 O1a O 21.0700 -20.9300
24 C1a C 28.1400 -21.2800
25 C5a C 25.5500 -19.3900
26 O5a O 24.3600 -18.6900
27 C1b C 26.7400 -18.6900
28 O7a O 27.9300 -19.3900
29 C7a C 29.1900 -18.6900
30 C1b C 30.3100 -19.3900
31 O6a O 29.1900 -17.2900
32 C1b C 31.5700 -18.6900
33 C8y C 32.7600 -19.3900
34 C8x C 32.7486 -20.7900
35 C8x C 33.9553 -21.4998
36 C8x C 35.1734 -20.8097
37 C8x C 35.1148 -19.4097
38 C8x C 33.9781 -18.6999
BOND 42
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 15 16 1
18 16 17 1
19 12 17 1
20 17 18 1 #Down
21 10 19 1 #Down
22 2 20 2
23 11 15 1
24 12 21 1 #Up
25 5 22 1 #Up
26 14 23 1 #Up
27 16 24 1 #Down
28 25 26 2
29 17 25 1 #Up
30 25 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 29 31 2
35 30 32 1
36 32 33 1
37 33 34 2
38 34 35 1
39 35 36 2
40 36 37 1
41 37 38 2
42 33 38 1
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